WO2007039749A3 - Antibacterial pyrrols - Google Patents
Antibacterial pyrrols Download PDFInfo
- Publication number
- WO2007039749A3 WO2007039749A3 PCT/GB2006/003713 GB2006003713W WO2007039749A3 WO 2007039749 A3 WO2007039749 A3 WO 2007039749A3 GB 2006003713 W GB2006003713 W GB 2006003713W WO 2007039749 A3 WO2007039749 A3 WO 2007039749A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkynylthiocarbonyl
- alkenylthiocarbonyl
- alkynylcarbonyl
- alkylthiocarbonyl
- alkenyloxycarbonyl
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- -1 alkenylcarbony Chemical group 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000005087 alkynylcarbonyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000005108 alkenylthio group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000005109 alkynylthio group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Use of a compound of formula (I), as shown in the description, or a physiologically acceptable salt thereof, in the manufacture of a medicament for the treatment of bacterial infection or disease: wherein, in formula (I), A is -NR1-, -O- or -S R1 is selected from hydrogen, a halogen or a substituted or unsubstituted heterocyclic, alkyl, alkyloxy, alkylthio, alkylcarbonyl, alkyloxycarbonyl, alkylthiocarbonyl, alkenyl, alkenylcarbony, alkenyloxycarbonyl, alkenylthiocarbonyl, alkynyl, alkynylcarbonyl, alkynyloxcarbonyl, alkynylthiocarbonyl, aryl, benzyl, arylcarbonyl or aryloxycarbonyl group; and Y and Z are not identical and are independently selected from hydrogen, a halogen, or a substituted or unsubstituted heterocyclic, alkyl, alkyloxy, alkylthio, alkylcarbonyl, alkyloxycarbonyl, alkylthiocarbonyl, alkenyl, alkenyloxy, alkenylthio, alkenylcarbonyl, alkenyloxycarbonyl, alkenylthiocarbonyl, alkynyl, alkynyloxy, alkynylthio, alkynylcarbonyl, alkynyloxycarbonyl, alkynylthiocarbonyl, aryl, benzyl, aryloxy, arylthio, arylcarbonyl, aryloxycarbonyl or arylthiocarbonyl, a NR1R2 group wherein R1' and R2 are as defined for R1 or NR1'R2 is NH2.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002624501A CA2624501A1 (en) | 2005-10-06 | 2006-10-06 | Antibacterial pyrrols |
EP06794664A EP1940390A2 (en) | 2005-10-06 | 2006-10-06 | Antibacterial pyrrols |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0520368.2A GB0520368D0 (en) | 2005-10-06 | 2005-10-06 | Antibacterial pyrrols |
GB0520368.2 | 2005-10-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007039749A2 WO2007039749A2 (en) | 2007-04-12 |
WO2007039749A3 true WO2007039749A3 (en) | 2008-05-08 |
Family
ID=35429943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/003713 WO2007039749A2 (en) | 2005-10-06 | 2006-10-06 | Antibacterial pyrrols |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1940390A2 (en) |
CA (1) | CA2624501A1 (en) |
GB (1) | GB0520368D0 (en) |
WO (1) | WO2007039749A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100179214A1 (en) | 2006-05-19 | 2010-07-15 | Somaxon Pharmaceuticals, Inc. | Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders |
JP5210598B2 (en) * | 2007-11-06 | 2013-06-12 | 花王株式会社 | Autoinducer-2 inhibitor and preventive and / or therapeutic agent for infectious diseases |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3337584A (en) * | 1967-01-06 | 1967-08-22 | Squibb & Sons Inc | N-substituted maleimide compounds |
FR1559600A (en) * | 1966-04-23 | 1969-03-14 | Fujisawa Pharm Co | PROCESS FOR MANUFACTURING DERIVATIVES OF 2-PHENYL MALEIMIDE AND SUCCINIMIDE |
DE1770042A1 (en) * | 1968-03-23 | 1971-04-08 | Basf Ag | Process for the preparation of alpha, ss-dihalo-gamma-hydroxycrotone lactams |
DE1770041A1 (en) * | 1968-03-23 | 1971-09-16 | Basf Ag | Process for the preparation of alpha-amino-maleimides |
US3816451A (en) * | 1971-11-02 | 1974-06-11 | Abbott Lab | Maleimide derivatives as plant growth regulators |
US3890270A (en) * | 1974-04-10 | 1975-06-17 | Tenneco Chem | Polyvinyl halide resin compositions |
US4353734A (en) * | 1977-07-25 | 1982-10-12 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Maleimide and succinimide derivatives and herbicidal method of use thereof |
EP0098953A2 (en) * | 1982-06-12 | 1984-01-25 | Bayer Ag | Substituted maleic-acid imides, process for their preparation and their use as pesticides |
JPS5931702A (en) * | 1982-08-16 | 1984-02-20 | Earth Chem Corp Ltd | Pest and mite repellent composition |
JPH01221302A (en) * | 1987-10-26 | 1989-09-04 | Katayama Chem Works Co Ltd | Bactericide for industry and sterilization |
JPH01299280A (en) * | 1988-05-24 | 1989-12-04 | Takara Shuzo Co Ltd | Novel antibiotic substance h9 and production thereof |
JPH05294952A (en) * | 1992-04-16 | 1993-11-09 | Wakamoto Pharmaceut Co Ltd | Antibiotic substance wap-4068, its derivative and production thereof |
JPH10316510A (en) * | 1997-05-14 | 1998-12-02 | Nissan Chem Ind Ltd | N-0194 and its production |
WO1999065483A1 (en) * | 1998-05-05 | 1999-12-23 | Astrazeneca Ab | Mycobacterial inhibitors |
JP2003012413A (en) * | 2001-07-03 | 2003-01-15 | Takeda Chem Ind Ltd | Industrial composition |
JP2004238309A (en) * | 2003-02-05 | 2004-08-26 | Soda Aromatic Co Ltd | Melanin production inhibitor |
JP2005218320A (en) * | 2004-02-03 | 2005-08-18 | Ajinomoto Co Inc | New antifungal agent fa424a(n), fa424a(o), fa424b and fa424d |
US20050197384A1 (en) * | 2004-03-08 | 2005-09-08 | Masao Hattori | Novel mixture and compounds from mycelia of Antrodia camphorata and use thereof |
-
2005
- 2005-10-06 GB GBGB0520368.2A patent/GB0520368D0/en not_active Ceased
-
2006
- 2006-10-06 CA CA002624501A patent/CA2624501A1/en not_active Abandoned
- 2006-10-06 WO PCT/GB2006/003713 patent/WO2007039749A2/en active Application Filing
- 2006-10-06 EP EP06794664A patent/EP1940390A2/en not_active Withdrawn
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1559600A (en) * | 1966-04-23 | 1969-03-14 | Fujisawa Pharm Co | PROCESS FOR MANUFACTURING DERIVATIVES OF 2-PHENYL MALEIMIDE AND SUCCINIMIDE |
US3337584A (en) * | 1967-01-06 | 1967-08-22 | Squibb & Sons Inc | N-substituted maleimide compounds |
DE1770042A1 (en) * | 1968-03-23 | 1971-04-08 | Basf Ag | Process for the preparation of alpha, ss-dihalo-gamma-hydroxycrotone lactams |
DE1770041A1 (en) * | 1968-03-23 | 1971-09-16 | Basf Ag | Process for the preparation of alpha-amino-maleimides |
US3816451A (en) * | 1971-11-02 | 1974-06-11 | Abbott Lab | Maleimide derivatives as plant growth regulators |
US3890270A (en) * | 1974-04-10 | 1975-06-17 | Tenneco Chem | Polyvinyl halide resin compositions |
US4353734A (en) * | 1977-07-25 | 1982-10-12 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Maleimide and succinimide derivatives and herbicidal method of use thereof |
EP0098953A2 (en) * | 1982-06-12 | 1984-01-25 | Bayer Ag | Substituted maleic-acid imides, process for their preparation and their use as pesticides |
JPS5931702A (en) * | 1982-08-16 | 1984-02-20 | Earth Chem Corp Ltd | Pest and mite repellent composition |
JPH01221302A (en) * | 1987-10-26 | 1989-09-04 | Katayama Chem Works Co Ltd | Bactericide for industry and sterilization |
JPH01299280A (en) * | 1988-05-24 | 1989-12-04 | Takara Shuzo Co Ltd | Novel antibiotic substance h9 and production thereof |
JPH05294952A (en) * | 1992-04-16 | 1993-11-09 | Wakamoto Pharmaceut Co Ltd | Antibiotic substance wap-4068, its derivative and production thereof |
JPH10316510A (en) * | 1997-05-14 | 1998-12-02 | Nissan Chem Ind Ltd | N-0194 and its production |
WO1999065483A1 (en) * | 1998-05-05 | 1999-12-23 | Astrazeneca Ab | Mycobacterial inhibitors |
JP2003012413A (en) * | 2001-07-03 | 2003-01-15 | Takeda Chem Ind Ltd | Industrial composition |
JP2004238309A (en) * | 2003-02-05 | 2004-08-26 | Soda Aromatic Co Ltd | Melanin production inhibitor |
JP2005218320A (en) * | 2004-02-03 | 2005-08-18 | Ajinomoto Co Inc | New antifungal agent fa424a(n), fa424a(o), fa424b and fa424d |
US20050197384A1 (en) * | 2004-03-08 | 2005-09-08 | Masao Hattori | Novel mixture and compounds from mycelia of Antrodia camphorata and use thereof |
Non-Patent Citations (18)
Title |
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ARGADE N P ET AL: "A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A.", BIOORGANIC & MEDICINAL CHEMISTRY JUN 1996, vol. 4, no. 6, June 1996 (1996-06-01), pages 881 - 883, XP002469069, ISSN: 0968-0896 * |
CARDENAS ET AL: "Production of tricarboxylic acid anhydrides from fatty acids by a lipase-producing strain of Pseudomonas cepacia", BIOCATALYSIS AND BIOTRANSFORMATION, HARWOOD ACADEMIC PUBL., BASEL, CH, vol. 20, no. 2, 2002, pages 117 - 128, XP009095933, ISSN: 1024-2422 * |
COONEY D A ET AL: "MALEIMIDE BIOCHEMICAL PHARMACOLOGIC AND TOXICOLOGIC STUDIES INTERACTION WITH L ASPARAGINASE METABOLISM", BIOCHEMICAL PHARMACOLOGY, vol. 27, no. 2, 1978, pages 151 - 166, XP002413425, ISSN: 0006-2952 * |
CORREA R ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CITRACONIMIDES", PHARMACEUTICAL SCIENCES, LONDON, GB, vol. 2, no. 8, 1996, pages 353 - 355, XP009076423, ISSN: 1356-6881 * |
DAVIS P D ET AL: "INHIBITORS OF PROTEIN KINASE C 1. 2,3-BISARYLMALEIMIDES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 1, 1992, pages 177 - 184, XP000910195, ISSN: 0022-2623 * |
FREEMAN BEVERLY A ET AL: "HALOGENATED 2,5-PYRROLIDINEDIONES: SYNTHESIS, BACTERIAL MUTAGENICITY IN AMES TESTER STRAIN TA-100 AND SEMI-EMPIRICAL MOLECULAR ORBITAL CALCULATIONS", MUTATION RESEARCH, AMSTERDAM, NL, vol. 490, no. 2, 2001, pages 89 - 98, XP009076425, ISSN: 0027-5107 * |
HENTZER M ET AL: "Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 112, no. 9, November 2003 (2003-11-01), pages 1300 - 1307, XP002316251, ISSN: 0021-9738 * |
JABBAR A ET AL: "Isolation and in vitro antibacterial screening of a tricarboxylic acid anhydride from Penicillium sp", PHARMAZIE, vol. 50, no. 10, 1995, pages 706 - 707, XP001538032, ISSN: 0031-7144 * |
JÄHNISCH ET AL.: "Reaktionen von Mucochlorsäurederivaten...", J. PRAKT. CHEM., vol. 332, no. 1, 1990, pages 117 - 121, XP002469072 * |
LÖSCHER ET AL., CHEM. BER., vol. 21, no. 2, 1888, pages 2718 - 2719, XP002469074 * |
MAHBOOBI S ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 4,4-DIMETHYL-5,5-DI(1-METHYLET HYL)-2,3,4,5-TETRAHYDRO-1 H-DIPYRROLO(3,4-D:2,1-F)(1,2)AZASILINE-1,3- DIONE AND OTHER PYRROLEDIONES AS NEW ANTIBACTERIAL ACTIVE AGENTS", PHARMAZIE, DIE, GOVI VERLAG, ESCHBORN, DE, vol. 54, no. 10, October 1999 (1999-10-01), pages 730 - 733, XP001248807, ISSN: 0031-7144 * |
MANGALESWARAN S ET AL: "A facile synthesis of naturally occurring aminopeptidase inhibitor tyromycin A", JOURNAL OF ORGANIC CHEMISTRY 27 JUL 2001 UNITED STATES, vol. 66, no. 15, 27 July 2001 (2001-07-27), pages 5259 - 5261, XP002469070, ISSN: 0022-3263 * |
MARRIAN D H ET AL: "The antibacterial effects of substances structurally resembling maleimide.", THE BIOCHEMICAL JOURNAL. APR 1953, vol. 54, no. 1, April 1953 (1953-04-01), pages 65 - 68, XP002413424, ISSN: 0264-6021 * |
OIKAWA HIDEAKI ET AL: "Synthetic study of tautomycetin: Synthesis of two large subunits", TETRAHEDRON LETTERS, vol. 38, no. 45, 10 November 1997 (1997-11-10), pages 7897 - 7900, XP004097200, ISSN: 0040-4039 * |
ROTHHAAS, ALEXANDER: "Reaction of hydroxymaleic anhydride with ammonia and aliphatic amines. Preparation of substituted maleinimides", ANN. , 501, 295 -304, 1933, XP002413426 * |
SAHOO M K ET AL: "Facile routes to alkoxymaleimides/maleic anhydrides", SYNTHESIS 2003 GERMANY, no. 3, 2003, pages 346 - 349, XP002469073, ISSN: 0039-7881 * |
WATANABE S ET AL: "ANTIMICROBIAL ACTIVITY OF SOME N-(ARYLALKYL)MALEIMIDES", PESTICIDE SCIENCE, ELSEVIER APPLIED SCIENCE PUBLISHER. BARKING, GB, vol. 34, no. 2, January 1992 (1992-01-01), pages 99 - 104, XP000287971, ISSN: 0031-613X * |
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Also Published As
Publication number | Publication date |
---|---|
CA2624501A1 (en) | 2007-04-12 |
GB0520368D0 (en) | 2005-11-16 |
EP1940390A2 (en) | 2008-07-09 |
WO2007039749A2 (en) | 2007-04-12 |
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