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WO2008011625A3 - Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide - Google Patents

Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide Download PDF

Info

Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Application number
PCT/US2007/074123
Other languages
English (en)
Other versions
WO2008011625A2 (fr
Inventor
Mark R Prausnitz
Jeong Woo Lee
Original Assignee
Georgia Tech Researh Corp
Mark R Prausnitz
Jeong Woo Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Researh Corp, Mark R Prausnitz, Jeong Woo Lee filed Critical Georgia Tech Researh Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/fr
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/fr
Priority to US12/357,195 priority Critical patent/US20090182306A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des dispositifs à micro-aiguille(s) et des procédés de fabrication et d'utilisation de ceux-ci. Dans un mode de réalisation, l'invention concerne un dispositif permettant la libération prolongée d'un médicament à travers ou dans une barrière biologique telle que la peau. Ce dispositif peut comporter un substrat de base comprenant un médicament dispersé dans une matière de matrice, et une ou plusieurs micro-aiguilles s'étendant à partir du substrat de base, la ou les micro-aiguilles comportant une matière soluble ou gonflable dans l'eau, matière grâce à laquelle la ou les micro-aiguilles se dissolvent ou gonflent après avoir été introduites dans la barrière biologique, permettant ainsi le passage du médicament du substrat de base dans la barrière biologique.
PCT/US2007/074123 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide WO2008011625A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (fr) 2008-01-24
WO2008011625A3 true WO2008011625A3 (fr) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 WO2008011625A2 (fr) 2006-07-21 2007-07-23 Dispositifs à micro-aiguille(s) et procédés d'administration de médicament ou de retrait de fluide

Country Status (1)

Country Link
WO (1) WO2008011625A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
CA2612005C (fr) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Microstructures revetues et procede de fabrication de celles-ci
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
JP5553612B2 (ja) 2007-01-22 2014-07-16 コリウム インターナショナル， インコーポレイテッド マイクロニードルアレイ用アプリケータ
ES2820335T3 (es) * 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US9549746B2 (en) 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
WO2009048607A1 (fr) 2007-10-10 2009-04-16 Corium International, Inc. Distribution de vaccin par l'intermédiaire de réseaux de micro-aiguilles
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
EP2231257A4 (fr) 2007-12-24 2013-11-06 Univ Queensland Procédé d'application
CA2749347C (fr) 2008-02-07 2018-03-27 The University Of Queensland Fabrication de timbre transdermique
US20090234322A1 (en) 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
WO2009142741A1 (fr) * 2008-05-21 2009-11-26 Theraject, Inc. Procédé de fabrication de patches de perforateur à solutions solides et applications associées
WO2009140735A1 (fr) 2008-05-23 2009-11-26 The University Of Queensland Détection de substances à analyser par un timbre à micro-aiguilles avec des réactifs sélectifs
DK2346563T3 (da) * 2008-10-07 2019-01-02 Tuo Jin Polymere faseovergangsmikronåle
US8734697B2 (en) 2008-12-22 2014-05-27 The University Of Queensland Patch production
EP2566501B1 (fr) 2010-05-04 2019-03-13 Corium International, Inc. Méthode et dispositif permettant l'administration transdermique d'hormone parathyroïdienne au moyen d'un réseau de microprojections
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
AU2013364053B2 (en) 2012-12-21 2018-08-30 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
US10646702B2 (en) * 2013-01-21 2020-05-12 Paean Aesthetics Inc. Microneedle, mould for producing same, and production method for same
MX383605B (es) 2013-03-12 2025-03-14 Corium Int Inc Aplicadores de microproyeccion.
CA2906541C (fr) 2013-03-15 2022-06-21 Corium International, Inc. Microreseau pour l'administration d'un agent therapeutique et ses procedes d'utilisation
EP2968751B1 (fr) 2013-03-15 2022-11-30 Corium, Inc. Applicateurs de microprojection d'impacts multiples
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
AU2014233541B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2015130891A2 (fr) 2014-02-26 2015-09-03 Illumicure Inc. Appareils et procédés de photothérapie ultraviolette
JP6579099B2 (ja) * 2014-04-03 2019-09-25 凸版印刷株式会社 穿刺注入器具
WO2016036866A1 (fr) 2014-09-04 2016-03-10 Corium International, Inc. Matrice de microstructures, procédé de production et procédés d'utilisation
CA3204959A1 (fr) 2015-02-02 2016-08-11 Vaxxas Pty Limited Applicateur a reseau de microprojections et procede
CA2983289C (fr) * 2015-04-21 2023-10-03 North Carolina State University Systeme de distribution d'insuline repondant au glucose au moyen de nanocomposites sensibles a l'hypoxie
WO2017004067A1 (fr) 2015-06-29 2017-01-05 Corium International, Inc. Micro-réseau pour l'administration d'un agent thérapeutique, procédés d'utilisation, et procédés de fabrication
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981A4 (fr) 2015-09-28 2019-05-22 Vaxxas Pty Limited Réseau de microsaillies ayant des propriétés de pénétration de la peau améliorées et procédés associés
CN109152878B (zh) * 2016-01-13 2021-04-13 综合医院公司以麻省总医院名义经营 用于从患者皮肤去除外源颗粒的系统和方法
CN109310527A (zh) 2016-02-09 2019-02-05 鲁玛治疗公司 用于通过光疗法来治疗牛皮癣的方法、组合物和设备
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
EP3639010B1 (fr) 2017-06-13 2025-08-06 Vaxxas Pty Limited Contrôle de la qualité de revêtements de substrats
EP4548954A3 (fr) 2017-08-04 2025-07-30 Vaxxas Pty Limited Actionneur à stockage d'énergie mécanique élevé compact et à force de déclenchement faible pour l'administration de patchs à réseaux de microprojections (prm)
CN108837238B (zh) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） 一种玻尿酸注射针
CN111588689B (zh) * 2020-06-20 2023-08-11 温州医科大学 一种角膜微创可溶性微针贴片及其制备方法与应用
US20220105029A1 (en) * 2020-10-07 2022-04-07 The Board Of Trustees Of The University Of Arkansas Biodegradable chitosan microneedle patch for transdermal delivery for livestock pain management
US20230415383A1 (en) * 2021-02-11 2023-12-28 The Boeing Company Method and apparatus for fabricating brittle microneedle
WO2022183122A1 (fr) * 2021-02-27 2022-09-01 The Brigham And Women's Hospital, Inc. Compositions de micro-aiguilles et méthodes d'administration les utilisant

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US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
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