[go: up one dir, main page]

WO2007048100A3 - Angio-inhibitory peptides derived from human timp-2 - Google Patents

Angio-inhibitory peptides derived from human timp-2 Download PDF

Info

Publication number
WO2007048100A3
WO2007048100A3 PCT/US2006/060059 US2006060059W WO2007048100A3 WO 2007048100 A3 WO2007048100 A3 WO 2007048100A3 US 2006060059 W US2006060059 W US 2006060059W WO 2007048100 A3 WO2007048100 A3 WO 2007048100A3
Authority
WO
WIPO (PCT)
Prior art keywords
angio
peptides derived
inhibitory peptides
human timp
proteins
Prior art date
Application number
PCT/US2006/060059
Other languages
French (fr)
Other versions
WO2007048100A2 (en
Inventor
William G Stetler-Stevenson
Dong-Wan Seo
Original Assignee
Us Gov Health & Human Serv
William G Stetler-Stevenson
Dong-Wan Seo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, William G Stetler-Stevenson, Dong-Wan Seo filed Critical Us Gov Health & Human Serv
Publication of WO2007048100A2 publication Critical patent/WO2007048100A2/en
Publication of WO2007048100A3 publication Critical patent/WO2007048100A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides proteins and polypeptides with anti-angiogenic activity. The proteins may be prepared by recombinant or other synthetic means and may be formulated in compositions as needed to facilitate their use. The invention further provides methods of inhibiting or reducing angiogenesis as well as the treatment of angiogenesis mediated diseases.
PCT/US2006/060059 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2 WO2007048100A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72814605P 2005-10-18 2005-10-18
US60/728,146 2005-10-18

Publications (2)

Publication Number Publication Date
WO2007048100A2 WO2007048100A2 (en) 2007-04-26
WO2007048100A3 true WO2007048100A3 (en) 2008-02-07

Family

ID=37963410

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/060059 WO2007048100A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2
PCT/US2006/060061 WO2007048102A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060061 WO2007048102A2 (en) 2005-10-18 2006-10-18 Angio-inhibitory peptides derived from human timp-2

Country Status (1)

Country Link
WO (2) WO2007048100A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1222180A1 (en) * 2013-08-07 2017-06-23 阿斯图特医药公司 Assays for timp2 having improved performance in biological samples
WO2018187453A1 (en) 2017-04-05 2018-10-11 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011287A1 (en) * 1989-03-21 1990-10-04 The United States Of America, Represented By The Secretary, United States Department Of Commerce Matrix metalloproteinase inhibitor peptides
WO2003057884A1 (en) * 2002-01-08 2003-07-17 Leadbio Inc. Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein
WO2004060275A2 (en) * 2002-12-19 2004-07-22 Kimberly-Clark Worldwide, Inc. Wound care compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011287A1 (en) * 1989-03-21 1990-10-04 The United States Of America, Represented By The Secretary, United States Department Of Commerce Matrix metalloproteinase inhibitor peptides
WO2003057884A1 (en) * 2002-01-08 2003-07-17 Leadbio Inc. Human serum albumin-timp2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-timp2 fusion protein
WO2004060275A2 (en) * 2002-12-19 2004-07-22 Kimberly-Clark Worldwide, Inc. Wound care compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FERNANDEZ CECILIA A ET AL: "Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2). Loop 6 is a novel angiogenesis inhibitor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 42, 17 October 2003 (2003-10-17), pages 40989 - 40995, XP002435349, ISSN: 0021-9258 *
SEO D-W ET AL: "TIMP-2 mediated inhibition of angiogenesis: An MMP-independent mechanism", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 114, no. 2, 25 July 2003 (2003-07-25), pages 171 - 180, XP002313229, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
WO2007048102A2 (en) 2007-04-26
WO2007048100A2 (en) 2007-04-26
WO2007048102A3 (en) 2007-12-27

Similar Documents

Publication Publication Date Title
WO2008101985A3 (en) Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
WO2007044534A3 (en) Vegf analogs and methods of use
WO2011123830A3 (en) Alpha 1-antitrypsin compositions and methods of making and using same
WO2011084808A3 (en) Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
CR20140465A (en) PROTEINS OF UNION TO INTERLEUQUINA-13
WO2012058393A3 (en) Dkk1 antibodies and methods of use
TN2012000372A1 (en) Fibronectin based scaffold domain proteins that bind il-23
ZA201001054B (en) Peptide with reduced dimer formation
WO2010130830A3 (en) Anti-sclerostin vhh and their use for treating bone diseases
WO2011036442A3 (en) Thrombin c- terminal polypeptides and uses thereof for treating inflammation coagulation disorders
IN2012DN03368A (en)
WO2006113681A3 (en) Plant-derived elastin binding protein ligands and methods of using the same
MX2010002716A (en) Neuroendocrine factors for treatment of degenerative diseases.
DE602008002693D1 (en) VACCINE PEPTIDE COMBINATIONS AGAINST CATERING ALLERGY
DE602007010764D1 (en) Benzamidglucokinaseaktivatoren
WO2010014830A3 (en) Peptide therapeutics that bind vegf and methods of use thereof
MX2010002769A (en) Recombinant preparation of selected bromelain fractions.
MX2009007085A (en) Microvesicles derived from recombinant yeast having haemostatic activities and uses thereof.
EP2388317A4 (en) Gene coding for human glucocaine mutant, enzyme encoded therewith, recombinant vectors and hosts, pharmaceutical compositions and their use, methods for the treatment and prevention of diseases
WO2008040190A8 (en) Small peptides for anti-angiogenesis and use thereof
WO2011115456A3 (en) Tnf-α and tweak dual antagonist for the prophylaxis and treatment of autoimmune diseases
WO2007100874A3 (en) Compositions containing peptides with non-natural amino acids and methods of use
WO2009130615A3 (en) Use of deuterium oxide as an elastase inhibitor
ATE457736T1 (en) COMPOSITION OF A PULMONARY SURFACTANT AND A PEPTIDE DERIVED FROM TNF
MX365560B (en) Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses.

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06839464

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06839464

Country of ref document: EP

Kind code of ref document: A2