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WO2008013994A3 - Processes for the synthesis of o-desmethylvenlafaxine - Google Patents

Processes for the synthesis of o-desmethylvenlafaxine Download PDF

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Publication number
WO2008013994A3
WO2008013994A3 PCT/US2007/017010 US2007017010W WO2008013994A3 WO 2008013994 A3 WO2008013994 A3 WO 2008013994A3 US 2007017010 W US2007017010 W US 2007017010W WO 2008013994 A3 WO2008013994 A3 WO 2008013994A3
Authority
WO
WIPO (PCT)
Prior art keywords
desmethylvenlafaxine
processes
synthesis
intermediates
preparation
Prior art date
Application number
PCT/US2007/017010
Other languages
French (fr)
Other versions
WO2008013994A2 (en
Inventor
Valerie Niddam-Hildesheim
Tamar Nidam
Original Assignee
Teva Pharma
Teva Pharmaceutical Usa Inc
Valerie Niddam-Hildesheim
Tamar Nidam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Teva Pharmaceutical Usa Inc, Valerie Niddam-Hildesheim, Tamar Nidam filed Critical Teva Pharma
Priority to PCT/US2007/017010 priority Critical patent/WO2008013994A2/en
Priority to CA002656167A priority patent/CA2656167A1/en
Priority to EP07836329A priority patent/EP1917237A2/en
Publication of WO2008013994A2 publication Critical patent/WO2008013994A2/en
Publication of WO2008013994A3 publication Critical patent/WO2008013994A3/en
Priority to IL196404A priority patent/IL196404A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Provides are intermediates and processes for preparation of o- desmethylvenlafaxine.
PCT/US2007/017010 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine WO2008013994A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/US2007/017010 WO2008013994A2 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine
CA002656167A CA2656167A1 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine
EP07836329A EP1917237A2 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine
IL196404A IL196404A0 (en) 2006-07-26 2009-01-08 Processes for the synthesis of o-desmethylvenlafaxine

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US83361606P 2006-07-26 2006-07-26
US60/833,616 2006-07-26
US83787906P 2006-08-14 2006-08-14
US60/837,879 2006-08-14
US84399806P 2006-09-11 2006-09-11
US60/843,998 2006-09-11
US84921606P 2006-10-03 2006-10-03
US84925506P 2006-10-03 2006-10-03
US60/849,216 2006-10-03
US60/849,255 2006-10-03
US90663907P 2007-03-12 2007-03-12
US60/906,639 2007-03-12
US90687907P 2007-03-13 2007-03-13
US60/906,879 2007-03-13
PCT/US2007/017010 WO2008013994A2 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine

Publications (2)

Publication Number Publication Date
WO2008013994A2 WO2008013994A2 (en) 2008-01-31
WO2008013994A3 true WO2008013994A3 (en) 2008-03-20

Family

ID=39750812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017010 WO2008013994A2 (en) 2006-07-26 2007-07-26 Processes for the synthesis of o-desmethylvenlafaxine

Country Status (3)

Country Link
CA (1) CA2656167A1 (en)
IL (1) IL196404A0 (en)
WO (1) WO2008013994A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0200898A3 (en) 1999-04-06 2005-09-28 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
UA80543C2 (en) 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAVAN S P ET AL: "An efficient and green protocol for the preparation of cycloalkanols: apractical synthesis of venlafaxine", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 45, 2004, pages 7291 - 7295, XP002419152, ISSN: 0040-4039 *
YARDLEY J P ET AL: "2-PHENYL-2-(1-HYDROXYCYCLOALKYL)ETHYLAMINE DERIVATIVES: SYNTHESIS AND ANTIDEPRESSANT ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, 1990, pages 2899 - 2905, XP000891765, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2008013994A2 (en) 2008-01-31
CA2656167A1 (en) 2008-01-31
IL196404A0 (en) 2009-11-18

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