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WO2008113992A3 - Compositions de gels - Google Patents

Compositions de gels Download PDF

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Publication number
WO2008113992A3
WO2008113992A3 PCT/GB2008/000928 GB2008000928W WO2008113992A3 WO 2008113992 A3 WO2008113992 A3 WO 2008113992A3 GB 2008000928 W GB2008000928 W GB 2008000928W WO 2008113992 A3 WO2008113992 A3 WO 2008113992A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
benzyl
urea derivatives
gel compositions
Prior art date
Application number
PCT/GB2008/000928
Other languages
English (en)
Other versions
WO2008113992A2 (fr
Inventor
Vesna Caplar
Leo Frkanec
Milan Jokic
Janja Makarevic
Tomislav Portada
Mladen Zinic
Zelimir Jelcic
Original Assignee
Pliva Hrvatska D O O
Bucks Teresa Anne
Vesna Caplar
Leo Frkanec
Milan Jokic
Janja Makarevic
Tomislav Portada
Mladen Zinic
Zelimir Jelcic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska D O O, Bucks Teresa Anne, Vesna Caplar, Leo Frkanec, Milan Jokic, Janja Makarevic, Tomislav Portada, Mladen Zinic, Zelimir Jelcic filed Critical Pliva Hrvatska D O O
Publication of WO2008113992A2 publication Critical patent/WO2008113992A2/fr
Publication of WO2008113992A3 publication Critical patent/WO2008113992A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

L'invention porte sur la composition dun gel comprenant un gélifiant et un solvant. le gélifiant est un composé de formule générale I): dans laquelle: R1 est hydrogène ou C1-14 alkyle; R3 est OH ou un groupe: R4 est hydrogène ou C1-6 alkyle, facultativement substitué par OR9, COR9 ou COOR9; R9 est hydrogène, C1-6 alkyle ou benzyle; R2 est hydrogène, C1-6 alkyle ou benzyle, dont l'un peut être facultativement substitué par OH ou, si R3 est R2 peut aussi être R7; R7 est un cycle aromatique ou hétéroaromatique à 5 ou 6 éléments pouvant de plus être facultativement substitué par C1-6 alkyle, benzyle ou hydroxy; ou l'un de leurs sels.
PCT/GB2008/000928 2007-03-20 2008-03-14 Compositions de gels WO2008113992A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0705264.0A GB0705264D0 (en) 2007-03-20 2007-03-20 Gel forming compounds
GB0705264.0 2007-03-20

Publications (2)

Publication Number Publication Date
WO2008113992A2 WO2008113992A2 (fr) 2008-09-25
WO2008113992A3 true WO2008113992A3 (fr) 2008-12-18

Family

ID=38008702

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000928 WO2008113992A2 (fr) 2007-03-20 2008-03-14 Compositions de gels

Country Status (2)

Country Link
GB (1) GB0705264D0 (fr)
WO (1) WO2008113992A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012015306A2 (pt) 2009-12-22 2016-03-15 Dow Global Technologies Llc poli (bisoxalamida), processo para preparar uma poli (bisoxalamida) e artigo
IE20100174A1 (en) * 2010-03-25 2012-02-29 Trinity College Dublin Transdermal administration of peptides
WO2012174091A2 (fr) * 2011-06-13 2012-12-20 The Procter & Gamble Company Compositions de soins personnels comprenant un agent gélifiant à ph accordable et procédés d'utilisation
US8668918B2 (en) * 2011-09-01 2014-03-11 Milliken & Company Bisurea gelling agents and compositions
SG193042A1 (en) * 2012-02-22 2013-09-30 Agency Science Tech & Res Organogels from ultrasmall peptides that can be used for biological and non-biological applications
CN106456704A (zh) 2014-04-16 2017-02-22 Veyx-药物有限公司 兽药组合物和其应用
JP2022123151A (ja) * 2019-05-10 2022-08-24 国立大学法人九州大学 脂質ペプチド型ゲル化剤とポリアルキレンオキシドとを含有する高分子複合材料
GB202404002D0 (en) 2024-03-20 2024-05-01 Univ Bristol Antimicrobial compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001014328A2 (fr) * 1999-08-20 2001-03-01 Merck & Co., Inc. Urees substituees inhibiteurs d'adhesion cellulaire

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001014328A2 (fr) * 1999-08-20 2001-03-01 Merck & Co., Inc. Urees substituees inhibiteurs d'adhesion cellulaire

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ESTROFF L A ET AL: "EFFECTIVE GELATION OF WATER USING A SERIES OF BIS-UREA DICARBOXYLIC ACIDS", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, vol. 39, no. 19, 1 January 2000 (2000-01-01), pages 3447 - 3450, XP001182155, ISSN: 1433-7851 *
FAGES-F VÖGTLE AND M ZINIC F: "Systemic Design of Amide- and Urea-Type gelators", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 256, 1 January 2005 (2005-01-01), pages 77 - 131, XP009105871, ISSN: 0340-1022 *
GUJUN WANG ET AL.: "LOW MOLECULAR WEIGHT ORGANOGELATORS FOR WATER", CHEMICAL COMMUNICATIONS, no. 3, 2003, SEINSTITUTE OF INORGANIC AND PHYSICAL CHEMISTRY, STOCKHOLM,, pages 310 - 311, XP002499287 *
MAAIKE DE LOOS ET AL.: "DESIGN AND APPLICATIONS OF SELF-ASSEMBLED LOW MOLECULAR WEIGHT HYDROGELS", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY., no. 17, September 2005 (2005-09-01), DEWILEY-VCH VERLAG, WEINHEIM., pages 3615 - 3631, XP002499285 *
TOMASIC ET AL: "Thermal phase transitions of solid chiral N,N'-carbonyl-bis-(l-amino acids) and their methyl and benzyl esters", THERMOCHIMICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 444, no. 1, 1 May 2006 (2006-05-01), pages 97 - 106, XP005394397, ISSN: 0040-6031 *

Also Published As

Publication number Publication date
WO2008113992A2 (fr) 2008-09-25
GB0705264D0 (en) 2007-04-25

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