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WO2008136378A1 - Nouveau dérivé de sulfonamide et son sel - Google Patents

Nouveau dérivé de sulfonamide et son sel Download PDF

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Publication number
WO2008136378A1
WO2008136378A1 PCT/JP2008/058015 JP2008058015W WO2008136378A1 WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1 JP 2008058015 W JP2008058015 W JP 2008058015W WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1
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WO
WIPO (PCT)
Prior art keywords
salt
bonding hand
sulfonamide derivative
hydrogen atom
aryl group
Prior art date
Application number
PCT/JP2008/058015
Other languages
English (en)
Japanese (ja)
Inventor
Junichi Yokotani
Yoichi Taniguchi
Yoshitake Konishi
Yukie Tada
Minori Yanai
Masaki Katai
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Priority to JP2009512960A priority Critical patent/JP5443975B2/ja
Publication of WO2008136378A1 publication Critical patent/WO2008136378A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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  • Indole Compounds (AREA)
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  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

L'invention porte sur un composé représenté par la formule générale suivante: (dans laquelle R1 représente un atome d'hydrogène ou similaire; R2 représente un groupe alkyle ou aryle facultativement substitué ou similaire; R3 et R4 peuvent être identiques ou différents et représentent chacun un groupe aryle ou similaire; R5 représente un atome d'hydrogène ou similaire; X1 représente un groupe alkylène, une main de liaison ou similaire; X2 représente un élément de liaison ou similaire; Y1 représente un élément de liaison ou similaire; et Z1 et Z2 représentent chacun CH ou similaire) ou un sel de celui-ci. Etant donné que le composé ou un sel de celui-ci a une forte activité inhibitrice de la production de PGE2, il est utile pour le traitement ou la prévention de maladies et conditions associées à PGE2.
PCT/JP2008/058015 2007-04-27 2008-04-25 Nouveau dérivé de sulfonamide et son sel WO2008136378A1 (fr)

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WO2012015723A1 (fr) 2010-07-26 2012-02-02 Bristol-Myers Squibb Company Composés de sulfonamide utiles en tant qu'inhibiteurs de cyp17
US8748615B2 (en) 2010-03-05 2014-06-10 Sanofi Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
US20160168144A1 (en) * 2011-05-24 2016-06-16 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
JP2016523974A (ja) * 2013-07-11 2016-08-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
WO2019219689A1 (fr) 2018-05-18 2019-11-21 Syngenta Participations Ag Dérivés hétérocycliques à activité pesticide incorporant des substituants contenant du sulfoximine
WO2022050385A1 (fr) * 2020-09-07 2022-03-10 大日本住友製薬株式会社 Dérivé de phénol
CN114262293A (zh) * 2022-01-10 2022-04-01 安徽有吉医药科技有限公司 2-氨基-3-溴吡啶的制备方法
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8748615B2 (en) 2010-03-05 2014-06-10 Sanofi Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
WO2012015723A1 (fr) 2010-07-26 2012-02-02 Bristol-Myers Squibb Company Composés de sulfonamide utiles en tant qu'inhibiteurs de cyp17
US8916553B2 (en) 2010-07-26 2014-12-23 Bristol-Myers Squibb Company Sulfonamide compounds useful as CYP17 inhibitors
US20160168144A1 (en) * 2011-05-24 2016-06-16 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
JP2016523974A (ja) * 2013-07-11 2016-08-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
WO2019219689A1 (fr) 2018-05-18 2019-11-21 Syngenta Participations Ag Dérivés hétérocycliques à activité pesticide incorporant des substituants contenant du sulfoximine
WO2022050385A1 (fr) * 2020-09-07 2022-03-10 大日本住友製薬株式会社 Dérivé de phénol
JPWO2022050385A1 (fr) * 2020-09-07 2022-03-10
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用
CN114262293A (zh) * 2022-01-10 2022-04-01 安徽有吉医药科技有限公司 2-氨基-3-溴吡啶的制备方法
CN114262293B (zh) * 2022-01-10 2023-09-22 上海有吉医药化工有限公司 2-氨基-3-溴吡啶的制备方法

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