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WO2008112990A3 - Methods of diagnosis and treatment of crohn's disease - Google Patents

Methods of diagnosis and treatment of crohn's disease Download PDF

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Publication number
WO2008112990A3
WO2008112990A3 PCT/US2008/057028 US2008057028W WO2008112990A3 WO 2008112990 A3 WO2008112990 A3 WO 2008112990A3 US 2008057028 W US2008057028 W US 2008057028W WO 2008112990 A3 WO2008112990 A3 WO 2008112990A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
crohn
locus
methods
diagnosis
Prior art date
Application number
PCT/US2008/057028
Other languages
French (fr)
Other versions
WO2008112990A2 (en
Inventor
Jerome I Rotter
Kent D Taylor
Original Assignee
Cedars Sinai Medical Center
Jerome I Rotter
Kent D Taylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center, Jerome I Rotter, Kent D Taylor filed Critical Cedars Sinai Medical Center
Publication of WO2008112990A2 publication Critical patent/WO2008112990A2/en
Publication of WO2008112990A3 publication Critical patent/WO2008112990A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a method of diagnosing or predicting susceptibility to Crohn's disease (CD) in an individual by determining the presence or absence of genetic risk variants. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the individual of a risk variant at the ATG1GL1 locus, the PHOX2B locus, the NCF4 gene, intron 4 of the FAM92B locus, and/or the intergenic region on 10q21.1 The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, ileal Crohn's disease, a subtype characterized by involvment of the ileal region of the small intestine.
PCT/US2008/057028 2007-03-15 2008-03-14 Methods of diagnosis and treatment of crohn's disease WO2008112990A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89506807P 2007-03-15 2007-03-15
US60/895,068 2007-03-15

Publications (2)

Publication Number Publication Date
WO2008112990A2 WO2008112990A2 (en) 2008-09-18
WO2008112990A3 true WO2008112990A3 (en) 2008-12-11

Family

ID=39760419

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/057028 WO2008112990A2 (en) 2007-03-15 2008-03-14 Methods of diagnosis and treatment of crohn's disease

Country Status (1)

Country Link
WO (1) WO2008112990A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062960A2 (en) * 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
KR20210157418A (en) 2013-03-27 2021-12-28 세다르스-신나이 메디칼 센터 Mitigation and reversal of fibrosis and inflammation by inhibition of tl1a function and related signaling pathways
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
CN109462996A (en) 2016-03-17 2019-03-12 西达-赛奈医疗中心 Method for diagnosing inflammatory bowel disease by RNASET2

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Business Wire", Retrieved from the Internet <URL:http://www.findarticles.com/p/articles/mi_m0EIN/is_2007_Jan_24/ai_n27122450> *
BECKER K.G. ET AL.: "Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases", PNAS, vol. 95, August 1998 (1998-08-01), pages 9979 - 9984, XP002960579 *

Also Published As

Publication number Publication date
WO2008112990A2 (en) 2008-09-18

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