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WO2009066774A1 - Selective expression inhibitor for aurora kinase a and aurora kinase b genes - Google Patents

Selective expression inhibitor for aurora kinase a and aurora kinase b genes Download PDF

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Publication number
WO2009066774A1
WO2009066774A1 PCT/JP2008/071258 JP2008071258W WO2009066774A1 WO 2009066774 A1 WO2009066774 A1 WO 2009066774A1 JP 2008071258 W JP2008071258 W JP 2008071258W WO 2009066774 A1 WO2009066774 A1 WO 2009066774A1
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WO
WIPO (PCT)
Prior art keywords
aurora kinase
hereinafter
referred
pair
unit
Prior art date
Application number
PCT/JP2008/071258
Other languages
French (fr)
Japanese (ja)
Inventor
Hiroki Nagase
Teruyuki Takahashi
Original Assignee
Nihon University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon University filed Critical Nihon University
Publication of WO2009066774A1 publication Critical patent/WO2009066774A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A drug containing a pyrrole-imidazole polyamide comprising an N-methylpyrrole unit (hereinafter sometimes referred to as Py), an N-methylimidazole unit (hereinafter sometimes referred to as Im) and a γ-aminobutyric acid unit which can be folded at the γ-aminobutyric acid unit to form a U-shape conformation within the minor groove in the double strand region (hereinafter referred to as the target region) containing a part of the -100 to -70 positions (SEQ ID NO:2) in the base sequence of human aurora kinase A (hereinafter sometimes referred to as hAURKA) promoter or the whole thereof and a chain that is complementary thereto, and in which the C-G base pair corresponds to the Py/Im pair, the G-C base pair corresponds to the Im/Py pair and the A-T and T-A base pairs correspond each to the Py/Py pair.
PCT/JP2008/071258 2007-11-22 2008-11-21 Selective expression inhibitor for aurora kinase a and aurora kinase b genes WO2009066774A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007303138A JP2011026203A (en) 2007-11-22 2007-11-22 Selective expression-inhibiting agent for aurora kinase a gene and aurora kinase b gene
JP2007-303138 2007-11-22

Publications (1)

Publication Number Publication Date
WO2009066774A1 true WO2009066774A1 (en) 2009-05-28

Family

ID=40667596

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071258 WO2009066774A1 (en) 2007-11-22 2008-11-21 Selective expression inhibitor for aurora kinase a and aurora kinase b genes

Country Status (2)

Country Link
JP (1) JP2011026203A (en)
WO (1) WO2009066774A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128547A1 (en) * 2008-04-17 2009-10-22 学校法人日本大学 Gene expression inhibitor selective for matrix metalloproteinase-9 gene
WO2010103684A1 (en) * 2009-03-13 2010-09-16 学校法人日本大学 Sequence-specific expression regulator which targets at myc downstream gene, and method for determining target or targets of myc downstream gene
WO2014142092A1 (en) * 2013-03-11 2014-09-18 学校法人日本大学 Novel pi polyamide
JP2016179973A (en) * 2015-03-23 2016-10-13 国立大学法人 宮崎大学 Compound or salt thereof and pharmaceutical composition
WO2017135311A1 (en) * 2016-02-01 2017-08-10 国立大学法人千葉大学 Target gene transcriptional repression inhibitor that can be designed in a sequence-specific manner, composition containing same, and use thereof.
JPWO2022019303A1 (en) * 2020-07-20 2022-01-27

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006022063A (en) * 2004-07-09 2006-01-26 Univ Nihon LOX-1 gene expression inhibitor
WO2006018967A1 (en) * 2004-08-18 2006-02-23 Nihon University TGF-β GENE EXPRESSION INHIBITOR
WO2007034784A1 (en) * 2005-09-20 2007-03-29 Nihon University Ctgf gene expression inhibitor
WO2007060860A1 (en) * 2005-11-22 2007-05-31 Nihon University Automated solid phase synthesis of pyrrole-imidazole polyamide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006022063A (en) * 2004-07-09 2006-01-26 Univ Nihon LOX-1 gene expression inhibitor
WO2006018967A1 (en) * 2004-08-18 2006-02-23 Nihon University TGF-β GENE EXPRESSION INHIBITOR
WO2007034784A1 (en) * 2005-09-20 2007-03-29 Nihon University Ctgf gene expression inhibitor
WO2007060860A1 (en) * 2005-11-22 2007-05-31 Nihon University Automated solid phase synthesis of pyrrole-imidazole polyamide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KIMURA, M. ET AL.: "Cell cycle-dependent regulation of the human aurora B promoter", BIOCHEM BIOPHYS RES COMMUN, vol. 316, no. 3, 2004, pages 930 - 936 *
TAKAHASHI, T. ET AL.: "Development of pyrrole- imidazole polyamide for specific regulation of human aurora kinase-A and -B gene expression", CHEM BIOL, vol. 15, no. 8, August 2008 (2008-08-01), pages 829 - 841 *
TANAKA, M. ET AL.: "Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1", J BIOL CHEM, vol. 277, no. 12, 2002, pages 10719 - 10726 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009128547A1 (en) * 2008-04-17 2009-10-22 学校法人日本大学 Gene expression inhibitor selective for matrix metalloproteinase-9 gene
WO2010103684A1 (en) * 2009-03-13 2010-09-16 学校法人日本大学 Sequence-specific expression regulator which targets at myc downstream gene, and method for determining target or targets of myc downstream gene
JP5520931B2 (en) * 2009-03-13 2014-06-11 浩喜 永瀬 Sequence-specific expression regulator targeting MYC downstream gene, and method for determining target or target group of MYC downstream gene
WO2014142092A1 (en) * 2013-03-11 2014-09-18 学校法人日本大学 Novel pi polyamide
US9522978B2 (en) 2013-03-11 2016-12-20 Nihon University PI polyamide
JP2016179973A (en) * 2015-03-23 2016-10-13 国立大学法人 宮崎大学 Compound or salt thereof and pharmaceutical composition
WO2017135311A1 (en) * 2016-02-01 2017-08-10 国立大学法人千葉大学 Target gene transcriptional repression inhibitor that can be designed in a sequence-specific manner, composition containing same, and use thereof.
JPWO2017135311A1 (en) * 2016-02-01 2018-11-22 国立大学法人千葉大学 Sequence-specific and designable target gene transcription repression inhibitor, composition containing the same, and use thereof
JP7030323B2 (en) 2016-02-01 2022-03-07 国立大学法人千葉大学 Sequence-specific and designable target gene transcriptional repression inhibitors and compositions containing them and their use
JPWO2022019303A1 (en) * 2020-07-20 2022-01-27
JP7750839B2 (en) 2020-07-20 2025-10-07 昇 福田 Pyrrole-imidazole polyamide, TGF-β gene expression inhibitor, and pharmaceutical composition

Also Published As

Publication number Publication date
JP2011026203A (en) 2011-02-10

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