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WO2008039351A3 - Method of manufacturing tablets containing pharmacologically active agents - Google Patents

Method of manufacturing tablets containing pharmacologically active agents Download PDF

Info

Publication number
WO2008039351A3
WO2008039351A3 PCT/US2007/020406 US2007020406W WO2008039351A3 WO 2008039351 A3 WO2008039351 A3 WO 2008039351A3 US 2007020406 W US2007020406 W US 2007020406W WO 2008039351 A3 WO2008039351 A3 WO 2008039351A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacologically active
active agents
tablets containing
containing pharmacologically
manufacturing tablets
Prior art date
Application number
PCT/US2007/020406
Other languages
French (fr)
Other versions
WO2008039351A2 (en
Inventor
Anasuya Ashok Ghosh
Yatindra Joshi
Shoufeng Li
Alan Edward Royce
Colleen Ruegger
Original Assignee
Novartis Ag
Anasuya Ashok Ghosh
Yatindra Joshi
Shoufeng Li
Alan Edward Royce
Colleen Ruegger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Anasuya Ashok Ghosh, Yatindra Joshi, Shoufeng Li, Alan Edward Royce, Colleen Ruegger filed Critical Novartis Ag
Publication of WO2008039351A2 publication Critical patent/WO2008039351A2/en
Publication of WO2008039351A3 publication Critical patent/WO2008039351A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of improving the physical properties of an solid oral dosage form, especially a tablet, uses an external lubricant during the compaction process. The solid oral dosage form comprises a pharmacologically active agent, for example a protein or polypeptide, and a delivery agent. Tablet properties, such as hardness, disintegration time and dissolution, are improved using the method.
PCT/US2007/020406 2006-09-22 2007-09-20 Method of manufacturing tablets containing pharmacologically active agents WO2008039351A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82659706P 2006-09-22 2006-09-22
US60/826,597 2006-09-22

Publications (2)

Publication Number Publication Date
WO2008039351A2 WO2008039351A2 (en) 2008-04-03
WO2008039351A3 true WO2008039351A3 (en) 2008-06-19

Family

ID=39227036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020406 WO2008039351A2 (en) 2006-09-22 2007-09-20 Method of manufacturing tablets containing pharmacologically active agents

Country Status (5)

Country Link
AR (1) AR062925A1 (en)
CL (1) CL2007002724A1 (en)
PE (1) PE20080845A1 (en)
TW (1) TW200820993A (en)
WO (1) WO2008039351A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3326620T1 (en) 2010-12-16 2020-07-31 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2- hydroxybenzoyl)amino)caprylic acid
CN103619175B (en) 2011-04-12 2016-08-17 诺沃—诺迪斯克有限公司 Diacylated GLP-1 derivatives
EP3542790B1 (en) 2012-03-22 2023-09-13 Novo Nordisk A/S Compositions comprising a delivery agent and preparation thereof
PT2827845T (en) 2012-03-22 2019-03-29 Novo Nordisk As Compositions comprising a delivery agent and preparation thereof
HRP20181447T1 (en) 2012-03-22 2018-11-02 Novo Nordisk A/S GLP-1 PEPTIDE PREPARATIONS AND THEIR PREPARATION
JP6517690B2 (en) 2012-06-20 2019-05-22 ノヴォ ノルディスク アー／エス Tablet formulation containing peptide and delivery agent
HUE040609T2 (en) 2013-05-02 2019-03-28 Novo Nordisk As Oral administration of GLP-1 compounds
PL3746111T3 (en) 2018-02-02 2024-01-15 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070496A1 (en) * 1998-04-08 2001-01-24 Kyowa Hakko Kogyo Co., Ltd. Tablet manufacturing method and tablet
WO2005004900A1 (en) * 2003-07-11 2005-01-20 Novartis Ag Orally dosed pharmaceutical compositions comprising a delivery agent in micronized form

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070496A1 (en) * 1998-04-08 2001-01-24 Kyowa Hakko Kogyo Co., Ltd. Tablet manufacturing method and tablet
WO2005004900A1 (en) * 2003-07-11 2005-01-20 Novartis Ag Orally dosed pharmaceutical compositions comprising a delivery agent in micronized form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARTHUR H. KIBBE: "Handbook of PHARMACEUTICAL EXCIPIENTS", 2000, AMERICAN PHARMACEUTICAL ASSOCIATION AND THE PHARMACEUTICAL PRESS, USA, XP002475352 *

Also Published As

Publication number Publication date
CL2007002724A1 (en) 2008-05-16
PE20080845A1 (en) 2008-08-13
TW200820993A (en) 2008-05-16
WO2008039351A2 (en) 2008-04-03
AR062925A1 (en) 2008-12-17

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