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WO2009036599A1 - Dispositif et système de rayonnement - Google Patents

Dispositif et système de rayonnement Download PDF

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Publication number
WO2009036599A1
WO2009036599A1 PCT/CN2007/002772 CN2007002772W WO2009036599A1 WO 2009036599 A1 WO2009036599 A1 WO 2009036599A1 CN 2007002772 W CN2007002772 W CN 2007002772W WO 2009036599 A1 WO2009036599 A1 WO 2009036599A1
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WO
WIPO (PCT)
Prior art keywords
light
energy
fluctuation
light irradiation
angle
Prior art date
Application number
PCT/CN2007/002772
Other languages
English (en)
Chinese (zh)
Inventor
Kai-Shu Song
Chin-Tien Huang
Original Assignee
Kai-Shu Song
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kai-Shu Song filed Critical Kai-Shu Song
Priority to PCT/CN2007/002772 priority Critical patent/WO2009036599A1/fr
Publication of WO2009036599A1 publication Critical patent/WO2009036599A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Definitions

  • the present invention relates to a medical device, and more particularly to an illumination device, and a system including the same, which can be used as a photobiostimulation illumination device for cell therapy.
  • BACKGROUND OF THE INVENTION In conventional medicine, a certain fixed frequency and a fixed energy of concentrated light are generally used as a light source for medical irradiation, and the effect on biological stimulation is limited, so that only a fixed light and a fixed energy concentrated light are used. It is impossible to fully function. In addition, this existing light source adopts a large divergence angle, and the energy density of the light source is weak, which has a poor effect on biological stimulation.
  • SUMMARY OF THE INVENTION It is an object of the present invention to provide an illumination device that can be used for biocellular therapy that produces different frequencies and different energy bundles of light.
  • the illumination device of the present invention comprises: at least one light emitting diode capable of generating a low-energy non-parallel beam that is concentrated in a narrow band of a pulse width and suitable as a biological stimulus for biological cell therapy,
  • the beam light has a wavelength between 600 and 850 nm, and the light energy density is between 2 and 16 joules/cm 2 , preferably between 2. 5 and 5 joules/cm 2 , and the light divergence angle is within 16 degrees. 4 to 10 degrees.
  • Another object of the present invention is to provide an illumination system that can be used for biological cell therapy.
  • the illumination system comprises: at least one set of light emitting diode devices having at least one light emitting diode, the light emitting diodes being capable of generating more than one narrow bandwidth centered at a wavelength, suitable for biological cell therapy 5 ⁇ 5 ⁇ / ⁇ 2 2 ⁇
  • the bio-stimulated low-energy non-parallel concentrating light the wavelength of the beam is between 600 and 850 nm, the light energy density is between 2 and; 16 joules / cm 2 , preferably between 2.
  • a driver includes a voltage control circuit and a microprocessor, the voltage control circuit mainly receives signals transmitted by the central processing unit, providing different The output voltage is applied to the light emitting diodes to generate bundled light of different energies; the calculation of the microprocessor is used to regulate different frequencies, and the signals are output to the voltage control circuit; a power supply device is provided to provide power to the device.
  • system further includes a button device coupled to the central processing unit to enable the operator to To enter the desired light energy and frequency data.
  • the system includes an overcurrent protection circuit to protect the unit.
  • the voltage control circuit of the system uses a pulse wave adjustment circuit to receive the pulse signal of the central processing unit and provide different output voltages to the diode.
  • the method includes the following six modes:
  • the first mode is that the method comprises a light irradiation step of three different numerical energies, and the light energy density is controlled to be in the range of 2 to 16 joules/cm 2 , and 0. 5X joules, IX joules, 1.
  • the light energy of 5X joules is increased, and X is a variable.
  • the light of each step illuminates the energy, the slope of the ⁇ angle increases, the angle of ⁇ , and the steps of the method can be repeated multiple times. 5 ⁇ ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
  • the second mode is that the method comprises a light irradiation step of three different numerical energies, wherein the three steps are to control the light energy density in the range of 2 to 16 joules/cm 2 , to 1.5 X joules, IX joules, 0. 5X Joule's light energy is decremented, and X is a variable.
  • the light of each step illuminates the energy, and the slope of the ⁇ angle increases.
  • the 9 angle is ⁇ 45 degrees, and this step can be repeated several times.
  • the volatility is 0. 5 ⁇ 1.
  • the fluctuation frequency is between 0 and 5 times.
  • the fluctuation frequency is between 0. 5 ⁇ 1. 5 seconds, the fluctuation mode is a slow rise and a sudden drop.
  • the third mode is that the method comprises a light irradiation step of two different numerical energies, wherein the two steps are to control the light energy density in the range of 2 to 16 joules/cm 2 , to 0. 5X joules, IX joules
  • the light energy is increased, and the X is a variable.
  • the light illuminating energy of the first step is increased by the ⁇ angle slope, the ⁇ angle is 60 degrees, and the step can be repeated several times.
  • the second step of the number of fluctuations is 0. 5 ⁇ 1. 5 seconds, the number of fluctuations in the first step is 0. 5 ⁇ 1. 5 seconds, the number of fluctuations in the first step is further increased by a slight fluctuation in the light of each step.
  • the fluctuation mode is a sudden rise and fall, and the second fluctuation is 6 times or 18 times.
  • the fluctuation mode is a slow rise and a sudden drop.
  • the fourth mode is that the method includes two different numerical energy light illumination steps, the two steps
  • the light energy density is controlled in the range of 2 to 16 joules/cm 2 , and the light energy of IX joules and 0.5X joules is decreased.
  • the X is a variable, and the light irradiation energy of the first step is increased by the slope of the angle ,.
  • the angle ⁇ is 60 degrees, and this step can be repeated several times.
  • the second step of the number of fluctuations is 0. 5 ⁇ 1. 5 seconds
  • the fluctuation frequency of the first step is 0. 5 ⁇ 1. 5 seconds
  • the number of fluctuations of the first step is further increased by a slight fluctuation in the light irradiation of each step.
  • the fluctuation mode is a slow rise and a sudden drop, and the second fluctuation is 9 times or 27 times.
  • the fluctuation mode is a sudden rise and fall.
  • the fifth mode is that the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of 2 to 16 joules/cm 2 , the irradiation energy is X joules, and X is a variable, and The illuminating energy is increased by the slope of the ⁇ angle, the ⁇ angle is about 45 degrees, and the step can be repeated several times. 5 ⁇ The number of fluctuations is 9 times, the amplitude of the fluctuation is 0. 5 ⁇ 1. 5 seconds, and the number of fluctuations is 9 times. Or 27 times, the fluctuation mode is a sudden rise and fall.
  • the sixth mode is that the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of 2 to 16 joules/cm 2 , the irradiation energy is X joules, and X is a variable, and the method
  • the illuminating energy is increased by the slope of the ⁇ angle, the ⁇ angle is about 45 degrees, and this step can be repeated several times.
  • the fluctuation frequency is 0. 25 ⁇ 1. 0 seconds, and the number of fluctuations is 6 times.
  • the method further applies a slight fluctuation in the light irradiation of each step, the fluctuation amplitude is within 20% of the light energy of the stage, and the fluctuation frequency is 0. 25 ⁇ 1. Or 18 times, the fluctuation mode is a slow rise and a sudden drop.
  • FIG. 1 is a block diagram of a preferred embodiment of an illumination device of the present invention.
  • Figure 2 is a circuit diagram compared to Figure 1.
  • Fig. 3 is a graph showing the energy fluctuation of the first mode method in the light irradiation method of the present invention.
  • Fig. 4 is a graph showing the energy fluctuation of the second mode method in the light irradiation method of the present invention.
  • Fig. 5 is a graph showing the energy fluctuation of the third mode method in the light irradiation method of the present invention.
  • Fig. 6 is a graph showing the energy fluctuation of the fourth mode method in the light irradiation method of the present invention.
  • Fig. 7 is a graph showing the energy fluctuation of the fifth mode method in the light irradiation method of the present invention.
  • Fig. 8 is a graph showing the energy fluctuation of the sixth mode method in the light irradiation method of the present invention.
  • the present invention provides an illumination system usable as a cell therapy, comprising at least one set of light emitting diode devices 1 1, at least one driver 1 2.
  • a power supply unit 13 is provided to the present invention
  • the light emitting diode device 11 of the present invention has at least one light emitting diode, such as an LD, an LED or the like, which can generate more than one narrow band concentrated in a pulse width, for example: infrared light or near infrared light spectral region, Suitable for low-energy non-parallel bundled light for biological stimulation of biological cell therapy, the wavelength of the bundled light is preferably between 600 and 850 nm, and the optical energy density is between 2 and 16 Joules/cm 2 , and preferably at 2. 5 to 5 joules/cm 2 , the divergence angle of the bundled light is within 16 degrees, and preferably between 4 and 10 degrees.
  • the LED device 11 can select a plurality of diodes of different wavelengths to form diode devices 1 1 of different wavelength bands, which can provide different applications.
  • the diode device 1 1 has two groups, and in actual use, one or more sets of designs can be used.
  • the driver 12 of the present invention is mainly used to drive the LED device 1 1 to generate concentrated light, which comprises a voltage control circuit 1 2 1, a central processing unit (CPU frequency control) 1 2 2, and the voltage control circuit 1 2 1 mainly receives the modulated pulse wave transmitted by the central processing unit 1 2 2, and provides different output voltages to the LED device 1 1 to generate bundled light of different intensity;
  • the voltage control circuit 1 2 1 adopts a pulse wave adjusting circuit as shown in the embodiment of FIG. 2, and the central processing unit 12 2 can control different frequencies by calculation and output a signal to the voltage control circuit 1 21 .
  • the power supply device 13 of the present invention can use a power supply, a battery, and an application, which can utilize the power management to supply the power supply of the present invention, and can obtain a better power supply.
  • the present invention has a memory 1 2 6 (memory) connected to the central processing unit 1 2 2, which can provide an operator to store information, such as storing a desired illumination mode.
  • a memory 1 2 6 memory connected to the central processing unit 1 2 2, which can provide an operator to store information, such as storing a desired illumination mode.
  • the present invention further includes an overcurrent protection circuit 1 2 3 for protecting the voltage control circuit 112.
  • the present invention has a button device 1 2 4 coupled to the central processing unit 1 2 2 for inputting required voltage values and frequency data for operating the irradiated light energy and frequency, and from a display unit 1 2 5 All the information is displayed on it.
  • the method for generating light irradiation energy by using the foregoing illumination system comprises the following steps:
  • the method of the first mode of the present invention comprises three light irradiation steps of different numerical energies, wherein the three steps control the optical energy density in the range of 2 to 16 joules/cm 2 to 0. 5X Joules, IX Joules, 1. 5X Joules of energy increase, and X is a variable, the light of each step illuminates the energy, the slope of the ⁇ angle increases, the angle of ⁇ , and this step can be repeated multiple times.
  • the oscillating frequency is 0. 5 ⁇
  • the frequency of the fluctuation is between 0. 5 ⁇ 1. 5 seconds, the fluctuation mode is a sudden rise and fall.
  • the method of the second mode of the present invention includes three different numerical energy light irradiation steps, wherein the three steps are to control the optical energy density within a range of 2 to 16 Joules/cm 2 to 1.
  • 5X joules, IX joules, 0. 5X joules of energy decrement, and X is a variable, the first step of the light illuminates the energy, increasing the slope of the ⁇ angle, the angle ⁇ 45 degrees, and can repeat this multiple times step.
  • the fluctuation frequency is between 0. 5 ⁇ .
  • the fluctuation frequency is between 0. 5 ⁇ 1. 5 seconds
  • the fluctuation mode is a slow rise and a sudden drop.
  • the method of the third mode of the present invention comprises two light irradiation steps of different numerical energies, wherein the two steps are to control the optical energy density within a range of 2 to 16 Joules/cm 2 to 0. 5X joules, IX joules of energy increase, and X is a variable, the light irradiation energy of each step increases with the ⁇ angle slope, the ⁇ angle ⁇ 60 degrees, and the steps of the method can be repeated multiple times.
  • the pulsation frequency is 0. 5 ⁇ 1. 5 seconds, the first wave of fluctuations is 9 Second or 27 times, the fluctuation mode is a sudden rise and fall, and the second fluctuation is 6 times or 18 times.
  • the fluctuation mode is a slow rise and a sudden drop.
  • the method of the fourth mode of the present invention comprises two light irradiation steps of different numerical energies, wherein the two steps are to control the optical energy density within a range of 2 to 16 Joules/cm 2 to IX Joules, 0. 5X Joules have a decreasing energy, and X is a variable.
  • the first step of the light illuminates the energy.
  • the slope of the angle is increased, the angle of the ⁇ is ⁇ 60 degrees, and the steps of the method can be repeated a plurality of times.
  • the method can apply a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the energy of the stage, the fluctuation frequency is 0.5 to 1.5 seconds, and the fluctuation frequency of the first step is 6 times or 18 times.
  • the fluctuation mode is a slow rise and a sudden drop.
  • the second fluctuation is 9 times or 27 times, and the fluctuation mode is a sudden rise and fall.
  • the method of the fifth mode of the present invention comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of 2 to 16 Joules/cm 2 and the irradiation energy is X Joules.
  • X is a variable, and the irradiation energy is increased by the slope of the ⁇ angle, the ⁇ angle is about 45 degrees, and the step can be repeated a plurality of times.
  • this method further applies a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the light energy of the stage, the fluctuation frequency is 0.5 to 1.5 seconds, and the number of fluctuations is 9 times or 27 times.
  • the wave pattern is a sudden rise and fall.
  • the method comprises a light irradiation step of numerical energy, wherein the light energy density is controlled within a range of 2 to 16 Joules/cm 2 , and the irradiation energy is X, X is a variable, and the irradiation energy is increased by the slope of the ⁇ angle, the ⁇ angle is about 45 degrees, and the step can be repeated a plurality of times.
  • the method can apply a slight fluctuation in the light irradiation at each step, the fluctuation amplitude is within 20% of the light energy of the stage, the fluctuation frequency is 0.25 to 1.0 second, and the fluctuation frequency is 6 times or 18 times, and the fluctuation The way is to slow down and drop.
  • X is between 4 and 10.66, and the light energy does not exceed 2 to 16 joules/cm 2 .
  • the second to six modes are the same.
  • the value and time of X are set according to the professional and experience of the system operator, and Record these parameters in memory.
  • the photo-energy passivation effect is inactivated when the light energy density exceeds about 16 joules/cm 2 , the photo-stimulating effect is inversely affected. If the optical energy density is too small to be less than about 2 joules/cm 2 , the biostimulating effect of the cells is poor or
  • the effect of the invention is preferably between 2 and 16 joules/cm 2 , especially 2. 5 to 5 joules/cm 2 .
  • the light divergence angle of the present invention is within 16 degrees, especially at 4 to 10 degrees, the light energy is the strongest, and the light stimulation effect is good.
  • the light-emitting diode selects the concentrated light with a divergence angle of less than 16 degrees, and the light energy density is 2 to 16 J/cm, and the penetration is good, and the tissue cells of the inflamed or wound have Excellent differentiation and ability to produce, at the same time increase the immunoglobulin, enhance the resistance, and quickly take away the tissue fluid, so that the wound healing time is accelerated. Therefore, the present invention can be widely applied to medical fields and is suitable for industrial applications.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'invention concerne un dispositif de rayonnement comprenant au moins une DEL (11). La DEL (11) peut générer plusieurs largeurs de bande étroites centrées sur une longueur d'ondes en tant que lumière concentrée de faible énergie, non parallèle. La longueur d'ondes de la lumière concentrée se situe entre 600 et 850 nm, la densité d'énergie de la lumière se situant entre 2 et 16 J/cm2, et l'angle de divergence de la lumière n'étant pas supérieur à 16 degrés. L'invention concerne un système de rayonnement utilisant le dispositif de rayonnement comprenant un pilote (12) pour conduire la DEL (11) à générer la lumière concentrée et une alimentation électrique (13) pour fournir de l'énergie au système.
PCT/CN2007/002772 2007-09-20 2007-09-20 Dispositif et système de rayonnement WO2009036599A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/002772 WO2009036599A1 (fr) 2007-09-20 2007-09-20 Dispositif et système de rayonnement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/002772 WO2009036599A1 (fr) 2007-09-20 2007-09-20 Dispositif et système de rayonnement

Publications (1)

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WO2009036599A1 true WO2009036599A1 (fr) 2009-03-26

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PCT/CN2007/002772 WO2009036599A1 (fr) 2007-09-20 2007-09-20 Dispositif et système de rayonnement

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WO (1) WO2009036599A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098957A (zh) * 1993-03-04 1995-02-22 中国科学院上海光学精密机械研究所 可见光半导体激光针疗仪
CN2205217Y (zh) * 1995-01-23 1995-08-16 石立军 波长可调节的红外发生装置
CN1247477A (zh) * 1997-01-10 2000-03-15 激光生化治疗公司 光能对生物组织的刺激
US6171331B1 (en) * 1996-04-11 2001-01-09 Nikolai T. Bagraev Method of treating of pathological tissues and device to effect the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098957A (zh) * 1993-03-04 1995-02-22 中国科学院上海光学精密机械研究所 可见光半导体激光针疗仪
CN2205217Y (zh) * 1995-01-23 1995-08-16 石立军 波长可调节的红外发生装置
US6171331B1 (en) * 1996-04-11 2001-01-09 Nikolai T. Bagraev Method of treating of pathological tissues and device to effect the same
CN1247477A (zh) * 1997-01-10 2000-03-15 激光生化治疗公司 光能对生物组织的刺激

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