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WO2008107167A1 - Dispositif et procédé de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier - Google Patents

Dispositif et procédé de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier Download PDF

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Publication number
WO2008107167A1
WO2008107167A1 PCT/EP2008/001732 EP2008001732W WO2008107167A1 WO 2008107167 A1 WO2008107167 A1 WO 2008107167A1 EP 2008001732 W EP2008001732 W EP 2008001732W WO 2008107167 A1 WO2008107167 A1 WO 2008107167A1
Authority
WO
WIPO (PCT)
Prior art keywords
bag
blood
outlet
component
whole blood
Prior art date
Application number
PCT/EP2008/001732
Other languages
German (de)
English (en)
Inventor
Hans-Jürgen Neumann
Original Assignee
Fresenius Hemocare Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Hemocare Deutschland Gmbh filed Critical Fresenius Hemocare Deutschland Gmbh
Priority to EP08716250A priority Critical patent/EP2121075A1/fr
Publication of WO2008107167A1 publication Critical patent/WO2008107167A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation

Definitions

  • the invention relates to a device for separating a cell suspension, in particular for separating at least one blood component from whole blood, with a drive unit having a receiving unit for a centrifuge chamber, wherein the centrifuge chamber of the drive unit is set in rotation.
  • the invention relates to an arrangement of a device for separating a cell suspension, in particular for separating at least one blood component from whole blood, and designed as a centrifuge chamber bag for receiving the cell suspension, in particular of the whole blood, which is inserted into the receiving unit of the separation device.
  • the invention relates to a method for separating at least one blood component from whole blood.
  • the whole blood of a donor is collected in a blood bag containing an anticoagulant solution.
  • Whole blood mixes with the anticoagulant solution during donation to prevent blood clotting.
  • the whole blood bag is part of a blood donation kit that has blood bags or storage solutions in addition to the blood bag.
  • the blood consists essentially of three components, which include the blood plasma (PLS), the red cell concentrate (RCC) and the platelets (Buffy Coat (BC)) count.
  • the buffy coat contains the leukocytes, which are generally undesirable for further transfusions and must be filtered out, as well as the platelets, which are obtained as a cell component of the buffy coat.
  • the blood donation set has to be removed by hand from the centrifuge and inserted into the separation device.
  • the blood donation set there is a risk of re-mixing the already separated whole blood.
  • Separation devices are known with which whole blood of a donor can be separated by centrifuging into different blood components as well as the separated blood components can be transferred into component bags.
  • the patient's whole blood flows into a rotating centrifuge chamber, to which the component bags are connected via tubing.
  • the incoming whole blood displaces the blood components from the centrifuge chamber during the separation process.
  • EP 1 252 918 A2 describes a separation device which has a receiving unit for a centrifuge chamber.
  • An embodiment of the known separation device provides a centrifuge chamber which extends along a quarter circle around the axis of rotation of the receiving unit.
  • the known cell separator is designed to be in the separation chamber from the outside to separate incoming blood into its blood components and to transfer the blood components into the component bags.
  • a blood centrifuge for a blood bag system with a whole blood bag containing whole blood collected from a donor during a blood donation is known from EP 1 351 772 B1.
  • the known centrifuge has a receiving unit, in which one or more cassettes can be used, the receiving pockets each receive a whole blood bag.
  • the blood bags in the cassettes rotate about a common axis of rotation.
  • the whole blood is separated into its components.
  • the cassettes have means for discharging the separated blood components into various component bags.
  • the centrifuge is designed to hold conventional blood donor bags. Consequently, the Aufhahmefacher the cassettes have the dimensions of the known blood bag.
  • a blood centrifuge for receiving conventional blood bags is also known from US Pat. No. 6,723,238 B2.
  • the invention is based on the object to provide a device for separating a cell suspension, in particular for separating at least one blood component from whole blood, which allows a relatively large volume of a cell suspension, in particular collected in a blood bag with high efficiency in a relatively short time To separate the whole blood of a donor into its blood components.
  • an object of the invention is to provide an arrangement with such a separation device and a bag designed as a centrifuge chamber for receiving the cell suspension, in particular for receiving whole blood, which enables a separation with high efficiency.
  • Another object of the invention is to provide a method with which a blood component can be separated from whole blood in a bag designed as a centrifuge chamber with high efficiency.
  • the receiving unit for receiving the centrifuge chamber has a substantially cylindrical contact surface which extends around the axis of rotation of the drive unit.
  • the receiving unit is intended to receive a centrifuge chamber designed as a bag, which can be inserted into the receiving unit in such a way that the bag resting against the cylindrical contact surface describes the shape of a cylinder.
  • the separation device according to the invention is not intended to separate a cell suspension, which flows into a centrifuge chamber from the outside, into the components, but a cell suspension, in particular whole blood, which is collected in a whole blood bag.
  • the bag to be loaded into the receiving unit which is a centrifuge chamber
  • the bag intended for the inventive separation device can be handled during the blood donation as the known blood donation bag
  • the designed as a centrifuge chamber bag of the separation device according to the invention describes the shape of a cylinder, there is a relatively large effective area for cell separation.
  • the effective area is significantly larger than when the bag describes only the shape of a sub-segment of a cylinder.
  • the radially symmetrical shape of the bag in the receiving unit also has the advantage that the centrifuge chamber has no imbalance.
  • a rectangular bag with two horizontally extending edges and two vertical edges and an inner side facing the axis of rotation of the drive unit and an outer side facing away from the axis of rotation of the drive unit are used.
  • a flat rectangular bag is used whose end faces have a smaller area than the side faces thereof.
  • the horizontally extending edges have a smaller length than the vertical edges.
  • the bag designed as a centrifuge chamber is part of a bag set which, in addition to the bag for receiving the cell suspension, in particular whole blood, also has at least one bag for accommodating a component of the cell suspension, in particular a blood component of the whole blood.
  • the bag formed as a centrifuge chamber is a blood bag filled with whole blood, which is part of a bag system containing, in addition to the whole blood bag, a first component bag for collecting RBC packed in the whole blood bag by centrifugation and a second component bag for collecting blood plasma (PLS).
  • the component bags are preferably connected to the blood bag via tubing.
  • the blood of the donor collected in the whole blood bag is mixed in known manner with an anticoagulant solution to prevent blood clotting.
  • the advantage of the invention is that although a bag for the separation device according to the invention is required, which does not correspond in dimensions to the dimensions of a known bag for the blood donation, which can be handled for the separation device according to the invention certain bags, however, as the known blood bag , for this purpose, the blood bag according to the invention only needs to be folded. It is desirable that the bag according to the invention for receiving the cell suspension has the same height as the known blood bag. It has been shown that results in the required parameters of the centrifugation, a length for the bag, which corresponds to about twice the length of the known blood bag. Therefore, it is possible to fold the bag of the invention once in half to obtain the dimensions of a known blood bag.
  • the bag according to the invention is folded once in the middle, it can be weighed like a known blood bag, for example with the known scales, such as the known bags. Consequently, it is not necessary to provide new equipment for the bag according to the invention.
  • a device For discharging at least one separated component of the cell suspension from the bag designed as a centrifuge chamber, a device is provided which, in a preferred embodiment, has at least one pump for conveying the at least one component.
  • the pump for conveying the component is a roller pump, in which a bag set can be inserted, which has the bag-formed centrifuge chamber and at least one component bag, which is connected by a hose to the bag-shaped centrifuge chamber.
  • the first and second outlet for the components of the cell suspension are arranged on one of the two end faces of the bag.
  • Under end surfaces are the narrow sides, ie the welds on the narrow sides of the flat rectangular bag understood.
  • the bag according to the invention corresponds to the known blood donation bags, which have at one of the two end faces outlets for the blood components. In principle, it is necessary for one of the two outlets to lie radially further inward with respect to the axis of rotation of the drive unit and radially outward for the other of the two outlets.
  • the bag according to the invention in which preferably both outlets lie on a common axis at one of the two end faces, advantageously tilted relative to the axis of rotation, so that there is an arrangement in which an outlet is located radially further inward than the other outlet.
  • the receiving unit has a substantially cylindrical contact surface to which a centrifuge chamber formed as a bag can be applied.
  • a preferred embodiment of the separation device according to the invention provides a radially outer substantially cylindrical contact surface and a radially inner substantially cylindrical contact surface, between which a gap for inserting the bag is formed.
  • Fig. 1 is a bag system for use in the inventive
  • FIG. 2 is a schematic diagram of the flat-lying bag intended for the separation device according to the invention and the bag describing the shape of a cylinder, FIG.
  • Fig. 5 is a table with the possible dimensions of as
  • Fig. 6 shows the g-force in the centrifugation of bags of different
  • Fig. 7 shows the rotational speed rpm in the centrifugation of bags of different dimensions with a predetermined centrifugation parameter CP as a function of the radius R of the bag.
  • FIG. 1 shows, in a simplified schematic representation, a bag system intended for the inventive separation device.
  • the bag system according to the invention has a bag 1 for receiving a cell suspension, in particular whole blood of a donor.
  • the whole blood bag 1 is a foil bag made of a film tube or two superimposed films.
  • the whole blood bag 1 is filled with whole blood and an anticoagulant solution.
  • the foil bag has a flat rectangular shape.
  • FIG. 2 shows a schematic diagram of the whole blood bag 1 prior to insertion into the receiving unit, not shown, of the separation device.
  • the blood bag has upper and lower horizontal edges IA, IB and left and right vertical edges IC, ID with respect to the position in the receiving unit when the bag lies flat on a flat surface.
  • the bag on an inner side 2A, which faces the rotation axis 3 of the drive unit, not shown, of the receiving unit for the bag, and an outer side 2B, which faces away from the axis of rotation 3.
  • the two vertical edges form the end faces IC, ID of the flat rectangular bag 1.
  • a first and second outlet 4, 5 are provided for the blood components.
  • the two outlets 4, 5 are located on the front side ID one above the other, wherein the one outlet 4 is arranged in the region of the top and the other outlet 5 in the region of the underside of the end face IC.
  • the whole blood contained in the blood bag 1 is separated into an erythrocyte concentrate RCC and blood plasma PLS, whereby the erythrocyte concentrate RCC is withdrawn from the lower outlet 5 and the blood plasma PLS is withdrawn from the upper outlet 4.
  • a first tubing 6 goes off, leading to a first component bag 7 for the blood plasma PLS.
  • a first hose clamp 8 for disconnecting the line.
  • a second hose 9 From the lower outlet 5 is a second hose 9 from which leads to a second component bag 10 for the packed red blood cell RCC, wherein on the second hose 9, a second hose clamp 11 is located.
  • the component bags 7, 10 still have further connections 7 A, 7 B; or 10A, 10B for later use of the component bags.
  • FIG. 3 shows, in a highly simplified schematic representation, the essential components of the separation device according to the invention, together with the bag system according to the invention, which is inserted into the receiving unit of the separation device.
  • the separation device has a drive unit 12, with which the receiving unit 13 for the blood bag 1 is set in rotation.
  • the drive unit 12 has an electric motor, not shown, with a rotational speed of 3000 to 4000 rpm, which drives the receiving unit 13.
  • the receiving unit 13 has two cylindrical bodies 14, 15 arranged concentrically about the rotation axis 3, between which a narrow gap 16 for insertion of the blood bag 1 is located.
  • the lying between the inner cylinder body 14 and the outer cylinder body 15 radius of the receiving unit is denoted by R.
  • the width B of the gap 16 is slightly larger than the thickness D of the blood bag 1, so that the blood bag can be inserted into the gap.
  • the bag When the blood bag 1 is set in the receiving unit 13, the bag describes the shape of a cylinder with its end faces IC and ID facing each other directly.
  • the bag is supported with its inner side 2A on the axis of rotation 3 facing contact surface 14 'of the inner cylinder body 14 and with its outer side facing away from the axis of rotation 3 contact surface 15' of the outer cylinder body 15 from.
  • Figure 4 shows a section through the receiving unit in an enlarged view in the area in which the terminals of the bag are located. While the bag is largely upright in the gap 16 of the receiving unit 13, the bag in the region of the terminals 4, 5 is tilted slightly opposite to the axis of rotation. In this position, the bag can be supported with corresponding support body or the like supported in the gap of the receiving unit. But it is also possible, the cylinder body 14, 15 in the region in which the terminals of the bag come to rest, slightly inclined relative to the axis of rotation to arrange. However, the receiving unit retains its cylindrical shape in principle.
  • FIG. 4 shows that the lower outlet 5 for the erythrocyte concentrate RCC of the blood bag 1 tilted in the region of the outlets 4, 5 is located farther outward than the upper outlet 4 for the blood plasma PLS with respect to the rotation axis 3.
  • the blood plasma PLS is from the inner upper outlet 4 and the packed red blood cells RCC withdrawn from the outer lower outlet 5, wherein the Buffy Coat PCC remains in the bag.
  • the separation device To remove the erythrocyte concentrate and the blood plasma from the blood bag 1, the separation device has a device 17, which is shown only schematically in FIG.
  • the device 17 has two pumps 18, 19 for conveying the concentrates and a detection device 20 with which the separation boundary between the phases is detected.
  • a control unit 21 controls the pumps 18, 19 as a function of the separation limit such that the individual phases are withdrawn simultaneously or successively.
  • the pumps are, for example, roller pumps 18, 19, in which the hose lines of the bag system are inserted.
  • the breather pipes 6, 9 of the bag system which are shown only schematically in FIG. 4, are guided by means of the known devices from the rotating receiving unit 13 for the blood bag 1 to the component bags 7, 10 located outside the receiving unit.
  • the devices with which twisting of the lines can be prevented are known to the person skilled in the art.
  • DE 32 42 541 A1 describes a sliding seal-free blood centrifuge, in which the lines are led around from a stationary connection point in a loop around the centrifuge chamber.
  • the line is connected to a rotating frame, which rotates with respect to the centrifuge chamber at half speed.
  • Such a flow centrifuge is known for example from DE 42 20 232 Al.
  • the dimensioning of the blood bag 1 is based on a predetermined centrifuging parameter CP, which is a measure of the centrifuging effect and is calculated from the product of the g-force, the effective area A during the centrifugation and the centrifugation time t.
  • the centrifugation factor CP should be 2,600,000.
  • the blood bag 1 should have a height H of 12 cm, which corresponds to the height of the known blood donor bag.
  • FIG. 5 shows the possible dimensions of different blood bags at the predetermined Zentrifugations perception and a predetermined height H of the bags for different lengths L of the bag depending on the individual parameters, such as the speed rpm and the centrifugation time t, wherein the effective area A of the product of the height H of the bag and the circumference 2 ⁇ R calculated.
  • the bag volume is calculated from the product of the effective area A and the thickness D of the bag.
  • Fig. 6 shows the g-force for the bags described in Fig. 5 as a function of the radius R of the bags, at which the predetermined centrifuging parameter CP can be obtained
  • Fig. 7 shows the rotational speed rpm as a function of the radius R of the individual bags
  • a bag with the dimensions proves to be particularly advantageous, whose length is 38, 41, 44 or 47 cm at a height H of 12 cm. This results in a radius R of 6 to 7.5 cm and a speed for the drive unit, which is between 3,779 and 3,023 rpm.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier, comportant une unité d'entraînement (12) présentant une unité de réception (13) destinée à une chambre de centrifugeuse conçue en tant que poche (1). L'unité de réception (13) destinée à la poche de sang présente une surface d'appui essentiellement cylindrique (15') s'étendant autour de l'axe de rotation (3) de l'unité d'entraînement. La poche s'appuyant contre la surface d'appui cylindrique décrit la forme d'un cylindre. Dans un mode de réalisation préféré, le dispositif de séparation comporte une surface d'appui cylindrique (15') située radialement à l'extérieur, et une surface d'appui cylindrique (14') située radialement à l'intérieur, entre lesquelles un espace (16) est formé pour l'insertion de la poche de sang (1). La poche de sang (1) est conçue de telle manière qu'elle peut être manipulée comme une poche de distribution de sang habituelle.
PCT/EP2008/001732 2007-03-08 2008-03-05 Dispositif et procédé de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier WO2008107167A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08716250A EP2121075A1 (fr) 2007-03-08 2008-03-05 Dispositif et procédé de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007011332A DE102007011332A1 (de) 2007-03-08 2007-03-08 Vorrichtung und Verfahren zum Separieren einer Zellsuspension, insbesondere zum Abtrennen mindestens einer Blutkomponente aus Vollblut
DE102007011332.5 2007-03-08

Publications (1)

Publication Number Publication Date
WO2008107167A1 true WO2008107167A1 (fr) 2008-09-12

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PCT/EP2008/001732 WO2008107167A1 (fr) 2007-03-08 2008-03-05 Dispositif et procédé de séparation d'une suspension cellulaire, notamment de séparation d'au moins un constituant sanguin à partir de sang entier

Country Status (3)

Country Link
EP (1) EP2121075A1 (fr)
DE (1) DE102007011332A1 (fr)
WO (1) WO2008107167A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415021B2 (en) 2009-08-25 2016-08-16 Nanoshell Company, Llc Synthesis of oxygen carrying, turbulence resistant, high density submicron particulates
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
CN113069614A (zh) * 2021-03-31 2021-07-06 上海广锋生物科技有限公司 全自动单袋血液成分分离装置
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2001024848A1 (fr) * 1999-10-01 2001-04-12 Gambro, Inc. Methodes et appareil de fractionnement extracorporel du sang
US20020068674A1 (en) * 2000-11-02 2002-06-06 Gambro, Inc. Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration
EP1252918A2 (fr) * 1992-10-22 2002-10-30 Baxter International Inc. Appareil et procédé pour la séparation de sang total

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Publication number Priority date Publication date Assignee Title
DE3242541A1 (de) 1982-11-18 1984-05-24 Fresenius AG, 6380 Bad Homburg Zentrifuge
DE4220232A1 (de) 1992-06-20 1993-12-23 Fresenius Ag Zentrifuge
WO2002024303A1 (fr) 2000-09-20 2002-03-28 Kendro Laboratory Products, L.P. Coupelle de centrifugeuse de sang a compartiment remplaçable pour support de filtre
DE10065283A1 (de) 2000-12-29 2002-07-04 Hettich Andreas Gmbh & Co Kg Zentrifuge mit Blutbeutelsystem mit oberem und unterem Abgang

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1252918A2 (fr) * 1992-10-22 2002-10-30 Baxter International Inc. Appareil et procédé pour la séparation de sang total
WO2001024848A1 (fr) * 1999-10-01 2001-04-12 Gambro, Inc. Methodes et appareil de fractionnement extracorporel du sang
US20020068674A1 (en) * 2000-11-02 2002-06-06 Gambro, Inc. Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415021B2 (en) 2009-08-25 2016-08-16 Nanoshell Company, Llc Synthesis of oxygen carrying, turbulence resistant, high density submicron particulates
US9956180B2 (en) 2009-08-25 2018-05-01 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10099227B2 (en) 2009-08-25 2018-10-16 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10675641B2 (en) 2009-08-25 2020-06-09 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
CN113069614A (zh) * 2021-03-31 2021-07-06 上海广锋生物科技有限公司 全自动单袋血液成分分离装置
CN113069614B (zh) * 2021-03-31 2022-10-14 上海广锋生物科技有限公司 全自动单袋血液成分分离装置

Also Published As

Publication number Publication date
DE102007011332A1 (de) 2008-09-11
EP2121075A1 (fr) 2009-11-25

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