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WO2009092810A3 - Composition pharmaceutique unique contenant des antibiotiques et des probiotiques - Google Patents

Composition pharmaceutique unique contenant des antibiotiques et des probiotiques Download PDF

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Publication number
WO2009092810A3
WO2009092810A3 PCT/EP2009/050803 EP2009050803W WO2009092810A3 WO 2009092810 A3 WO2009092810 A3 WO 2009092810A3 EP 2009050803 W EP2009050803 W EP 2009050803W WO 2009092810 A3 WO2009092810 A3 WO 2009092810A3
Authority
WO
WIPO (PCT)
Prior art keywords
probiotics
probiotic
pharmaceutical composition
cinetic
pharmaco
Prior art date
Application number
PCT/EP2009/050803
Other languages
English (en)
Other versions
WO2009092810A2 (fr
Inventor
Vygantas Kirejevas
Original Assignee
Bacterfield Oü
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bacterfield Oü filed Critical Bacterfield Oü
Publication of WO2009092810A2 publication Critical patent/WO2009092810A2/fr
Publication of WO2009092810A3 publication Critical patent/WO2009092810A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Oncology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention porte sur un procédé d'utilisation d'une combinaison d'antibiotique et de probiotique de façon contrôlée dans le temps dans une composition pharmaceutique unique, procédé suivant lequel, lors de l'utilisation de la composition pharmaceutique à une première étape du cycle pharmaco-cinétique, l'antibiotique déploie son effet contre une infection, permettant d'obtenir le taux maximal suivi par une libération contrôlée dans le temps des probiotiques. Après obtention du taux maximal, peu de temps avant la fin du cycle pharmaco-cinétique de la dose unique, la population probiotique est libérée, le temps de libération du probiotique dépendant du rapport antibiotique/probiotique, qui permet une multiplication rapide des probiotiques pour diminuer encore l'activité pathogène entre deux cycles pharmaco-cinétiques.
PCT/EP2009/050803 2008-01-24 2009-01-23 Composition pharmaceutique unique contenant des antibiotiques et des probiotiques WO2009092810A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2326308P 2008-01-24 2008-01-24
US61/023,263 2008-01-24

Publications (2)

Publication Number Publication Date
WO2009092810A2 WO2009092810A2 (fr) 2009-07-30
WO2009092810A3 true WO2009092810A3 (fr) 2009-12-17

Family

ID=40586185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/050803 WO2009092810A2 (fr) 2008-01-24 2009-01-23 Composition pharmaceutique unique contenant des antibiotiques et des probiotiques

Country Status (1)

Country Link
WO (1) WO2009092810A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102711819A (zh) * 2009-09-23 2012-10-03 托马斯·朱利叶斯·波洛迪 肠道感染疗法
US9138441B2 (en) * 2009-12-31 2015-09-22 Ira Milton Trachtman Compositions and method for treatment and prophylaxis of inflammatory bowel disease
AU2016259871B2 (en) 2015-05-11 2020-04-16 Mybiotics Pharma Ltd Systems and methods for growing a biofilm of probiotic bacteria on solid particles for colonization of bacteria in the gut
IL294171A (en) 2016-05-25 2022-08-01 Mybiotics Pharma Ltd Composition and methods for microbiota therapy
BR112021019437A2 (pt) * 2019-03-28 2021-11-30 Mybiotics Pharma Ltd Composições de biofilme probiótico e métodos para preparar as mesmas

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000010582A2 (fr) * 1998-08-24 2000-03-02 Ganeden Biotech, Inc. Bacteries probiotiques produisant de l'acide lactique et leurs utilisations
US6306391B1 (en) * 1997-03-27 2001-10-23 Cadila Pharmaceuticals, Ltd. Preparation of an oral pharmaceutical formulation containing an anti-infective agent and a microorganism
US20020192201A1 (en) * 1998-09-24 2002-12-19 Ira Shafran Crohn's disease treatment methods
WO2004067013A1 (fr) * 2003-01-24 2004-08-12 Flora Technology Inc. Compositions et procedes pour restaurer la flore bacterienne
EP1566176A1 (fr) * 2004-02-16 2005-08-24 Sanjeev Prem Nivas Khandelwal Formulation antibacterielle synergique et méthode de péparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306391B1 (en) * 1997-03-27 2001-10-23 Cadila Pharmaceuticals, Ltd. Preparation of an oral pharmaceutical formulation containing an anti-infective agent and a microorganism
WO2000010582A2 (fr) * 1998-08-24 2000-03-02 Ganeden Biotech, Inc. Bacteries probiotiques produisant de l'acide lactique et leurs utilisations
US20020192201A1 (en) * 1998-09-24 2002-12-19 Ira Shafran Crohn's disease treatment methods
WO2004067013A1 (fr) * 2003-01-24 2004-08-12 Flora Technology Inc. Compositions et procedes pour restaurer la flore bacterienne
EP1566176A1 (fr) * 2004-02-16 2005-08-24 Sanjeev Prem Nivas Khandelwal Formulation antibacterielle synergique et méthode de péparation

Also Published As

Publication number Publication date
WO2009092810A2 (fr) 2009-07-30

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