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WO2008121355A1 - Traitement des symptômes de dermatose touchant un tégument mammalien avec des formulations désinfectantes émollientes - Google Patents

Traitement des symptômes de dermatose touchant un tégument mammalien avec des formulations désinfectantes émollientes Download PDF

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Publication number
WO2008121355A1
WO2008121355A1 PCT/US2008/004120 US2008004120W WO2008121355A1 WO 2008121355 A1 WO2008121355 A1 WO 2008121355A1 US 2008004120 W US2008004120 W US 2008004120W WO 2008121355 A1 WO2008121355 A1 WO 2008121355A1
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WO
WIPO (PCT)
Prior art keywords
jojoba
composition
oil
emollient
alcohol
Prior art date
Application number
PCT/US2008/004120
Other languages
English (en)
Inventor
Lawrence A. Rheins
David A. Ashley
John Reinhardt
James H. Brown
James S. Brown
John C. Hill
Original Assignee
International Flora Technologies, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Flora Technologies, Ltd. filed Critical International Flora Technologies, Ltd.
Priority to JP2010501014A priority Critical patent/JP2010522757A/ja
Priority to CA002678780A priority patent/CA2678780A1/fr
Priority to EP08742370.3A priority patent/EP2124868A4/fr
Publication of WO2008121355A1 publication Critical patent/WO2008121355A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Definitions

  • the present invention generally relates to emollient and sanitation compositions; and more particularly, representative embodiments of the present invention generally concern delivery of emollients in topically applied disinfectant formulations.
  • Antibiotic resistant strains of disease-causing bacteria such as Staphylococcus aureus
  • Staphylococcus aureus are now commonly acquired in hospital settings due to close contact of patients who are more susceptible to infection and the extensive use of antibiotics, which generally provide selection pressure for these strains of bacteria. Consequently, people infected with these microbes are likely to have longer hospital stays and may require treatment with second- and third- choice antibiotics that may be less effective and more expensive.
  • non-compliance with these policies has been reported to be between 45% and 70%.
  • a prominent reason cited for non-compliance is the incidence of acute and chronic irritated skin and, to a lesser extent, contact allergic hand dermatitis due to repeated use of antibacterial soaps and the use of alcohol-based (either ethanol or isopropanol, 60%- 95% wt/wt) hand sanitizers.
  • the use of these sanitizers can be as high as fifty or more times during each work day.
  • the chronic stripping of the lipid barrier usually results in xerosis, scaling, erythema, rough skin, and tight skin.
  • More serious and painful side effects include inflammation, fissures, allergic contact dermatitis, and the harboring of transient pathogenic organisms that may cause infections.
  • Common sensations associated with de-lipidization include itching, tingling, burning, stinging, and the like.
  • the present invention provides compositions and methods for providing botanically-sourced and/or botanically-derived topical emollient compositions with disinfectant properties to ameliorate dermatitic symptoms of mammalian integument.
  • the sanitizing component of the composition may include an antimicrobial sanitizer.
  • the emollient component of the composition may include botanical lipid materials (and/or their derivatives) selected to demonstrate properties at least partially analogous to mammalian sebum.
  • the combination of sanitizing and emollient components of the resulting formulations may be employed to manage dermatitic symptoms and sanitize mammalian integument.
  • FIG. 1 illustrates clinical data relating to transepidermal water loss (TEWL) associated with use and non-use of an emollient sanitizing formulation in accordance with a representative embodiment of the present invention
  • FIG. 2 illustrates clinical data relating to TEWL associated with use and non-use of an emollient sanitizing formulation in accordance with a representative embodiment of the present invention
  • FIG. 3 is a photomicrographic representation of a cross-section of human skin tissue obtained via punch biopsy prior to application of an emollient sanitizing composition in accordance with a representative embodiment of the present invention
  • FIG. 4 is a photomicrographic representation of a cross-section of human skin tissue obtained via punch biopsy after fourteen (14) days of regular application (at least 8 times/day) of an emollient sanitizing composition in accordance with a representative embodiment of the present invention.
  • Various representative implementations of the present invention may be applied to any system for providing botanically-sourced (or botanically-derived) topical emollient sanitizing compositions.
  • the terms “derivative,” “extract,” “source,” or any combinatorial, variational or contextual equivalent thereof are generally intended to include anything that may be regarded as at least being susceptible to characterization as, or generally referring to, one or more compounds as they exist in nature and/or chemically altered forms thereof.
  • the terms “sanitize”, “sanitizing”, “sanitization”, or any combinatorial, variational or contextual equivalent thereof, are generally intended to include anything that may be regarded as at least being susceptible to characterization as, or generally referring to, a material having anti-microbial, bactericidal, antiviral and/or disinfectant activity, including the prevention and/or inhibition of growth and/or killing of bacteria, viruses, fungi of any kind and by any mechanism of action or system of activation.
  • topical formulation As used herein, the terms “topical formulation”, “topical composition”, or any combinatorial, variational or contextual equivalent thereof, are generally intended to include anything that may be regarded as at least being susceptible to characterization as, or generally referring to, a cosmetic, a pharmaceutical, a topical medicament, a personal care product, a shampoo, a conditioner, a leave-in conditioner, a hair product, a hair- styling product, a mousse, a nail product, a skin product, a moisturizer, a soap, a body wash, a shaving product, a gel, a lotion, a cream, an ointment, a fragrance, a foundation, a mascara, a gloss, a Hp balm, a lip stick, a lip liner, an eye liner, a cosmetic remover, a cleanser, a scrub, a wax, a spray, a foam, a paste, a solid, a liquid, a towelette, a napkin, a feminine hygiene product,
  • topical application or any combinatorial, variational or contextual equivalent thereof, is generally intended to include anything that may be regarded as at least susceptible to characterization as, or generally referring to, use of a topical composition or topical formulation on or in conjunction with the hair, skin or a component layer of the skin, nails and/or any surface of any subject (animate or otherwise) or object.
  • the terms "subject”, “user”, or any combinatorial, variational or contextual equivalent thereof, are generally intended to include anything that may be regarded as at least being susceptible to characterization as, or generally referring to, an animal, a human, and/or any at least partially porous surface (living or inanimate) suitably adapted for receiving a topical application of a topical formulation or topical composition.
  • the term "botanical”, including any combinatorial, variational or contextual equivalent thereof, generally refers to anything that may be regarded as at least being susceptible to characterization as, or generally indicative of, a material or combination of materials that may be sourced, liberated or derived (chemically or otherwise) from a naturally occurring resource.
  • botanical and equivalents thereof may certainly be intended to reference the vernacular meaning ordinarily ascribed to the term as designating properties of or relating to plant life, the scope of the term “botanical” (as used herein) should be understood to extend to various other "naturally occurring" materials that may be sourced or otherwise liberated from any material that at one time comprised living matter (plant-based or otherwise; e.g., petrolatum, mineral oil, etc.) and/or other mineral resources.
  • living matter plant-based or otherwise; e.g., petrolatum, mineral oil, etc.
  • organic As used herein, the terms "organic”, “organic certification”, “organically derived” or any combinatorial, variational or contextual equivalent thereof, are generally intended to include anything that may be regarded as at least being susceptible to characterization as, or generally referring to, materials that have satisfied the criteria of a certification process generally imposed on producers of organic agricultural products. In general, any business supplying natural- and/or naturally-derived products may be certified, including seed suppliers, farmers, food processors, retailers and restaurants.
  • Requirements vary from country to country, and generally involve production standards for growing, storage, processing, packaging and shipping that include, for example: (i) avoidance of most synthetic chemical inputs (e.g., fertilizer, pesticides, antibiotics, food additives, etc.), genetically modified organisms, irradiation, and the use of sewage sludge; use of farmland that has been free from chemicals for a number of years (e.g., often, three (3) or more); keeping detailed written production and sales records (e.g., audit trail); maintaining strict physical separation of organic products from non-certified products; submitting to periodic on-site inspections; and other procedures/requirements prescribed by various organic certifying authorities.
  • synthetic chemical inputs e.g., fertilizer, pesticides, antibiotics, food additives, etc.
  • genetically modified organisms e.g., irradiation, and the use of sewage sludge
  • farmland that has been free from chemicals for a number of years (e.g.,
  • the terms “improvement”, “improved”, “benefit”, “beneficial”, or any combinatorial, variational or contextual equivalent thereof may mean an increased incidence in observance of a favorable property or a decreased incidence in observance of an unfavorable property. That notwithstanding, these same terms may also refer to a decrease in incidence in observance of what may correspond in alternative, conjunctive or sequential applications to an otherwise favorable property or the increase in incidence in observance of an otherwise unfavorable property.
  • a detailed description of a representative embodiment namely a composition and method for providing a botanically-sourced or botanically-derived topical emollient sanitizing composition, is provided as a specific enabling disclosure that may be generalized to any application of the disclosed compositions and methods in accordance with various representative aspects of the present invention.
  • the present invention relates to botanically-sourced and botanically-derived topical emollient compositions having disinfectant properties.
  • a composition may comprise a sanitizing component and a botanically-sourced or botanically-derived emollient component.
  • a suitable emollient sanitizing composition may comprise an anti-microbial sanitizer and a botanically- sourced or botanically-derived emollient.
  • the emollient sanitizing composition may representatively be applied to a topical surface of a subject, such as the skin of a mammalian subject.
  • the emollient sanitizing composition may then be rubbed on the skin until the emollient components are substantially absorbed and/or the sanitizing components are substantially evaporated or otherwise dissipated.
  • the disclosed emollient sanitizing compositions may be implemented to at least maintain or otherwise improve lipid profiles of the skin of a mammalian subject while concurrently, conjunctively or sequentially sanitizing the skin's surface after application.
  • an anti-microbial sanitizer may comprise any composition suitably adapted to provide an at least partially disinfecting function when topically applied to a surface.
  • a suitable anti-microbial sanitizer may at least partially penetrate cell walls of bacteria and denature proteins within the cells. This denaturing generally operates to interrupt the life -cycle of the bacterium, thereby killing it.
  • representative sanitizing compositions may include alcohols and/or other disinfectant/anti-microbial formulations and/or botanical extracts (or derivatives thereof) including, but not limited to, chlorhexidine gluconate, benzalkonium chloride, iodine, grapeseed oil, lemon juice, tea tree oil, citronellol, camphor oil, cade oil, eucalyptol, clove oil, and/or the like.
  • an anti-microbial sanitizer may comprise a lower hydrocarbon chain alcohol, such as a Ci -4 alcohol.
  • the alcohol may comprise ethanol, 2-propanol, and/or n-propanol.
  • an anti-microbial sanitizer may further comprise a dermatological active agent, a pharmaceutical composition, an antibiotic, a bactericidal agent, an antiseptic agent, a disinfectant agent, an antiviral agent, a nitrogenous cationic surface-active agent, a fruit juice, a fruit extract, and/or the like.
  • a suitable anti-microbial sanitizer may comprise a combination of water and alcohol, such as an ethanol azeotrope.
  • alcohol such as an ethanol azeotrope.
  • ethanol may be present in concentrations between about 60%-95% (wt/wt).
  • an anti-microbial sanitizer may be suitably adapted for combination with a botanically-sourced or botanically-derived emollient composition to provide both sanitizing and moisturizing function.
  • a representative emollient composition in accordance with various aspects of the present invention may comprise any components that are suitably adapted for providing moisture retention, reduction of transepidermal water loss (TEWL), smooth feel, softness, increased substantivity, and/or the like. Additionally, representative emollient compositions may be employed to soften or smooth the skin by reducing roughness, cracking, irritation, and/or the like.
  • a botanically -source or botanically-derived emollient may be selected to provide a lipid profile substantially similar to that of mammalian sebum (e.g., human sebum).
  • botanical emollient compositions may include bland, fatty, oleaginous substances that smooth the skin by penetration into the surface layers of skin tissue through the action of rubbing and massaging after application by the user.
  • Sources of representative botanical emollients in accordance with various aspects of the present invention include a number of fatty acids, wax esters, sterols, and/or the like (e.g., jojoba oil, shea oil, macadamia oil, rice bran wax, African dry zone mahogany seed oil, custard apple seed oil, sugar apple seed oil, common seabuckthorn seed oil, and/or the like - including derivatives thereof).
  • Fatty acids generally comprise aliphatic hydrocarbons or other organic chains with carboxylic substitutes therein, typically having between 8 and 24 carbon atoms in the backbone.
  • Fatty acids generally include at least one of stearic acid, oleic acid, myristic acid and palmitic acid.
  • Typical fatty acids include linoleic acid, behenic acid, arachidic, lignoceric, and other common fatty acids of the general formulae C n Hp n+1) COOH, C n Hp n-1) COOH or C n Hp n-3) COOH where "n" is an integer from 8 to 24.
  • Fatty alcohols have been found to be less sticky and less heavy than many other fatty materials (such as fatty acids), and are frequently used to improve the viscosity and stability of lotions and creams.
  • Representative examples of fatty alcohols which find use in cosmetics and personal care products are cetyl alcohol, lauryl alcohol, stearyl alcohol, and oleyl alcohol.
  • emollients include fatty esters.
  • One of the qualities of fatty esters is that they generally do not feel as oily to the touch as some other types of fatty emollient ingredients.
  • Representative examples include isopropyl palmitate, isopropyl myristate, myristyl propionate, ethylhexyl palmitate, and glyceryl stearate.
  • a topical emollient composition may be derived or extracted from a botanical source.
  • a botanically-sourced (or botanically-derived) emollient composition may include fatty acids, esters of fatty acids, alkoxylated fatty acids, fatty alcohols, esters of fatty alcohols, esters of fatty alcohols with fatty acids, sugar alcohols, isopropyl esters, wax esters and/or combinations thereof derived from the seed oil of the jojoba plant (Simmondsia chinensis), such as, for example: raw and/or refined jojoba oil, a jojoba ester, hydrogenated jojoba oil, a jojoba hydrolysate, a hydrolyzed jojoba ester, a jojoba alcohol, an alkoxylated jojoba wax, an alkoxylated and at least partially hydrogenated jojoba wax, an al
  • a botanical emollient composition may include jojoba oil and/or derivatives including hydrogenated jojoba oil, isopropyl jojobate, jojoba alcohol, jojoba esters, and/or hydrolyzed jojoba esters.
  • Jojoba oil and jojoba derivatives according to the present invention may comprise about more than 6% unsaponifiables.
  • the term "unsaponifiable” generally refers to a portion of the fat and/or oil (or in the case of jojoba, a wax ester) that is not susceptible to saponification.
  • unsaponifiable materials typically comprise components that are naturally found in the fats and/or oils, such as phenols, tocopherols, triterpenes, steroids, sterols, hydrocarbons such as squalene, alcohols, and/or the like.
  • Unsaponifiable material may be retained with the saponified material through an in situ saponification process, in which the unsaponifiable material is generally not removed and/or separated from the saponified material.
  • a saponification reaction may be accomplished by the hydrolysis of an ester under basic conditions, such as in the presence aqueous alkali metal hydroxides (e.g. , NaOH, LiOH, KOH, CaOH, MgOH, and/or the like) to form an alcohol and a salt of a carboxylic acid.
  • aqueous alkali metal hydroxides e.g. , NaOH, LiOH, KOH, CaOH, MgOH, and/or the like
  • in situ saponification may be affected through a base -catalyzed hydrolysis reaction between jojoba oil (a liquid wax ester at room temperature) and/or jojoba derivatives and an alkyl alcohol.
  • the products of the in situ saponification of jojoba oil typically comprise jojoba hydrolysates, which include a mixture of: (i) salts of jojoba fatty acids (saponifiables); and (ii) non-polar, lipophilic materials (unsaponifiables), with the possibility of other materials also present, depending on the source, state and form of the initial reactant (include residual jojoba wax ester).
  • the in situ production of unsaponifiable materials in tandem with saponified material from fats, oils and/or their derivatives having high levels of unsaponifiables in accordance with various aspects of the present invention may provide various benefits in compositions prepared for topical application to the skin of a subject. These benefits may include, for example, moisturization, a desirable texture, substantivity, resistance to wear, and water- and/or rinse-resistance. The presence of high unsaponifiables may also provide occlusive properties to the topical formulation where water is maintained in the skin, providing retained softness and smoothness.
  • botanical emollient material comprising in situ products of saponification may function to preserve superior skin feel and substantivity generally attributed to the polar hydrophilic properties of, for example, jojoba oil components.
  • emollient materials in accordance with various representative embodiments of the present invention may generally form stable emulsions more readily than those incorporating naturally occurring jojoba oil.
  • representative emollient materials may also impart an improved lipid profile to the skin of a subject after multiple treatments, as compared with conventional skin sanitizers.
  • botanical emollient components of the disclosed compositions may be employed to at least partially reconstitute the lipid profile of the stratum corneum barrier of the skin by providing lipids and derivatives thereof that chemically resemble human sebum.
  • botanical emollient compositions in accordance with the present invention generally provide superior smoothness and substantive skin-feel by being absorbing into the skin and/or maintaining a persisting presence on the surface of the skin.
  • Representative botanical emollient and anti-microbial sanitizer compositions may be formulated in any suitable manner.
  • a suitably adapted anti-microbial sanitizer may comprise a substantially transparent, translucent and/or opaque liquid.
  • a suitably adapted botanical ('sourced' or 'derived') emollient component of the composition may comprise carrier particles, such as natural and/or synthetic emollient beads.
  • Representative carrier particles may comprise any suitable synthetic and/or natural components.
  • carrier particles at least partially comprising natural emollient beads may be produced from combinations of fatty alcohols, isopropyl esters, wax esters, and/or the like, obtained from jojoba oil and/or jojoba derivatives.
  • Carrier particles comprising at least partially synthetic beads may also include components such as polyethylene, petrolatum, ethylhexyl palmitate, and/or the like.
  • representative carrier particles may include any suitable texture, size, shape, and/or the like.
  • suitably adapted carrier particles may comprise visible mono-sized beads having a diameter on the order of at least about 50 microns to more than about 5,000 microns.
  • suitably configured carrier particles may comprise beads that are generally soft and adapted to rub into the skin while leaving substantially no debris behind.
  • suitably configured carrier particles may be adapted to carry active ingredients.
  • carrier particle beads may be comprised of materials that are solid at room temperature and configured in various shapes and/or sizes.
  • carrier particle beads may provide color and/or texture so as to be visible in product suspension.
  • the color and/or texture of carrier particles may at least partially assist the user in topical application or delivery of a botanical component of an emollient sanitizing composition to a surface via visual verification of deposition.
  • Botanical emollient sanitizing compositions for topical use may be formulated in any suitable manner.
  • an anti-microbial sanitizer and a botanical emollient may be combined with one or more additives.
  • Representative additives may include, for example: a coloring agent, a dye, a color shifting pigment, a preservative, a pH adjusting material, a pH buffering agent, a thickening agent/polymer, a fragrance material, a polar extract of a fragrance material, water, a polyacrylic acid, polymer, a sugar alcohol, glitter, a special effect pigment, a vitamin, a provitamin, an amino acid, a protein, a peptide, a peptide complex, an active agent, and/or the like.
  • a botanical emollient sanitizing composition may be formulated with glycerine (alternatively spelled "glycerin ", but equivalent to glycerine in material respect).
  • glycerine generally functions to enhance or at least substantially maintain substantivity of an emollient composition.
  • a humectant is generally regarded as a hygroscopic substance and is often a molecule with several hydrophilic groups, most often hydroxyl groups; however, amines and carboxyl groups (sometimes esterified) may be employed as well. Humectants typically demonstrate an affinity to form hydrogen bonds with molecules of water.
  • Humectants are often found in many cosmetic products where moisturization is desired, including, for example, moisturizing treatments for the hair.
  • Representative examples of humectants include glycerine, propylene glycol (E 1520), butylene glycol, poly glycerol, polyglycerol esters, and glyceryl triacetate (E1518) and the like.
  • Others may include polyols like sorbitol (E420), xylitol and maltitol (E965), or polymeric polyols like polydextrose (E1200) or natural extracts like quillaia (E999), or lactic acid or urea, and the like.
  • the property of a material demonstrating "substantivity" may generally be regarded as its propensity to persist and reside on a surface to which it is applied. With enhanced substantivity, the combination of glycerine with an emollient may provide improved moisture retention properties.
  • a botanical emollient sanitizing composition may be formulated into one or more commercial formulations, as generally illustrated by the Examples given below. The percentages detailed below should be regarded as approximate.
  • a representative antibacterial emollient sanitizing composition may be formulated as a hand sanitizer gel in accordance with the following:
  • Jojoba OU PEG- 150 Esters 0.10 f Floratech” ⁇ , Chandler, AZ, USA) PEG- 150 Hydrogenated Jojoba
  • CARBOPOL Librizol Advanced Materials, Inc., Acrylates/C 10-30 Alkyl Acrylate Cleveland, Ohio, USA
  • ETD Crosspolymer 2020 (1.0% in water);
  • FLORAMAC 10 and Dermolene are excluded while additional FLORAESTERS K-IOO may be used to modify pH. Fragrance and preservative may also be added.
  • Jojoba Esters (and) lsopropyl Jojobate
  • Example 3 In this representative formulation, the amount of CARBOPOL, glycerine, FLORAESTERS IPJ, SIMULGEL 600, FLORASOMES, TEA and preservative is reduced as compared to Example 2, while water is added to compensate for the decreased formulation volume. Optionally, fragrance may be excluded as well. [0059] Example 3
  • Jojoba Esters (and) lsopropyl Jojobate
  • Example 3 illustrates a representative embodiment that may serve to reduce stickiness and/or "tack" otherwise associated with conventional hand sanitizers.
  • Example 3 may also reduce production costs.
  • representative botanical emollients may comprise
  • FLORAESTERS IPJ are generally obtained from the product of incomplete saponification of jojoba oil (Simmondsia chinensis) yielding in approximately equal amounts: wax esters, jojoba alcohols, and isopropyl esters of jojoba fatty acids.
  • FLORAMAC 10 corresponds to ethyl esters of macadamia oil ⁇ Macadamia integrifolia) fatty acids. Macadamia oil and FLORAMAC 10 are high in palmitoleic acid (C16:l) - a fatty acid know to be present as a significant fraction of human sebum.
  • FLORAESTERS KlOO corresponds to saponification products of jojoba oil in conjunction with unsaponifiable material produced from that reaction.
  • FLORAESTERS KlOO is generally comprised of potassium salts of jojoba fatty acids, the corresponding jojoba free fatty alcohols, and a small amount of residual jojoba wax ester.
  • FLORASOMES generally comprise jojoba oil randomized with fully hydrogenated jojoba oil, yielding wax esters of varying degrees of unsaturation. Unsaturated alcohols of human sebum have not been fully characterized previously, however, somewhat similar alcohols have been observed in the seed oil of Simmondsia chinsensis.
  • FLORAESTERS KlOO provides a significant source of unsaturated alcohols derived from botanically-sourced jojoba oil. Human sebum also contains wax esters, with more active sebaceous glands producing sebum lipids with a higher proportion of C16:l straight chain fatty acids. Similar wax esters may be obtained from, for example, FLORAESTERS IPJ and FLORASOMES - both representing derived compounds from botanically-sourced jojoba oil. Additionally, a C16:l lipid profile similar to that of mammalian sebum may be obtained with FLORAMAC 10 - a derived material of botanically-sourced macadamia oil.
  • Disclosed botanical topical emollient sanitizing compositions may be formulated for delivery via in any suitable manner, such as with a towelette, a pre-saturated towelette, a wipe, a napkin, a feminine hygiene product, a spray, a liquid, a gel, a cream, a lotion, a foam, a paste, a facial mask, a soap, and/or any other suitable formulation vehicle.
  • representative topical emollient sanitizing compositions may be formulated in a towelette, where the towelette may be suitably adapted to absorb and/or retain the emollient sanitizing composition. Additionally, a towelette may be implemented so as to prevent drying or evaporation of an emollient sanitizing composition.
  • the material of the towelette may also be disposable, washable, reusable, and/or the like.
  • a topical emollient sanitizing composition may be added to the material of a towelette in sufficient quantity to dampen the towelette material so that the composition may be transferred to the skin or other surface of application upon contact with the towelette.
  • the user may rub and/or wipe the towelette on the skin until emollient sanitizing composition is substantially absorbed. Debris on the surface of the skin may be further removed by contact of the towelette material on the skin.
  • an emollient sanitizing composition may be formulated to produce a sanitizing and moisturizing detergent for use as, for example, an anti-microbial soap for the removal of apolar bacteria, dirt, grease, oils, and/or the like from skin.
  • Apolar materials may be lifted from the skin by association with micelles formed with soap molecules for subsequent washing away with water.
  • an emollient sanitizing soap may comprise the products of the saponification of a variety of botanical and/or synthetic fats.
  • an emollient sanitizing soap may be provided as a solid, liquid, foam, spray, gel, cream, lotion, and/or the like.
  • Representative botanical emollient sanitizing compositions in accordance with the present invention may also be formulated with a skin toner.
  • Skin toners generally function to sanitize the skin and diminish the size of pores.
  • Conventional skin toners may vary according to their concentration of alcohol.
  • an astringent is a type of skin toner that generally comprises alcohol up to about 60%.
  • a Skin tonic is a type of skin toner that generally comprises less alcohol than astringents and may have up to about 20% alcohol.
  • a skin refresher is a type of skin toner that generally comprises the least amount of alcohol - on the order of about less than 10% alcohol.
  • botanical emollient sanitizing compositions may increase the range of applications for skin sanitizing compositions that may be suitably formulated for use by persons in which conventional sanitizing formulations may be contra-indicated.
  • individuals with sensitive skin, eczema, shingles, the skin of infants or young children, and/or the like may experience significant adverse dermatitic symptoms upon repeated use of conventional sanitizer products.
  • Individuals with these same dermatological conditions generally do not experience such symptoms, or at least observe a reduction of symptoms, after use of botanical emollient sanitizing compositions in accordance with representative embodiments of the present invention.
  • botanical emollient sanitizing compositions in accordance with the present invention may also be suitably adapted for use on artificial (e.g., inanimate) surfaces that require sanitization without drying effects.
  • an emollient sanitizing composition may be employed to alleviate dermatitis, such as acquired occupational hand dermatitis, and/or the like.
  • dermatitis such as acquired occupational hand dermatitis, and/or the like.
  • all fourteen (14) participants in the study exhibited substantial reduction of dermatitic symptoms after topical application of the emollient sanitizing composition corresponding to Example 1.
  • the study participants used the emollient sanitizing composition a minimum of eight (8) times per day over a fourteen (14) day period.
  • the subjects cleansed their hands with CETAPHIL (Galderma Laboratories, L.P., Cham Switzerland) soap, which was used to replace their daily hand soap to provide a baseline reference.
  • CETAPHIL Cosmetic Acids, Inc.
  • the use of other hand moisturizers and topical products were not permitted during the duration of the study.
  • a physician's assessment was conducted to evaluate abnormal skin symptoms.
  • TEWL evaporative skin moisture loss
  • Table 1 representatively illustrates a physician's clinical assessments of the hands of study participants.
  • the physician evaluated both dorsal and palmar sides of the hands before treatment and after fourteen (14) days of treatment.
  • Subjects were evaluated for symptoms corresponding to various dermatological abnormalities, including, for example: erythema (e.g., redness of the skin caused by capillary congestion); scaling (e.g., flaking of the skin); fissuring (e.g., cracks in the skin that may bleed); xerosis (e.g., dry skin); edema (e.g., swelling of the skin); vesiculation (e.g., formation of blisters); and lichenification (e.g., the formation of thick, leathery skin, usually the result of constant scratching and rubbing).
  • erythema e.g., redness of the skin caused by capillary congestion
  • scaling e.g., flaking of the skin
  • fissuring e.g., cracks in
  • TEWL TEWL
  • TEWL TEWL was measured in units of grams of water lost per square-centimeter per hour (g/cm 2 h).
  • the mean dorsal TEWL 105 was 17.12 g/cm 2 h and the mean palmar TEWL 110 was 45.71 g/cm 2 h.
  • dorsal 130 and palmar 135 values decreased again to 11.04 g/cm 2 h and 18.51 g/cm 2 h, respectively. This corresponded to a 20.00% reduction of dorsal TEWL and a 44.75% reduction of palmar TEWL from day seven (7) thru day fourteen (14).
  • the aggregate effect observed over the course of the entire study corresponded to a 35.51% reduction of dorsal TEWL and a 59.51% reduction of palmar TEWL from baseline thru day fourteen (14).
  • untreated sites 125, 140 were measured on medial inner-wrist patches for each subject on day seven (7) and day fourteen (14), respectively.
  • the mean value for TEWL control readings on wrist patches at seven (7) days 125 corresponded to 30.00 g/cm h.
  • the mean value for TEWL control readings on wrist patches at fourteen (14) days 140 was 32.5 g/cm 2 h.
  • both dorsal and palmar TEWL readings were dramatically reduced.
  • the mean value for TEWL control readings on wrist patches at seven (7) days 215 corresponded to 30.00 g/cm h.
  • the mean value for TEWL control readings on wrist patches at fourteen (14) days 225 was 32.5 g/cm 2 h.
  • the combined averages of mean dorsal and palmar TEWL readings were dramatically reduced.
  • Figures 3 and 4 illustrate histopathology associated with a representative dermatological inflammatory process ⁇ i.e., contact dermatitis) both before and following application of an emollient sanitizer composition corresponding to Example 1.
  • Figure 3 corresponds to baseline photomicrograph results of a 3mm punch biopsy of untreated skin stained with Hematoxylin and Eosin at a magnification of 40Ox.
  • the histology depicts a thickening of the stratum corneum 310 and a mild-moderate inflammatory infiltrate of polymorphonuclear leukocytes (PMN' s; i.e., white blood cells) 320 in the basal portion of the epidermis.
  • PMN' s polymorphonuclear leukocytes
  • This histological evaluation is consistent with common signs and symptoms associated with hand irritant contact dermatitis (e.g., redness, dryness, and fissuring).
  • Figure 4 corresponds to measurement at fourteen (14) days post-treatment following use of the emollient sanitizing formulation of Example 1.
  • the photomicrograph was made from a 3mm punch biopsy stained with Hematoxylin and Eosin at 40Ox magnification.
  • the vacuolization observed as open areas in the stratum corneum 310 depicted in Figures 3 and 4 correspond to artifacts of the method employed to prepare the cross-sectional samples for photomicrography and, as such, represent no difference between the photomicrographs.
  • the histology of Figure 4 demonstrates a less thick stratum corneum 310 and less inflammatory (PMN) infiltrate 420 residing in the basal portion of the epidermis.
  • emollient sanitizing compositions corresponding to various representative embodiments of the present invention generally provide a demonstrated reduction in transepidermal water loss, increase in substantivity and smooth skin-feel, as well as anti- inflammatory activity useful for the mitigation of adverse dermatitic symptoms.
  • any method or process embodiment may be executed in any order and are not limited to the specific order presented in the claims.
  • the components and/or elements recited in any apparatus or composition embodiment may be assembled or otherwise operationally configured in a variety of permutations to produce substantially the same result as the present invention and are accordingly not limited to the specific configuration recited in claims.

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Abstract

La présente invention concerne des compositions désinfectantes émollientes d'origine botanique et dérivés de composés botaniques pour une utilisation topique. Des compositions représentatives aident généralement à la reconstitution du profil lipidique du stratum corneum (310) en fournissant des lipides et/ou des dérivés de lipides d'origine botanique qui ressemblent au sébum humain - ces composants étant ordinairement réduits par l'utilisation de produits traditionnels désinfectants pour les mains. Les caractéristiques et spécifications décrites peuvent être diversement contrôlées, adaptées ou éventuellement modifiées pour réaliser, par exemple, des formulations désinfectantes pour les mains améliorées. Des modes de réalisation représentatifs de la présente invention concernent généralement des compositions anti-microbiennes mélangées avec des lipides et/ou des dérivés lipidiques d'origine botanique pour contrôler ou sinon améliorer les symptômes de dermatoses (par exemple, 320) associés à une utilisation fréquente de produits désinfectants pour les mains traditionnels.
PCT/US2008/004120 2007-03-29 2008-03-29 Traitement des symptômes de dermatose touchant un tégument mammalien avec des formulations désinfectantes émollientes WO2008121355A1 (fr)

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JP2010501014A JP2010522757A (ja) 2007-03-29 2008-03-29 哺乳動物外皮の皮膚炎症状の皮膚軟化殺菌製剤による処置
CA002678780A CA2678780A1 (fr) 2007-03-29 2008-03-29 Traitement des symptomes de dermatose touchant un tegument mammalien avec des formulations desinfectantes emollientes
EP08742370.3A EP2124868A4 (fr) 2007-03-29 2008-03-29 Traitement des symptômes de dermatose touchant un tégument mammalien avec des formulations désinfectantes émollientes

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JP2011173815A (ja) * 2010-02-23 2011-09-08 Nippon Shokuhin Kk 皮膚消毒用組成物
WO2013080205A1 (fr) * 2011-11-30 2013-06-06 Ibr - Israeli Biotechnology Research Ltd. Extrait de jojoba utilisé dans l'amélioration des fonctions barrières de la peau
WO2012148706A3 (fr) * 2011-04-29 2013-08-15 International Flora Technologies , Ltd. Insaponifiables en taux élevé et leurs méthodes d'utilisation
CN105748309A (zh) * 2016-05-04 2016-07-13 浙江焜之琳生物医药科技股份有限公司 一种免洗抗菌洗手液及制备方法
WO2017222429A1 (fr) 2016-06-20 2017-12-28 Sca Hygiene Products Ab Composition désinfectante pour les mains
WO2018185508A1 (fr) * 2017-04-04 2018-10-11 Gojo Industries Inc Procédés et composés permettant d'augmenter l'efficacité virucide dans des systèmes hydroalcooliques
CN111617063A (zh) * 2020-05-29 2020-09-04 广州润虹医药科技股份有限公司 一种免洗消毒液

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DE60030090T2 (de) 2000-04-06 2007-02-15 Quest International B.V. Aromatisieren von Nahrungsmitteln mit Verbindungen die ein mit zwei spezifischen Atomen oder Gruppen verbundenes Schwefelatom enthalten

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Cited By (16)

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US8529970B2 (en) 2000-01-03 2013-09-10 International Flora Technologies, Ltd. High unsaponifiables and methods of using the same
JP2011173815A (ja) * 2010-02-23 2011-09-08 Nippon Shokuhin Kk 皮膚消毒用組成物
WO2012148706A3 (fr) * 2011-04-29 2013-08-15 International Flora Technologies , Ltd. Insaponifiables en taux élevé et leurs méthodes d'utilisation
US9949918B2 (en) 2011-11-30 2018-04-24 IBR—Israeli Biotechnology Research Ltd. Jojoba extract useful in improving skin barrier functions
WO2013080205A1 (fr) * 2011-11-30 2013-06-06 Ibr - Israeli Biotechnology Research Ltd. Extrait de jojoba utilisé dans l'amélioration des fonctions barrières de la peau
CN103957884A (zh) * 2011-11-30 2014-07-30 Ibr以色列生物科技研究有限公司 可用于改善皮肤屏障功能的荷荷巴提取物
CN105708870A (zh) * 2011-11-30 2016-06-29 Ibr以色列生物科技研究有限公司 可用于改善皮肤屏障功能的荷荷巴提取物
AU2012345458B2 (en) * 2011-11-30 2017-07-27 Ibr- Israeli Biotechnology Research Ltd. Jojoba extract useful in improving skin barrier functions
CN105748309A (zh) * 2016-05-04 2016-07-13 浙江焜之琳生物医药科技股份有限公司 一种免洗抗菌洗手液及制备方法
WO2017222429A1 (fr) 2016-06-20 2017-12-28 Sca Hygiene Products Ab Composition désinfectante pour les mains
CN109414397A (zh) * 2016-06-20 2019-03-01 易希提卫生与保健公司 手部消毒组合物
AU2016410550B2 (en) * 2016-06-20 2019-06-06 Essity Hygiene And Health Aktiebolag Hand sanitizing composition
RU2714885C1 (ru) * 2016-06-20 2020-02-20 Эссити Хайджин Энд Хелт Актиеболаг Дезинфицирующая композиция для рук
EP3471696A4 (fr) * 2016-06-20 2020-03-11 Essity Hygiene And Health Aktiebolag Composition désinfectante pour les mains
WO2018185508A1 (fr) * 2017-04-04 2018-10-11 Gojo Industries Inc Procédés et composés permettant d'augmenter l'efficacité virucide dans des systèmes hydroalcooliques
CN111617063A (zh) * 2020-05-29 2020-09-04 广州润虹医药科技股份有限公司 一种免洗消毒液

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