WO2008037037A3 - Médicament anti-asthmatique - Google Patents
Médicament anti-asthmatique Download PDFInfo
- Publication number
- WO2008037037A3 WO2008037037A3 PCT/BG2007/000021 BG2007000021W WO2008037037A3 WO 2008037037 A3 WO2008037037 A3 WO 2008037037A3 BG 2007000021 W BG2007000021 W BG 2007000021W WO 2008037037 A3 WO2008037037 A3 WO 2008037037A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- asthmatic
- medicine
- hydrochloricum
- sulfuricum
- sulfaguajacolicum
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 title abstract 4
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 title abstract 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 3
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 title abstract 3
- -1 aminophyyline Chemical compound 0.000 title abstract 2
- 230000001088 anti-asthma Effects 0.000 title abstract 2
- 239000000924 antiasthmatic agent Substances 0.000 title abstract 2
- RUZIUYOSRDWYQF-HNNXBMFYSA-N (S)-glaucine Chemical compound CN1CCC2=CC(OC)=C(OC)C3=C2[C@@H]1CC1=C3C=C(OC)C(OC)=C1 RUZIUYOSRDWYQF-HNNXBMFYSA-N 0.000 title 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 title 1
- 229930003347 Atropine Natural products 0.000 title 1
- DABPOQZSGVNAAS-UHFFFAOYSA-N Glaucocalactone Natural products O=CC12C3C(C4)OC(=O)C2C(C)(C)CCC1OC(=O)C13CC4C(=C)C1OC(=O)C DABPOQZSGVNAAS-UHFFFAOYSA-N 0.000 title 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 title 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 title 1
- 229960000396 atropine Drugs 0.000 title 1
- 229960001948 caffeine Drugs 0.000 title 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 title 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 title 1
- 229960004943 ergotamine Drugs 0.000 title 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 title 1
- 229940113086 glaucine Drugs 0.000 title 1
- 229930004041 glaucine Natural products 0.000 title 1
- 229960001789 papaverine Drugs 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
- 208000006673 asthma Diseases 0.000 abstract 5
- ICKFFNBDFNZJSX-UHFFFAOYSA-N N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-(2-pyridinyl)ethane-1,2-diamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=C(Cl)C=C1 ICKFFNBDFNZJSX-UHFFFAOYSA-N 0.000 abstract 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 2
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 abstract 2
- 230000001154 acute effect Effects 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- JROGBPMEKVAPEH-GXGBFOEMSA-N emetine dihydrochloride Chemical compound Cl.Cl.N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC JROGBPMEKVAPEH-GXGBFOEMSA-N 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne un médicament anti-asthmatique qui peut être utilisé en médecine humaine pour traiter un asthme ou une bronchite asthmatique. Ce médicament contient coffeinum purum, ergotamintartarat, zincum sulfuricum, papaverinum hydrochloricum, atropinum sulfuricum, aminophyllinum, glaucinum hydrochloricum, kalium sulfaguajacolicum et chlorpyraminum, dans les proportions suivantes [en mg] : coffeinum purum 30,00 à 250,00; ergotamintartarat 0,25 à 2,00; zincum sulfuricum 10,00 à 400,00; papaverinum hydrochloricum 30,00 à 200,00; atropinum sulfuricum 0,25 à 1,00; aminophyllinum 40,00 à 250,00; glaucinum hydrochloricum 30,00 à 250,00; kalium sulfaguajacolicum 100,00 à 600,00; chlorpyraminum 30,00 à 200,00. Ce médicament est avantageux en ce qu'il permet de maîtriser les crises d'asthme les plus aigües en l'espace de 30-40 minutes, en ce qu'il empêche la réapparition d'une respiration asthmatique douloureuse et de crises asthmatiques résultantes sur une période de 10 à 20 ans, voire au-delà, c'est-à-dire que la maladie est traitée en pratique, en ce qu'il empêche les effets secondaires importants et les complications causés par les corticostéroïdes et en ce qu'il est très bien supporté et n'engendre pas de complications.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG109687 | 2006-09-26 | ||
BG109687A BG109687A (bg) | 2006-09-26 | 2006-09-26 | Антиастматично лекарствено средство |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008037037A2 WO2008037037A2 (fr) | 2008-04-03 |
WO2008037037A3 true WO2008037037A3 (fr) | 2008-07-10 |
Family
ID=39060181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/BG2007/000021 WO2008037037A2 (fr) | 2006-09-26 | 2007-09-19 | Médicament anti-asthmatique |
Country Status (2)
Country | Link |
---|---|
BG (1) | BG109687A (fr) |
WO (1) | WO2008037037A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113633710A (zh) * | 2021-09-29 | 2021-11-12 | 浙江养和健康管理科技有限公司 | 一种治疗支气管炎、哮喘和肺气肿的中药组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996031222A1 (fr) * | 1994-03-23 | 1996-10-10 | Ivan Dimitrov Hristov | Preparation antiashtmatique |
US20010010825A1 (en) * | 1998-07-28 | 2001-08-02 | Toshihiro Shimizu | Rapidly disintegrable solid preparation |
BG105687U (en) * | 2001-07-10 | 2003-01-31 | "Софарма" Ад | Combined means for affecting the respiratory system |
-
2006
- 2006-09-26 BG BG109687A patent/BG109687A/bg unknown
-
2007
- 2007-09-19 WO PCT/BG2007/000021 patent/WO2008037037A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996031222A1 (fr) * | 1994-03-23 | 1996-10-10 | Ivan Dimitrov Hristov | Preparation antiashtmatique |
US20010010825A1 (en) * | 1998-07-28 | 2001-08-02 | Toshihiro Shimizu | Rapidly disintegrable solid preparation |
BG105687U (en) * | 2001-07-10 | 2003-01-31 | "Софарма" Ад | Combined means for affecting the respiratory system |
Non-Patent Citations (3)
Title |
---|
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002478408 * |
SZEMERE P A ET AL: "Consumption of antihistamines and antiasthmatics in Hungary during 1992-1996", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, vol. 118, no. 2-4, February 1999 (1999-02-01), pages 335 - 337, XP009096574, ISSN: 1018-2438 * |
WAN HUAN-YING ET AL: "Effect of theophylline and glucose injection in treating acute asthma", ZHONGGUO XINYAO YU LINCHUANG ZAZHI, vol. 23, no. 3, March 2004 (2004-03-01), pages 159 - 163, XP002470608, ISSN: 1007-7669 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008037037A2 (fr) | 2008-04-03 |
BG109687A (bg) | 2008-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005099715A3 (fr) | Traitement de pathologies ophtalmiques | |
AU6918700A (en) | Pharmaceutical compositions and methods for reducing the appearance of cellulite | |
WO2007133816A3 (fr) | PROCÉDÉS DE TRAITEMENT DE LA DOULEUR ET DE L'INFLAMMATION DANS LE TISSU NEURONAL METTANT EN OEUVRE DES ANTAGONISTES IL-31Ra ET OSMRb | |
CN102002767A (zh) | 具有护肤保健功能的珍珠中药纤维及其制备方法 | |
WO2009079451A3 (fr) | Compositions et procédés pour favoriser la guérison d'une plaie | |
EP2759302A3 (fr) | 4F-benzoyl-TN14003 combiné avec rituximab pour une utilisation dans le traitement d'une tumeure | |
WO2009065093A3 (fr) | Utilisation de cellules souches pour la cicatrisation de plaie | |
CN101926393A (zh) | 一种冬虫夏草保健食用油 | |
CN101427844A (zh) | 无花果保健香烟 | |
CN101584651A (zh) | 一种珍珠护肤品 | |
WO2008037037A3 (fr) | Médicament anti-asthmatique | |
CN102793438A (zh) | 抗菌蚕丝枕 | |
CN102755507B (zh) | 一种治疗风燥伤肺型急性支气管炎的中药汤剂 | |
CN102210827B (zh) | 用于戒烟的中药 | |
KR20130142326A (ko) | 발모 촉진제 조성물 | |
CN101185722B (zh) | 一种治疗脚气的浸剂药物 | |
CN202197887U (zh) | 一种防治冻疮手套 | |
CN207785521U (zh) | 一种治疗口疮的中药保健贴 | |
CN1977820A (zh) | 一种丝瓜美容品 | |
CN104005254A (zh) | 一种具有清热解酒功能的水松纸原纸及其制备方法 | |
CN102370665A (zh) | 治疗儿童盗汗的中药组合物及方法 | |
CN101455685A (zh) | 一种治疗小儿虚汗症的脐贴剂 | |
CN101062090A (zh) | 缓解癌症患者疼痛制剂的制备方法 | |
CN2796427Y (zh) | 足跟皲裂防治套 | |
CN1243729A (zh) | 一种治疗鸡眼的药物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07815698 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07815698 Country of ref document: EP Kind code of ref document: A2 |