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WO2009001840A1 - ADCC活性又はCDC活性を有する抗Prominin-1抗体 - Google Patents

ADCC活性又はCDC活性を有する抗Prominin-1抗体 Download PDF

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Publication number
WO2009001840A1
WO2009001840A1 PCT/JP2008/061516 JP2008061516W WO2009001840A1 WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1 JP 2008061516 W JP2008061516 W JP 2008061516W WO 2009001840 A1 WO2009001840 A1 WO 2009001840A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
activity
humanized
adcc
human
Prior art date
Application number
PCT/JP2008/061516
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English (en)
French (fr)
Inventor
Kenji Yoshida
Original Assignee
Forerunner Pharma Research Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forerunner Pharma Research Co., Ltd. filed Critical Forerunner Pharma Research Co., Ltd.
Priority to US12/666,418 priority Critical patent/US8722858B2/en
Priority to EP08777573A priority patent/EP2175016A4/en
Priority to JP2009520606A priority patent/JP5469456B2/ja
Publication of WO2009001840A1 publication Critical patent/WO2009001840A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明は、Prominin-1に結合し、ADCC活性及び／又はCDC活性を有する抗体、並びに該抗体を有効成分とする医薬組成物を提供することを目的とする。 　本発明者らは、上記の課題を解決するために、AC133の抗体可変領域塩基配列をクローニングし、組換え抗体を作製することで、もともとのAC133抗体には存在しないADCC/CDC誘導作用が組換え抗体に付与されていることを見出し、本発明を完成させた。定常領域配列をヒトIgG1/kに変換したキメラ抗体は、ヒトキメラ抗体・ヒトエフェクター細胞との組み合わせにおいて強いADCCが誘導されることを見出した。また、本発明者らはAC133抗体のCDRをヒト抗体配列に移植したヒト化抗体を作製し、さらにヒト化L鎖配列にアミノ酸置換を導入することでキメラ抗体と同等の結合活性を有するヒト化抗体を作製した。本発明により抗腫瘍作用を有する非標識のAC133ヒトキメラ抗体、そしてヒト化抗体が提供される。
PCT/JP2008/061516 2007-06-25 2008-06-25 ADCC活性又はCDC活性を有する抗Prominin-1抗体 WO2009001840A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/666,418 US8722858B2 (en) 2007-06-25 2008-06-25 Anti-Prominin-1 antibody having ADCC activity or CDC activity
EP08777573A EP2175016A4 (en) 2007-06-25 2008-06-25 ANTI-PROMININ-1 ANTIBODY WITH ADCC ACTIVITY OR CDC ACTIVITY
JP2009520606A JP5469456B2 (ja) 2007-06-25 2008-06-25 ＡＤＣＣ活性又はＣＤＣ活性を有する抗Ｐｒｏｍｉｎｉｎ−１抗体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-166253 2007-06-25
JP2007166253 2007-06-25

Publications (1)

Publication Number Publication Date
WO2009001840A1 true WO2009001840A1 (ja) 2008-12-31

Family

ID=40185652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061516 WO2009001840A1 (ja) 2007-06-25 2008-06-25 ADCC活性又はCDC活性を有する抗Prominin-1抗体

Country Status (4)

Country Link
US (1) US8722858B2 (ja)
EP (1) EP2175016A4 (ja)
JP (1) JP5469456B2 (ja)
WO (1) WO2009001840A1 (ja)

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WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
WO2024243340A1 (en) 2023-05-23 2024-11-28 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods

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US9493569B2 (en) * 2005-03-31 2016-11-15 Chugai Seiyaku Kabushiki Kaisha Structural isomers of sc(Fv)2
US9309322B2 (en) 2010-11-12 2016-04-12 Scott & White Healthcare (Swh) Antibodies to tumor endothelial marker 8
WO2012065705A1 (en) * 2010-11-19 2012-05-24 Roche Diagnostics Gmbh Novel complex mutation in the epidermal growth factor receptor kinase domain
WO2013173745A1 (en) * 2012-05-18 2013-11-21 Galaxy Biotech, Llc Monoclonal antibodies to macrophage stimulating protein
EP2769989A1 (en) 2013-02-21 2014-08-27 Universitätsklinikum Freiburg Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor
WO2016154623A2 (en) 2015-03-26 2016-09-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-cd133 monoclonal antibodies and related compositions and methods
WO2017023704A1 (en) * 2015-07-31 2017-02-09 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES
EP4179105A4 (en) * 2020-07-09 2024-07-31 Lankenau Institute for Medical Research COMPOSITIONS COMPRISING ANTIBODIES DIRECTED AGAINST HUMAN IDO-2
CN114057875B (zh) * 2020-07-31 2023-05-05 北京市神经外科研究所 抗cd133的单链抗体及其在制备治疗肿瘤的药物中的用途
CN113214396B (zh) * 2020-07-31 2022-04-19 北京市神经外科研究所 抗tim3的单链抗体及其在制备治疗肿瘤的药物中的用途
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024249954A1 (en) 2023-05-31 2024-12-05 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles

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