[go: up one dir, main page]

WO2008114812A1 - Jak阻害剤 - Google Patents

Jak阻害剤 Download PDF

Info

Publication number
WO2008114812A1
WO2008114812A1 PCT/JP2008/055052 JP2008055052W WO2008114812A1 WO 2008114812 A1 WO2008114812 A1 WO 2008114812A1 JP 2008055052 W JP2008055052 W JP 2008055052W WO 2008114812 A1 WO2008114812 A1 WO 2008114812A1
Authority
WO
WIPO (PCT)
Prior art keywords
jak
substituted
disclosed
jak inhibitor
acceptable salt
Prior art date
Application number
PCT/JP2008/055052
Other languages
English (en)
French (fr)
Inventor
Yukimasa Shiotsu
Kenichi Ishii
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of WO2008114812A1 publication Critical patent/WO2008114812A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　式（I）（式中、R1は置換もしくは非置換のアリールまたは置換もしくは非置換の複素環基を表す）で表されるインダゾール誘導体またはその薬理学的に許容される塩を有効成分として含有するJAK阻害剤、JAKが関与する疾患の治療剤等、 　式（Ia）［式中、R2はCONR4aR4b（式中、R4a及びR4bは、同一または異なって水素原子、置換もしくは非置換の低級アルキル等を表すか、またはR4a及びR4bが隣接する窒素原子と一緒になって置換もしくは非置換の複素環基を形成する）等を表し、R3は水素原子等を表す］で表されるインダゾール誘導体またはその薬理学的に許容される塩を有効成分として含有するJAK阻害剤、JAKが関与する疾患の治療剤等を提供する。
PCT/JP2008/055052 2007-03-19 2008-03-19 Jak阻害剤 WO2008114812A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-069776 2007-03-19
JP2007069776 2007-03-19

Publications (1)

Publication Number Publication Date
WO2008114812A1 true WO2008114812A1 (ja) 2008-09-25

Family

ID=39765916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055052 WO2008114812A1 (ja) 2007-03-19 2008-03-19 Jak阻害剤

Country Status (1)

Country Link
WO (1) WO2008114812A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
CN103804362A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
CN103800337A (zh) * 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103804299A (zh) * 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN103804305A (zh) * 2012-11-05 2014-05-21 韩文毅 一类治疗湿疹的化合物及其用途
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
JP2018153194A (ja) * 2011-04-28 2018-10-04 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０併用療法
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212395A1 (en) 2019-04-16 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
WO2023222565A1 (en) 2022-05-16 2023-11-23 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532059A (ja) * 1991-07-26 1993-02-09 Konica Corp 画像形成方法及びその画像形成装置
WO2005012258A1 (ja) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. タンパク質キナーゼ阻害剤
WO2005012257A1 (ja) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. インダゾール誘導体
WO2006080450A1 (ja) * 2005-01-27 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Igf-1r阻害剤
JP2006523721A (ja) * 2003-04-16 2006-10-19 シグナル ファーマシューティカルズ，エルエルシー Ｊｎｋ阻害剤としてのインダゾール誘導体
WO2007058626A1 (en) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
WO2008001886A1 (fr) * 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. Inhibiteur d'aurora
WO2008001885A1 (fr) * 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. INHIBITEUR DE KINASE Abl
WO2008020606A1 (fr) * 2006-08-16 2008-02-21 Kyowa Hakko Kirin Co., Ltd. Agent anti-angiogénique

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532059A (ja) * 1991-07-26 1993-02-09 Konica Corp 画像形成方法及びその画像形成装置
JP2006523721A (ja) * 2003-04-16 2006-10-19 シグナル ファーマシューティカルズ，エルエルシー Ｊｎｋ阻害剤としてのインダゾール誘導体
WO2005012258A1 (ja) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. タンパク質キナーゼ阻害剤
WO2005012257A1 (ja) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. インダゾール誘導体
WO2006080450A1 (ja) * 2005-01-27 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. Igf-1r阻害剤
WO2007058626A1 (en) * 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
WO2008001886A1 (fr) * 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. Inhibiteur d'aurora
WO2008001885A1 (fr) * 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. INHIBITEUR DE KINASE Abl
WO2008020606A1 (fr) * 2006-08-16 2008-02-21 Kyowa Hakko Kirin Co., Ltd. Agent anti-angiogénique

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018153194A (ja) * 2011-04-28 2018-10-04 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０併用療法
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
CN103804305A (zh) * 2012-11-05 2014-05-21 韩文毅 一类治疗湿疹的化合物及其用途
CN103800337A (zh) * 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103804362A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
CN103804299A (zh) * 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212395A1 (en) 2019-04-16 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
WO2023222565A1 (en) 2022-05-16 2023-11-23 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Similar Documents

Publication Publication Date Title
WO2008114812A1 (ja) Jak阻害剤
WO2008111441A1 (ja) 医薬組成物
AU2009258496A8 (en) Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
WO2009038064A1 (ja) Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体
WO2008126901A1 (ja) 含窒素複素環化合物およびそれを含有する医薬組成物
MX2011012627A (es) Derivados aminobutiricos sustituidos como inhibidores de nepralisina.
TNSN08407A1 (en) Organic compounds
WO2010014930A3 (en) Piperidine derivatives as jak3 inhibitors
EP1845081A4 (en) amide
WO2009069736A1 (ja) 含窒素化合物
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2008104175A3 (en) Novel phosphodiesterase inhibitors
MX2012002528A (es) Agente terapeutico para trastornos del estado de animo.
WO2009020137A1 (ja) アミノピラゾールアミド誘導体
WO2008153042A1 (ja) 抗腫瘍剤
IN2012DN00770A (ja)
PL1753723T3 (pl) Podstawione pochodne chinoliny jako inhibitory kinezyn mitotycznych
WO2008136377A1 (ja) 二環式複素環化合物
WO2008120744A1 (ja) ５員環アミド化合物およびその用途
WO2006110173A3 (en) Novel compounds
WO2008114505A1 (ja) Ｅｇ５阻害剤および該化合物を含有してなる細胞増殖性疾患治療薬
WO2008156102A1 (ja) ピラゾロン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
MX2012002529A (es) Agente terapeutico para trastornos de ansiedad.
WO2009057733A1 (ja) 血管新生阻害活性を有する新規インドール誘導体
WO2008049997A3 (fr) Derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08722442

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08722442

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP