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WO2007030009A2 - Revetement de reduction du frottement - Google Patents

Revetement de reduction du frottement Download PDF

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Publication number
WO2007030009A2
WO2007030009A2 PCT/NL2006/050142 NL2006050142W WO2007030009A2 WO 2007030009 A2 WO2007030009 A2 WO 2007030009A2 NL 2006050142 W NL2006050142 W NL 2006050142W WO 2007030009 A2 WO2007030009 A2 WO 2007030009A2
Authority
WO
WIPO (PCT)
Prior art keywords
iol
parylene
insertion device
coating
friction
Prior art date
Application number
PCT/NL2006/050142
Other languages
English (en)
Other versions
WO2007030009A3 (fr
Inventor
Bernardus Franciscus Maria Wanders
Original Assignee
Procornea Nederland B. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procornea Nederland B. V. filed Critical Procornea Nederland B. V.
Priority to EP06824305A priority Critical patent/EP1906880A2/fr
Publication of WO2007030009A2 publication Critical patent/WO2007030009A2/fr
Publication of WO2007030009A3 publication Critical patent/WO2007030009A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1675—Instruments for inserting intraocular lenses into the eye with a lubricated inner surface, e.g. the lubricant being coated on the inner surface or being injected through a port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A61F2/1678—Instruments for inserting intraocular lenses into the eye with a separate cartridge or other lens setting part for storage of a lens, e.g. preloadable for shipping

Definitions

  • the present invention relates to an assembly comprising an insertion device
  • the insertion device comprises an insertion tip with insertion channel and a folding construction adjacent thereto, wherein in said folding construction a receptacle for said IOL is delimited, wherein said IOL is placed in said receptacle.
  • An assembly of this type is generally known in the state of the art. In this case the
  • IOL is stored in the position for use as far as possible. This may be either in the insertion device or in a separate holder. During use the IOL is rolled up with the aid of the wings and can then be moved into the eye through the channel in the insertion tip by means of, for example, a plunger which is part of an injector, which may or may not be separate. Because there is considerable friction between the IOL and the insertion device and damage to the IOL must be prevented under all circumstances, it is proposed in the state of the art to use a lubricant, whereby movement of the IOL in the channel of the insertion device is made easier.
  • WO 99/21513 describes an assembly of an IOL and an insertion device.
  • the insertion device has a flexible, deformable sleeve in which the IOL is stored in a liquid.
  • the IOL is brought out of the sleeve for insertion into an eye by pinching together the deformable sleeve, as a result of which the IOL is driven out of the sleeve with the liquid.
  • the flexible, deformable sleeve is preferably made of PTFE and is provided with a friction-reducing layer on the inside.
  • WO 99/21514 describes an assembly of an IOL and an insertion device, wherein the IOL is put into a sleeve of the insertion device with the aid of a guide.
  • Both the guide and the sleeve are made of flexible, defo ⁇ nable and smooth polymer material such as PTFE and are provided with friction-reducing material on the inside.
  • US Al 2004/267359 describes an assembly of an IOL and an insertion device.
  • the insertion device has a folding part where the IOL is folded by folding together two hinged parts.
  • the insertion device furthermore has an insertion channel through which the IOL is fed in order to insert it into an eye.
  • the insertion device is made of polypropylene and the insertion channel is provided on an inner wall with a lubricating layer of hydrophilic material covalently bonded thereto.
  • WO 01/10352 and WO 96/22062 describe the use of such a covalently bonded coating layer.
  • the aim of the present invention is to avoid the disadvantages described above and to provide an assembly where it is possible to fit an IOL ready for immediate use without further measures.
  • a further aim is to improve the insertion of the IOL.
  • a further aim is to provide an IOL and insertion device which are easier to tolerate.
  • a further aim is to provide an assembly which is simpler and cheaper to produce. This aim is achieved with an assembly described above in that a friction-reducing coating is applied to the contact surface between IOL and said receptacle.
  • a friction-reducing coating is applied to the contact surface between IOL and said receptacle.
  • the coating can be applied to either the insertion device or the lens in advance. Moreover, by using such a coating or coating layer more freedom arises in the choice of the plastics material for the IOL.
  • the coating layer is hydrophobic.
  • the folding construction is a winged construction with two wings connected to one another in a hinged manner.
  • the insertion channel and the insertion tip are rigid, that is to say rigid enough to insert the insertion channel into an eye.
  • Such a friction-reducing coating according to the invention can be any coating known in the state of the art which gives reduced friction under the conditions during insertion of a lens into the human body.
  • a lubricant or lubricating jelly is desirable because the properties of the IOL are primarily determined by subsequent use in the eye. Particularly with hydrophobic IOLs it has been found that they have a very high friction coefficient, making it difficult to move them through the insertion part, with all the associated problems.
  • the friction-reducing coating layer to the IOL, which moreover has a number of other advantages mentioned in this patent application, the IOL is not only easier to insert, but other advantages are also attained.
  • the coating layer is applied by means of vapour deposition polymerisation (VDP).
  • VDP vapour deposition polymerisation
  • a layer obtained in this way is also often known as synthetic metarial applied under vacuum or vacuum deposited plastic.
  • the coating consists of parylene or polyparaxylylene.
  • parylene such as parylene type N, C, D or HT. It will be understood that combinations can be used as desired for providing the coating on either the insertion device or the lens.
  • the coating is applied to the insertion device, it is obviously applied to the boundary wall between insertion device and lens.
  • the surface of this boundary wall can even be decreased by providing the receptacle with elevations for supporting the IOL. Consequently the surface where friction occurs between the IOL and the receptacle is decreased.
  • the elevation comprises a rib which extends in the receptacle towards the insertion channel. That is to say the rib extends in an insertion direction from proximal to distal direction .
  • the parylene layer which is completely sealed. Moreover, it is possible to regulate the thickness thereof very precisely during application. A range of between 100 nm and 20 ⁇ m and more, in particular between 0.5 and 5 ⁇ m, is mentioned as an example of the thickness. Since the parylene layer can form a complete seal it is possible when it is used on the IOL to make this IOL from a material which is not (completely) biocompatible. The same applies to the insertion device or cartridge. There is no longer a risk of material from the cartridge ending up in the eye.
  • the outer surface of the insertion device is for this purpose also at least partially to be provided with a coating layer, preferably a parylene coating layer.
  • the outside of an insertion channel of the insertion device is provided with a coating layer of this type, in particular a sealing coating layer. Because of this the material of the insertion device virtually does not come into contact with the eye.
  • parylene material can be applied in any way known in the state of the art.
  • parylene material is applied to either the insertion device or the IOL by vapour deposition polymerisation.
  • this pre-cursor is vaporised. This is done at a temperature of 120 - 180 0 C.
  • a pyrolysis reaction then takes place at a temperature of between 650 0 C and 700 0 C.
  • the vaporised dimer changes into a monomer gas.
  • This monomer gas is then deposited on the part concerned in a PVD chamber. This is preferably done at room temperature at a reduced pressure of 50 mtorr, for example. It will be understood that parylene derivative coatings should also be regarded as parylene.
  • Fig. 1 shows an insertion device in opened state for receiving an IOL, also drawn
  • Fig.2 shows the assembly of insertion device and IOL.
  • Fig. 1 20 indicates an assembly consisting of an insertion device 1 and an IOL 10.
  • Said IOL 10 is provided with haptics 11.
  • the insertion device 1 consists of an insertion tip 2 provided with an internal insertion channel 8. Upstream therefrom are two wings 3 and 4, which can move towards one another according to a hinge line 5 and delimit a receptacle 7 between them. There are ribs 6 in the receptacle 7 extending over the entire length thereof.
  • Fig. 2 shows the state where the lens has been rolled up into the desired position with the aid of the wings and possibly the other removable aids and has to be displaced through the channel 8 in the direction of the arrow with the aid of a plunger of an integrated or separate injector.
  • both parts can be provided with a friction-reducing coating and this coating comprises in particular polyparaxylylene (parylene).
  • Parylene in particular is found to be favourable because a layer can be made with it which is bio-inert for the eye in particular. Besides, the layer can be excellently defined and a closed layer can be formed.
  • the provision of the coating layer on an IOL is found to be a favourable in preventing so-called secondary cataract.
  • the insertion device By using a parylene coating in the insertion device the latter can be injection- moulded from a cheaper material, for example normal injection-mouldable polypropene instead of Class VI approved PP for medical applications) .
  • the insertion tip 2 In this case the outside of the insertion channel, the insertion tip 2, can also be provided with the coating layer.
  • a favourable embodiment can be achieved by providing the entire insertion device with a virtually completely enveloping coating layer. It is also conceivable to apply a similar coating layer by means of a plasma technique.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

On décrit un ensemble constitué d'un dispositif d'insertion et d'une LIO, l'un et/ou l'autre étant muni(s) d'un revêtement de réduction du frottement. Ce revêtement comprend un matériau en parylène appliqué en couche sur le produit visé, si bien que la LIO peut être déplacée plus facilement dans l'oeil à travers le dispositif d'insertion. Comme le matériau en parylène assure une étanchéité complète, son application sur la LIO offre le choix de la matière pour la LIO, de sorte que celui-ci ne dépende plus uniquement des propriétés de biocompatibilité, ce qui permet d'utiliser le plastique qui n'est pas biocompatible. En variante, un matériau très hydrophobe est utilisé. L'invention concerne en outre un procédé qui permet d'enrober une LIO ou un dispositif d'insertion (cartouche) d'un matériau en parylène.
PCT/NL2006/050142 2005-06-21 2006-06-21 Revetement de reduction du frottement WO2007030009A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06824305A EP1906880A2 (fr) 2005-06-21 2006-06-21 Revetement de reduction du frottement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1029301A NL1029301C2 (nl) 2005-06-21 2005-06-21 Wrijving verminderende bekleding.
NL1029301 2005-06-21

Publications (2)

Publication Number Publication Date
WO2007030009A2 true WO2007030009A2 (fr) 2007-03-15
WO2007030009A3 WO2007030009A3 (fr) 2008-05-02

Family

ID=36046746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2006/050142 WO2007030009A2 (fr) 2005-06-21 2006-06-21 Revetement de reduction du frottement

Country Status (3)

Country Link
EP (1) EP1906880A2 (fr)
NL (1) NL1029301C2 (fr)
WO (1) WO2007030009A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2111822A2 (fr) 2008-04-21 2009-10-28 Oculentis B.V. Lentille intraoculaire avec une optique torique
WO2013117863A1 (fr) 2012-02-07 2013-08-15 Polymerexpert Sa Composition polymeres metastables pour dispositifs d'injection d'implants ophtalmiques
JP2017113289A (ja) * 2015-12-22 2017-06-29 美樺興業股▲ふん▼有限公司Ｍａｙ−Ｈｗａ Ｅｎｔｅｒｐｒｉｓｅ Ｃｏｒｐｏｒａｔｉｏｎ 眼内レンズ及びその製造方法
WO2022112730A1 (fr) 2020-11-30 2022-06-02 Polymerexpert Sa Polymère apte à former un revêtement glissant pour injecteur ophtalmique
FR3148372A1 (fr) 2023-05-05 2024-11-08 Polymerexpert Sa Polymères thermogélifiants aptes à former un revêtement glissant pour injecteur ophtalmique

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801475A (en) * 1984-08-23 1989-01-31 Gregory Halpern Method of hydrophilic coating of plastics
US4663233A (en) * 1985-10-24 1987-05-05 Universal High Technologies Lens with hydrophilic coating
US5094876A (en) * 1987-04-10 1992-03-10 University Of Florida Surface modified surgical instruments, devices, implants, contact lenses and the like
US5803925A (en) * 1995-01-17 1998-09-08 Allergan IOL insertion apparatus with covalently bonded lubricant
WO1996022062A1 (fr) * 1995-01-17 1996-07-25 Allergan Appareil destine a l'insertion d'une lentille intra-oculaire et son mode d'emploi
US5932299A (en) * 1996-04-23 1999-08-03 Katoot; Mohammad W. Method for modifying the surface of an object
US6283975B1 (en) * 1996-07-10 2001-09-04 Allergan Sales, Inc. IOL insertion apparatus and method for making and using same
US5716364A (en) * 1996-07-10 1998-02-10 Allergan IOL insertion apparatus and method for making and using same
US6280449B1 (en) * 1997-10-24 2001-08-28 Tekia, Inc. Ophthalmologic insertor apparatus and methods of use
AU8283298A (en) * 1997-10-24 1999-05-17 Tekia, Inc. Mobile guide for an ophthalmologic insertor apparatus and methods of use
EP1175187B1 (fr) * 1999-04-30 2004-01-28 Advanced Medical Optics, Inc. Dispositif d'insertion de lentille intra-oculaire
US20040039401A1 (en) * 2000-03-31 2004-02-26 Chow Alan Y. Implant instrument
WO2003045285A1 (fr) * 2001-11-30 2003-06-05 Medicel Ag Appareil d'implantation d'une lentille intraoculaire
US7476229B2 (en) * 2003-04-07 2009-01-13 Anton Meyer & Co. Ag Cartridge for an intraocular lens
US20040267359A1 (en) * 2003-06-27 2004-12-30 Harish Makker IOL insertion apparatus and methods for making and using same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2111822A2 (fr) 2008-04-21 2009-10-28 Oculentis B.V. Lentille intraoculaire avec une optique torique
WO2013117863A1 (fr) 2012-02-07 2013-08-15 Polymerexpert Sa Composition polymeres metastables pour dispositifs d'injection d'implants ophtalmiques
US9708480B2 (en) 2012-02-07 2017-07-18 Polymerexpert Sa Metastable polymer compositions for ophthalmic implant injection devices
JP2017113289A (ja) * 2015-12-22 2017-06-29 美樺興業股▲ふん▼有限公司Ｍａｙ−Ｈｗａ Ｅｎｔｅｒｐｒｉｓｅ Ｃｏｒｐｏｒａｔｉｏｎ 眼内レンズ及びその製造方法
WO2022112730A1 (fr) 2020-11-30 2022-06-02 Polymerexpert Sa Polymère apte à former un revêtement glissant pour injecteur ophtalmique
FR3116715A1 (fr) 2020-11-30 2022-06-03 Polymerexpert Sa Polymère apte à former un revêtement glissant pour injecteur ophtalmique
FR3148372A1 (fr) 2023-05-05 2024-11-08 Polymerexpert Sa Polymères thermogélifiants aptes à former un revêtement glissant pour injecteur ophtalmique
WO2024231629A1 (fr) 2023-05-05 2024-11-14 Polymerexpert Sa Polymères thermogélifiants aptes à former un revêtement glissant pour injecteur ophtalmique

Also Published As

Publication number Publication date
NL1029301C2 (nl) 2006-12-22
WO2007030009A3 (fr) 2008-05-02
EP1906880A2 (fr) 2008-04-09

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