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WO2008143014A1 - がん治療剤 - Google Patents

がん治療剤 Download PDF

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Publication number
WO2008143014A1
WO2008143014A1 PCT/JP2008/058568 JP2008058568W WO2008143014A1 WO 2008143014 A1 WO2008143014 A1 WO 2008143014A1 JP 2008058568 W JP2008058568 W JP 2008058568W WO 2008143014 A1 WO2008143014 A1 WO 2008143014A1
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
therapeutic agent
lymphocytes
treatment
reduction
Prior art date
Application number
PCT/JP2008/058568
Other languages
English (en)
French (fr)
Inventor
Hiroshi Shiku
Shinichi Kageyama
Shigehisa Kitano
Mitsuko Ideno
Keisuke Tomita
Tatsuji Enoki
Kazutoh Takesako
Ikunoshin Kato
Original Assignee
Takara Bio Inc.
Mie University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc., Mie University filed Critical Takara Bio Inc.
Priority to US12/599,541 priority Critical patent/US20100247579A1/en
Priority to JP2009515147A priority patent/JPWO2008143014A1/ja
Publication of WO2008143014A1 publication Critical patent/WO2008143014A1/ja

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　本発明は、下記（Ａ）工程及び（Ｂ）工程を包含することを特徴とするがんの治療方法： （Ａ）患者にリンパ球数減少を伴う処置を実施する工程、及び （Ｂ）上記（Ａ）工程に続いて速やかに患者にリンパ球を投与する工程、 当該治療方法に使用されるがん治療剤及びがん治療用キットを提供する。当該治療方法は、免疫再建療法として、リンパ球数の減少に起因する免疫能の低下が回避されることにより、感染症へのリスクを低減させることができる。
PCT/JP2008/058568 2007-05-11 2008-05-08 がん治療剤 WO2008143014A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/599,541 US20100247579A1 (en) 2007-05-11 2008-05-08 Therapeutic agent for cancer
JP2009515147A JPWO2008143014A1 (ja) 2007-05-11 2008-05-08 がん治療剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-127436 2007-05-11
JP2007127436 2007-05-11

Publications (1)

Publication Number Publication Date
WO2008143014A1 true WO2008143014A1 (ja) 2008-11-27

Family

ID=40031726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058568 WO2008143014A1 (ja) 2007-05-11 2008-05-08 がん治療剤

Country Status (4)

Country Link
US (1) US20100247579A1 (ja)
JP (1) JPWO2008143014A1 (ja)
TW (1) TW200908988A (ja)
WO (1) WO2008143014A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011051937A (ja) * 2009-09-02 2011-03-17 Takara Bio Inc がん治療剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2937699T3 (es) * 2016-04-22 2023-03-30 Crage Medical Co Ltd Composiciones y métodos de inmunoterapia celular
CN110511909B (zh) * 2019-07-29 2022-01-04 吉林大学 体外扩增造血干细胞的生长因子组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080817A1 (fr) * 2002-03-25 2003-10-02 Takara Bio Inc. Procede de production de lymphocyte cytotoxique
JP2007061020A (ja) * 2005-08-31 2007-03-15 Takara Bio Inc リンパ球の製造方法
WO2007040105A1 (ja) * 2005-09-30 2007-04-12 Takara Bio Inc. Ｔ細胞集団の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100858857B1 (ko) * 2001-08-15 2008-09-17 다카라 바이오 가부시키가이샤 항원특이적 세포상해성 ｔ 세포 확대배양방법
JP4870432B2 (ja) * 2003-08-22 2012-02-08 タカラバイオ株式会社 細胞傷害性リンパ球の製造方法
WO2007020880A1 (ja) * 2005-08-17 2007-02-22 Takara Bio Inc. リンパ球の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080817A1 (fr) * 2002-03-25 2003-10-02 Takara Bio Inc. Procede de production de lymphocyte cytotoxique
JP2007061020A (ja) * 2005-08-31 2007-03-15 Takara Bio Inc リンパ球の製造方法
WO2007040105A1 (ja) * 2005-09-30 2007-04-12 Takara Bio Inc. Ｔ細胞集団の製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ITO K. ET AL.: "Kagaku Ryoho ni Yoshi Men'eki Ryoho o Heiyo shita Hishosaibo Shinkogan no Ichirei", JAPANESE JOURNAL OF LUNG CANCER, vol. 32, no. 1, February 1992 (1992-02-01), pages 81 - 87 *
YAMANO Y. ET AL.: "Kogan Mouse ni Okeru lymphokine activated killer (LAK) Saibo Oyobi interleukin-2 (IL-2) o Mochiita adoptive immunotherapy to Koganzai no Heiyo Koka", JOURNAL OF NIPPON MEDICAL SCHOOL, vol. 64, no. 3, 1997, pages 211 - 219 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011051937A (ja) * 2009-09-02 2011-03-17 Takara Bio Inc がん治療剤

Also Published As

Publication number Publication date
TW200908988A (en) 2009-03-01
JPWO2008143014A1 (ja) 2010-08-05
US20100247579A1 (en) 2010-09-30

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WO2008143014A1 (ja) がん治療剤

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