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WO2007066189A3 - Sels, promedicaments et formulations de 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-uree - Google Patents

Sels, promedicaments et formulations de 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-uree Download PDF

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Publication number
WO2007066189A3
WO2007066189A3 PCT/IB2006/003416 IB2006003416W WO2007066189A3 WO 2007066189 A3 WO2007066189 A3 WO 2007066189A3 IB 2006003416 W IB2006003416 W IB 2006003416W WO 2007066189 A3 WO2007066189 A3 WO 2007066189A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
pyrrolo
prodrugs
dichloro
pyrimidine
Prior art date
Application number
PCT/IB2006/003416
Other languages
English (en)
Other versions
WO2007066189A2 (fr
Inventor
Tracy Lee Boyden
Feng Guo
Susan Deborah Lagreca
Douglas Alan Lorenz
Ravi Mysore Shanker
Franzanne Vreeland
Original Assignee
Pfizer Prod Inc
Tracy Lee Boyden
Feng Guo
Susan Deborah Lagreca
Douglas Alan Lorenz
Ravi Mysore Shanker
Franzanne Vreeland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Tracy Lee Boyden, Feng Guo, Susan Deborah Lagreca, Douglas Alan Lorenz, Ravi Mysore Shanker, Franzanne Vreeland filed Critical Pfizer Prod Inc
Publication of WO2007066189A2 publication Critical patent/WO2007066189A2/fr
Publication of WO2007066189A3 publication Critical patent/WO2007066189A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des composés représentés par la formule (I) ou leur sel pharmaceutiquement acceptable, leur promédicament ou leurs hydrates. L'invention concerne également des compositions pharmaceutiques contenant les composés représentés par la formule 1 et des méthodes de traitement de troubles hyperprolifératifs chez un mammifère consistant à administrer les composés représentés par la formule (I).
PCT/IB2006/003416 2005-12-09 2006-11-24 Sels, promedicaments et formulations de 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-uree WO2007066189A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74907005P 2005-12-09 2005-12-09
US60/749,070 2005-12-09

Publications (2)

Publication Number Publication Date
WO2007066189A2 WO2007066189A2 (fr) 2007-06-14
WO2007066189A3 true WO2007066189A3 (fr) 2008-08-14

Family

ID=38123252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003416 WO2007066189A2 (fr) 2005-12-09 2006-11-24 Sels, promedicaments et formulations de 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-uree

Country Status (8)

Country Link
AR (1) AR058293A1 (fr)
DO (1) DOP2006000271A (fr)
GT (1) GT200600496A (fr)
NL (1) NL2000337A1 (fr)
PE (1) PE20071037A1 (fr)
TW (1) TW200733965A (fr)
UY (1) UY29991A1 (fr)
WO (1) WO2007066189A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9321772B2 (en) 2011-09-02 2016-04-26 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US10131668B2 (en) 2012-09-26 2018-11-20 The Regents Of The University Of California Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1

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TW200922549A (en) * 2007-10-19 2009-06-01 Abbott Gmbh & Amp Co Kg Solid dispersion product containing N-aryl urea-based compound
EP2197425A2 (fr) * 2007-10-19 2010-06-23 Abbott GmbH & Co. KG Produit de dispersion solide de médicaments de type n-aryle à base d'urée
AU2009305669A1 (en) * 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
BR112012016376A2 (pt) 2009-12-30 2019-09-24 Arqule Inc compostos de pirrolo-aminopirimida substituída
EP2585048B1 (fr) * 2010-06-23 2018-04-11 CymaBay Therapeutics, Inc. Compositions de 5-éthyl-2-{4-[4-(4-tétrazol-1-yl-phénoxyméthyl)-thiazol-2-yl]-pipéridin-1-yl}-pyrimidine
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
US20140004192A1 (en) * 2012-04-13 2014-01-02 Ziopharm Oncology, Inc. Pharmaceutical formulations of indibulin and uses thereof
ES2618003T3 (es) 2012-06-13 2017-06-20 Incyte Holdings Corporation Compuestos tricíclicos sustituidos como inhibidores de FGFR
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
PT2986610T (pt) 2013-04-19 2018-03-09 Incyte Holdings Corp Heterociclos bicíclicos como inibidores de fgfr
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
KR102632018B1 (ko) 2015-02-20 2024-02-02 인사이트 홀딩스 코포레이션 Fgfr 저해제로서의 이환식 복소환
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN107722012B (zh) * 2016-08-11 2020-05-29 斯福瑞（南通）制药有限公司 制备4-氯-7H-吡咯并[2,3-d]嘧啶的方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (fr) 2019-07-09 2021-01-14 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
PH12022550892A1 (en) 2019-10-14 2023-05-03 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
CA3162010A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Derives d'un inhibiteur de fgfr
JP7720840B2 (ja) 2019-12-04 2025-08-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
WO2021146424A1 (fr) 2020-01-15 2021-07-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
WO2022261160A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
JP2024522188A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式ヘテロ環
JP2025015449A (ja) * 2023-07-18 2025-01-30 信越化学工業株式会社 固体分散体用組成物、固体分散体及び固体分散体の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901786A2 (fr) * 1997-08-11 1999-03-17 Pfizer Products Inc. Dispersions solides pharmaceutiques à biodisponibilité accrue
WO2004056830A1 (fr) * 2002-12-19 2004-07-08 Pfizer Products Inc. Derives de pyrrolopyrimidine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901786A2 (fr) * 1997-08-11 1999-03-17 Pfizer Products Inc. Dispersions solides pharmaceutiques à biodisponibilité accrue
WO2004056830A1 (fr) * 2002-12-19 2004-07-08 Pfizer Products Inc. Derives de pyrrolopyrimidine

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9321772B2 (en) 2011-09-02 2016-04-26 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US9895373B2 (en) 2011-09-02 2018-02-20 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US10131668B2 (en) 2012-09-26 2018-11-20 The Regents Of The University Of California Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1
US10822340B2 (en) 2012-09-26 2020-11-03 The Regents Of The University Of California Substituted imidazolopyrazine compounds and methods of using same
US11613544B2 (en) 2012-09-26 2023-03-28 The Regents Of The University Of California Substituted imidazo[1,5-a]pyrazines for modulation of IRE1

Also Published As

Publication number Publication date
NL2000337A1 (nl) 2007-06-12
DOP2006000271A (es) 2007-08-15
PE20071037A1 (es) 2007-11-19
GT200600496A (es) 2007-07-17
TW200733965A (en) 2007-09-16
AR058293A1 (es) 2008-01-30
WO2007066189A2 (fr) 2007-06-14
UY29991A1 (es) 2007-07-31

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