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WO2015071841A1 - Complexes de dabigatran et ses dérivés, procédé de préparation de ceux-ci et compositions pharmaceutiques contenant ceux-ci - Google Patents

Complexes de dabigatran et ses dérivés, procédé de préparation de ceux-ci et compositions pharmaceutiques contenant ceux-ci Download PDF

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Publication number
WO2015071841A1
WO2015071841A1 PCT/IB2014/065992 IB2014065992W WO2015071841A1 WO 2015071841 A1 WO2015071841 A1 WO 2015071841A1 IB 2014065992 W IB2014065992 W IB 2014065992W WO 2015071841 A1 WO2015071841 A1 WO 2015071841A1
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Prior art keywords
complex
dabigatran
sodium
diseases
acetate
Prior art date
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PCT/IB2014/065992
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English (en)
Inventor
Erzsébet Réka ANGI
Tamás SOLYMOSI
Richard Balázs Kárpáti
Zsófia FENYVESI
Zsolt ÖTVÖS
László MOLNÁR
Hristos Glavinas
Genovéva FILIPCSEI
Katalin Ferenczi
Gábor HELTOVICS
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Druggability Technologies Holdings Limited
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Priority claimed from HU1300648A external-priority patent/HUP1300648A2/hu
Priority claimed from HU1400084A external-priority patent/HUP1400084A2/hu
Application filed by Druggability Technologies Holdings Limited filed Critical Druggability Technologies Holdings Limited
Publication of WO2015071841A1 publication Critical patent/WO2015071841A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the invention is directed to a stable complex with increased apparent solubility and increased dissolution rate comprising as active compound Dabigatran, its esters, preferably Dabigatran etexilate, its salts, preferably Dabigatran etexilate mesylate, or derivatives thereof, which is useful in the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • the complex of the present invention possesses increased apparent solubility in the whole physiologically relevant pH range resulting in increased absorption and higher overall bioavailability. This allows the reduction of dose which delivers significantly less anticoagulant to the GI tract.
  • the complex Dabigatran, its esters, preferably Dabigatran etexilate, its salts, preferably Dabigatran etexilate mesylate, or derivatives thereof of the present invention contains no tartaric acid or any other acid which further decreases the incidence of GI tract bleeding. This also makes the bioavailability of the compound independent of the way it is administered; the final dosage form is not sensitive to being broken, chewed, or opened.
  • the complex Dabigatran, its esters, preferably Dabigatran etexilate, its salts, preferably Dabigatran etexilate mesylate, or derivatives thereof of the present invention allows safer administration of a lower dose from the active ingredient.
  • Dabigatran was discovered from a panel of chemicals with similar structure to benzamidine- based thrombin inhibitor a-NAPAP (N-alpha-(2-naphthylsulfonylglycyl)-4- amidinophenylalanine piperidide), which had been known since the 1980s as a powerful inhibitor of various serine proteases, specifically thrombin, but also trypsin.
  • a-NAPAP N-alpha-(2-naphthylsulfonylglycyl)-4- amidinophenylalanine piperidide
  • Dabigatran etexilate mesylate is ⁇ -Alanine, N-[[2-[[[4-
  • Dabigatran etexilate mesylate is a yellow-white to yellow powder.
  • a saturated solution in pure water has a solubility of 1.8 mg/mL. It is freely soluble in methanol, slightly soluble in ethanol, and sparingly soluble in isopropanol.
  • the active substance is susceptible to hydrolysis in presence of humidity under acidic conditions. Batch analysis results confirm that alkyl methane sulfonates (genotoxic impurities) that could potentially be formed during manufacturing are not formed at detectable levels during the manufacturing of the finished product.
  • the 150 mg capsule (PRAXADA) for oral administration contains 172.95 mg Dabigatran etexilate mesylate, which is equivalent to 150 mg of Dabigatran etexilate, and the following pharmaceutically acceptable excipients: acacia, dimethicone, hypromellose, hydroxypropyl cellulose, talc, and tartaric acid.
  • the capsule shell is composed of carrageenan, FD&C Blue No. 2 (150 mg only), FD&C Yellow No.
  • the 75 mg capsule contains 86.48 mg dabigatran etexilate mesylate, equivalent to 75 mg Dabigatran etexilate, and is otherwise similar to the 150 mg capsule.
  • PRAXADA should be swallowed as a whole with water, with or without food. Patients have to be instructed not to open the capsule as this may increase the risk of bleeding.
  • Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin and thrombin-induced platelet aggregation are inhibited by the active moieties.
  • thrombin serine protease
  • Dabigatran etexilate mesylate is absorbed as the Dabigatran etexilate ester. The ester is then hydrolyzed, forming Dabigatran, the active moiety. Dabigatran is metabolized to four different acyl glucuronides and both the glucuronides and Dabigatran have similar pharmacological activity. Pharmacokinetics described here refer to the sum of Dabigatran and its glucuronides. Dabigatran displays dose-proportional pharmacokinetics in healthy subjects and patients in the range of doses from 10 to 400 mg.
  • Dabigatran etexilate is a substrate of the efflux transporter P-gp.
  • P-gp efflux transporter
  • C ma x occurs at 1 hour post-administration in the fasted state.
  • Coadministration of PRADAXA with a high-fat meal delays the time to C max by approximately 2 hours but has no effect on the bioavailability of Dabigatran; PRADAXA may be administered with or without food.
  • Dabigatran is approximately 35% bound to human plasma proteins.
  • the red blood cell to plasma partitioning of Dabigatran measured as total radioactivity is less than 0.3.
  • the volume of distribution of Dabigatran is 50 to 70 L.
  • Dabigatran pharmacokinetics are dose proportional after single doses of 10 to 400 mg. Given twice daily, Dabigatran's accumulation factor is approximately two.
  • Dabigatran is eliminated primarily in the urine. Renal clearance of Dabigatran is 80% of total clearance after intravenous administration. After oral administration of radiolabeled Dabigatran, 7% of radioactivity is recovered in urine and 86% in feces. The half-life of Dabigatran in healthy subjects is 12 to 17 hours.
  • Dabigatran etexilate After oral administration, Dabigatran etexilate is converted to Dabigatran.
  • the cleavage of the Dabigatran etexilate by esterase-catalyzed hydrolysis to the active principal Dabigatran is the predominant metabolic reaction.
  • Dabigatran is not a substrate, inhibitor, or inducer of CYP450 enzymes.
  • Dabigatran is subject to conjugation forming pharmacologically active acyl glucuronides.
  • Four positional isomers, 1-0, 2-0, 3-0, and 4-O-acylglucuronide exist, and each accounts for less than 10% of total Dabigatran in plasma.
  • the European Medicines Agency has recommended updating the product information for the blood thinner PRAXADA, to give clearer guidance to doctors and patients on how to reduce and manage the risk of bleeding associated with the anticoagulant medicine. Bleeding is a well-known complication of all anticoagulant medicines and PRAXADA has therefore been kept under close review by the Agency's Committee for Medicinal Products for Human Use (CHMP) since its initial authorization (25 May 2012, EMA/337406/2012).
  • CHMP Agency's Committee for Medicinal Products for Human Use
  • PRAXADA provides an important health benefit when used as directed. Healthcare professionals who prescribe PRAXADA should carefully follow the dosing recommendations in the drug label, especially for patients with renal impairment (when kidneys don't function normally) to reduce the risk of bleeding. Patients with atrial fibrillation should not stop taking PRAXADA without first talking to their healthcare professional. Stopping use of anticoagulant medications such as PRAXADA can increase the risk of stroke. Strokes can lead to permanent disability and death (FDA Drug Safety Communication of 12/19/2012).
  • the solubility of the Dabigatran ester is pH sensitive. Below pH 4.2 its solubility is actually appreciable. Above this pH it decreases rapidly reaching practically insoluble levels in the 6-7 pH range.
  • Dabigatran etexilate is available in capsule form (PRADAXA). It is formulated together with tartaric acid to reduce the variability of Dabigatran etexilate absorption, which is dependent on an acid environment. A Dabigatran etexilate coating is applied onto a tartaric acid core to form tiny pellets ( ⁇ lmm diameter). A single capsule contains hundreds of these pellets, the exact number depending on the dose strength of the capsule. In this way, Dabigatran etexilate absorption is independent of gastrointestinal tract acidity and is not materially affected by co- administration of a proton pump inhibitor. The oral bioavailability of Dabigatran etexilate increases by 75% when the pellets are taken without the capsule shell compared to the intact capsule formulation. PRADAXA capsules should therefore not be broken, chewed, or opened before administration.
  • the low systemic oral bioavailability is attributed to the low solubility of the compound at physiologically relevant pH.
  • the above formulation strategy ensures the absorption of the compound by creating a low pH milieu in the upper intestine (the first part of the duodenum) which dissolves the compound. At the lower parts of the GI track where pH is raised to the 6- 7 range the compound precipitates. This creates a short window (around 0.5 h) for the compound to get absorbed.
  • the absolute bioavailability of Dabigatran following oral administration of Dabigatran etexilate is approximately 3 to 7% even when using the above detailed formulation strategy.
  • WO2002/000196 WO2001/085345; US 8,074,906; US 7,441,717; US 6,921,458; US 6,641,063; US 5,389,382; WO2000/040220; WO2010/146406; WO2010/146408;
  • a stable complex comprising as active compound chosen from Dabigatran, its salts or derivatives thereof; and at least one complexation agent chosen from polyvinylcaprolactam-polyvinyl acetate-polyethylene-glycol graft copolymers and poloxamers; polyvinylpyrrolidone; polyoxyglicerides; copolymers of vinylpyrrolidone and vinyl-acetate; and poly(maleic acid-co-methyl-vinyl-ether); said complex characterized in that it possesses at least one of the following properties: having a particle size in the range between 50 nm and 600 nm, preferably 50 nm and 300 nm;
  • PAMPA permeability in the physiological pH range has a PAMPA permeability of at least 0.3* 10 "6 cm/s when dispersed in FaSSIF or FeSSIF biorelevant media;
  • ATR infrared
  • the invention is a complex formula having increased and pH independent permeability in the physiological relevant pH range and enhanced biological performance including higher C ma x and AUC, faster onset of action and decreased fed/fasted effect.
  • Dabigatran is generally used for Dabigatran, its esters, such as Dabigatran etexilate or its salts such as Dabigatran etexilate mesylate, Dabigatran etexilate methanesulfonate, Dabigatran etexilate bismesylate or derivatives of Dabigatran.
  • said complexation agent is chosen from polyvinylcaprolactam-polyvinyl acetate-polyethylene-glycol graft copolymers and poloxamers; polyvinylpyrrolidone; polyoxyglicerides; copolymers of vinylpyrrolidone and vinyl-acetate; and poly(maleic acid- co-methyl -vinyl -ether) .
  • said complex further comprises at least one pharmaceutically acceptable excipient selected from the group of sodium-acetate, sodium-lauryl-sulfate, dioctyl sodium sulfosuccinate, cetylpyridinium chloride and sodium saccharine.
  • said complex has a controlled particle size in the range between 50 nm and 600 nm. In an embodiment, said particle size is between 50 nm and 300 nm.
  • said complex further comprises one or more additional active agents.
  • said additional active agent is chosen from agents useful for the prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • said complex is orally available.
  • said complex possesses at least two of the properties described in a) - f).
  • said complex possesses at least three of the properties described in a) - f).
  • said complex has an increased dissolution rate.
  • a stable complex comprising an active compound selected from the group of Dabigatran, its salt, or derivatives thereof; at least one complexation agent chosen from polyvinylcaprolactam-polyvinyl acetate-polyethylene-glycol graft copolymers and poloxamers; polyvinylpyrrolidone; polyoxyglicerides; copolymers of vinylpyrrolidone and vinyl-acetate; and poly(maleic acid-co-methyl-vinyl-ether); and at least one pharmaceutically acceptable excipient chosen from sodium-acetate, sodium-lauryl-sulfate, dioctyl sodium sulfosuccinate, cetylpyridinium chloride and sodium saccharine; wherein said complex obtained via a mixing process.
  • said complex is obtained via a continuous flow mixing process.
  • a complex comprises a complexation agent and a pharmaceutically acceptable excipient in a total amount ranging from about 1.0 weight% to about 95.0 weight % based on the total weight of the complex.
  • said complexation agent and pharmaceutically acceptable excipient comprise 50 weight% to about 95 weight% of the total weight of the complex.
  • a process for the preparation of the complex comprising the steps of mixing a solution of Dabigatran, its salt, or derivatives thereof; and at least one complexation agent chosen from polyvinylcaprolactam-polyvinyl acetate-polyethylene-glycol graft copolymers and poloxamers; polyvinylpyrrolidone; polyoxyglicerides; copolymers of vinylpyrrolidone and vinyl-acetate; and poly(maleic acid-co-methyl-vinyl-ether) in a pharmaceutically acceptable solvent with an aqueous solution containing and at least one pharmaceutically acceptable excipient chosen from sodium-acetate, sodium-lauryl-sulfate, dioctyl sodium sulfosuccinate, cetylpyridinium chloride and sodium saccharine.
  • said process is performed in a continuous flow instrument.
  • said continuous flow instrument is a microfluidic flow instrument.
  • said pharmaceutically acceptable solvent is chosen from methanol, ethanol, i-propanol, n-propanol, acetone, acetonitrile, dimethyl-sulfoxyde, or tetrahydrofuran, or combinations thereof.
  • said pharmaceutically acceptable solvent and said aqueous solvent are miscible with each other.
  • said aqueous solvent comprises 0.1 to 99.9% weight of the final solution.
  • said aqueous solvent comprises 50 to 90% weight of the final solution.
  • said aqueous solvent comprises 50 to 80% weight of the final solution.
  • said aqueous solvent comprises 50 to 70% weight of the final solution. In an embodiment, said aqueous solvent comprises 50 to 60% weight of the final solution.
  • said aqueous solvent comprises 50 % weight of the final solution.
  • a pharmaceutical composition comprising the complex together with pharmaceutically acceptable carrier.
  • said composition is suitable for oral, pulmonary, rectal, colonic, parenteral, intracisternal, intravaginal, intraperitoneal, ocular, otic, local, buccal, nasal, or topical administration. In an embodiment, said composition is suitable for oral administration.
  • said complex is for use in the manufacture of a medicament for the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • diseases in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • said complex is used for the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • diseases in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • a method of treatment and/or prophylaxis of diseases comprises administration of a therapeutically effective amount of a complex or a pharmaceutical composition as described herein.
  • a method for reducing the therapeutically effective dosage of Dabigatran compared to orally available formulations comprises oral administration of a pharmaceutical composition as described herein.
  • a stable complex wherein said complex has a controlled particle size in the range between 50 nm and 600 nm; and wherein said complex is not obtained via a milling process or by high pressure homogenization process, encapsulation process and solid dispersion process, but it is obtained by a mixing process, preferable continuous flow mixing process.
  • said particle size is between 50 nm and 300 nm.
  • said complex shows reduced fed/fasted effect based on in vivo studies.
  • said complex shows significantly improved exposure, earlier t max , higher Cmax which will allow the oral administration and reduction of the dose.
  • said complex has a faster onset of action compared to the marketed formulations. In an embodiment, said complex is instantaneously redispersable in physiological relevant media.
  • said complex is stable in solid form and in colloid solution and/or dispersion. In an embodiment, said complex exhibits pH independent PAMPA permeability in the physiological pH range.
  • said complex has a PAMPA permeability of at least 0.3* 10 "6 cm/s when dispersed in FaSSIF or FeSSIF biorelevant media
  • said complex is characterized by infrared (ATR) spectrum having charateristic absorption peaks at 1730 cm “1 , 1608 cm “1 , 1468 cm “1 , 1437 cm “1 , 1384 cm “1 , 1328 cm “1 , 1252 cm “1 , 1193 cm “1 , 1144 cm “1 , 1118 cm “1 , 1098 cm “1 , 1052 cm “1 , 993 cm “1 , 948 cm “1 , 888 cm “1 , 837 cm “1 , 811 768 cm “1 , 754 cm “1 , 704 cm “1 , 680 cm “1 , 632 cm “1 , 604 cm “1 , 567 cm “1 , 545 cm “1 and 524 cm “1 , preferable at 1730 cm “1 , 1608 cm “1 , 1437 cm “1 , 1328 cm “1 ,! 118 cm “1 , 1098 cm “1 , and 754
  • the complexation agents and pharmaceutically acceptable excipients of the Dabigatran complex formulae of the invention are selected from the group of pharmaceutically acceptable nonionic, anionic, cationic, ionic polymers, surfactants and other types of excipients.
  • the complexation agents themselves or together with the pharmaceutically accepted excipients have the function to form a complex structure with an active pharmaceutical ingredient through non-covalent secondary interactions.
  • the secondary interactions can form through electrostatic interactions such as ionic interactions, H-bonding, dipole-dipole interactions, dipole-induced dipole interactions, London dispersion forces, ⁇ - ⁇ interactions, and hydrophobic interactions.
  • compositions may additionally include one or more pharmaceutically acceptable excipients, auxiliary materials, carriers, active agents or combinations thereof.
  • active agents may include agents useful for the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesis.
  • Another aspect of the invention is the complex formulae of the Dabigatran with complexation agents and pharmaceutically acceptable excipients in which the complexation agents and pharmaceutically acceptable excipients preferably are associated or interacted with the Dabigatran especially as the results of the mixing process, preferably continuous flow mixing process.
  • the structure of the complex Dabigatran formula is different from the core-shell type milled particle, precipitated encapsulated particles, micelles and solid dispersions.
  • the pharmaceutical composition of the invention can be formulated: (a) for administration selected from the group consisting of oral, pulmonary, rectal, colonic, parenteral, intracisternal, intravaginal, intraperitoneal, ocular, otic, local, buccal, nasal, and topical administration; (b) into a dosage form selected from the group consisting of liquid dispersions, gels, aerosols, ointments, creams, lyophilized formulations, tablets, capsules; (c) into a dosage form selected from the group consisting of controlled release formulations, fast melt formulations, delayed release formulations, extended release formulations, pulsatile release formulations, and mixed immediate release and controlled release formulations; or (d) any combination of (a), (b), and (c).
  • compositions can be formulated by adding different types of excipients for oral administration in solid, liquid, local (powders, ointments or drops), or topical administration, and the like.
  • compositions can be formulated by adding different types of pharmaceutically acceptable excipients for oral administration in solid, liquid, local (powders, ointments or drops), or topical administration, and the like.
  • a preferred dosage form of the invention is a solid dosage form, although any pharmaceutically acceptable dosage form can be utilized.
  • Solid dosage forms for oral administration include, but are not limited to, capsules, tablets, pills, powders, and granules.
  • the active agent is admixed with at least one of the following excipients: (a) one or more inert excipients (or carriers), such as sodium citrate or dicalcium phosphate; (b) fillers or extenders, such as starches, lactose, sucrose, glucose, mannitol, microcrystalline cellulose and silicic acid; (c) binders, such as cellulose derivatives, alginates, gelatin, polyvinylpyrrolidone, sucrose and acacia; (d) humectants, such as glycerol; (e) disintegrating agents, such as crospovidon, sodium starch glycolate, effervescent compositions, croscarmellose sodium,, calcium carbonate, potato or tap
  • composition can also include adjuvants, such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents.
  • adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents.
  • compositions of the invention include, but are not limited to (1) physical and chemical stability, (2) instantaneous redispersibility, (3) stability in colloid solution or dispersion in the therapeutic time window, (4) increased solubility compared to the conventional Dabigatran formulation at physiologically relevant pH, (5) increased and pH independent permeability in the physiological relevant pH range, (6) possibility of dose reduction, (7) reduced GI tract bleeding adverse effect due to decreased anticoagulant dose and no strong acid necessary to be added to the formula and (8) good processability.
  • One of the preferred characteristics of the complex Dabigatran formulae of the present invention is their increased apparent solubility and pH independent increased permeability.
  • the permeability of the complex Dabigatran formulae is at least 0.574* 10 " 6 cm/s, 0.376* 10 "6 cm/s and 0.421 * 10 "6 cm/s in the 5-8.5 pH range, respectively.
  • the invention relates to a method for the treatment of a subject in need for the treatment and/or prophylaxis of diseases, in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia, as well as oncological diseases of any pathogenesisby administering to the subject an effective amount of the complex or the pharmaceutical composition according to the invention.
  • diseases in particular thrombotic diseases, stroke, cardiac infarction and/or atrial fibrillation and cardiac arrhythmia
  • oncological diseases of any pathogenesis by administering to the subject an effective amount of the complex or the pharmaceutical composition according to the invention.
  • Another preferred characteristic of the complex Dabigatran formulae of the present invention relates to the enhanced pharmacokinetic performance of the complex Dabigatran formulae.
  • the complex Dabigatran is available for absorption in the whole GI tract extending the window for absorption from 0.5 hour to 4-5 hours and allows safer administration of a lower dose from the active ingredient.
  • Figure 1 shows complexation agent and pharmaceutically acceptable excipient screening for formula selection
  • Figure 2. shows particle size of the redispersed solid complex of the selected formula Figure 3. shows SEM photos of complex Dabigatran (A) and placebo sample (B)
  • Figure 4 shows infrared (ATR) spectra of Crystalline Dabigatran etexilate (A), amorphous Dabigatran etexilate (B), complex Dabigatran exeilate (C), placebo (D), Gelucire 44/14 (E), CPC (F) and Sacharine (G)
  • Figure 5 shows comparative PAMPA assays of complex Dabigatran formula and the marketed compound (Pradaxa)
  • a colloid solution of Dabigatran complex formula with the optimal ratio of the pharmaceutically acceptable excipients of the present invention was prepared by continuous flow mixing in a flow instrument.
  • 200 mg Dabigatran etexilate and 600 mg polyoxygliceride (Gelucire 44/14) dissolved in 100 mL tetrahydrofuran was used.
  • the prepared solution was passed into the instrument with 2 mL/min flow rate.
  • aqueous solvent containing 50 mg cetylpyridinium chloride and 250 mg sodium saccharine in 500 mL water was passed into the instrument with 8 mL/min flow rate, where Dabigatran formed complex Dabigatran composition.
  • the colloid solution of the complex Dabigatran is continuously produced at atmospheric pressure.
  • the produced colloid solution was frozen on dry-ice and then it was lyophilized using a freeze drier equipped with -110°C ice condenser, with a vacuum pump. Particle size of complex Dabigatran was measured in reconstituted colloid solution right after the lyophilisation. It was found to be 156 nm as shown in Figure 2.
  • Dabigatran etexilate Continuous flow mixing of Dabigatran etexilate in the presence of selected complexation agents and pharmaceutically accepted excipients, such as polyoxygliceride (Gelucire 44/14), cetylpyridinium chloride and sodium saccharine resulted in a stable complex of Dabigatran as shown in Figure 4.
  • complexation agents such as polyoxygliceride (Gelucire 44/14), cetylpyridinium chloride and sodium saccharine
  • the complex or the pharmaceutical composition according to the invention characterized by at least one of the following characteristic infrared (ATR ) peak at 1730 cm “1 , 1608 cm “1 , 1468 cm “1 , 1437 cm “1 , 1384 cm “1 , 1328 cm “1 , 1252 cm “1 , 1193 cm “1 , 1144 cm “1 , 1118 cm “1 , 1098 cm “ 1052 cm “1 , 993 cm “1 , 948 cm “1 , 888 cm “1 , 837 cm “1 , 811 768 cm “1 , 754 cm “1 , 704 cm “1 , 680 cm “1 , 632 cm “1 , 604 cm “1 , 567 cm _1 ,_545 cm “1 and 524 cm “1 , preferable at 1730 cm “1 , 1608 cm “ cm “1 , 1328 cm “1 , 1118 cm “1 , 1098 cm “1 , and 754 cm
  • PAMPA permeability measurements were performed as described by M. Kansi et al. (Journal of medicinal chemistry, 41, (1998) pp 1007) with modifications based on S. Bendels et al (Pharmaceutical research, 23 (2006) pp 2525).
  • Sample containing the reference compound was a suspension of crystals visible by the naked eye, while samples of the novel complex were opalescent colloid solutions.
  • Permeability was measured in a 96-well plate assay across an artificial membrane composed of dodecane with 20% soy lecithin supported by a PVDF membrane (Millipore, USA).
  • the receiver compartment was phosphate buffered saline (pH 7.0) supplemented with 1% sodium dodecyl sulfate.
  • the assay was performed at room temperature; incubation time was 1-24 hours.
  • the concentration in the receiver compartment was determined by UV-VIS spectrophotometry (Thermo Scientific Genesys S10).
  • PAMPA permeability of complex Dabigatran formula of Example 2 was 0.574* 10 "6 cm/s, 0.376* 10 "6 cm/s and 0.421 * 10 "6 cm/s when dispersed in a buffer pH 5.0, 6.5 or 8.5, respectively, while permeability of the marketed compound (Pradaxa) was 0.094* 10 "6 cm/s, 0.060* 10 "6 cm/s and 0.020* 10 "6 cm/s when dispersed in the same buffers as shown in Figure 5.
  • the test item was administered to the rats orally by gavage.
  • the granules of the reference item were administered through a plastic gavage into the stomach of the rats.
  • the granules were pushed out with the help of a mandrin then water was administered in a same amount as the test item administration amount.
  • Blood was collected in the following time points using sodium heparin as anticoagulant: 15m, 30m, 45m, lh, 1.5h, 2h, 4h, 6h, and 8h.
  • the plasma was separated and stored in an ultra- freezer (below -70°C) until analysis.
  • Dabigatran plasma kinetics showed high inter-individual variability after dosing the reference item.
  • the shape of the individual curves and the t max values (0.25h - 4h) showed very high variability and the C max values varied in a range (80.6 ⁇ 37.0).

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Abstract

La présente invention concerne des formules de complexes pharmaceutiquement acceptables comprenant des complexes de dabigatran, ses esters, de préférence l'étexilate de dabigatran, ses sels, de préférence le mésylate d'étexilate de dabigatran, ou des dérivés de ceux-ci et des agents de complexation et des excipients pharmaceutiquement acceptables, un procédé pour leur préparation et des compositions pharmaceutiques les contenant. Les formules de complexes de la présente invention ont des propriétés physico-chimiques améliorées et des performances biologiques renforcées et sont utiles dans le traitement et/ou la prophylaxie de maladie, en particulier des maladies thrombotiques, un accident vasculaire cérébral, un infarctus cardiaque et/ou une fibrillation auriculaire et une arythmie cardiaque, ainsi que des maladies oncologiques de pathogenèse quelconque. Plus spécifiquement, le complexe de la présente invention possède une solubilité apparente augmentée dans l'ensemble de la plage de pH physiologique, ce qui conduit à une absorption augmentée et une biodisponibilité globale supérieure. Cela permet la réduction de dose qui délivre significativement moins d'anticoagulant dans le tube digestif. De plus, la composition de complexes de la présente invention ne contient pas d'acide tartrique ni d'autre acide quelconque, ce qui diminue davantage la fréquence de saignement du tube digestif. Cela rend également la biodisponibilité du composé indépendamment de la façon selon laquelle il est administré ; la forme pharmaceutique finale n'est pas sensible à la rupture, au mâchage ou à l'ouverture. Globalement, la composition de complexe de dabigatran de la présente invention permet une administration plus sûre d'une dose plus faible de la substance active.
PCT/IB2014/065992 2013-11-12 2014-11-12 Complexes de dabigatran et ses dérivés, procédé de préparation de ceux-ci et compositions pharmaceutiques contenant ceux-ci WO2015071841A1 (fr)

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HU1400084A HUP1400084A2 (hu) 2014-02-17 2014-02-17 Dabigatran és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói

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WO2017187338A1 (fr) * 2016-04-25 2017-11-02 Druggability Technologies Ip Holdco Limited Complexes de lumacaftor et de ses sels et dérivés, leur procédé de préparation et compositions pharmaceutiques en contenant
WO2017187336A1 (fr) * 2016-04-25 2017-11-02 Druggability Technologies Ip Holdco Limited Complexes d'ivacaftor et de ses sels et dérivés, leur procédé de préparation et compositions pharmaceutiques en contenant
WO2017187340A1 (fr) * 2016-04-25 2017-11-02 Druggability Technologies Ip Holdco Limited Composition pharmaceutique combinée comprenant des formulations complexes d'ivacaftor et de lumacaftor ainsi que leurs sels et dérivés, procédés pour leur préparation, et compositions pharmaceutiques les contenant
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CN111163807A (zh) * 2017-09-19 2020-05-15 耶路撒冷希伯来大学伊森姆研究发展有限公司 亲脂性肽前体药物
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CN113893356A (zh) * 2020-11-27 2022-01-07 上海博志研新药物技术有限公司 甲磺酸达比加群酯包合物、制备方法及应用
US11965041B2 (en) 2017-09-19 2024-04-23 Technische Universitaet Muenchen N-methylated cyclic peptides and their prodrugs
CN118766857A (zh) * 2024-09-12 2024-10-15 潍坊大耀新材料有限公司 一种内部微环境可控的中空多壳层结构口服药物载体及制备方法与应用

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