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WO2009072598A1 - 掻痒症治療剤 - Google Patents

掻痒症治療剤 Download PDF

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Publication number
WO2009072598A1
WO2009072598A1 PCT/JP2008/072142 JP2008072142W WO2009072598A1 WO 2009072598 A1 WO2009072598 A1 WO 2009072598A1 JP 2008072142 W JP2008072142 W JP 2008072142W WO 2009072598 A1 WO2009072598 A1 WO 2009072598A1
Authority
WO
WIPO (PCT)
Prior art keywords
pruritus
therapeutic agent
neutralizing antibody
mouse
clone
Prior art date
Application number
PCT/JP2008/072142
Other languages
English (en)
French (fr)
Inventor
Yoshinobu Higuchi
Keiko Kasutani
Hidetomo Kitamura
Masakazu Hasegawa
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to US12/746,229 priority Critical patent/US8431127B2/en
Priority to BRPI0821145A priority patent/BRPI0821145B8/pt
Priority to CN200880126534.1A priority patent/CN101939025B/zh
Priority to EP08857461A priority patent/EP2241332A4/en
Priority to CA2708065A priority patent/CA2708065C/en
Priority to MX2010006097A priority patent/MX2010006097A/es
Priority to AU2008332276A priority patent/AU2008332276B2/en
Priority to JP2009544731A priority patent/JP5475460B2/ja
Priority to RU2010127291/10A priority patent/RU2541780C2/ru
Priority to HK11105302.9A priority patent/HK1151226B/xx
Publication of WO2009072598A1 publication Critical patent/WO2009072598A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明者らは、ヒト抗体ファージライブラリーから、ＩＬ－３１依存性Ｂａ／Ｆ３細胞増殖アッセイ系に於いて、強い増殖抑制活性を示すクローンＢＭ０９５を得た。この抗マウスＮＲ１０中和抗体を用いて、掻痒症モデルマウスに投与したところ、顕著な症状の抑制効果が示された。抗ＮＲ１０中和抗体が掻痒症治療薬として有用であることが明らかとなった。
PCT/JP2008/072142 2007-12-05 2008-12-05 掻痒症治療剤 WO2009072598A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US12/746,229 US8431127B2 (en) 2007-12-05 2008-12-05 Method for treating pruritus comprising administering an NR10 antagonist
BRPI0821145A BRPI0821145B8 (pt) 2007-12-05 2008-12-05 uso de um anticorpo anti-nr10 como agente preventivo ou terapêutico para prurido
CN200880126534.1A CN101939025B (zh) 2007-12-05 2008-12-05 搔痒症治疗药
EP08857461A EP2241332A4 (en) 2007-12-05 2008-12-05 THERAPEUTIC AGENT AGAINST PRITURE
CA2708065A CA2708065C (en) 2007-12-05 2008-12-05 Therapeutic agent for pruritus
MX2010006097A MX2010006097A (es) 2007-12-05 2008-12-05 Agentes terapeuticos para tratar el prurito.
AU2008332276A AU2008332276B2 (en) 2007-12-05 2008-12-05 Therapeutic agent for pruritus
JP2009544731A JP5475460B2 (ja) 2007-12-05 2008-12-05 掻痒症治療剤
RU2010127291/10A RU2541780C2 (ru) 2007-12-05 2008-12-05 Терапевтическое средство от зуда
HK11105302.9A HK1151226B (en) 2007-12-05 2008-12-05 Therapeutic agent for pruritus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007315144 2007-12-05
JP2007-315144 2007-12-05

Publications (1)

Publication Number Publication Date
WO2009072598A1 true WO2009072598A1 (ja) 2009-06-11

Family

ID=40717776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072142 WO2009072598A1 (ja) 2007-12-05 2008-12-05 掻痒症治療剤

Country Status (14)

Country Link
US (1) US8431127B2 (ja)
EP (1) EP2241332A4 (ja)
JP (1) JP5475460B2 (ja)
KR (1) KR101595134B1 (ja)
CN (2) CN101939025B (ja)
AU (1) AU2008332276B2 (ja)
BR (1) BRPI0821145B8 (ja)
CA (1) CA2708065C (ja)
HK (1) HK1200697A1 (ja)
MX (1) MX2010006097A (ja)
MY (2) MY162546A (ja)
RU (2) RU2541780C2 (ja)
TW (1) TWI441649B (ja)
WO (1) WO2009072598A1 (ja)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064697A1 (ja) * 2008-12-05 2010-06-10 中外製薬株式会社 抗nr10抗体、およびその利用
WO2011137395A1 (en) * 2010-04-30 2011-11-03 Rother Russell P Anti-c5a antibodies and methods for using the antibodies
JPWO2010064697A1 (ja) * 2008-12-05 2012-05-10 中外製薬株式会社 抗ｎｒ１０抗体、およびその利用
US8431127B2 (en) 2007-12-05 2013-04-30 Chugai Seiyaku Kabushiki Kaisha Method for treating pruritus comprising administering an NR10 antagonist
US9028821B2 (en) 2006-06-08 2015-05-12 Chugai Seiyaku Kabushiki Kaisha Method of treating an inflammatory disease comprising administering an NR 10 antibody antagonist
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US9399680B2 (en) 2007-12-05 2016-07-26 Chugai Seiyaku Kabushiki Kaisha Nucleic acids encoding anti-NR10 antibodies
US9688762B2 (en) 2007-09-26 2017-06-27 Chugai Sciyaku Kabushiki Kaisha Modified antibody constant region
US9868948B2 (en) 2008-04-11 2018-01-16 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US10253091B2 (en) 2009-03-19 2019-04-09 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US10544227B2 (en) 2015-04-14 2020-01-28 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
KR20210145295A (ko) 2015-04-14 2021-12-01 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
US11260125B2 (en) 2019-11-20 2022-03-01 Chugai Seiyaku Kabushiki Kaisha Anti-IL31RA antibody-containing formulations
WO2022049614A1 (ja) 2020-09-01 2022-03-10 中外製薬株式会社 Ｉｌ－３１アンタゴニストを有効成分として含有する、透析そう痒症の予防用及び／又は治療用医薬組成物
US11891434B2 (en) 2010-11-30 2024-02-06 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
US12441804B2 (en) 2015-04-14 2025-10-14 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient

Families Citing this family (4)

* Cited by examiner, † Cited by third party
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US9770195B2 (en) * 2012-08-09 2017-09-26 The Regents Of The University Of California Automated scratch detection system and signal processing algorithm for the study of pruritus in animals
EA201792527A1 (ru) 2015-07-16 2018-06-29 Эли Лилли Энд Компани Лечение зуда
CN110563844A (zh) * 2019-09-04 2019-12-13 华中农业大学 一种抗犬白介素31受体的多克隆抗体及其应用
BR112023016043A2 (pt) * 2021-02-22 2023-12-05 Zoetis Services Llc Modelo de prurido induzido por il-31 de cavalo

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