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WO2007113598A3 - Compositions vaccinales - Google Patents

Compositions vaccinales Download PDF

Info

Publication number
WO2007113598A3
WO2007113598A3 PCT/GB2007/050181 GB2007050181W WO2007113598A3 WO 2007113598 A3 WO2007113598 A3 WO 2007113598A3 GB 2007050181 W GB2007050181 W GB 2007050181W WO 2007113598 A3 WO2007113598 A3 WO 2007113598A3
Authority
WO
WIPO (PCT)
Prior art keywords
pneumococcal
6bpp
pneumococcal infection
vaccine
peptide mimetope
Prior art date
Application number
PCT/GB2007/050181
Other languages
English (en)
Other versions
WO2007113598A2 (fr
Inventor
Peter Andrew
Claire Mary Smith
Carla Lopasso
Helen Baxendale
David Goldblatt
Franco Felici
Original Assignee
Univ Leicester
Peter Andrew
Claire Mary Smith
Carla Lopasso
Helen Baxendale
David Goldblatt
Franco Felici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leicester, Peter Andrew, Claire Mary Smith, Carla Lopasso, Helen Baxendale, David Goldblatt, Franco Felici filed Critical Univ Leicester
Publication of WO2007113598A2 publication Critical patent/WO2007113598A2/fr
Publication of WO2007113598A3 publication Critical patent/WO2007113598A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/315—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un mimotope peptidique de polysaccharide pneumococcique de sérotype 6B (6BPP) de Streptococcus pneumoniae, éventuellement conjugué à une protéine support, capable de stimuler une réponse immunitaire protectrice contre une infection pneumococcique. L'invention concerne également un anticorps monoclonal (AcM) dirigé contre un polysaccharide pneumococcique 6B et des fragments de liaison à 6BPP correspondants, pouvant conférer une immunité passive contre une infection pneumococcique. Par ailleurs, l'invention concerne des compositions comprenant ce mimotope peptidique, ce conjugué, cet AcM ou un fragment de liaison correspondant. Les peptides mimétiques, leurs conjugués, l'AcM et les fragments de liaison à 6BPP de l'invention sont utilisés comme médicaments et dans la fabrication de médicaments destinés à traiter une infection pneumococcique. L'invention se rapporte en outre à des méthodes de traitement prophylactique ou thérapeutique d'une infection pneumococcique.
PCT/GB2007/050181 2006-04-05 2007-04-05 Compositions vaccinales WO2007113598A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0606856A GB0606856D0 (en) 2006-04-05 2006-04-05 Vaccine compositions
GB0606856.3 2006-04-05

Publications (2)

Publication Number Publication Date
WO2007113598A2 WO2007113598A2 (fr) 2007-10-11
WO2007113598A3 true WO2007113598A3 (fr) 2007-12-06

Family

ID=36539375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/050181 WO2007113598A2 (fr) 2006-04-05 2007-04-05 Compositions vaccinales

Country Status (2)

Country Link
GB (1) GB0606856D0 (fr)
WO (1) WO2007113598A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011660A2 (fr) * 1997-09-04 1999-03-11 Institut Pasteur Polypeptides immunogenes mimant un antigene de surface polysaccharidique d'un micro-organisme pathogene, technique de production de ces polypeptides et utilisation dans des compositions vaccinales
US20040198960A1 (en) * 2001-03-29 2004-10-07 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011660A2 (fr) * 1997-09-04 1999-03-11 Institut Pasteur Polypeptides immunogenes mimant un antigene de surface polysaccharidique d'un micro-organisme pathogene, technique de production de ces polypeptides et utilisation dans des compositions vaccinales
US20040198960A1 (en) * 2001-03-29 2004-10-07 Janoff Edward N Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BAXENDALE H E ET AL: "Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies.", INFECTION AND IMMUNITY FEB 2006, vol. 74, no. 2, February 2006 (2006-02-01), pages 1025 - 1031, XP002450971, ISSN: 0019-9567 *
BUCHWALD ULRIKE K ET AL: "A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice.", INFECTION AND IMMUNITY JAN 2005, vol. 73, no. 1, January 2005 (2005-01-01), pages 325 - 333, XP002450973, ISSN: 0019-9567 *
JESSUP C F ET AL: "Preparation of human-mouse heterohybridomas against an immunising antigen", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 246, no. 1-2, 1 December 2000 (2000-12-01), pages 187 - 202, XP004220753, ISSN: 0022-1759 *
JONSSON S ET AL: "Vaccination of COPD patients with a pneumococcus type 6B tetanus toxoid conjugate vaccine", EUROPEAN RESPIRATORY JOURNAL, vol. 20, no. 4, October 2002 (2002-10-01), pages 813 - 818, XP002450974, ISSN: 0903-1936 *
LUCAS A H ET AL: "Combinatorial library cloning of human antibodies to Streptococcus pneumoniae capsular polysaccharides: variable region primary structures and evidence for somatic mutation of Fab fragments specific for capsular serotypes 6B, 14, and 23F.", INFECTION AND IMMUNITY FEB 2001, vol. 69, no. 2, February 2001 (2001-02-01), pages 853 - 864, XP002450976, ISSN: 0019-9567 *
SHIN JEON-SOO ET AL: "Peptide mimotopes of pneumococcal capsular polysaccharide of 6B serotype: a peptide mimotope can bind to two unrelated antibodies.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUN 2002, vol. 168, no. 12, 15 June 2002 (2002-06-15), pages 6273 - 6278, XP002450970, ISSN: 0022-1767 *
SUN Y ET AL: "Repertoire of human antibodies against the polysaccharide capsule of Streptococcus pneumoniae serotype 6B.", INFECTION AND IMMUNITY MAR 1999, vol. 67, no. 3, March 1999 (1999-03-01), pages 1172 - 1179, XP002450975, ISSN: 0019-9567 *
ZHOU JIANHUI ET AL: "Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B.", INFECTION AND IMMUNITY JUN 2004, vol. 72, no. 6, June 2004 (2004-06-01), pages 3505 - 3514, XP002450972, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
WO2007113598A2 (fr) 2007-10-11
GB0606856D0 (en) 2006-05-17

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