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WO2008152421A3 - Nouvelles méthodes - Google Patents

Nouvelles méthodes Download PDF

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Publication number
WO2008152421A3
WO2008152421A3 PCT/GB2008/050434 GB2008050434W WO2008152421A3 WO 2008152421 A3 WO2008152421 A3 WO 2008152421A3 GB 2008050434 W GB2008050434 W GB 2008050434W WO 2008152421 A3 WO2008152421 A3 WO 2008152421A3
Authority
WO
WIPO (PCT)
Prior art keywords
modification
vivo
compound
glucosylamine
compounds
Prior art date
Application number
PCT/GB2008/050434
Other languages
English (en)
Other versions
WO2008152421A2 (fr
Inventor
Michael Peter Seed
Joe Albert Mancini
Laura Dugo
Margaret Lees
Michael Burnet
Hans Juergen Gutke
Original Assignee
Diosamine Dev Corp
Michael Peter Seed
Joe Albert Mancini
Laura Dugo
Margaret Lees
Michael Burnet
Hans Juergen Gutke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diosamine Dev Corp, Michael Peter Seed, Joe Albert Mancini, Laura Dugo, Margaret Lees, Michael Burnet, Hans Juergen Gutke filed Critical Diosamine Dev Corp
Publication of WO2008152421A2 publication Critical patent/WO2008152421A2/fr
Publication of WO2008152421A3 publication Critical patent/WO2008152421A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

La présente invention concerne des méthodes de modification ou d'essai de modification du niveau d'une cytokine in vivo, ex vivo ou in vitro. La méthode consiste à mettre en contact un composé ou un sel pharmaceutiquement acceptable de celui-ci avec une cellule, ledit composé comprenant au moins une sous-unité de monosaccharide contenant un groupe amine glycosidique. La présente invention concerne également une méthode de modification ou d'essai de modification du niveau de VEGF in vivo, ex vivo ou in vitro, ladite méthode consistant à mettre en contact un composé avec une cellule, ledit composé étant PHA (phytohémagglutinine) ou une protéine semblable d'un point de vue structurel.
PCT/GB2008/050434 2007-06-11 2008-06-11 Nouvelles méthodes WO2008152421A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0711140A GB2450088A (en) 2007-06-11 2007-06-11 Optionally modified monosaccharides with imine/iminium or glycosidic amine/ammonium group for use in modifying the level of cytokines & in therapy
GB0711140.4 2007-06-11

Publications (2)

Publication Number Publication Date
WO2008152421A2 WO2008152421A2 (fr) 2008-12-18
WO2008152421A3 true WO2008152421A3 (fr) 2009-02-26

Family

ID=38319061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/050434 WO2008152421A2 (fr) 2007-06-11 2008-06-11 Nouvelles méthodes

Country Status (2)

Country Link
GB (1) GB2450088A (fr)
WO (1) WO2008152421A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201000196D0 (en) * 2010-01-07 2010-02-24 Galvez Julian M Novel combination

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855283A (en) * 1985-06-20 1989-08-08 Bayer Aktiengesellschaft Novel pharmaceutically active N-(2-aminoacylamido-2-deoxy-hexosyl)-amides, -carbamates and -ureas
EP0692475A1 (fr) * 1993-04-01 1996-01-17 Limited Liability Partnership "Polysan" N-METHYLE-N-/$g(a),$g(D)-GLUCOPYRANOZIL/AMMONIAC-2-/ACRIDON-9-ON-10-YLE/ACETATE/CYCLOPHERONE DOTEE DE PROPRIETES DE PRODUCTION D'INTERFERON, ANTIVIRALES (Y COMPRIS L'ACTIVITE ANTI-VIH), ANTIPARASITAIRES, ANTI-PROMOTEUR ET RADIOPROTECTRICES
JPH0853486A (ja) * 1994-08-11 1996-02-27 Sankyo Co Ltd １位にアミド結合を有する３−ホスホノグルコサミン類
WO1996035700A1 (fr) * 1995-05-10 1996-11-14 Glycomed Incorporated Saccharopeptides et derives
US5631245A (en) * 1995-06-06 1997-05-20 Biodynamics Pharmaceuticals, Inc. Method for medicating the inflammatory controlling system and adverse inflammatory reactions and for making compounds for treating the pathology of adverse inflammatory reactions
US5908836A (en) * 1987-12-21 1999-06-01 Bar-Shalom; Daniel Protecting skin from radiation damage using sulphated sugars
WO2008059003A1 (fr) * 2006-11-14 2008-05-22 Diosamine Development Corporation Nouveaux composés

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855283A (en) * 1985-06-20 1989-08-08 Bayer Aktiengesellschaft Novel pharmaceutically active N-(2-aminoacylamido-2-deoxy-hexosyl)-amides, -carbamates and -ureas
US5908836A (en) * 1987-12-21 1999-06-01 Bar-Shalom; Daniel Protecting skin from radiation damage using sulphated sugars
EP0692475A1 (fr) * 1993-04-01 1996-01-17 Limited Liability Partnership "Polysan" N-METHYLE-N-/$g(a),$g(D)-GLUCOPYRANOZIL/AMMONIAC-2-/ACRIDON-9-ON-10-YLE/ACETATE/CYCLOPHERONE DOTEE DE PROPRIETES DE PRODUCTION D'INTERFERON, ANTIVIRALES (Y COMPRIS L'ACTIVITE ANTI-VIH), ANTIPARASITAIRES, ANTI-PROMOTEUR ET RADIOPROTECTRICES
JPH0853486A (ja) * 1994-08-11 1996-02-27 Sankyo Co Ltd １位にアミド結合を有する３−ホスホノグルコサミン類
WO1996035700A1 (fr) * 1995-05-10 1996-11-14 Glycomed Incorporated Saccharopeptides et derives
US5631245A (en) * 1995-06-06 1997-05-20 Biodynamics Pharmaceuticals, Inc. Method for medicating the inflammatory controlling system and adverse inflammatory reactions and for making compounds for treating the pathology of adverse inflammatory reactions
WO2008059003A1 (fr) * 2006-11-14 2008-05-22 Diosamine Development Corporation Nouveaux composés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HENDELES L ET AL: "Evaluation of cytokine modulators for asthma", PAEDIATRIC RESPIRATORY REVIEWS, W.B. SAUNDERS, vol. 5, 1 January 2004 (2004-01-01), pages S107 - S112, XP004581556, ISSN: 1526-0542 *

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Publication number Publication date
WO2008152421A2 (fr) 2008-12-18
GB0711140D0 (en) 2007-07-18
GB2450088A (en) 2008-12-17

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