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WO2013024067A1 - Utilisation des antioxydants pour améliorer la santé animale - Google Patents

Utilisation des antioxydants pour améliorer la santé animale Download PDF

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Publication number
WO2013024067A1
WO2013024067A1 PCT/EP2012/065806 EP2012065806W WO2013024067A1 WO 2013024067 A1 WO2013024067 A1 WO 2013024067A1 EP 2012065806 W EP2012065806 W EP 2012065806W WO 2013024067 A1 WO2013024067 A1 WO 2013024067A1
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Prior art keywords
antioxidants
cows
dairy
antioxidant
goats
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Ceased
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PCT/EP2012/065806
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German (de)
English (en)
Inventor
Elke VON HEIMENDAHL
Frank Menn
Antje Holthausen
Christpoh HUTTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lohmann Animal Health GmbH and Co KG
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Lohmann Animal Health GmbH and Co KG
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Publication of WO2013024067A1 publication Critical patent/WO2013024067A1/fr
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Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Definitions

  • the invention relates to a new use of antioxidants for improving animal health.
  • an increase or improvement of the endogenous radical defense system a reduction of inflammatory processes and / or a prevention and / or reduction of fertility problems is achieved by the use of antioxidants and antioxidant substances.
  • the need for food has increased worldwide.
  • there was an intensification of production especially in the area of meat and milk production.
  • the increased number of animals also brings problems. Infections can spread more easily and affect a variety of consumers more quickly.
  • prophylactic efforts are made, which focus primarily on the hygiene in the farms.
  • Dangerous pathogens of diseases include in particular bacteria. Diseases caused by bacteria and endangering livestock, in particular in the dairy industry e.g. Mastitis, phlegmitis and metritis. These are one of the main causes of losses in the dairy industry.
  • antibiotics have been withdrawn in the European Union as prophylaxis in feed.
  • mastitis e.g. Antiseptic emulsions or disinfectants are proposed, with which the udder of the dairy cattle is treated.
  • an antiseptic composition comprising from 10 to 50% by volume of lemongrass oil.
  • a dietary intake of active ingredients would be a simpler and less expensive solution.
  • DE 000060217319 T2 proposes the use of a prebiotic which was produced from an oligosaccharide.
  • a reduction in inflammatory processes was suggested only by the reduced expression of IL-6 mRNA peripheral blood immunocytes.
  • a mixture of at least two antioxidants one of which is a quinoline compound, is added to the feed to prevent oxidation of the fats and lipids contained in the feed, even after feeding to ruminants. It is thought that this could improve the antioxidant status of ruminants.
  • Feed additives with antioxidant effects are also known from DE 600 30 253 T2, US Pat. No. 6,156,355, EP 1 392 131 B1, WO 01/58271 A1, WO 2004/091307 A2 and CA 26 183 80 A1.
  • the human and veterinary use of antioxidant compositions is further described in DE 696 17 945 T2, DE 60 2004 013 441 T2, WO 2004/1 12776 A2 and WO 2009/108120 A1.
  • a prediction of the effect and in particular the effectiveness of antioxidants is not possible, since the effect and effectiveness are not limited to individual oxidation reactions, but are dependent on numerous parameters and complex relationships at the cellular level and even at the animal level.
  • Another object of the present invention is to provide substances which are not only used in prophylaxis and act only here, but which can also be used to directly assist in the treatment of diseases and / or problems, in particular fertility problems.
  • An additional object of the present invention is the provision of substances which fulfill the abovementioned objects, in particular in ruminants.
  • the aim is to reduce oxidative processes that take place in the digestive tract of the animals, so that the oxidative stress for the animal is reduced
  • the object is achieved by using antioxidants and antioxidant substances to increase and / or improve the endogenous radical defense system and / or reduce inflammatory processes.
  • Another solution is the use of antioxidants to reduce inflammatory processes and / or fertility problems.
  • Another solution is the use of antioxidants to help treat inflammatory processes and / or fertility problems.
  • antioxidants are used to improve animal health and to increase the endogenous radical defense system and / or to reduce inflammatory processes in such a way that markers for oxidative stress, such as e.g. dROMS (derivatives of reactive oxygen metabolites) and TBARS (
  • Thiobarbituric acid reactive substances are reduced in the blood.
  • antioxidants in dairy cows in the transit phase and in the phase of high lactation has a positive effect on animal health, preferably on udder health, expressed by a lower cell count (Somatic cell count, SCC) in the milk and by a change in the milk Levels of gene expression of GPX, SOD, catalase and proinflammatory cytokines such as TNF-alpha, interleukin 1 beta or interleukin 6.
  • SCC Somatic cell count
  • antioxidants for antioxidants as well as for substances with antioxidant effect, where singular and plural of these terms are equivalent.
  • Antioxidants in the context of the present invention are substances which bind free radicals and thus prevent their harmful effects.
  • Antioxidants can be substances that trap free radicals and block chain reactions. However, they may also be substances with reducing properties, i. Substances that are easily oxidized without forming harmful products. In this case, the antioxidants have a lower redox potential than the substances to be protected. However, antioxidants are also substances which enhance the antioxidant action of others and are included in the group of synergistic antioxidants.
  • One embodiment of the present invention relates to the use of antioxidants as well as antioxidant agents for the preparation of an agent for preventing and assisting the treatment of inflammatory processes in animals, preferably selected from the group consisting of mastitis, metritis, laminitis and fertility problems.
  • the following embodiments relate to both the use of antioxidants to improve animal health, as well as their use in support of animal health Treatment of inflammatory processes and support of the treatment of fertility problems.
  • the following embodiments relate to the use of antioxidants for improving animal health, as well as their use for the preparation of an agent for the prevention of inflammatory processes and prevention of fertility problems.
  • the inflammatory processes are mastitis, laminitis, and / or metritis.
  • antioxidants are used to reduce fertility problems.
  • Fertility problems in the sense of the invention relate to one or more features selected from the following group:
  • the animals whose animal health is improved according to the invention are animals selected from the group consisting of farm animals, e.g. Ruminants, non-ruminants, cattle, cows, dairy cows, goats, dairy goats, sheep, dairy sheep, swine, sows, broilers, poultry, parents, chicks, chickens, turkeys, geese, ducks, horses.
  • farm animals e.g. Ruminants, non-ruminants, cattle, cows, dairy cows, goats, dairy goats, sheep, dairy sheep, swine, sows, broilers, poultry, parents, chicks, chickens, turkeys, geese, ducks, horses.
  • animals selected from the group consisting of ruminants, in particular cattle, cows, dairy cows, goats, dairy goats, sheep and milk sheep, in particular dairy cows.
  • antioxidants are used selected from the group consisting of BHT (E 321), BHA (E320), propyl gallate, (E 310), ethoxyquin (E 324), citric acid (E 330), THBQ (319), tocopherols, rosemary extract, and carnitine.
  • a combination of antioxidants comprising at least one antioxidant selected from the group consisting of BHT (E 321), BHA (E320), propyl gallate (E310), ethoxyquin (E 324), citric acid (E 330 ), THBQ (E 319), as well as carnitine.
  • antioxidant mixture It is particularly preferable to use a combination of these antioxidants as an antioxidant mixture.
  • antioxidants alone or in combination with each other or with the o.g. can be used are selected from the group consisting of:
  • E220-E228 sulfur dioxide and • E350-E352: malate salts
  • E300-E302 E304: ascorbic acid, • E355: adipic acid
  • E306-E309 tocopherol and its • E357: potassium adipate
  • E310-E312 Gallate •
  • E385 calcium disodium ethylene
  • E319 tert-butylhydroquinone (TBHQ) diamine tetraacetate (CaNa2EDTA)
  • E334-E337 tartaric acid and salts of • N-acetylcysteine
  • E338-E343 phosphoric acid and • aminobenzoic acid, dihydroxy salts of phosphoric acid benzoic acid Caffeic acid • gluconic acid
  • Flavonoids Flavonoids, flavones and / or • Q10
  • Zeaxanthin • lonox for example 100, 300
  • a preferred antioxidant mixture contains 5 to 25 wt% BHT (E 321), 1 to 10 wt% propyl gallate (E 310), 1 to 5% ethoxyquin (E 324), 1 to 5% TBHQ and / or 10 to 50% citric acid (E 330).
  • the antioxidant mixture contains 10 to 20 wt% BHT, 3 to 8% propyl gallate, 2 to 4% ethoxyquin, 2 to 4% TBHQ, and / or 15 to 40% citric acid.
  • a particularly preferred antioxidant mixture contains 17% BHT, 6% propyl gallate, 2%, ethoxyquin, 4% TBHQ and / or 25% citric acid.
  • the antioxidant mixture contains 5 to 15% rosemary extract, 5 to 20% natural tocopherol, 1 to 10% TBHQ and / or 1 to 5% BHT, preferably 7.5% rosemary extract, 10% natural tocopherol, 5% TBHQ and / or 3.2% BHT.
  • the antioxidant mixture contains 10 to 30% propyl gallate, 1 to 10% BHA (E 320), 1 to 20% citric acid.
  • the antioxidant mixture contains 15 to 25% propyl gallate, 5 to 15% BHA and 5 to 15% citric acid, more preferably 20% propyl gallate, 10% BHA and 10% citric acid.
  • Antioxidants mixtures liquid A preferred liquid antioxidant mixture contains 1 to 20% by weight of propyl gallate (E 310), 10 to 40% ethoxyquin (E 324), 1 to 25% TBHQ and / or 1 to 15% citric acid (E 330). In a preferred embodiment, the liquid antioxidant mixture contains 1 to 15% by weight of propyl gallate (E 310), 15 to 30% ethoxyquin (E 324), 1 to 20% TBHQ and / or 1 to 10% citric acid (E 330).
  • a particularly preferred liquid antioxidant mixture 1 to 10% by weight of propyl gallate (E 310), 20 to 30% ethoxyquin (E 324), 1 to 25% TBHQ and / or 1 to 8% citric acid (E 330), in particular 26, 5% Etoxyquin, 10% TBHQ, 7.5% propyl gallate and / or citric acid 4%.
  • the antioxidant mixture contains 1-30% TBHQ, 1-10% propyl gallate and / or 4% citric acid.
  • At least 2, 3, 4, 5 or more of the abovementioned antioxidants are preferably used for the antioxidant mixture, preferably 3 or 4, in particular 4.
  • ethoxyquin is replaced by THBQ, wherein the antioxidant mixture contains 1 to 20% by weight, preferably 2 to 10% THBQ.
  • the antioxidant mixture is used in a proportion of 1 to 1,000 mg per kg of feed TS, preferably 50 to 750 mg per kg, more preferably 75 to 500 mg per kg, in particular 100 to 200 mg per kg of feed TS.
  • the antioxidant mixture may also contain the following additional substances: silicates, salts, carbonates, dicalcium phosphates, dextrins, starches, dextrose, fatty acids, vegetable oils, emulsifiers (E490, E484, E432, E433, E434, E435, E436)
  • the subject matter of the present invention is furthermore one of the antioxidant mixtures described above.
  • the present invention also provides a process for the preparation of one of the antioxidant mixtures described above.
  • composition containing antioxidants, the feed, feed or drinking water of the animals is admixed.
  • the present invention relates to a method of producing an animal feed comprising the following steps:
  • the preparation is carried out in the simplest case by mixing the components.
  • the simplest form of mixing is bringing the components together in a mixer.
  • Such mixers are known to the person skilled in the art.
  • the mixers can be operated discontinuously or continuously.
  • the components to be mixed are introduced in the desired ratio and then mixed for a sufficient time in the range of minutes to hours.
  • the mixing time and the mixing stress are determined so that the two components are homogeneously distributed in the mixture.
  • both components are added continuously, optionally after a premix.
  • the residence time and mixing stress should be selected so that both components are homogeneously distributed in the mixture.
  • the mixture is usually carried out at room temperature, but can also be carried out at higher or lower temperatures. In a preferred embodiment, the mixtures are carried out at room temperatures.
  • the mixture can be carried out at atmospheric pressure, in a vacuum or at elevated pressure.
  • mixing at normal pressure is to be preferred.
  • the mixture is possible in a mill or over a movement of the entire container. Examples of this are tumble mixers, drum mixers or the like.
  • pneumatic mixers Another possibility is the use of pneumatic mixers.
  • the mixture of solids is described, for example, in Ullmann's Encyclopedia of Industrial Chemistry, Sixth Edition, 2000, Mixing of Solids.
  • the mixtures are optionally prepared at room temperature by combining the components in a mixer and optionally heating to 60 ° C.
  • a premix of parts of the mixture is prepared.
  • the present invention thus relates to feed additives for animals comprising an antioxidant mixture according to the invention and / or prepared by the process according to the invention and the use of the antioxidants or antioxidant mixture as feed additive or in feed additives or corresponding mixtures of substances.
  • the feed additives can be added to all common feeds.
  • the invention also includes feed containing the feed additives of the invention and their use for animal nutrition
  • feed or “animal feed” and feed additives are any substances or products which are processed, partially processed or unprocessed and intended for oral administration. Accordingly, animal feeds and feed additives may be both in solid form and in liquid form. Thus, also drinking water for animals is included.
  • the feedingstuffs are feed within the meaning of Article 3 (4) of Regulation (EC) No. 178/2002.
  • the feedstuffs may be either feed materials, compound feeds, premixes or additives, these being defined in LFGB ⁇ 3, numbers 1 1, 12 and 13 in the version of 26.4.2006.
  • Suitable feeds may include one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more ingredients selected from the group consisting of: corn, barley, wheat, oats, rye, triticale, sorghum , Silage (eg corn silage, grass silage), rice and bran, semolina and flours, soybeans, soya products such as soybean meal, rapeseed, rape seed extract, cottonseed and meal, sunflower seeds, sunflower seed meal, linseed, linseed meal, oil seed expeller, field beans and peas, gluten , Gelatin, tapioca, yeasts, single cell protein, fishmeal, salts, minerals, trace elements, vitamins, amino acids, oils / fats and the like.
  • ingredients selected from the group consisting of: corn, barley, wheat, oats, rye, triticale, sorghum , Silage (eg corn silage, grass silage), rice and bran,
  • the feeds are regularly put together so that the corresponding need for nutrients for the respective species is optimally covered.
  • the feed also contains substances which, in particular, individually or in the form of preparations, are intended to be added to feed
  • further ingredients may be included.
  • the choice of other ingredients depends on the selected field of use and the selected dosage form of the agent thus available.
  • Further constituents in the context of the present invention are, for example, the following substances: vitamins, carotenoids, trace elements, further antioxidants, enzymes, amino acids, minerals, carnitine, emulsifiers, stabilizers, preservatives, binders, anti-caking agents and / or flavorings.
  • the feed and the feed additives may contain additives or carriers.
  • additives or carriers is understood to mean substances in solid and liquid form which serve to improve product properties, such as dust behavior, flow properties, water absorption capacity, dissolution behavior and storage stability, for example silicates and carbonates / or mixtures thereof may be based on sugars such as lactose or maltodextrin, based on cereal or legume products such as corn cob meal, wheat bran and soybean meal, based on mineral salts including calcium, magnesium, sodium, potassium salts, as well as D - Pantothenic acid or its salts themselves (chemically or fermentatively produced D-Pantothenklasalz) be.
  • Suitable liquid components are listed, for example, in US Pat. No. 7,910,604 B2, in Sp. 5, Z. 52 - Sp.10, Z. 50.
  • a compilation of usable dry components can be found in US Pat. No. 7,910,604 B2, Sp. 10, Z. 15 - Sp. 1 1, No. 64.
  • the terms “improvement”, “increase”, “increase”, “decrease”, “reduction”, the corresponding verbs as well as synonyms of all these terms mean a change of 1% - 100%, preferably 5% - 20% of a property compared to a control.
  • prevention and / or "avoidance”
  • the corresponding verbs as well as synonyms of all these terms mean that animals to which antoxidants according to the invention are administered exhibit significantly lower symptoms of oxidative stress, inflammatory processes and / or fertility problems compared to a control.
  • control means identical or approximately identical animals compared with and without treatment by the feed additive according to the invention
  • suitable controls is a routine component of each experimental set-up known to the person skilled in the art Animal animals around groups of animals, in a number that allows the expert to perform a statistical evaluation, In particular, a statistical evaluation can be made that indicates a significant change in characteristics, such as with the Student T-Test.
  • analogous conditions means that all environmental conditions, such as food, feed, water, temperature, humidity, housing conditions, etc., are kept equal between the experiments to be compared.
  • the characteristic referred to above may in one embodiment be animal health.
  • animal health is used in the present invention in the same sense as EFSA (European Food Safety Authority) or the Federal Veterinary Office (BfT) and the EU as part of the Animal Health Strategy for the European Union 2007-2013.
  • an improvement in animal health can also be made clear by an increase or improvement of the endogenous radical defense system and / or the reduction of inflammatory processes compared to control animals.
  • animal health means the absence of diseases such as mastitis, claw inflammation and / or metritis.
  • animal health means that normal values of one or more parameters are present selected from the group consisting of:
  • Oxidative stress markers dROMS and / or TBARS
  • TNF-alpha TNF-alpha
  • interleukin 1-beta TNF-alpha
  • interleukin 1-beta TNF-alpha
  • interleukin 6-beta TNF-alpha
  • improved animal health can also mean a faster recovery, a more easy course of disease-for example, fewer or weaker symptoms-compared to control animals.
  • improved animal health in a variant of the present invention means that fewer animals within a group of experimental animals become ill and / or have disease symptoms than a group of control animals.
  • a positive side effect of the use of antioxidants according to the invention is the increase in the vitamin E content in blood, milk and body tissue.
  • antioxidants according to the invention are the increased expression of GPX (glutathione peroxidase) and SOD (superoxide dismutase).
  • the expression per inflammatory cytokines such as TNF-alpha, interleukin 1 - beta and / or interleukin 6 is reduced.
  • the support of the treatment of inflammatory processes in animals by the antioxidants according to the invention can lead to positive effects, preferably synergistic effects in the treatment, that is, the effects, such as diminution or disappearance of the symptoms, are greater or occur faster than by treatment the animals with pharmaceutical and / or medicinal agents alone, without administration of the antioxidants of the invention.
  • Example 1 a) Animal nutrition For the experiments, 60 cows with the same average lactation and milk yield are used. The 60 cows are divided into 3 groups of 20 animals. To obtain a representative average, one group has the following composition: 8 cows with first lactation, 6 cows with second lactation and 6 cows with third or higher lactation.
  • the cows receive their normal feed, in the form of a, TMR (Total Mixted Ration of Alfalfa, Maissillage, Dried Meat (DDGS), corn, barley and soybean meal).
  • TMR Total Mixted Ration of Alfalfa, Maissillage, Dried Meat (DDGS), corn, barley and soybean meal.
  • a group of 20 cows serves as a control.
  • antioxidants are added according to the invention, e.g. 150 mg of a mixture of antioxidant to 1 kg / feed TM.
  • This food has a recommended vitamin E content (1 000 IU / D).
  • the third group contains a diet free of antioxidants but with an elevated vitamin E content (3,000 IU / D).
  • the feed intake of the individual animals is determined, for example by means of the Calan gates and a Data Ranger feeding system.
  • the amount of milk is determined daily.
  • composition of the milk is determined monthly as part of the DHIA test (Dairy herd Information Association)
  • a milk analysis is carried out to determine, for example, the fat content, protein content, lactose content, solids content, MUN (milk urea) and SCC (the number of somatic cells).
  • the weight of the dairy cows and the general condition are determined on the following days: 28a. p., 21 ap, 14a. p., 7a. p., 0, 7p.p., 14 pp, 21 pp, 28p. p., 56 pp and 84p. p.
  • the vitamin E content is determined in blood, liver, adipose tissue and / or milk.
  • the determination is advantageously carried out on at least 10 animals from a group on the days DIM: - 21, 7 and 56, for example. A larger number of measurements is particularly advantageous.
  • the activity of glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase in blood and liver is measured at the same time as described above.
  • the oxidative stress on the markers dROMS and TBARS in blood is also determined at this time.
  • the change in gene expression in adipose tissue and liver can be determined with a so-called Bovine Affymetrix Gene Array.
  • the level of gene expression of GPX and SOD, the proinflammatory cytokines, e.g. TNF-alpha, interleukin 1 beta or interleukin 6 are determined using these DNA arrays.
  • the number of somatic cells in the milk in the animals receiving anti-oxidants according to the invention was significantly lower than in the control animals, indicating a better udder health.

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Abstract

L'invention concerne une nouvelle utilisation d'antioxydants pour améliorer la santé animale. En utilisant notamment des antioxydants comme des substances à action antioxydante, on parvient à renforcer ou à améliorer le système de défense anti-radicalaire endogène, à réduire les processus inflammatoires et/ou à prévenir/diminuer les problèmes de fertilité.
PCT/EP2012/065806 2011-08-12 2012-08-13 Utilisation des antioxydants pour améliorer la santé animale Ceased WO2013024067A1 (fr)

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CN104824371A (zh) * 2015-04-10 2015-08-12 周建康 一种新型液体抗氧化剂及其制备方法
CN110810643A (zh) * 2019-12-17 2020-02-21 北京九州大地生物技术集团股份有限公司 一种促进奶绵羊产奶量的饲料及其制备方法和应用

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EP2904911A1 (fr) * 2014-02-11 2015-08-12 Evonik Degussa GmbH Utilisation d'acide guanidinoacétique et/ou de créatine pour augmenter le taux d'éclosion

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104824371A (zh) * 2015-04-10 2015-08-12 周建康 一种新型液体抗氧化剂及其制备方法
CN110810643A (zh) * 2019-12-17 2020-02-21 北京九州大地生物技术集团股份有限公司 一种促进奶绵羊产奶量的饲料及其制备方法和应用

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