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WO2008131842A1 - Dispositif de collecte et/ou de détection de lumière diffusée - Google Patents

Dispositif de collecte et/ou de détection de lumière diffusée Download PDF

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Publication number
WO2008131842A1
WO2008131842A1 PCT/EP2008/002726 EP2008002726W WO2008131842A1 WO 2008131842 A1 WO2008131842 A1 WO 2008131842A1 EP 2008002726 W EP2008002726 W EP 2008002726W WO 2008131842 A1 WO2008131842 A1 WO 2008131842A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
measuring surface
detector
collecting
annular
Prior art date
Application number
PCT/EP2008/002726
Other languages
German (de)
English (en)
Inventor
Vera Hermann
Original Assignee
Nirlus Engineering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nirlus Engineering Ag filed Critical Nirlus Engineering Ag
Publication of WO2008131842A1 publication Critical patent/WO2008131842A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array

Definitions

  • the invention relates to a medical device for collecting or detecting scattered light backscattered on or in a sample body, in particular in the course of noninvasive measurements on living tissue.
  • specimens in the context of the invention means, in particular, living tissue, e.g. a human body.
  • Non-invasive measurement means, for example, the non-invasive measurement of the concentration of blood components in (central) blood vessels, e.g. Measurement of Hemoglobin Concentration, Oxygen Saturation, Blood Glucose Content or the like.
  • light from a laser light source is introduced into the sample body, e.g.
  • the sought parameters are determined in a variety of ways.
  • electromagnetic radiation e.g., laser radiation
  • living tissue is substantially transparent to electromagnetic radiation between about 550 nm and 1000 nm ("biological window").
  • the backscattered light is measured under the influence of ultrasound radiation in order to optimize the measuring method.
  • DE 103 11 408 B3 discloses such a method for the non-invasive measurement of the concentration of blood constituents by measuring backscattered light under the influence of ultrasound radiation.
  • the ultrasound radiation is focused on the interior of a central blood vessel and a fixed pulse length and repetition time for the ultrasound radiation is specified.
  • a light source and an adjacent detection unit for detecting the backscattered light on the skin surface are positioned over the blood vessel such that the distance between the light source and the majority of the light receptors of the detection unit correspond to the depth of the examined blood vessel.
  • the target tissue is illuminated with at least two discrete wavelengths of light, and the backscattered light is measured and integrated over the detector surface and a plurality of ultrasound pulses.
  • the concentration in the blood vessel can be calculated taking into account the volume of the ultrasound focus and the blood flow velocity which contribute to the signal.
  • a matrix detector is used as measuring device, which consists of surface-side, photosensitive pixels which generate an electrical signal proportional to the light intensity. This matrix detector is arranged on the skin surface so that the exit points adjacent to the injection point are covered by the detector.
  • DE 10 2005 034 219 A1 discloses a method for classifying living tissue in which backscattered light is also measured under the action of ultrasound radiation.
  • the device known so far comprises a plurality of light sources with narrow spectral distribution, which may be in particular laser diodes.
  • the light is guided via optical fibers next to an ultrasonic source.
  • the backscattered infrared photons can re-enter the optical fibers and be led to a detector.
  • a planar sensor array as a light detector, which is placed directly on the tissue to be examined.
  • the invention is based on the object, a device for collecting and / or detecting backscattered on and / or in a sample body To provide scattered light of the type described above, which is characterized by high efficiency in a simple and inexpensive construction.
  • the device for collecting or detecting backscattered on or in a sample body scattered light especially in the course of non-invasive measurements on living tissue, in which light of a light source is irradiated at a Einstrahlddling in the sample body, characterized by at least one den Einstrahlddling surrounding annular measuring surface for the backscattered light.
  • the Einstrahltician is preferably centrally within the annular measuring surface.
  • ring-shaped means any type of measuring surface which surrounds the injection point, that is, in the context of the invention it is particularly important that the injection point is arranged within a measuring surface or integrated into the measuring surface.
  • the annular measuring surface is designed as an annular measuring surface with a predetermined radius.
  • the (average) radius of such an annular measuring surface corresponds approximately to half of the scattering depth and thus half of the depth of the scattering centers in the sample body. In this respect, it is the depth of the tissue area to be examined, e.g. of a blood vessel.
  • the invention is based on the (known) knowledge that the backscattered scattered light exits the tissue farther away from the point of injection, the deeper it is scattered in the tissue.
  • scattered light of particularly high intensity is statistically determined at a certain distance from the irradiation point, which corresponds approximately to half the depth of the scattering center.
  • This circumstance is exploited by the invention and arranges an annular and preferably circular measuring surface around the injection point, whereby the diameter of the eg annular measuring surface preferably corresponds approximately to the depth of the region to be examined.
  • the light of the light source can preferably be connected by means of at least one source optical fiber are irradiated into the sample body, wherein the outlet end of this source optical fiber forms the Einstrahlddling.
  • the device for collecting the scattered light has a plurality of collecting optical fibers.
  • the annular, e.g. circular measuring surface is thereby formed by the inlet ends of the collection optical fibers.
  • the device according to the invention consequently collects the scattered light which is decisive for the desired examination by means of a multiplicity of optical waveguides, which are arranged in a circular ring around the point of injection.
  • a particularly efficient measurement is achieved because the relevant scattered light is optimally utilized.
  • this arrangement allows detection as it were, so that stray light from other depths is suppressed.
  • the annular measuring surface may e.g.
  • the width of the annular measuring surface then corresponds approximately to the thickness of the light guides. However, it may also be expedient to combine a plurality (concentric) rows of optical fibers into an annular measuring surface whose width is then greater than the thickness of a single optical fiber.
  • the thickness of the individual light guides depends i.a. from the purpose and the wavelength of light used. It can basically be between e.g. 2 microns and 800 microns are.
  • the width of the annular measuring surface is smaller than its (average) radius, preferably smaller than 2 mm, e.g. less than 1, 5 mm. It is e.g.
  • the exit end of this source optical waveguide is preferably arranged (substantially in one plane) centrally within the entry ends of the collecting optical waveguides.
  • the collecting optical fibers are fastened with eg their entrance ends to a retaining ring.
  • This retaining ring can be hollow-cylindrical or hollow-cone be shaped, with hollow cone-shaped in particular means the shape of a hollow cone section. It is particularly expedient in this context if the radius of the retaining ring and thus the radius of the annular measuring surface is variable and therefore adjustable. In this way, the collecting device according to the invention can be adapted without great effort, eg during the examination, individually to the intended use and in particular to the depth of the tissue to be examined or of the blood vessel to be examined.
  • the collecting device selectively intensifies the scattered light relevant for the measurement as a function of the desired measuring depth.
  • the retaining ring of several adjustable, for example, mutually displaceable ring segments are made, so that the retaining ring can be opened and closed like dazzling.
  • the inlet ends of the collecting optical fibers form an annular measuring surface with the desired radius.
  • the radius of the circular disk-shaped exit surface is consequently significantly smaller than the radius of the annular measuring surface, since the optical waveguides are preferably combined to form a compact optical waveguide bundle, with the individual optical waveguides being essentially parallel to one another in the region of this optical waveguide bundle.
  • This circular-disk-shaped exit surface can be designed as a completely filled-out circular disk with optical waveguides distributed uniformly over the entire surface.
  • the exit surface can also have a central optical waveguide-free cutout.
  • the exit surface may also have a different cross-sectional shape from the circular shape.
  • this exit surface is assigned at least one optical element, for example a lens, which focuses the light emerging from the (circular disk-shaped) exit surface into a focal point.
  • another optical waveguide can now be positioned, namely the entrance end of a detector optical waveguide, which then guides the entire collected and, as it were, focused scattered light, for example, to a detector. This means that the exit end of the detector light guide can be assigned to the detector.
  • the device according to the invention collects in the context of the first embodiment, the relevant for the measurement scattered light, which exits first on a circular measuring surface with a relatively large radius of the sample body and leads this light using the described optical waveguide and / or the described lens together until it Finally, in a single detector optical fiber or a few detector optical fibers is guided to the detector.
  • the device according to the invention can operate as a self-sufficient collection device , This means that the probe-type collecting device freely positionable by the user does not itself have to be equipped with a light source and / or a detector. This allows a particularly compact design.
  • the invention includes embodiments in which the light source ⁇ ), eg a laser diode (s), is integrated into the collecting device.
  • the invention also includes embodiments in which the detector or detectors is integrated into the collecting device. So can the detector may be arranged, for example, in the region of the focus of the described collecting lens. The detector can also be connected at the end to a detector optical waveguide which is integrated in the mobile collecting device.
  • second embodiment of the invention can be dispensed with the described collection optical fiber, if directly on the measuring surface a plurality of detectors, such as semiconductor detectors are arranged, which thus form the measuring surface itself.
  • a multiplicity of individual detectors eg photo diodes
  • the detector elements are formed by individual measurement areas or pixels of an annular area detector, for example an annular diode array.
  • this second embodiment with fixed detector elements too, a particularly efficient measurement takes place, since the light irradiated in one point statistically escapes from the body with an extremely high probability from an exit surface surrounding the irradiation point in an annular manner.
  • the detector elements are arranged on a fixed circular ring, so that the diameter of this circle corresponds substantially exactly to the desired measuring depth. Such an approach is particularly useful, if not by further measures an assignment takes place, from which depth the backscattered photons come. If a specification of the region to be measured takes place, for example, by means of ultrasound radiation, it may be expedient if not only a single detector ring is provided, but if a large number of detectors are arranged on an annular measuring surface with a relatively large width.
  • the ring-shaped measuring surface can also be characterized by a "square" detector field are formed, which has a detector-free area in the middle, so that in the middle of the irradiation can be done.
  • FIG. 2 shows a first embodiment of a collecting device according to the invention
  • Fig. 3 shows a second embodiment of the invention
  • the specimen is a body part of a human body.
  • the device 1 according to the invention is placed on the skin surface of the body part 2, for example for measuring the blood sugar content of the blood.
  • the blood vessel 3 to be examined which is located at a predetermined depth T below the skin surface, is also indicated.
  • laser light is irradiated in the area of the blood vessel 3. This purpose is served only by a laser light source 4, which itself need not be the subject of the collecting device according to the invention.
  • this laser light source 4 is guided by means of an optical waveguide 5 in the region of the Einstrahlmens 6 on the skin surface.
  • the desired parameters eg the blood sugar content
  • the intensity of the scattered scattered light measured.
  • the measurement can additionally be carried out by means of ultrasound radiation.
  • an optionally usable ultrasonic source U is indicated.
  • the device 1 now makes use of the fact that, statistically speaking, the light irradiated in the region of the irradiation point 6 is backscattered by the tissue to be examined, eg the blood vessel 3, from a substantially circular measuring surface 7 of the specimen 2
  • the radius R of this circular measuring surface 7 corresponds essentially to half of the spreading depth and consequently to half of the depth T of the tissue to be examined, eg blood vessel, in the sample body 2.
  • the device 1 according to the invention has a plurality of collecting optical fibers 8, of which only a few are indicated in the figure. These collecting optical fibers 8 are arranged with their inlet ends 8a on the substantially annular measuring surface 7 of the width B.
  • the irradiation point 6 and consequently the outlet end 5b of the source optical waveguide 5 is consequently located in the center of the circle of this circular ring-shaped measuring surface 7 and consequently in the center of the circular end 8a of the collecting optical waveguides 8b arranged around this outlet end 5b.
  • the width B of the annular measuring surface is ( clearly) smaller than the (average) radius R.
  • a "real" photon orbit of a scattered photon is shown.
  • the curved or banana-shaped statistical photon orbits are also shown. It can be seen that the photons emerging from the exit end 5b of the source optical waveguide 5 are scattered (multiply) in the tissue and, taking into account the depth T of the blood vessel 3 to be examined, statistically preferably in the region of the circular measuring surface 7 and consequently in FIG the area of the entry ends 8a of the collection Light guide 8 are backscattered.
  • the collecting device 1 according to the invention consequently collects the portions of the backscattered light which are decisive for the measuring process, so that a particularly efficient or selective evaluation is possible.
  • the collecting optical fibers 8 can be fastened with their inlet ends 8a to a retaining ring 9 or held by such a retaining ring 9.
  • this retaining ring has the shape of a portion of a hollow cone, so that the collecting optical fibers 8 converge conical or conical.
  • the radius R of the annular measuring surface can be adjusted according to the invention, for example by the radius of the retaining ring 9 being variable and consequently adjustable.
  • the retaining ring 9 may for example consist of a plurality of adjustable, e.g. in one another or mutually displaceable ring segments consists. This is not shown in detail in the figure. In any case, this adjustability ensures the adaptation of the collecting device to different measuring depths or scattering depths T.
  • the collecting optical fibers 8 can be brought together with their outlet ends 8b to form a substantially circular disk-shaped outlet surface 10.
  • This circular disk-shaped exit surface 10 has a significantly lower Radius on than the annular measuring surface 7.
  • the outlet ends 8b of the collection optical fiber 8 are thus brought together to form a very compact fiber optic bundle.
  • this exit surface 10 is assigned an optical element, namely an only indicated lens 11 which functions as a converging lens and focuses the entire scattered light emerging from the exit surface 10 in the focal point 12.
  • This can be a GRIN lens (gradient index lens).
  • a further light guide namely the detector light guide 13 is provided, which is arranged with its inlet end 13a in the region of the focal point 12 of the lens 11. Consequently, this detector optical waveguide 13 makes it possible to flexibly guide the completely collected scattered light into the region of an optionally externally arranged detector 14, which is also merely indicated.
  • This detector 14 is then associated, for example, with the outlet end 13b of the detector optical waveguide 13.
  • Fig. 2 shows an embodiment in which the light source 4 and the detector 14 itself are not the subject of the collecting device. Rather, it is possible to create a flexible collecting device which can be combined via the source light guide 5 on the one hand and the detector light guide 13 on the other hand with a (possibly stationary) light source 4 and / or a (possibly stationary) detector 14.
  • the invention also includes embodiments in which light source 4 and / or detector 14, on the other hand, are integrated into such a collecting unit, which then forms a detection device.
  • a guide tube 15 for the source optical fiber 5 is indicated.
  • the wavelength of the laser radiation used can be e.g. between 650 and 2000 nm. In the exemplary embodiment, only one laser source is indicated. However, it may also be convenient to use several, e.g. to work two or four lasers, which may optionally have different wavelengths. Then it may be advantageous for optimization to work with multiple detectors that are set up for different wavelength ranges. Often it is sufficient to work with two different detectors, which then cover a sufficient spectral range. In such a case, not shown in the figures, it is possible to arrange the collecting optical fibers with their output ends into several, e.g. to summarize circular exit surfaces, e.g. can be arranged side by side.
  • the corresponding entry ends of these collecting optical fibers can then be mixed or alternately arranged on the measuring surface, while the outlet ends are then sorted out, as it were. It is therefore worked with several groups of optical fibers, each group being e.g. associated with a detector. Incidentally, it is expedient in the case of several laser sources, e.g. Laser diodes, also multiple source light guide to use.
  • laser sources e.g. Laser diodes
  • Optical fiber in the context of the invention means optical fiber (LWL), e.g. Glass fiber or fiber optic cables that can be made of glass or plastic.
  • LWL optical fiber
  • Glass fiber or fiber optic cables that can be made of glass or plastic.
  • FIG. 3 An alternative second embodiment of the invention, in which omits the described collection optical fiber is shown in FIG. 3 greatly simplified.
  • a multiplicity of detector elements 14a are arranged directly on the measuring surface 7, ie the detector elements 14a themselves form the circular measuring surface 7.
  • the exemplary embodiment concerns semiconductor detector elements, namely photo-diodes, either with a plurality of individual ones Photo diodes or alternatively can be used with an area detector or a diode array whose individual detector pixels form the individual detector elements.
  • such a detector is made with a plurality of detector pixels on a unitary detector chip.
  • the embodiment with a measuring surface formed by the detectors themselves without collecting optical fibers may also be provided with or without additional localization of the measuring depth, e.g. via ultrasound radiation.
  • this depth can be selected via the radius of the measuring surface. Consequently, only the photons coming from a certain depth are measured.
  • the detectors can have a fairly large surface and are arranged as close as possible to one another, preferably on a (exact) circular path, which represents the measuring depth.
  • the individual detector elements 14a preferably each have a relatively small measuring surface, which preferably has a diameter of less than 20 ⁇ m, preferably less than 10 ⁇ m, particularly preferably less than 5 ⁇ m.
  • the invention is based on the recognition that the intensity of the photon current is a random variable with statistical properties.
  • the intensity of the photon current is a random variable with statistical properties.
  • coherent light passes through a medium such as a specimen, the light exiting the body has a "speckled" pattern called “speckle”. Within such a "speckle” the signal is coherent.
  • the surface of a typical "speckle" is 3 to 5 microns. If the target area is localized, for example, with ultrasound radiation, then only the ultrasound radiation is used for the measurement modulated fractions of light relevant. The number of modulated speckies is very small.
  • FIGS. 4a and 4b show that a plurality are provided by detector elements or pixels, which have a relatively small active measuring surface, wherein the distance between the measuring surfaces or pixels is preferably equal to or greater than the diameter of the measuring surface.
  • the light can be irradiated with the aid of a source optical waveguide, as shown by way of example in FIG. 3.
  • the ultrasonic source is e.g. can be arranged in a separate chamber 16 of the device. This is preferably “electromagnetically protected” or shielded.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un dispositif de collecte ou de détection de lumière diffusée, rétrodiffusée sur / ou dans / un corps échantillon, en particulier au cours d'une mesure non invasive effectuée sur des tissus vivants, dispositif dans lequel la lumière d'une source lumineuse (4) est injectée, en un point d'irradiation (6), dans le corps échantillon (2). Ce dispositif est caractérisé en ce qu'il présente une surface de mesure annulaire entourant le point d'irradiation. On peut prévoir, par exemple, une pluralité de guides de lumière collecteurs (8) dont les extrémités d'entrée (8a) sont disposées dans la zone du corps échantillon (2), sur au moins une surface de mesure (7) sensiblement annulaire, de rayon prédéterminé (R), le point d'irradiation (6) étant situé sensiblement au centre de ladite surface de mesure annulaire (7). En variante, une pluralité d'éléments détecteurs, par exemple des photodiodes, peuvent être disposés directement sur la surface de mesure annulaire elle-même.
PCT/EP2008/002726 2007-04-26 2008-04-05 Dispositif de collecte et/ou de détection de lumière diffusée WO2008131842A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007020078.3 2007-04-26
DE200710020078 DE102007020078A1 (de) 2007-04-26 2007-04-26 Vorrichtung zum Sammeln von Streulicht

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Publication Number Publication Date
WO2008131842A1 true WO2008131842A1 (fr) 2008-11-06

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014107250A1 (de) 2014-05-22 2015-11-26 Nirlus Engineering Ag Verfahren und Vorrichtung zur nichtinvasiven optischen in-vivo-Bestimmung der Glukosekonzentration in fließendem Blut
EP3170446A1 (fr) 2015-11-20 2017-05-24 NIRLUS Engineering AG Procédé et dispositif de détermination optique in vivo non invasive de la concentration de glucose dans le sang en circulation
EP3616603A1 (fr) 2018-08-30 2020-03-04 RSP Systems A/S Structure de blocage de lumière et procédé de blocage de la lumière ambiante
DE102018124537A1 (de) 2018-10-04 2020-04-09 Nirlus Engineering Ag Verfahren und Vorrichtung zur nichtinvasiven optischen Messung von Eigenschaften von lebendem Gewebe
DE102020134911A1 (de) 2020-12-23 2022-06-23 Nirlus Engineering Ag Verfahren und Vorrichtung zur nicht-invasiven optischen In-vivo-Bestimmung der Glukosekonzentration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9308617U1 (de) * 1993-06-09 1993-07-22 Fa. Carl Zeiss, 7920 Heidenheim Vorrichtung zur nicht-invasiven Bestimmung der Sauerstoff-Konzentration
US5513642A (en) * 1994-10-12 1996-05-07 Rensselaer Polytechnic Institute Reflectance sensor system
US5844239A (en) * 1996-05-31 1998-12-01 Kurashiki Boseki Kabushiki Kaisha Optical measuring apparatus for light scattering
US6031603A (en) * 1995-06-09 2000-02-29 Cybro Medical, Ltd. Sensor, method and device for optical blood oximetry

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10311408B3 (de) 2003-03-13 2004-09-02 Universität Zu Lübeck Verfahren zur nichtinvasiven Messung der Konzentration von Blutbestandteilen
DE102005034219A1 (de) 2005-07-19 2007-02-22 Fachhochschule Lübeck Verfahren zur in vivo Gewebeklassifizierung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9308617U1 (de) * 1993-06-09 1993-07-22 Fa. Carl Zeiss, 7920 Heidenheim Vorrichtung zur nicht-invasiven Bestimmung der Sauerstoff-Konzentration
US5513642A (en) * 1994-10-12 1996-05-07 Rensselaer Polytechnic Institute Reflectance sensor system
US6031603A (en) * 1995-06-09 2000-02-29 Cybro Medical, Ltd. Sensor, method and device for optical blood oximetry
US5844239A (en) * 1996-05-31 1998-12-01 Kurashiki Boseki Kabushiki Kaisha Optical measuring apparatus for light scattering

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