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WO2008101671A3 - PROTÉINES HYBRIDES IL4-Fc - Google Patents

PROTÉINES HYBRIDES IL4-Fc Download PDF

Info

Publication number
WO2008101671A3
WO2008101671A3 PCT/EP2008/001293 EP2008001293W WO2008101671A3 WO 2008101671 A3 WO2008101671 A3 WO 2008101671A3 EP 2008001293 W EP2008001293 W EP 2008001293W WO 2008101671 A3 WO2008101671 A3 WO 2008101671A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
domain
relates
constant immunoglobulin
polypeptide
Prior art date
Application number
PCT/EP2008/001293
Other languages
English (en)
Other versions
WO2008101671A2 (fr
WO2008101671A9 (fr
Inventor
Oliver Hill
Christian Gieffers
Meinolf Thiemann
Original Assignee
Apogenix Gmbh
Oliver Hill
Christian Gieffers
Meinolf Thiemann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogenix Gmbh, Oliver Hill, Christian Gieffers, Meinolf Thiemann filed Critical Apogenix Gmbh
Publication of WO2008101671A2 publication Critical patent/WO2008101671A2/fr
Publication of WO2008101671A3 publication Critical patent/WO2008101671A3/fr
Publication of WO2008101671A9 publication Critical patent/WO2008101671A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des protéines hybrides comprenant au moins un domaine polypeptidique d'IL-4 et un domaine constant d'immunoglobuline.
PCT/EP2008/001293 2007-02-19 2008-02-19 PROTÉINES HYBRIDES IL4-Fc WO2008101671A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07003443.4 2007-02-19
EP07003443 2007-02-19

Publications (3)

Publication Number Publication Date
WO2008101671A2 WO2008101671A2 (fr) 2008-08-28
WO2008101671A3 true WO2008101671A3 (fr) 2008-12-11
WO2008101671A9 WO2008101671A9 (fr) 2009-02-19

Family

ID=39670915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/001293 WO2008101671A2 (fr) 2007-02-19 2008-02-19 PROTÉINES HYBRIDES IL4-Fc

Country Status (1)

Country Link
WO (1) WO2008101671A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623693B (zh) * 2017-03-20 2022-03-25 徐寒梅 一种融合蛋白及其制备方法和其在制备治疗眼科疾病、抗炎、抗肿瘤药物中的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2850093B1 (fr) 2012-01-27 2019-01-09 The Board of Trustees of the Leland Stanford Junior University Polypeptides d'il-13 thérapeutiques
DK2875045T3 (en) * 2012-07-18 2018-07-02 Apogenix Ag COMPOSITION comprising a mixture of CD95-FC ISOFORMs
CN110615835A (zh) 2012-08-09 2019-12-27 利兰斯坦福初级大学董事会 选择性地操纵靶细胞中对两个或更多个共有受体多肽识别的配体的细胞反应的方法
JP6936934B2 (ja) * 2013-09-24 2021-09-22 メディシナ セラピューティクス インコーポレイテッド インターロイキン−４受容体結合融合タンパク質及びその使用
US20200362058A1 (en) * 2017-05-24 2020-11-19 Novartis Ag Antibody-cytokine engrafted proteins and methods of use
CN111405911A (zh) 2017-10-10 2020-07-10 梅迪塞纳医疗股份有限公司 用于治疗中枢神经系统(cns)肿瘤的il-4融合制剂
US12404497B2 (en) 2018-06-01 2025-09-02 Medicenna Therapeutics Inc. Uses and methods for oncolytic virus targeting of IL-4/IL-13 and fusions thereof
EP4285913A1 (fr) * 2022-05-30 2023-12-06 Ecole Polytechnique Fédérale de Lausanne (EPFL) Thérapie de lymphocytes t adoptive hautement efficace
EP4612165A1 (fr) * 2022-11-02 2025-09-10 Synerkine Pharma B.V. Immunocytokines modifiées, polypeptides de fusion et polypeptides il10

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
US6130318A (en) * 1994-07-01 2000-10-10 Bayer Aktiengellschaft hIL-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
WO2001003737A1 (fr) * 1999-07-13 2001-01-18 Bolder Biotechnology Inc. Proteines de fusion d'immunoglobine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6130318A (en) * 1994-07-01 2000-10-10 Bayer Aktiengellschaft hIL-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
WO2001003737A1 (fr) * 1999-07-13 2001-01-18 Bolder Biotechnology Inc. Proteines de fusion d'immunoglobine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PICCIRILLO C ET AL: "Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors", HUMAN GENE THERAPY, MARY ANN LIEBERT, NEW YORK ,NY, US, vol. 10, 10 August 1999 (1999-08-10), pages 1915 - 1922, XP002202211, ISSN: 1043-0342 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623693B (zh) * 2017-03-20 2022-03-25 徐寒梅 一种融合蛋白及其制备方法和其在制备治疗眼科疾病、抗炎、抗肿瘤药物中的应用

Also Published As

Publication number Publication date
WO2008101671A2 (fr) 2008-08-28
WO2008101671A9 (fr) 2009-02-19

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