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WO2008053684A1 - Procédé de production de poudre de microcapsules - Google Patents

Procédé de production de poudre de microcapsules Download PDF

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Publication number
WO2008053684A1
WO2008053684A1 PCT/JP2007/069914 JP2007069914W WO2008053684A1 WO 2008053684 A1 WO2008053684 A1 WO 2008053684A1 JP 2007069914 W JP2007069914 W JP 2007069914W WO 2008053684 A1 WO2008053684 A1 WO 2008053684A1
Authority
WO
WIPO (PCT)
Prior art keywords
microcapsules
film
producing
shell
microcapsule
Prior art date
Application number
PCT/JP2007/069914
Other languages
English (en)
Japanese (ja)
Inventor
Shinya Izumida
Takashi Iwade
Takashi Nagayama
Masashi Motoi
Kiyoto Yamamoto
Original Assignee
Toray Engineering Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Engineering Co., Ltd. filed Critical Toray Engineering Co., Ltd.
Priority to JP2008542028A priority Critical patent/JPWO2008053684A1/ja
Publication of WO2008053684A1 publication Critical patent/WO2008053684A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Definitions

  • the present invention relates to a method for producing a microcapsule assembly in which a predetermined amount of microcapsules encapsulating a core material in a fine shell are stored in a package.
  • microcapsules have been used in various fields, focusing on the functions of preventing deterioration of active ingredients, releasing core materials when necessary, and releasing slowly (releasing core materials). It ’s getting better. Then, it has been proposed to produce microcapsules by forming a base layer, a holding layer, and a surface layer on a substrate (see Patent Document 1 and Patent Document 2).
  • Patent Document 1 International Publication No. WO2001 / 89486A1
  • Patent Document 2 Japanese Patent Laid-Open No. 2002_531394
  • Patent Document 1 and Patent Document 2 merely describe the production of microcapsules on a base material, and how to package microcapsules in a predetermined amount.
  • the force for producing the microcapsule assembly housed in the container is not described at all.
  • a microcapsule assembly is produced by removing microcapsules from a base material and storing the removed microcapsules in a package in a predetermined amount.
  • the present invention has been made in view of the above-described problems, and the work for producing a microcapsule assembly can be simplified as a whole, and a decrease in yield can be suppressed. To provide a method for producing a microcapsule assembly that can be controlled!
  • a plurality of microcapsules each including a core layer surrounded by a first shell film and a second shell film are arranged on a substrate made of a soluble film. Then, the base material is dissolved in a liquid such as a solvent or water to separate microcapsules, and the separated microcapsules are collected from the solvent by a method such as filtration and stored in a predetermined amount in a package. is there.
  • the microcapsules are separated by dissolving the base material. Therefore, the work of separating the microcapsules can be simplified, and as a result It is possible to simplify the work for producing the assembly as a whole, and to suppress a decrease in yield.
  • FIG. 1 is a flow chart for explaining one embodiment of a method for producing a microcapsule assembly of the present invention.
  • step SP1 a micro force capsule sheet is produced, in which a plurality of microcapsules 5 each including a core layer surrounded by a first shell film and a second shell film are arranged on a substrate made of a soluble film.
  • step SP2 the microcapsule sheet is immersed in a liquid in which the substrate dissolves to separate the microcapsules 5, and in step SP3, the separated microcapsules 5 are collected using a filter or the like, and in step SP4
  • a microcapsule assembly is prepared by storing a predetermined amount of microcapsules 5 in a package.
  • the soluble film is soluble in a liquid such as a solvent or water, and examples thereof include a film made of pullulan, denpun, agar, etc.
  • the first shell membrane is, for example, soluble in the stomach.
  • enteric polymer film can be exemplified, examples of the second shell membrane include water-insoluble polymers and waxes, and examples of the core layer include insulin, erythropoietin, bioactive protein, peptide, and the like. You can add it.
  • the packaging body preferably has a force that can be exemplified by any hollow-shaped member as a whole in a substantially cylindrical shape and both hemispherical ends.
  • the first shell film does not need to be an enteric polymer film.
  • FIG. 2 is a schematic view showing an example of an apparatus for producing a microcapsule sheet.
  • This apparatus includes an XY stage 2 that supports and moves a base material 1 made of a soluble film in a two-dimensional manner, a droplet including a first shell material from above the base material 1, and a core material. A droplet and a droplet containing a second shell material are respectively supplied and adhered to the surface of the substrate 1. A nozzle device 3 having three droplet supply nozzles, and the adhered droplet are dried to form a first shell. And a drying device 4 for forming a second shell film.
  • the droplet supply nozzle is used in an ink jet printer! /, For example, a piezo head that ejects droplets by utilizing the property of distorting a piezoelectric ceramic, and thermal energy. Since the droplets are discharged by the thermal ink jet head that discharges the droplets, the discharge amount can be controlled with high accuracy.
  • the nozzle device 3 has three droplet supply nozzles, so that the nozzle device 3 sequentially has the same position.
  • the three droplet supply nozzles In order to operate the three droplet supply nozzles, it is configured to be reciprocated according to the arrangement of the three droplet supply nozzles!
  • an infrared heater can be employed as the drying device 4 for example.
  • the substrate 1 is moved to a predetermined position by the XY stage 2, and one of the three droplet supply nozzles of the nozzle device 3 is driven, so that the droplet including the first shell material is transferred to the substrate. Adhere to 1. In this state, the droplet is almost hemispherical (see (A) in Fig. 3).
  • the surface is first dried to form a film, and then the drying operation is continued to evaporate the internal solvent and the like.
  • Recessed membrane ⁇ See Fig. 3 (B) ⁇ .
  • the film may simply be flattened.
  • the other one of the three droplet supply nozzles of the nozzle device 3 is driven to deposit a droplet including the second shell material so as to cover the core layer.
  • the assembly of the microcapsules 5 can be manufactured through the separation process in step SP2 and the collection process in step SP3.
  • microcapsules 5 produced as described above examples include pharmaceuticals.
  • microcapsule sheet Since the microcapsule sheet is used as a medicine, it is preferable to adopt a capsule that has been conventionally used for pharmaceutical use as a package.
  • a microcapsule assembly can be produced by a simple operation.
  • FIG. 1 A flow chart illustrating an embodiment of the method for producing a microcapsule assembly of the present invention is used.
  • FIG. 2 is a schematic view showing an example of an apparatus for producing a microcapsule sheet.
  • FIG. 3 is a schematic view illustrating a process for producing microcapsules on a substrate.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Pour simplifier la totalité d'une opération de production de poudre de microcapsules et empêcher la baisse du rendement, on dispose sur un substrat (1) fait d'un film soluble les microcapsules (5) obtenues en entourant une couche noyau d'une première coquille de film et d'une deuxième coquille de film. Le substrat (1) est ensuite dissous pour séparer les microcapsules (5) et les microcapsules (5) séparé sont recueillies et placées en quantités données dans des paquets.
PCT/JP2007/069914 2006-10-12 2007-10-12 Procédé de production de poudre de microcapsules WO2008053684A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008542028A JPWO2008053684A1 (ja) 2006-10-12 2007-10-12 マイクロカプセル集合体作製方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-278542 2006-10-12
JP2006278542 2006-10-12

Publications (1)

Publication Number Publication Date
WO2008053684A1 true WO2008053684A1 (fr) 2008-05-08

Family

ID=39344031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/069914 WO2008053684A1 (fr) 2006-10-12 2007-10-12 Procédé de production de poudre de microcapsules

Country Status (2)

Country Link
JP (1) JPWO2008053684A1 (fr)
WO (1) WO2008053684A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160475A (ja) * 2001-11-28 2003-06-03 Bf Co Ltd マイクロカプセルの製造方法
WO2006004069A1 (fr) * 2004-07-01 2006-01-12 Ngk Insulators, Ltd. Très petite capsule et sa méthode de production
WO2006112235A1 (fr) * 2005-04-14 2006-10-26 Toray Engineering Co., Ltd. Procede de fabrication de microcapsules, appareil de fabrication de microcapsules et feuille a microcapsules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160475A (ja) * 2001-11-28 2003-06-03 Bf Co Ltd マイクロカプセルの製造方法
WO2006004069A1 (fr) * 2004-07-01 2006-01-12 Ngk Insulators, Ltd. Très petite capsule et sa méthode de production
WO2006112235A1 (fr) * 2005-04-14 2006-10-26 Toray Engineering Co., Ltd. Procede de fabrication de microcapsules, appareil de fabrication de microcapsules et feuille a microcapsules

Also Published As

Publication number Publication date
JPWO2008053684A1 (ja) 2010-02-25

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