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WO2009038289A3 - Pharmaceutical compositions for preventing or treating fibrosis - Google Patents

Pharmaceutical compositions for preventing or treating fibrosis Download PDF

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Publication number
WO2009038289A3
WO2009038289A3 PCT/KR2008/004806 KR2008004806W WO2009038289A3 WO 2009038289 A3 WO2009038289 A3 WO 2009038289A3 KR 2008004806 W KR2008004806 W KR 2008004806W WO 2009038289 A3 WO2009038289 A3 WO 2009038289A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibrosis
preventing
pharmaceutical compositions
treating fibrosis
therapeutics
Prior art date
Application number
PCT/KR2008/004806
Other languages
French (fr)
Other versions
WO2009038289A2 (en
Inventor
In-Gyu Kim
Dong-Myung Shin
Sung-Yup Cho
Eui-Man Jeong
Gi-Yong Jang
Sang-Chul Park
Dong-Sup Lee
Keun-Hee Oh
Young-Whan Kim
Original Assignee
Seoul Nat Univ Ind Foundation
In-Gyu Kim
Dong-Myung Shin
Sung-Yup Cho
Eui-Man Jeong
Gi-Yong Jang
Sang-Chul Park
Dong-Sup Lee
Keun-Hee Oh
Young-Whan Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seoul Nat Univ Ind Foundation, In-Gyu Kim, Dong-Myung Shin, Sung-Yup Cho, Eui-Man Jeong, Gi-Yong Jang, Sang-Chul Park, Dong-Sup Lee, Keun-Hee Oh, Young-Whan Kim filed Critical Seoul Nat Univ Ind Foundation
Publication of WO2009038289A2 publication Critical patent/WO2009038289A2/en
Publication of WO2009038289A3 publication Critical patent/WO2009038289A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating fibrosis comprising (a) a therapeutically effective amount of a transglutaminase 2 (TGase2) inhibitor or N-acetylcysteine (NAC); and (b) a pharmaceutically acceptable carrier, and a method for screening a substance to prevent or treat fibrosis. The present invention definitely demonstrates molecular mechanism underlying fibrosis development and provides a novel molecular target of fibrosis therapeutics. Moreover, fibrosis therapeutics of this invention effectively prevent or treat fibrosis with much higher safety.
PCT/KR2008/004806 2007-09-17 2008-08-19 Pharmaceutical compositions for preventing or treating fibrosis WO2009038289A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070093995A KR20090028880A (en) 2007-09-17 2007-09-17 Pharmaceutical composition for preventing or treating fibrosis
KR10-2007-0093995 2007-09-17

Publications (2)

Publication Number Publication Date
WO2009038289A2 WO2009038289A2 (en) 2009-03-26
WO2009038289A3 true WO2009038289A3 (en) 2009-05-07

Family

ID=40468568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/004806 WO2009038289A2 (en) 2007-09-17 2008-08-19 Pharmaceutical compositions for preventing or treating fibrosis

Country Status (2)

Country Link
KR (1) KR20090028880A (en)
WO (1) WO2009038289A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021527669A (en) * 2018-06-20 2021-10-14 アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． Compositions and Methods for Relieving or Treating Fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004245A1 (en) * 1996-07-25 1998-02-05 The Victoria University Of Manchester Use of transglutaminase modulators to promote wound healing
KR20050102304A (en) * 2004-04-21 2005-10-26 주식회사 피플바이오 Interaction between transglutaminase and prion protein
US20070049641A1 (en) * 2005-08-24 2007-03-01 Rabindra Tirouvanziam Methods for treating and monitoring inflammation and redox imbalance cystic fibrosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004245A1 (en) * 1996-07-25 1998-02-05 The Victoria University Of Manchester Use of transglutaminase modulators to promote wound healing
KR20050102304A (en) * 2004-04-21 2005-10-26 주식회사 피플바이오 Interaction between transglutaminase and prion protein
US20070049641A1 (en) * 2005-08-24 2007-03-01 Rabindra Tirouvanziam Methods for treating and monitoring inflammation and redox imbalance cystic fibrosis

Also Published As

Publication number Publication date
WO2009038289A2 (en) 2009-03-26
KR20090028880A (en) 2009-03-20

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