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WO2009011112A1 - プロスタグランジンe1を含む安定な脂肪乳剤 - Google Patents

プロスタグランジンe1を含む安定な脂肪乳剤 Download PDF

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Publication number
WO2009011112A1
WO2009011112A1 PCT/JP2008/001865 JP2008001865W WO2009011112A1 WO 2009011112 A1 WO2009011112 A1 WO 2009011112A1 JP 2008001865 W JP2008001865 W JP 2008001865W WO 2009011112 A1 WO2009011112 A1 WO 2009011112A1
Authority
WO
WIPO (PCT)
Prior art keywords
fat emulsion
emulsion containing
prostaglandin
containing prostaglandin
stable fat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/001865
Other languages
English (en)
French (fr)
Inventor
Takayuki Fukuyama
Kazuhiko Ozaki
Kenichi Hirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Taisho Pharmaceutical Co Ltd
Original Assignee
Mitsubishi Tanabe Pharma Corp
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Taisho Pharmaceutical Co Ltd filed Critical Mitsubishi Tanabe Pharma Corp
Priority to JP2009523535A priority Critical patent/JP5890599B2/ja
Priority to KR1020157002118A priority patent/KR101588558B1/ko
Priority to CN200880024114A priority patent/CN101743010A/zh
Publication of WO2009011112A1 publication Critical patent/WO2009011112A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　プロスタグランジンE1活性を有する化合物を含有する脂肪乳剤であって、ガラス製容器に密封された後に加熱滅菌されており、5°Cで16ヶ月間保存後にプロスタグランジンE1活性の残存量が保存開始時の65％以上100％以下である脂肪乳剤。
PCT/JP2008/001865 2007-07-13 2008-07-11 プロスタグランジンe1を含む安定な脂肪乳剤 Ceased WO2009011112A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009523535A JP5890599B2 (ja) 2007-07-13 2008-07-11 プロスタグランジンｅ１を含む安定な脂肪乳剤
KR1020157002118A KR101588558B1 (ko) 2007-07-13 2008-07-11 프로스타글란딘 ｅ１을 포함하는 안정한 지방 유제
CN200880024114A CN101743010A (zh) 2007-07-13 2008-07-11 含有前列腺素e1的稳定的脂肪乳剂

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-184358 2007-07-13
JP2007184358 2007-07-13

Publications (1)

Publication Number Publication Date
WO2009011112A1 true WO2009011112A1 (ja) 2009-01-22

Family

ID=40259458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001865 Ceased WO2009011112A1 (ja) 2007-07-13 2008-07-11 プロスタグランジンe1を含む安定な脂肪乳剤

Country Status (6)

Country Link
JP (2) JP5890599B2 (ja)
KR (2) KR101588558B1 (ja)
CN (1) CN101743010A (ja)
MY (1) MY158088A (ja)
TW (1) TW200920379A (ja)
WO (1) WO2009011112A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013006811A (ja) * 2011-06-27 2013-01-10 Fujifilm Corp 容器詰製剤
WO2019230964A1 (ja) * 2018-05-31 2019-12-05 富士フイルム株式会社 容器詰水中油型乳化組成物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102038639B (zh) * 2010-12-24 2012-05-02 海南碧凯药业有限公司 一种前列地尔注射制剂
CN102198095A (zh) * 2011-05-03 2011-09-28 北京中海康医药科技发展有限公司 一种依前列醇脂肪乳及其制备方法
CN107519132A (zh) * 2017-08-29 2017-12-29 辅必成（上海）医药科技有限公司 一种前列地尔的纳米脂肪乳剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02175630A (ja) * 1988-12-27 1990-07-06 Matsumoto Seiyaku Kogyo Kk 医療用ガラス製品内表面の金属酸化物処理によるアルカリ等の溶出防止法
JPH06263481A (ja) * 1992-11-18 1994-09-20 Koa Glass Kk アルカリ等の溶出防止機能を有するガラス製品及びその製造方法
JPH0769897A (ja) * 1993-09-01 1995-03-14 Green Cross Corp:The 血中トリグリセリド低下作用剤
JPH09235230A (ja) * 1995-12-29 1997-09-09 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用製剤
WO1999009992A1 (en) * 1997-08-27 1999-03-04 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters
JP2006188474A (ja) * 2005-01-07 2006-07-20 Nichi-Iko Pharmaceutical Co Ltd 安定性に優れた脂肪乳剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07206472A (ja) * 1994-01-12 1995-08-08 Nippon Electric Glass Co Ltd 医薬用ホウケイ酸ガラス
JPH08104620A (ja) * 1994-10-05 1996-04-23 Green Cross Corp:The 薬物含有脂肪乳剤
JPH08175998A (ja) * 1994-12-19 1996-07-09 Takada Seiyaku Kk シリコート容器を用いた凍結乾燥製剤
JP2001328612A (ja) * 2000-05-22 2001-11-27 Daiwa Tokushu Glass Kk 低アルカリガラス容器及びその製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02175630A (ja) * 1988-12-27 1990-07-06 Matsumoto Seiyaku Kogyo Kk 医療用ガラス製品内表面の金属酸化物処理によるアルカリ等の溶出防止法
JPH06263481A (ja) * 1992-11-18 1994-09-20 Koa Glass Kk アルカリ等の溶出防止機能を有するガラス製品及びその製造方法
JPH0769897A (ja) * 1993-09-01 1995-03-14 Green Cross Corp:The 血中トリグリセリド低下作用剤
JPH09235230A (ja) * 1995-12-29 1997-09-09 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用製剤
WO1999009992A1 (en) * 1997-08-27 1999-03-04 Yoshitomi Pharmaceutical Industries, Ltd. Neovascularization promoters
JP2006188474A (ja) * 2005-01-07 2006-07-20 Nichi-Iko Pharmaceutical Co Ltd 安定性に優れた脂肪乳剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TEAGARDEN D.L. ET AL.: "Dehydration Kinetics of Prostaglandin E1 in a lipid Emulsion", PHARMACEUTICAL RESEARCH, vol. 6, no. 3, 1989, pages 210 - 215, XP000942335 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013006811A (ja) * 2011-06-27 2013-01-10 Fujifilm Corp 容器詰製剤
WO2019230964A1 (ja) * 2018-05-31 2019-12-05 富士フイルム株式会社 容器詰水中油型乳化組成物

Also Published As

Publication number Publication date
KR101588558B1 (ko) 2016-01-28
JP5965944B2 (ja) 2016-08-10
TW200920379A (en) 2009-05-16
KR20100053541A (ko) 2010-05-20
JPWO2009011112A1 (ja) 2010-09-16
CN101743010A (zh) 2010-06-16
KR20150017775A (ko) 2015-02-17
JP5890599B2 (ja) 2016-03-22
MY158088A (en) 2016-08-30
JP2014224131A (ja) 2014-12-04

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