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WO2011068998A3 - Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths - Google Patents

Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths Download PDF

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Publication number
WO2011068998A3
WO2011068998A3 PCT/US2010/058771 US2010058771W WO2011068998A3 WO 2011068998 A3 WO2011068998 A3 WO 2011068998A3 US 2010058771 W US2010058771 W US 2010058771W WO 2011068998 A3 WO2011068998 A3 WO 2011068998A3
Authority
WO
WIPO (PCT)
Prior art keywords
diffuse reflectance
hemoglobin concentration
systems
methods
isosbestic wavelengths
Prior art date
Application number
PCT/US2010/058771
Other languages
French (fr)
Other versions
WO2011068998A2 (en
Inventor
Nirmala Ramanujam
Janelle E. Phelps
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of WO2011068998A2 publication Critical patent/WO2011068998A2/en
Publication of WO2011068998A3 publication Critical patent/WO2011068998A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths are provided. In one embodiment, the method includes emitting light onto a tissue mass, measuring diffuse reflectance from the tissue mass, and calculating a ratio of diffuse reflectance intensities at two isosbestic wavelengths using the measured diffuse reflectance. The method also includes determining a hemoglobin concentration associated with the tissue mass by applying the calculated ratio to a predefined analytical expression associated with the two isosbestic wavelengths.
PCT/US2010/058771 2009-12-02 2010-12-02 Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths WO2011068998A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26611909P 2009-12-02 2009-12-02
US61/266,119 2009-12-02

Publications (2)

Publication Number Publication Date
WO2011068998A2 WO2011068998A2 (en) 2011-06-09
WO2011068998A3 true WO2011068998A3 (en) 2011-11-17

Family

ID=44115501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/058771 WO2011068998A2 (en) 2009-12-02 2010-12-02 Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths

Country Status (1)

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WO (1) WO2011068998A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2501522C2 (en) * 2012-03-07 2013-12-20 Белорусский Государственный Университет (Бгу) Method of determining hemoglobin concentration in biological tissues
EP3359950B1 (en) 2015-10-05 2020-02-12 Universiteit Gent Dried blood sample analysis
CN112689749B (en) * 2018-09-11 2024-08-23 皇家飞利浦有限公司 Optical method for gingivitis detection
EP3685746A1 (en) * 2019-01-24 2020-07-29 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Hemoglobin measurement by retinal imaging

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284137A (en) * 1988-07-26 1994-02-08 Manfred Kessler Process and device for the determination of local dye concentrations and of scattering parameters in animal and human tissues
US6986747B2 (en) * 2002-01-29 2006-01-17 Johnson & Johnson Consumer Companies Method of measuring the stress or relaxation level of a mammal
US20070038041A1 (en) * 2005-04-25 2007-02-15 Ye Yang Systems and methods for correcting optical reflectance measurements
WO2008117286A2 (en) * 2007-03-27 2008-10-02 Ariel Navon Device and method for monitoring blood parameters

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284137A (en) * 1988-07-26 1994-02-08 Manfred Kessler Process and device for the determination of local dye concentrations and of scattering parameters in animal and human tissues
US6986747B2 (en) * 2002-01-29 2006-01-17 Johnson & Johnson Consumer Companies Method of measuring the stress or relaxation level of a mammal
US20070038041A1 (en) * 2005-04-25 2007-02-15 Ye Yang Systems and methods for correcting optical reflectance measurements
WO2008117286A2 (en) * 2007-03-27 2008-10-02 Ariel Navon Device and method for monitoring blood parameters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PHELPS, JANELLE E. ET AL.: "Rapid ratiometric determination of hemoglobin co ncentration using UV-VIS diffuse reflectance at isosbestic wavelengths", OPTI CS EXPRESS, vol. 18, no. 18, 18 August 2010 (2010-08-18), pages 18779 - 18792 *

Also Published As

Publication number Publication date
WO2011068998A2 (en) 2011-06-09

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