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WO2009040726A3 - Rhamnose antagonists and use thereof - Google Patents

Rhamnose antagonists and use thereof Download PDF

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Publication number
WO2009040726A3
WO2009040726A3 PCT/IB2008/053851 IB2008053851W WO2009040726A3 WO 2009040726 A3 WO2009040726 A3 WO 2009040726A3 IB 2008053851 W IB2008053851 W IB 2008053851W WO 2009040726 A3 WO2009040726 A3 WO 2009040726A3
Authority
WO
WIPO (PCT)
Prior art keywords
rhamnose
antagonists
gram
negative bacteria
infections
Prior art date
Application number
PCT/IB2008/053851
Other languages
French (fr)
Other versions
WO2009040726A2 (en
Inventor
Laurence Zulianello
Paolo Meda
Original Assignee
Universite De Geneve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite De Geneve filed Critical Universite De Geneve
Publication of WO2009040726A2 publication Critical patent/WO2009040726A2/en
Publication of WO2009040726A3 publication Critical patent/WO2009040726A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is related to new molecules capable of inhibiting rhamnolipids and especially epithelial infiltration by Gram-negative bacteria. In particular, the invention provides proteins useful in the prevention and/or treatment of Gram-negative bacteria induced infections or disorders, including nosocomial infections.
PCT/IB2008/053851 2007-09-24 2008-09-23 Rhamnose antagonists and use thereof WO2009040726A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07117077 2007-09-24
EP07117077.3 2007-09-24

Publications (2)

Publication Number Publication Date
WO2009040726A2 WO2009040726A2 (en) 2009-04-02
WO2009040726A3 true WO2009040726A3 (en) 2009-09-24

Family

ID=40361523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053851 WO2009040726A2 (en) 2007-09-24 2008-09-23 Rhamnose antagonists and use thereof

Country Status (1)

Country Link
WO (1) WO2009040726A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113648409B (en) * 2021-06-23 2024-03-01 山东第一医科大学(山东省医学科学院) Application of L-rhamnose antibody in preparation of medicine for preventing and/or treating drug-resistant bacterial infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066679A1 (en) * 2002-02-07 2003-08-14 Solbec Pharmaceuticals Limited Rhamnose binding protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066679A1 (en) * 2002-02-07 2003-08-14 Solbec Pharmaceuticals Limited Rhamnose binding protein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BABAOGLU KERIM ET AL: "Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 19, 6 October 2003 (2003-10-06), pages 3227 - 3230, XP002516869, ISSN: 0960-894X *
TATENO HIROAKI ET AL: "A novel rhamnose-binding lectin family from eggs of steelhead trout (Oncorhynchus mykiss) with different structures and tissue distribution", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 65, no. 6, June 2001 (2001-06-01), pages 1328 - 1338, XP002517665, ISSN: 0916-8451 *

Also Published As

Publication number Publication date
WO2009040726A2 (en) 2009-04-02

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