WO2008135524A3 - Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments - Google Patents
Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments Download PDFInfo
- Publication number
- WO2008135524A3 WO2008135524A3 PCT/EP2008/055410 EP2008055410W WO2008135524A3 WO 2008135524 A3 WO2008135524 A3 WO 2008135524A3 EP 2008055410 W EP2008055410 W EP 2008055410W WO 2008135524 A3 WO2008135524 A3 WO 2008135524A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicaments
- analogues
- manufacturing
- substituted anthranilamides
- anthranilamides
- Prior art date
Links
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to substituted anthranilamides of general formula (I), wherein D, M, A4, A5, R2, R3, R4 and R6 are defined as in the specification. The compounds have an antithrombotic and a factor Xa inhibiting activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07107357 | 2007-05-02 | ||
EP07107357.1 | 2007-05-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008135524A2 WO2008135524A2 (en) | 2008-11-13 |
WO2008135524A3 true WO2008135524A3 (en) | 2009-06-11 |
Family
ID=39885206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/055410 WO2008135524A2 (en) | 2007-05-02 | 2008-05-02 | Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008135524A2 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5524852B2 (en) | 2007-11-15 | 2014-06-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Substituted amides, their production and use as pharmaceuticals |
PT3102576T (en) | 2014-02-03 | 2019-07-17 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
BR112017007460A2 (en) | 2014-10-14 | 2017-12-19 | Vitae Pharmaceuticals Inc | ror-gamma dihydropyrrolopyridine inhibitors |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
ES2856931T3 (en) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | ROR-gamma modulators |
AU2016355710B2 (en) | 2015-11-20 | 2021-03-25 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
TWI757266B (en) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | Modulators of ror-gamma |
WO2017192304A1 (en) * | 2016-05-02 | 2017-11-09 | Inception 1, Inc. | Arylcarboxamides and uses thereof |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | Inhibitors of ror gamma |
CN115716826A (en) | 2017-07-24 | 2023-02-28 | 生命医药有限责任公司 | Inhibitors of RORγ |
US20190270733A1 (en) * | 2018-03-01 | 2019-09-05 | Reaction Biology Corp. | Quinoline and Isoquinoline Based HDAC Inhibitors and Methods of Use Thereof |
WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
CR20230057A (en) | 2020-07-02 | 2023-08-15 | Incyte Corp | Tricyclic urea compounds as jak2 v617f inhibitors |
WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
EP4298099A1 (en) | 2021-02-25 | 2024-01-03 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
MX2024011378A (en) | 2022-03-17 | 2024-09-23 | Incyte Corp | Tricyclic urea compounds as jak2 v617f inhibitors. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999032477A1 (en) * | 1997-12-19 | 1999-07-01 | Schering Aktiengesellschaft | Ortho-anthranilamide derivatives as anti-coagulants |
WO2002042270A1 (en) * | 2000-11-22 | 2002-05-30 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted benzene derivatives or salts thereof |
JP2004210716A (en) * | 2002-12-27 | 2004-07-29 | Dai Ichi Seiyaku Co Ltd | Diamide derivative |
-
2008
- 2008-05-02 WO PCT/EP2008/055410 patent/WO2008135524A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999032477A1 (en) * | 1997-12-19 | 1999-07-01 | Schering Aktiengesellschaft | Ortho-anthranilamide derivatives as anti-coagulants |
WO2002042270A1 (en) * | 2000-11-22 | 2002-05-30 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted benzene derivatives or salts thereof |
EP1336605A1 (en) * | 2000-11-22 | 2003-08-20 | Yamanouchi Pharmaceutical Co. Ltd. | Substituted benzene derivatives or salts thereof |
JP2004210716A (en) * | 2002-12-27 | 2004-07-29 | Dai Ichi Seiyaku Co Ltd | Diamide derivative |
Non-Patent Citations (2)
Title |
---|
DATABASE HCAPLUS [online] ACS; XP002502775, retrieved from STN Database accession no. 141:156930 (DN) * |
KOCHANNY ET AL: "Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 15, no. 5, 31 January 2007 (2007-01-31), pages 2127 - 2146, XP005867178, ISSN: 0968-0896 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008135524A2 (en) | 2008-11-13 |
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