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WO2008140598A3 - Nouvelles microbactéries immunothérapeutiques, formulations pharmaceutiques et utilisation de celle-ci - Google Patents

Nouvelles microbactéries immunothérapeutiques, formulations pharmaceutiques et utilisation de celle-ci Download PDF

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Publication number
WO2008140598A3
WO2008140598A3 PCT/US2007/086335 US2007086335W WO2008140598A3 WO 2008140598 A3 WO2008140598 A3 WO 2008140598A3 US 2007086335 W US2007086335 W US 2007086335W WO 2008140598 A3 WO2008140598 A3 WO 2008140598A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterium strains
mycobacteria
pharmaceutic
methods
genetically modified
Prior art date
Application number
PCT/US2007/086335
Other languages
English (en)
Other versions
WO2008140598A2 (fr
Inventor
David M. Hone
Original Assignee
Bacilligen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bacilligen, Inc. filed Critical Bacilligen, Inc.
Publication of WO2008140598A2 publication Critical patent/WO2008140598A2/fr
Publication of WO2008140598A3 publication Critical patent/WO2008140598A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des souches de Mycobacterium génétiquement modifiées qui sont utiles comme agents immunothérapeutiques anti-cancers. Les souches de Mycobacterium génétiquement modifiées présentent de préférence au moins une modification génétique conduisant à une adhérence tissulaire accrue, qui peut être combinée avec des modifications génétiques qui augmentent l'immunopuissance et conduisent à une production d'adjuvants. L'invention concerne également des compositions et des procédés pour le développement desdites souches de Mycobacterium, et des compositions pharmaceutiques et des procédés pour l'utilisation desdites souches de Mycobacterium comme agents thérapeutiques anti-cancer.
PCT/US2007/086335 2006-12-04 2007-12-04 Nouvelles microbactéries immunothérapeutiques, formulations pharmaceutiques et utilisation de celle-ci WO2008140598A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86845006P 2006-12-04 2006-12-04
US60/868,450 2006-12-04

Publications (2)

Publication Number Publication Date
WO2008140598A2 WO2008140598A2 (fr) 2008-11-20
WO2008140598A3 true WO2008140598A3 (fr) 2016-06-09

Family

ID=40002815

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/086335 WO2008140598A2 (fr) 2006-12-04 2007-12-04 Nouvelles microbactéries immunothérapeutiques, formulations pharmaceutiques et utilisation de celle-ci

Country Status (1)

Country Link
WO (1) WO2008140598A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US9139809B2 (en) * 2009-01-08 2015-09-22 Albert Einstein College Of Medicine Of Yeshiva University Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
US12359209B2 (en) 2018-04-17 2025-07-15 The Johns Hopkins Unversity Recombinant therapeutic interventions for cancer
WO2022203308A1 (fr) * 2021-03-22 2022-09-29 클립스비엔씨 주식회사 Nouvelle souche recombinée de mycobacterium smegmatis et son utilisation
WO2023150848A1 (fr) * 2022-02-11 2023-08-17 Instituto Butantan Compositions comprenant des souches de mycobacterium recombinantes, leurs utilisations et méthodes pour la prévention et/ou le traitement de cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050220811A1 (en) * 2002-04-05 2005-10-06 Stewart Cole Identification of virulence associated regions rd1 and rd5 leading to improve vaccine of m. bovis bcg and m. microti
EP1882741A1 (fr) * 2006-07-25 2008-01-30 Institut Pasteur Souche de Mycobacterium exprimant une proteine FAP sous le contrôle d'un promoteur qui est actif en conditions d' hypoxie et ses applications pour la thérapie du cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050220811A1 (en) * 2002-04-05 2005-10-06 Stewart Cole Identification of virulence associated regions rd1 and rd5 leading to improve vaccine of m. bovis bcg and m. microti
EP1882741A1 (fr) * 2006-07-25 2008-01-30 Institut Pasteur Souche de Mycobacterium exprimant une proteine FAP sous le contrôle d'un promoteur qui est actif en conditions d' hypoxie et ses applications pour la thérapie du cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LEWIS ET AL.: "Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette-Guerin Attenuation.", JOURNAL OF INFECTIOUS DISEASES, vol. 187, no. 1, 2003, pages 117 - 23, XP002987276, DOI: doi:10.1086/345862 *
MIYAMOTO ET AL.: "Aggregation of mycobacteria caused by disruption of fibronectin-attachment protein-encoding gene .", FEMS MICROBIOLOGY LETTERS, vol. 236, no. 2, 2004, pages 227 - 234 *
SECOTT ET AL.: "Fibronectin Attachment Protein Is Necessary for Efficient Attachment and Invasion of Epithelial Cells by Mycobacterium avium subsp. paratuberculosis.", INFECTION AND IMMUNITY, vol. 70, no. 5, May 2002 (2002-05-01), pages 2670 - 2675 *
ZHAO ET AL.: "Characterization of the Fibronectin Binding Motif for a Unique Mycobacterial Fibronectin Attachment Protein, FAP.", J. BIOL CHEM, vol. 274, no. 8, 19 February 1999 (1999-02-19), pages 4521 - 4526 *
ZHAO ET AL.: "ROLE OF A BACILLUS CALMETTE-GUERIN FIBRONECTIN ATTACHMENT PROTEIN IN BCG-INDUCED ANTITUMOR ACTIVITY.", INT. J. CANCER, vol. 86, no. 1, 2000, pages 83 - 88, XP002401487, DOI: doi:10.1002/(SICI)1097-0215(20000401)86:1<83::AID-IJC13>3.0.CO;2-R *

Also Published As

Publication number Publication date
WO2008140598A2 (fr) 2008-11-20

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