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WO2007031621A3 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents

Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation Download PDF

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Publication number
WO2007031621A3
WO2007031621A3 PCT/FR2006/002038 FR2006002038W WO2007031621A3 WO 2007031621 A3 WO2007031621 A3 WO 2007031621A3 FR 2006002038 W FR2006002038 W FR 2006002038W WO 2007031621 A3 WO2007031621 A3 WO 2007031621A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
metronidazole
emulsions
production
based dermatological
Prior art date
Application number
PCT/FR2006/002038
Other languages
English (en)
Other versions
WO2007031621A2 (fr
WO2007031621B1 (fr
Inventor
Dov Tamarkin
Doron Friedman
Original Assignee
Galderma Sa
Dov Tamarkin
Doron Friedman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa, Dov Tamarkin, Doron Friedman filed Critical Galderma Sa
Priority to EP06808066A priority Critical patent/EP1928417A2/fr
Priority to CA2619474A priority patent/CA2619474C/fr
Publication of WO2007031621A2 publication Critical patent/WO2007031621A2/fr
Publication of WO2007031621A3 publication Critical patent/WO2007031621A3/fr
Publication of WO2007031621B1 publication Critical patent/WO2007031621B1/fr
Priority to US12/076,114 priority patent/US20090053146A1/en
Priority to US13/154,478 priority patent/US20110237638A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de la composition : (a) 72% à 76% d'eau ; (b) 0,1% à 5% d'un agent gélifiant de la phase aqueuse de l’émulsion ; (c) 0,75% à 2% de métronidazole ; (d) 5% à 10% d'huile minérale ; (e) 0,5% à 10% d'un agent tensioactif ; (f) 0,5% à 5% d'un acide gras ; (g) 0% à 4% d'un promoteur d'absorption du métronidazole (c) ; et (h) 0,1% à 5% d'un agent conservateur choisi parmi le groupe constitué par le méthylparabène, le propylparabène, le phénoxyéthanol et leurs mélanges. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
PCT/FR2006/002038 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation WO2007031621A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06808066A EP1928417A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
CA2619474A CA2619474C (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
US12/076,114 US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof
US13/154,478 US20110237638A1 (en) 2005-09-13 2011-06-07 Metronidazole-based dermatological foam and emulsions for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0509340 2005-09-13
FR0509340A FR2890559B1 (fr) 2005-09-13 2005-09-13 Mousses dermatologiques a base de metronidazole et emulsions pour la preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/076,114 Continuation US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof

Publications (3)

Publication Number Publication Date
WO2007031621A2 WO2007031621A2 (fr) 2007-03-22
WO2007031621A3 true WO2007031621A3 (fr) 2007-05-03
WO2007031621B1 WO2007031621B1 (fr) 2007-06-21

Family

ID=36592928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002038 WO2007031621A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Country Status (5)

Country Link
US (2) US20090053146A1 (fr)
EP (1) EP1928417A2 (fr)
CA (1) CA2619474C (fr)
FR (1) FR2890559B1 (fr)
WO (1) WO2007031621A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
EP1556009B2 (fr) 2002-10-25 2021-07-21 Foamix Pharmaceuticals Ltd. Mousse cosmetique et pharmaceutique
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008146030A1 (fr) * 2007-05-31 2008-12-04 Syntopix Limited Formulation antibactérienne contenant du sulphosuccinate de dialkyle et un agent antibactérien à base de diphénylcarbamide
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (fr) 2007-11-30 2009-06-04 Foamix Ltd. Peroxyde de benzoyle contenant de la mousse
WO2009090495A2 (fr) 2007-12-07 2009-07-23 Foamix Ltd. Vecteurs moussants siliconés à base d'huile et de liquide, et formulations
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
CA2712120A1 (fr) 2008-01-14 2009-07-23 Foamix Ltd. Compositions pharmaceutiques pouvant mousser de poloxamere avec des agents actifs et/ou des cellules therapeutiques, et utilisations
CA2760186C (fr) 2009-04-28 2019-10-29 Foamix Ltd. Vehicule moussant et compositions pharmaceutiques comportant des solvants polaires aprotiques et leurs utilisations
CA2769625C (fr) 2009-07-29 2017-04-11 Foamix Ltd. Compositions hydro-alcooliques moussantes non tensioactives, mousses legeres, et leurs utilisations
WO2011013008A2 (fr) 2009-07-29 2011-02-03 Foamix Ltd. Compositions hydro-alcooliques moussantes à base d'agents non tensioactifs non polymères, mousses légères, et leurs utilisations
CN102686205A (zh) 2009-10-02 2012-09-19 弗艾米克斯有限公司 局部四环素组合物
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
AU2012275292B2 (en) 2011-06-28 2015-11-12 Chemo Research, S.L. High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
US11278025B2 (en) 2017-05-17 2022-03-22 The General Hospital Corporation Antibiotic compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300491A (en) * 1991-10-31 1994-04-05 Apothekernes Laboratorium A.S. Treatment of protozoal infection
WO2005115336A2 (fr) * 2004-05-15 2005-12-08 Collegium Pharmaceutical, Inc. Formulations pulverisables destinees au traitement d'etats dermiques inflammatoires aigus
US20060024243A1 (en) * 2004-08-02 2006-02-02 Agis Industries (1983) Ltd. Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Also Published As

Publication number Publication date
CA2619474C (fr) 2012-01-10
FR2890559A1 (fr) 2007-03-16
US20090053146A1 (en) 2009-02-26
FR2890559B1 (fr) 2011-06-24
WO2007031621A2 (fr) 2007-03-22
WO2007031621B1 (fr) 2007-06-21
CA2619474A1 (fr) 2007-03-22
EP1928417A2 (fr) 2008-06-11
US20110237638A1 (en) 2011-09-29

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