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WO2008108309A1 - 縮環ピリジン誘導体 - Google Patents

縮環ピリジン誘導体 Download PDF

Info

Publication number
WO2008108309A1
WO2008108309A1 PCT/JP2008/053692 JP2008053692W WO2008108309A1 WO 2008108309 A1 WO2008108309 A1 WO 2008108309A1 JP 2008053692 W JP2008053692 W JP 2008053692W WO 2008108309 A1 WO2008108309 A1 WO 2008108309A1
Authority
WO
WIPO (PCT)
Prior art keywords
pyridine derivative
fused pyridine
formula
fused
symbols
Prior art date
Application number
PCT/JP2008/053692
Other languages
English (en)
French (fr)
Inventor
Atsuko Sato
Mariko Osakada
Kimihisa Ueno
Mirai Mizutani
Daisuke Harada
Katsuya Kobayashi
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Priority to JP2009502564A priority Critical patent/JPWO2008108309A1/ja
Publication of WO2008108309A1 publication Critical patent/WO2008108309A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

　式（I） （式中、各記号は明細書中に定義したとおりである。） で表される縮環ピリジン誘導体またはその薬理学的に許容される塩等を提供する。
PCT/JP2008/053692 2007-03-02 2008-02-29 縮環ピリジン誘導体 WO2008108309A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009502564A JPWO2008108309A1 (ja) 2007-03-02 2008-02-29 縮環ピリジン誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007052361 2007-03-02
JP2007-052361 2007-03-02

Publications (1)

Publication Number Publication Date
WO2008108309A1 true WO2008108309A1 (ja) 2008-09-12

Family

ID=39738191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053692 WO2008108309A1 (ja) 2007-03-02 2008-02-29 縮環ピリジン誘導体

Country Status (3)

Country Link
JP (1) JPWO2008108309A1 (ja)
TW (1) TW200900408A (ja)
WO (1) WO2008108309A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009041591A1 (ja) * 2007-09-28 2009-04-02 Kyowa Hakko Kirin Co., Ltd. 縮環ピリジン誘導体
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
WO2021009365A1 (en) * 2019-07-18 2021-01-21 Ctxt Pty Limited Benzothiophene, thienopyridine and thienopyrimidine derivatives for the modulation of sting
WO2021009362A1 (en) * 2019-07-18 2021-01-21 Ctxt Pty Limited Benzothiophene, thienopyridine and thienopyrimidine derivatives for the modulation of sting

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051587A1 (fr) * 1998-04-01 1999-10-14 Ono Pharmaceutical Co., Ltd. Derives de thiophene condenses et medicaments contenant ceux-ci comme principe actif
WO2002012189A1 (en) * 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
JP2003530393A (ja) * 2000-04-08 2003-10-14 アストラゼネカ・アクチエボラーグ 化学化合物
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
WO2005113560A2 (en) * 2004-05-14 2005-12-01 Wyeth THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051587A1 (fr) * 1998-04-01 1999-10-14 Ono Pharmaceutical Co., Ltd. Derives de thiophene condenses et medicaments contenant ceux-ci comme principe actif
JP2003530393A (ja) * 2000-04-08 2003-10-14 アストラゼネカ・アクチエボラーグ 化学化合物
WO2002012189A1 (en) * 2000-08-09 2002-02-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
WO2005113560A2 (en) * 2004-05-14 2005-12-01 Wyeth THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DORSEY, BRUCE D. ET AL.: "Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 18, 2000, pages 3386 - 3399, XP002564479 *
WYATT, PAUL G. ET AL.: "Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 10, 2002, pages 1405 - 1411, XP055352034 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009041591A1 (ja) * 2007-09-28 2009-04-02 Kyowa Hakko Kirin Co., Ltd. 縮環ピリジン誘導体
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
WO2021009365A1 (en) * 2019-07-18 2021-01-21 Ctxt Pty Limited Benzothiophene, thienopyridine and thienopyrimidine derivatives for the modulation of sting
WO2021009362A1 (en) * 2019-07-18 2021-01-21 Ctxt Pty Limited Benzothiophene, thienopyridine and thienopyrimidine derivatives for the modulation of sting
CN114206882A (zh) * 2019-07-18 2022-03-18 Ctxt私人有限公司 用于调节sting的苯并噻吩、噻吩并吡啶和噻吩并嘧啶衍生物
CN114206880A (zh) * 2019-07-18 2022-03-18 Ctxt私人有限公司 用于调节sting的苯并噻吩、噻吩并吡啶和噻吩并嘧啶衍生物
JP2022541044A (ja) * 2019-07-18 2022-09-21 シーティーエックスティー・ピーティーワイ・リミテッド Ｓｔｉｎｇのモジュレーションのためのベンゾチオフェン、チエノピリジンおよびチエノピリミジン誘導体
JP2022541043A (ja) * 2019-07-18 2022-09-21 シーティーエックスティー・ピーティーワイ・リミテッド Ｓｔｉｎｇのモジュレーションのためのベンゾチオフェン、チエノピリジンおよびチエノピリミジン誘導体
CN114206882B (zh) * 2019-07-18 2024-11-12 Ctxt私人有限公司 用于调节sting的苯并噻吩、噻吩并吡啶和噻吩并嘧啶衍生物
CN114206880B (zh) * 2019-07-18 2024-12-06 Ctxt私人有限公司 用于调节sting的苯并噻吩、噻吩并吡啶和噻吩并嘧啶衍生物
JP7607627B2 (ja) 2019-07-18 2024-12-27 シーティーエックスティー・ピーティーワイ・リミテッド Ｓｔｉｎｇのモジュレーションのためのベンゾチオフェン、チエノピリジンおよびチエノピリミジン誘導体
JP7607626B2 (ja) 2019-07-18 2024-12-27 シーティーエックスティー・ピーティーワイ・リミテッド Ｓｔｉｎｇのモジュレーションのためのベンゾチオフェン、チエノピリジンおよびチエノピリミジン誘導体

Also Published As

Publication number Publication date
JPWO2008108309A1 (ja) 2010-06-17
TW200900408A (en) 2009-01-01

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