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WO2007012000A3 - Classifier for particles in a liquid using a large-orifice droplet ejector - Google Patents

Classifier for particles in a liquid using a large-orifice droplet ejector Download PDF

Info

Publication number
WO2007012000A3
WO2007012000A3 PCT/US2006/028014 US2006028014W WO2007012000A3 WO 2007012000 A3 WO2007012000 A3 WO 2007012000A3 US 2006028014 W US2006028014 W US 2006028014W WO 2007012000 A3 WO2007012000 A3 WO 2007012000A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid sample
particles
liquid
droplets
interest
Prior art date
Application number
PCT/US2006/028014
Other languages
French (fr)
Other versions
WO2007012000A2 (en
Inventor
Steven Clyde Hill
Richard Kounai Chang
Hermes Chi-Yuan Huang
Yongle Pan
Original Assignee
Steven Clyde Hill
Richard Kounai Chang
Hermes Chi-Yuan Huang
Yongle Pan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steven Clyde Hill, Richard Kounai Chang, Hermes Chi-Yuan Huang, Yongle Pan filed Critical Steven Clyde Hill
Publication of WO2007012000A2 publication Critical patent/WO2007012000A2/en
Publication of WO2007012000A3 publication Critical patent/WO2007012000A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G01N15/1492—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties within droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1481—Optical analysis of particles within droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A classifier for particles in liquid for enumerating particles of interest in a liquid sample according to an optical property of the particles of interest, which includes: (a) a large-orifice droplet ejector that holds the liquid sample and ejects droplets of the liquid sample, wherein the droplets of the liquid sample ejected are at least several times smaller than any orifice surrounding the liquid sample at the liquid-air interface, so that clogging of the orifice by particles that are in the liquid sample is minimized, and (b) an airborne-droplet measurement subsystem that measures an optical property of each of these droplets of the liquid sample, so that the optical property of any particles of interest in the droplets of the liquid sample can be estimated from this measured optical property. Because the droplets of the liquid sample can be very small, the particles of interest can be measured with high sensitivity, one at a time, as in flow cytometry, with small chance of clogging the device even though no sheath flow is used.
PCT/US2006/028014 2005-07-19 2006-07-19 Classifier for particles in a liquid using a large-orifice droplet ejector WO2007012000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70079605P 2005-07-19 2005-07-19
US60/700,796 2005-07-19

Publications (2)

Publication Number Publication Date
WO2007012000A2 WO2007012000A2 (en) 2007-01-25
WO2007012000A3 true WO2007012000A3 (en) 2008-12-04

Family

ID=37669542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/028014 WO2007012000A2 (en) 2005-07-19 2006-07-19 Classifier for particles in a liquid using a large-orifice droplet ejector

Country Status (1)

Country Link
WO (1) WO2007012000A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3409377A4 (en) 2016-01-26 2019-06-26 Ricoh Company, Ltd. DROPLET FORMING DEVICE AND DISTRIBUTOR DEVICE

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6827287B2 (en) * 2002-12-24 2004-12-07 Palo Alto Research Center, Incorporated High throughput method and apparatus for introducing biological samples into analytical instruments
US20050127206A1 (en) * 2003-12-10 2005-06-16 Xerox Corporation Device and system for dispensing fluids into the atmosphere

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6827287B2 (en) * 2002-12-24 2004-12-07 Palo Alto Research Center, Incorporated High throughput method and apparatus for introducing biological samples into analytical instruments
US20050127206A1 (en) * 2003-12-10 2005-06-16 Xerox Corporation Device and system for dispensing fluids into the atmosphere

Also Published As

Publication number Publication date
WO2007012000A2 (en) 2007-01-25

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DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
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