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WO2007033369A3 - Assessing risk of cerebrovascular thrombosis by measuring c4d on platelets - Google Patents

Assessing risk of cerebrovascular thrombosis by measuring c4d on platelets Download PDF

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Publication number
WO2007033369A3
WO2007033369A3 PCT/US2006/036007 US2006036007W WO2007033369A3 WO 2007033369 A3 WO2007033369 A3 WO 2007033369A3 US 2006036007 W US2006036007 W US 2006036007W WO 2007033369 A3 WO2007033369 A3 WO 2007033369A3
Authority
WO
WIPO (PCT)
Prior art keywords
platelets
measuring
assessing risk
cerebrovascular thrombosis
risk
Prior art date
Application number
PCT/US2006/036007
Other languages
French (fr)
Other versions
WO2007033369A2 (en
Inventor
Joseph M Ahearn
Susan M Manzi
Amy Kao
Original Assignee
Univ Pittsburgh
Joseph M Ahearn
Susan M Manzi
Amy Kao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh, Joseph M Ahearn, Susan M Manzi, Amy Kao filed Critical Univ Pittsburgh
Publication of WO2007033369A2 publication Critical patent/WO2007033369A2/en
Publication of WO2007033369A3 publication Critical patent/WO2007033369A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention provides for a convenient, economical, and sensitive test for assessing the risk of a person suffering from a thrombotic stroke. More specifically, it has been determined that persons at risk for cerebrovascular thrombosis have an elevated deposition of C4d on their platelets.
PCT/US2006/036007 2005-09-14 2006-09-14 Assessing risk of cerebrovascular thrombosis by measuring c4d on platelets WO2007033369A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71752505P 2005-09-14 2005-09-14
US60/717,525 2005-09-14
US52005406A 2006-09-11 2006-09-11
US11/520,054 2006-09-11

Publications (2)

Publication Number Publication Date
WO2007033369A2 WO2007033369A2 (en) 2007-03-22
WO2007033369A3 true WO2007033369A3 (en) 2007-11-01

Family

ID=37865605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/036007 WO2007033369A2 (en) 2005-09-14 2006-09-14 Assessing risk of cerebrovascular thrombosis by measuring c4d on platelets

Country Status (1)

Country Link
WO (1) WO2007033369A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976540A (en) * 1993-05-17 1999-11-02 T Cell Sciences, Inc. Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
US6312693B1 (en) * 1998-02-19 2001-11-06 Alejandro A. Aruffo Antibodies against human CD40
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation
US20020192758A1 (en) * 2000-08-01 2002-12-19 Welcher Andrew A. C3b/C4b complement receptor-like molecules and uses thereof
US20040077934A1 (en) * 1999-07-06 2004-04-22 Intercure Ltd. Interventive-diagnostic device
US20050130230A1 (en) * 2003-09-23 2005-06-16 Antoni Davalos Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976540A (en) * 1993-05-17 1999-11-02 T Cell Sciences, Inc. Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
US6312693B1 (en) * 1998-02-19 2001-11-06 Alejandro A. Aruffo Antibodies against human CD40
US6413514B1 (en) * 1998-02-19 2002-07-02 Bristol-Myers Squibb Company Methods of using antibodies against human CD40
US20020081293A1 (en) * 1998-02-20 2002-06-27 Tanox, Inc., Delaware Corporation Inhibitors of complement activation
US20040077934A1 (en) * 1999-07-06 2004-04-22 Intercure Ltd. Interventive-diagnostic device
US20020192758A1 (en) * 2000-08-01 2002-12-19 Welcher Andrew A. C3b/C4b complement receptor-like molecules and uses thereof
US20050130230A1 (en) * 2003-09-23 2005-06-16 Antoni Davalos Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof

Also Published As

Publication number Publication date
WO2007033369A2 (en) 2007-03-22

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