[go: up one dir, main page]

WO2007031845A3 - Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation - Google Patents

Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation Download PDF

Info

Publication number
WO2007031845A3
WO2007031845A3 PCT/IB2006/002520 IB2006002520W WO2007031845A3 WO 2007031845 A3 WO2007031845 A3 WO 2007031845A3 IB 2006002520 W IB2006002520 W IB 2006002520W WO 2007031845 A3 WO2007031845 A3 WO 2007031845A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
processes
magnesium salts
polymorphic forms
omeprazole magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/002520
Other languages
French (fr)
Other versions
WO2007031845A2 (en
Inventor
Bobba Venkata Siva Kumar
Pravin Bhalchandra Kulkarni
Changdev Namdev Raut
Anil Ganpat Suryawanshi
Nitin Sharad Chandra Pradhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Pharmaceuticals Ltd
Original Assignee
Glenmark Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd
Publication of WO2007031845A2 publication Critical patent/WO2007031845A2/en
Publication of WO2007031845A3 publication Critical patent/WO2007031845A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel polymorphs of a magnesium salt of (S)-omeprazole trihydrate and processes for their preparation are disclosed. Also disclosed is a process for the preparation of an amorphous form of a magnesium salt of (S)-omeprazole. Pharmaceutical compositions containing the magnesium salts are also disclosed.
PCT/IB2006/002520 2005-09-14 2006-09-13 Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation Ceased WO2007031845A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1110/MUM/2005 2005-09-14
IN1110MU2005 2005-09-14
US75393105P 2005-12-23 2005-12-23
US60/753,931 2005-12-23

Publications (2)

Publication Number Publication Date
WO2007031845A2 WO2007031845A2 (en) 2007-03-22
WO2007031845A3 true WO2007031845A3 (en) 2007-05-18

Family

ID=37714230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002520 Ceased WO2007031845A2 (en) 2005-09-14 2006-09-13 Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation

Country Status (1)

Country Link
WO (1) WO2007031845A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009074997A2 (en) * 2007-12-10 2009-06-18 Lee Pharma Ltd. A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate
WO2009099933A2 (en) * 2008-02-01 2009-08-13 Dr. Reddy's Laboratories Ltd. Preparation of esomeprazole magnesium and hydrates thereof
EP2147918A1 (en) 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Process for the preparation of S-omeprazole magnesium in a stable form
FR2959509B1 (en) 2010-05-03 2012-07-13 Prod Chim Auxiliaires Et De Synthese PRECURSOR PHASE AND USE THEREOF FOR PREPARING MAGNESIUM TETRAHYDRATE SALT OF AN OMEPRAZOLE ENANTIOMER
CN102911158B (en) * 2011-07-31 2015-07-22 连云港润众制药有限公司 Crystal form of esomeprazole magnesium
CN103509001B (en) * 2012-06-15 2016-12-21 石药集团中奇制药技术（石家庄）有限公司 A kind of esomeprazole magnesium trihydrate and preparation method thereof
CN105936632A (en) * 2016-05-23 2016-09-14 江苏中邦制药有限公司 Purifying method of crude esomeprazole magnesium trihydrate
CN116102538B (en) * 2023-01-29 2024-10-18 山东省分析测试中心 Method for preparing magnesium esomeprazole trihydrate by crystal transformation

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027988A1 (en) * 1993-05-28 1994-12-08 Astra Aktiebolag Optically pure salts of pyridinylmethyl sulfinyl-ih-benzimidazole compounds
WO1998054171A1 (en) * 1997-05-30 1998-12-03 Astra Aktiebolag Novel form of s-omeprazole
WO2004020436A1 (en) * 2002-08-30 2004-03-11 Reddy's Laboratories Limited Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof
WO2004037253A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Amorphous form of esomeprazole salts
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
WO2005118567A2 (en) * 2004-05-28 2005-12-15 Aaipharma Inc. Magnesium complexes of s-omeprazole

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027988A1 (en) * 1993-05-28 1994-12-08 Astra Aktiebolag Optically pure salts of pyridinylmethyl sulfinyl-ih-benzimidazole compounds
WO1998054171A1 (en) * 1997-05-30 1998-12-03 Astra Aktiebolag Novel form of s-omeprazole
WO2004020436A1 (en) * 2002-08-30 2004-03-11 Reddy's Laboratories Limited Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof
WO2004037253A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Amorphous form of esomeprazole salts
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
WO2005118567A2 (en) * 2004-05-28 2005-12-15 Aaipharma Inc. Magnesium complexes of s-omeprazole

Also Published As

Publication number Publication date
WO2007031845A2 (en) 2007-03-22

Similar Documents

Publication Publication Date Title
WO2007031845A3 (en) Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation
IL185419A0 (en) Improved process for the synthesis of enantiomeric indanylamine derivatives
IL216449A0 (en) Process for the preparation of tetrazole derivatives
WO2010001257A3 (en) Novel solid state forms of laquinimod and its sodium salt
WO2005062897A3 (en) Polymorphs of ezetimibe and processes for the preparation thereof
WO2009047775A3 (en) Polymorphs of esomeprazole salts
TW200420541A (en) Crystalline forms
WO2006035277A3 (en) Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium
IL183591A0 (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
IL180311A0 (en) Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters
WO2007118873A3 (en) Polymorphs of atorvastatin sodium and magnesium salts
ZA200701016B (en) Process for the preparation of isothiazole derivatives
WO2008117305A3 (en) A novel process for preparing pregabalin and its acid addition salts
AU2003290269A1 (en) Process for the production of synthetic magnesium silicate compositions
WO2008034912A3 (en) Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
AU2003238671A1 (en) Novel crystalline forms of s-omeprazole magnesium
PT1737820E (en) Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives
WO2010038948A3 (en) Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders
IL186499A (en) Processes for the preparation of crystalline atorvastatin hemicalcium form
WO2006066044A3 (en) Processes for producing 4-aminoquinazolines
WO2005056563A3 (en) Process for the preparation of thiazolopyrimidines
WO2008006720A3 (en) Crystalline nemorubicin hydrochloride
FR2894596B1 (en) PROCESS FOR AUTOCALIBRATION OF BIOPUCES
WO2007029096A3 (en) Novel polymorphic forms of clopidogrel hydrochloride
EP1863775A4 (en) Process for preparing crystalline form i of olanzapine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06820751

Country of ref document: EP

Kind code of ref document: A2