[go: up one dir, main page]

WO2009038107A1 - ２型糖尿病治療用の組合せ医薬 - Google Patents

２型糖尿病治療用の組合せ医薬 Download PDF

Info

Publication number
WO2009038107A1
WO2009038107A1 PCT/JP2008/066809 JP2008066809W WO2009038107A1 WO 2009038107 A1 WO2009038107 A1 WO 2009038107A1 JP 2008066809 W JP2008066809 W JP 2008066809W WO 2009038107 A1 WO2009038107 A1 WO 2009038107A1
Authority
WO
WIPO (PCT)
Prior art keywords
acceptable salt
pharmacologically acceptable
diabetes
type
pharmaceutical preparation
Prior art date
Application number
PCT/JP2008/066809
Other languages
English (en)
French (fr)
Inventor
Mitsutaka Shimasaki
Naoki Kobayashi
Tatsuro Takei
Original Assignee
Kissei Pharmaceutical Co., Ltd.
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company Limited filed Critical Kissei Pharmaceutical Co., Ltd.
Priority to JP2009533167A priority Critical patent/JPWO2009038107A1/ja
Publication of WO2009038107A1 publication Critical patent/WO2009038107A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、２型糖尿病の治療に有用なミチグリニド又はその薬理学的に許容される塩とピオグリタゾン又はその薬理学的に許容される塩とを組み合わせてなる医薬を提供する。また、本発明は、ピオグリタゾン又はその薬理学的に許容される塩の単剤投与では十分な血糖コントロールが得られない患者において、ピオグリタゾン又はその薬理学的に許容される塩の２型糖尿病治療作用を増強し、相互に副作用を増強しない組合せ医薬を提供する。すなわち、式（Ｉa）で表されるミチグリニド又はその薬理学的に許容される塩と、式（ＩＩa）で表されるピオグリタゾン又はその薬理学的に許容される塩とを組み合わせてなる２型糖尿病治療用の医薬。  
PCT/JP2008/066809 2007-09-21 2008-09-18 ２型糖尿病治療用の組合せ医薬 WO2009038107A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009533167A JPWO2009038107A1 (ja) 2007-09-21 2008-09-18 ２型糖尿病治療用の組合せ医薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-245437 2007-09-21
JP2007245437 2007-09-21

Publications (1)

Publication Number Publication Date
WO2009038107A1 true WO2009038107A1 (ja) 2009-03-26

Family

ID=40467917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066809 WO2009038107A1 (ja) 2007-09-21 2008-09-18 ２型糖尿病治療用の組合せ医薬

Country Status (2)

Country Link
JP (1) JPWO2009038107A1 (ja)
WO (1) WO2009038107A1 (ja)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1817347A (zh) * 2006-03-10 2006-08-16 北京阜康仁生物制药科技有限公司 一种以盐酸吡格列酮和米格列奈为活性成分的药用组合物及其制备方法、用途
WO2008026668A1 (fr) * 2006-08-31 2008-03-06 Daiichi Sankyo Company, Limited Composition médicale contenant un agent d'amélioration de la résistance à l'insuline

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1817347A (zh) * 2006-03-10 2006-08-16 北京阜康仁生物制药科技有限公司 一种以盐酸吡格列酮和米格列奈为活性成分的药用组合物及其制备方法、用途
WO2008026668A1 (fr) * 2006-08-31 2008-03-06 Daiichi Sankyo Company, Limited Composition médicale contenant un agent d'amélioration de la résistance à l'insuline

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
EIJI KUDO: "Insulin Chusha kara Mitiglinide eno Kirikae no Kanosei", PHARMA MEDICA, vol. 24, no. 6, 10 June 2006 (2006-06-10), pages 125 - 132 *
MASATOSHI KIKUCHI ET AL.: "Sokkosei·Tanjikan Sayogata Insulin Bunpitsu Sokushin'yaku Mitiglinide to Insulin Teikosei Kaizen'yaku Pioglitazone no Heiyo Ryoho no Yuyosei", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 51, no. 1, 25 April 2008 (2008-04-25), pages S-184 *
MASAZUMI FUJIWARA: "SU-yaku kara Mitiglinide eno Kirikae ni yori HbAlC ga Yui ni Teika shita 2-gata Tonyobyo Shorei no Kento", PROGRESS IN MEDICINE, vol. 28, no. 6, 10 June 2008 (2008-06-10), pages 1541 - 1545 *
RYO MORIKAWA ET AL.: "Tandoku o Gappei shita Michiryo 2-gata Tonyobyo no 1-rei", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 50, no. 3, 30 March 2007 (2007-03-30), pages 224 *
SHOICHI HATAKE ET AL.: "Mitiglinide ni yoru To Fukago no Ketto Koka Sayo ni Taisuru Pioglitazone Choki Toyo no Koka -OLETF Rat o Mochiita Kento", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 51, no. 1, 25 April 2008 (2008-04-25), pages S-285 *
SHOICHI HATAKE ET AL.: "Pioglitazone nite Chiryochu no 2-gata Tonyobyo Kanja ni Okeru Mitiglinide Heiyo Koka no Kento -Teiyoryo SU-yaku Heiyo Koka tono Hikaku", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 49, no. 1, 25 April 2006 (2006-04-25), pages S-129 *

Also Published As

Publication number Publication date
JPWO2009038107A1 (ja) 2011-01-06

Similar Documents

Publication Publication Date Title
EA200800198A1 (ru) Способы предупреждения и лечения метаболических нарушений и новые производные пиразол-о-гликозида
NO2014028I2 (no) Glukopyranosyl-substituerte benzenderivater, fremgangsmåte for fremstilling av disse, fysiologisk akseptable salter av slike forbindelser, medikamenter inneholdende slike forbindelser og kombinasjoner med andre aktive substanser samt deresanvendelse for fremstilling av medikamenter for behandling av sykdom
WO2006031856A3 (en) Biosynchronous transdermal drug delivery
WO2005105213A3 (en) Indole and azaindole derivatives with antitumor action
EP2371853A3 (en) Insulin derivatives or its pharmaceutically acceptable salt, pharmaceutical composition, use of insulin derivative or its pharmaceutically acceptable salt and method of treatment
WO2007098479A3 (en) Localized insulin delivery for bone healing
EA200501420A1 (ru) Устройство доставки для лекарственной и клеточной терапии
EA200900896A1 (ru) Соединения-агонисты гетероциклических рецепторов (варианты), фармацевтическая композиция на их основе, способ лечения диабета и метаболических расстройств, способ стимулирования выработки инсулина (варианты) и способы снижения уровня глюкозы и триглицеридов в крови посредством указанных соединений
MY145590A (en) Phenylacetamides and their use as glucokinase modulators
NO20083863L (no) Pyrazoler som 11-beta-hsd-1
CL2007002347A1 (es) Compuestos derivados de fenilo, piridina y quinolina; procedimiento de preparacion; composicion farmaceutica; y uso del compuesto en el tratamiento de diabetes mellitus, trastornos en la tolerancia de la glucosa, obesidad, enfermedad de crohn, enferm
MX2013011174A (es) Prevencion de hipoglucemia en pacientes con diabetes sacarina de tipo 2.
TN2009000317A1 (en) Solid preparation comprising alogliptin and pioglitazone
WO2009127974A3 (ko) 심혈관계 질환 치료용 약제학적 제제
WO2010015849A3 (en) Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity
EP2216024A3 (en) Use of Ranolazine for the treatment of cardiovascular diseases
WO2007064448A3 (en) Cancer treatment using fts and 2-deoxyglucose
WO2010005980A8 (en) Tacrolimus for improved treatment of transplant patients
WO2006122139A3 (en) Use of tfpi to treat severe bacterial infections
WO2008149802A1 (ja) アンドログラホリドを有効成分とする抗疲労剤及び経口組成物
TW200604193A (en) Substituted oxazole-benzoisothiazole dioxide derivatives, process for their preparation and their use
WO2006131923A3 (en) Novel salts of conjugated psychotropic drugs and processes of preparing same
MX2009011900A (es) Curacion de herida diabetica.
WO2008070010A3 (en) Hydroxylamine derivatives for the treatment of stroke
EA201100916A1 (ru) Комбинация инсулина с триазиновыми производными и их применение для лечения диабета

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08831697

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009533167

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08831697

Country of ref document: EP

Kind code of ref document: A1