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WO2018146467A1 - Commande d'une pompe entraînée par un fil en alliage à mémoire de forme - Google Patents

Commande d'une pompe entraînée par un fil en alliage à mémoire de forme Download PDF

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Publication number
WO2018146467A1
WO2018146467A1 PCT/GB2018/050341 GB2018050341W WO2018146467A1 WO 2018146467 A1 WO2018146467 A1 WO 2018146467A1 GB 2018050341 W GB2018050341 W GB 2018050341W WO 2018146467 A1 WO2018146467 A1 WO 2018146467A1
Authority
WO
WIPO (PCT)
Prior art keywords
movable element
resistance
shape memory
memory alloy
alloy wires
Prior art date
Application number
PCT/GB2018/050341
Other languages
English (en)
Inventor
James Howarth
David Charles William Richards
Andreas FLOURIS
Original Assignee
Cambridge Mechatronics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Mechatronics Limited filed Critical Cambridge Mechatronics Limited
Priority to GB1913010.3A priority Critical patent/GB2574535B/en
Publication of WO2018146467A1 publication Critical patent/WO2018146467A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M2005/16863—Occlusion detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/332—Force measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature

Definitions

  • the present invention relates to a pump driven by shape memory alloy (SMA) wire.
  • SMA shape memory alloy
  • the pump has particular application for the pumping of relatively small amounts of fluid, for example a therapeutic product that may be delivered to a human body.
  • infusion pumps are medical devices used to administer a predetermined amount of therapeutic product (e.g. insulin) to the human body (e.g. in the subcutaneous tissue) in a controlled manner.
  • a predetermined amount of therapeutic product e.g. insulin
  • the delivered volume of insulin at a basal rate (background) and at a bolus rate (an increased dose for a mealtime) should be of sufficient accuracy to ensure that the glucose
  • concentration in the bloodstream is always maintained within the desired levels.
  • a method that can be used in pumps with a leadscrew-driven piston is to measure the rotations of the shaft that drives the piston. The shaft rotation is related to the piston displacement and therefore can be used to calculate the volume of delivered insulin.
  • a method for delivering a bolus dose involves the use of a mechanical system that releases a fixed volume of insulin when a button is pressed fully and releases no insulin when the button is pressed partially.
  • occlusions stop the insulin flow and no accurate dosing is possible until the occlusion is detected and corrected. Therefore, occlusions should be detected as quickly as possible so that an alarm can be raised to notify the user. Occlusions cause the insulin pressure inside the pumping unit to increase progressively as the infusion device tries to pump the insulin.
  • a common method to detect occlusions is to detect the progressive increase in insulin pressure using pressure sensors or by detecting the progressive increase in force required to actuate the pumping unit. The pressure and force increase progressively because of the elastic response of the system.
  • a pump comprising: a pumping arrangement comprising a movable element arranged to pump a fluid; one or more shape memory alloy wires coupled to the movable element for moving the movable element; a resistance measurement circuit arranged to measure the resistance of at least one of said one or more shape memory alloy wires; and a control system arranged to supply drive signals to the one or more shape memory alloy wires, and arranged to monitor the measured resistance for verifying the operation of the pumping arrangement.
  • the pump uses one or more SMA wires to move a movable element of a pumping arrangement that is arranged to pump a fluid, for example a therapeutic product such as insulin.
  • a control system that supplies drive signals to the one or more SMA wires also monitors the electrical resistance of at least one of the one or more shape memory alloy wires that is measured by a resistance measurement system. As the electrical resistance provides an accurate measure of the length of the SMA wire, this allows verification of the proper operation in a convenient and reliable manner, without requiring any additional sensor elements.
  • control system may calculate the length of the at least one of the one or more shape memory alloy wires from the measured resistance.
  • the control system may control the drive signals in response to the measured resistance so as to pump a desired amount of fluid.
  • the movable element has a reciprocating stroke and is arranged to deliver a fixed volume on each stroke.
  • the control system may monitor the measured resistance and verify that the movable element moves the full extent of the stroke.
  • the control system may detect abnormal operation of the pumping arrangement on the basis of the measured resistance and may output a warning signal in response to detecting abnormal operation of the pumping arrangement.
  • control system is arranged to detect abnormal resistance to movement of the movable element, for example as may occur in the case of an occlusion.
  • the control system may output a warning signal in response to detecting abnormal resistance to movement of the movable element.
  • the one or more shape memory alloy wires comprise opposed shape memory alloy wires coupled to move the movable element in opposite directions, one of the opposed shape memory alloy wires being coupled to the movable element in series with a spring.
  • the resistance measurement circuit is arranged to measure the resistance of both of the opposed shape memory alloy wires
  • the control system is arranged to calculate a measure of the tension in the spring from the measured resistances, and to detect abnormal resistance to movement of the movable element on the basis of the calculated measure of the tension in the spring.
  • control system is arranged to monitor the power of the drive signals and to detect abnormal resistance to movement of the movable element on the basis of the power of the drive signals being abnormally high.
  • the pump comprises a temperature sensing arrangement arranged to sense the temperature of the one or more shape memory alloy wires.
  • the control system is arranged to monitor the sensed temperatures and to detect abnormal resistance to movement of the movable element on the basis the sensed temperature being abnormally high.
  • control system is arranged to detect abnormal resistance to movement of the movable element on the basis of the measured resistance changing abnormally slowly.
  • a pump comprising: a pumping arrangement comprising a movable element arranged to pump a fluid; opposed shape memory alloy wires coupled to the movable element for moving the movable element in opposite directions, one of the opposed shape memory alloy wires being coupled to the movable element in series with a spring; a control system arranged to supply drive signals to the one or more shape memory alloy wires, the control system further being arranged to monitor the length of the spring and to detect abnormal resistance to movement of the movable element on the basis of the monitored length.
  • the pump uses opposed SMA wires to move a movable element of a pumping arrangement that is arranged to pump a fluid, for example a therapeutic product such as insulin.
  • a fluid for example a therapeutic product such as insulin.
  • Use of SMA wire as an actuator for the pump has numerous advantages compared to other types of actuator, particularly for miniature devices. Such advantages include provision of high forces in compact arrangements.
  • one of the opposed shape memory alloy wires is coupled to the movable element in series with a spring. As the spring is coupled in series, the length of the spring is indicative of the force applied by the SMA wire.
  • a control system that supplies drive signals to the one or more SMA wires also monitors the length of the spring and detects abnormal resistance to movement of the movable element on the basis of the monitored length.
  • FIGs. 1 and 2 are schematic views of a first pump
  • Figs. 3 and 4 are schematic views of a second pump
  • Fig. 5 is a diagram of a control system
  • Fig. 6 is a graph of power dissipated by an SMA wire of the second pump in some different circumstances.
  • Figs. 1 and 2 illustrate a first pump 1 and Figs 3 and 4 illustrate a second pump 2.
  • the first and second pumps 1 and 2 are piston pumps that are arranged as follows.
  • the first and second pumps 1 and 2 pump a fluid.
  • the fluid may be a liquid.
  • the fluid may be a therapeutic product.
  • Such a therapeutic product may in general be of any type and have any therapeutic effect.
  • the therapeutic product may be insulin.
  • the first and second pumps 1 and 2 each comprise a pumping arrangement 3 arranged as follows.
  • the pumping arrangement comprises a cylinder 4 in which a piston 5 is movable by sliding.
  • the piston 5 therefore forms a movable element and is connected to a piston rod 6.
  • the cylinder 4 has a one-way inlet valve 7 and a one-way outlet valve 8, which allow flow of fluid in the direction of the arrows only.
  • the piston 5 has a reciprocating stroke between the position shown in Fig. 1 where the cylinder 4 has a maximum volume and the position shown in Fig. 2 where the cylinder 4 has a minimum volume.
  • the piston 5 pumps a fluid by expelling fluid from the cylinder 4 through the outlet valve 8 during the compression stroke (from Fig. 1 to Fig. 2 or from Fig. 3 to Fig. 4) and drawing fluid into the cylinder 4 through the inlet valve 7 during the induction stroke (from Fig. 2 to Fig. 1 or from Fig. 4 to Fig. 3).
  • the piston 5 therefore pumps a fixed volume of fluid on each stroke.
  • first and second pumps 1 and 2 each comprise an SMA actuator arrangement 10 arranged as follows.
  • the SMA actuator arrangement 10 comprises a first SMA wire 11 and a second SMA wires 12 arranged as follows.
  • the first and second SMA wires 11 and 12 are each coupled between a fixed body 13 and the piston rod 6.
  • the fixed body 13 is fixed with respect the pumping arrangement 3.
  • the first and second SMA wires 11 and 12 are opposed to each other and on contraction drive movement of the piston 5 in opposite directions, as shown by the arrow A.
  • contraction of the first SMA wire 11 drives the induction stroke of the piston 5
  • contraction of the second SMA wire 12 drives the compression stroke of the piston 5.
  • the temperature of the first SMA wire 11 is increased compared to the temperature of the second SMA wire 12 by supplying it with a drive current of larger electrical power. This increase in temperature has caused the length of the first SMA wire 11 to decrease, and the piston rod 6 is pulled to the left.
  • the second SMA wire 12 is heated and contracts, causing the length of the first SMA wire 11 to increase, and the piston rod 6 is pulled to the right.
  • the second SMA wire 12 is coupled between the fixed body 13 and the piston rod 6 in series with a mechanical spring 14.
  • the spring 14 effectively couples the first and second SMA wires 11 and 12 together.
  • the spring 14 is arranged between the second SMA wire 12 and the piston rod 6.
  • the spring 14 could be arranged between the second SMA wire 12 and the fixed body 13.
  • the spring 14 is omitted and so the second SMA wire 12 is coupled directly between the fixed body 13 and the piston rod 6.
  • the first and second pumps 1 and 2 are controlled by a control system 20 shown in Fig. 5 and configured as follows.
  • the length of the first and second SMA wires 11 and 12 is varied by varying the temperature of the first and second SMA wires 11 and 12 by regulating the power of the drive signals that pass through them.
  • the first and second SMA wires 11 and 12 reset to their original length at ambient temperature.
  • the control system 20 is connected to the first and second SMA wires 1 1 and 12 and supplies drive signals thereto.
  • the control system 20 may be implemented in any suitable manner, for example in an integrated circuit chip.
  • the control system 20 includes a drive circuit 21 arranged to generate the drive signals, and a control unit 22 that is arranged to control the drive circuit 21.
  • the drive circuit 21 may be implemented by suitable electronic components.
  • the control unit 22 may be implemented by a processor executing an appropriate program.
  • the control unit 22 controls the power of the drive signals supplied by the circuit 21.
  • the drive signals may be pulse-width modulated signals whose pulse- width is controlled by the control unit 22 to vary the power of the drive signals and thereby control the first and second SMA wires 1 1 and 12.
  • the control system 20 further includes a resistance measurement circuit 23 that is connected to the first and second SMA wires 1 1 and 12 and measures the resistances Rl and R2 thereof. A measure of the resistance of the first and second SMA wires 1 1 and 12 output from the resistance measurement circuit 23 is supplied to control unit 22 which uses it as a feedback signal to control the power of the drive signals under closed loop control.
  • the control unit 22 of the control system 20 monitors the measured resistance and verifies the operation of the pumping arrangement 3 as follows.
  • the control unit 22 detects abnormal operation of the pumping arrangement on the basis of the measured resistance, and outputs a warning signal in response to detecting abnormal operation of the pumping arrangement.
  • the warning signal may be of any suitable type, for example an electrical signal, a visible signal or an audible signal.
  • the resistance of the first and second SMA wires 1 1 and 12 is related to their length, and so the control unit 22 calculates the length of the first and second SMA wires 1 1 and 12 from the measured resistances, and hence the position of the piston 5.
  • the length of the first SMA wire 1 1 is directly related to the position of piston rod 6 and hence the piston 5. Therefore, the measured resistance of the first SMA wire 11 is used to calculate its length which is used to detect the position of piston rod 6 to verify that the full piston stroke has been achieved.
  • both the first and second SMA wires 1 1 and 12 are directly related to the position of piston rod 6 and hence the piston 5. Therefore, the measured resistances of both the first and second SMA wires 1 1 and 12 are used to calculate their lengths which are used to detect the position of piston rod 6 to verify that the piston 5 has moved the full extent of its stroke.
  • the control unit 22 may target a predetermined value for each of the resistances Rl and R2 at different instances that respectively correspond to the ends of the stroke of the piston 5.
  • the drive signal flowing through the first and second SMA wires 11 and 12 can be varied until the predetermined resistance values have been achieved so that the pump is fully actuated and a fixed volume of fluid is pumped on each stroke of the piston 5. A number of repeated pump actuations can be performed to pump a desired amount of fluid.
  • the desired amount may be chosen depending on the nature and use of the fluid. For example, in the case that the fluid is a therapeutic product, then the desired amount may be chosen to provide a desired therapeutic effect.
  • the desired amount may be in a range from a lower limit at or below 0.05 U/hour to an upper limit at or above 20 U/hour, corresponding to a lower limit at or below 1.735 ⁇ g/hour to an upper limit at or above 714 ⁇ g /hour.
  • the flow range may cover both basal and bolus insulin delivery, which for a typical population of patients may be of the order of three orders of magnitude.
  • the flow rate range may be 0.025 to 25 U/hour (U represents an international unit of insulin which is the biological equivalent of 34.7 ⁇ g of human insulin), in increments of 0.025 U/hour.
  • the control unit 22 also detects abnormal resistance to movement of the piston 5, and outputs a warning signal in response to detecting such resistance to movement.
  • the warning signal may be of any suitable type, for example an electrical signal, a visible signal or an audible signal.
  • a first technique for detecting abnormal resistance to movement of the piston 5 that is applied in the first pump 1 is as follows.
  • the first and second SMA wires 11 and 12 have stabilised at a desired values of Rl and R2
  • the first and second SMA wires 11 and 12 and the spring 14 have an equal tension that is also equal to the initial tension in the system.
  • the initial tension can be determined during initiation.
  • the piston 5 is moved across the extent of the compression stroke by the second SMA wire 12.
  • the tension in the first and second SMA wires 11 and 12 and the spring 14 are monitored by the control unit 22 monitoring the measured electrical resistances Rl and R2 of the first and second SMA wires 11 and 12.
  • the control unit 22 calculates the length of the mechanical spring 14 which is a measure of the tension in the spring 14, the length and tension of the spring 14 being proportional.
  • the tension in the second SMA wire 12 is equal to the tension in the spring 14.
  • This tension is monitored during the compression stroke and can be compared against known data stored in the control unit 22 to detect abnormal resistance to movement of the piston. For example, the presence of an occlusion will cause a progressive increase in the pressure, above the pressure when no occlusion is present, increasing the resistance to movement of the piston 5. This will be observed as a progressive increase in the tension in the spring 14 and the second SMA wire 12 during the compression stroke.
  • control unit 22 may also monitor the measured electrical resistance R2 and may detect abnormal physical resistance to movement when the target value for the resistance R2 is not achieved. This will occur in the case that the force required to drive movement of the piston 5 is larger than the maximum actuation force provided by the second SMA wire 12.
  • a similar method in reverse may be implemented also in the induction stroke.
  • the first technique for detecting abnormal resistance to movement of the piston 5 cannot be applied in the second pump 2 because of the absence of the spring 14. Instead, any of the following techniques may be applied in the second pump 2 (or in principle in the first pump 1 also).
  • a second technique for detecting abnormal resistance to movement of the piston 5 that is applied in the second pump 2 is for the control unit 22 to monitor the power of the drive signals and to detect abnormal resistance to movement of the piston 5 on the basis of the power of the drive signals being abnormally high. This is because an abnormally high resistance to movement, for example due to an occlusion, increases the power that that is dissipated in the first and second SMA wires 11 and 12.
  • Fig. 6 illustrates the power P2 dissipated by the second SMA wire 12 of the second pump 2 over time during the compression stroke.
  • the solid line 30 in Fig. 6 represents the power P2 dissipated in normal operation.
  • the power rises to the peak 31 and settles to the plateau 32.
  • the presence of an occlusion will cause the power P2 to follow one of the dotted lines 33, which each have a similar peak 31 but settle to respective plateaus 34 at a higher power level than during normal operation.
  • the power of the plateau increases with each successive actuation because of the larger force requirement.
  • a third technique for detecting abnormal resistance to movement of the piston 5 that is applied in the second pump 2 is for the control system 20 to include temperature sensors 24 which act as a temperature sensing arrangement arranged to sense the temperature of the first and second SMA wires.
  • the control unit 22 monitors the sensed temperatures and detect abnormal resistance to movement of the piston 5 on the basis the sensed temperature being abnormally high.
  • An abnormally high sensed temperature is indicative of an abnormally high resistance to movement, for example due to an occlusion, for the same reasons as discussed above with respect to an increase in power.
  • the temperature of the first and second SMA wires 11 and 12 above the ambient temperature is indicative of the electrical power dissipated in the first and second SMA wires 11 and 12.
  • the temperature measurements can be compared against the electrical current measurements as a validation check or temperature parameters Tl and T2 can be used instead of the power values PI and P2 for occlusion detection as described above.
  • a fourth technique for detecting abnormal resistance to movement of the piston 5 that is applied in the second pump 2 is for the control unit 22 to detect abnormal resistance to movement of the piston 5 on the basis of the measured resistance changing abnormally slowly.
  • An abnormally slow change of electrical resistance is indicative of an abnormally high resistance to movement, for example due to an occlusion, for the same reasons as discussed above with respect to an increase in power.
  • the detection may be performed on the basis solely of the resistance measured by the resistance measurement circuit 23.
  • the various techniques for detecting abnormal resistance to movement of the piston 5 may be used in combination for increased accuracy of detection.
  • first and second pumps 1 and 2 may be replaced by a single SMA wire biased by resilient biasing element such as a biasing spring.
  • first and second pumps 1 and 2 as piston pumps is not limitative.
  • the techniques described herein may be applied to any type of positive displacement pump (e.g. diaphragm pump) in which one or more SMA wires drive movement of a movable element that pumps a fluid.
  • the cylinder 4 and piston 5 may be replaced by any chamber having a volume that is varied by a movable member, for example formed by a flexible wall.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Control Of Positive-Displacement Pumps (AREA)
  • Reciprocating Pumps (AREA)

Abstract

Une pompe comprend un agencement de pompage comprenant un élément mobile conçu pour pomper un fluide et des fils en alliage à mémoire de forme couplés à l'élément mobile pour déplacer l'élément mobile. La résistance d'au moins un desdits fils en alliage à mémoire de forme est mesurée. Un système de commande fournit des signaux d'entraînement aux fils en alliage à mémoire de forme et surveille la résistance mesurée pour vérifier le fonctionnement de l'agencement de pompage. Le système de commande détecte un fonctionnement anormal de l'agencement de pompage sur la base de la résistance mesurée et détecte une résistance anormale au mouvement de l'élément mobile.
PCT/GB2018/050341 2017-02-08 2018-02-07 Commande d'une pompe entraînée par un fil en alliage à mémoire de forme WO2018146467A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1913010.3A GB2574535B (en) 2017-02-08 2018-02-07 Control of a pump driven by shape memory alloy wire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1702038.9 2017-02-08
GBGB1702038.9A GB201702038D0 (en) 2017-02-08 2017-02-08 SMA dose verification

Publications (1)

Publication Number Publication Date
WO2018146467A1 true WO2018146467A1 (fr) 2018-08-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2018/050341 WO2018146467A1 (fr) 2017-02-08 2018-02-07 Commande d'une pompe entraînée par un fil en alliage à mémoire de forme

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Country Link
GB (2) GB201702038D0 (fr)
WO (1) WO2018146467A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111730980A (zh) * 2020-06-18 2020-10-02 浙江大学 新型水下示踪储墨器
GB2600367A (en) * 2017-05-17 2022-04-27 Cambridge Mechatronics Ltd Shape memory alloy based drug delivery device
CN115500034A (zh) * 2022-10-19 2022-12-20 Oppo广东移动通信有限公司 电子设备的控制方法及电子设备

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198558A1 (en) * 2002-04-22 2003-10-23 Nason Clyde K. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US20050238503A1 (en) * 2002-10-09 2005-10-27 Rush Benjamin M Variable volume, shape memory actuated insulin dispensing pump
US20070112326A1 (en) * 2005-11-04 2007-05-17 David Bosshard Device for Automated Delivery of a Liquid Medicament into a Patient's Body
US20090283377A1 (en) * 2008-05-15 2009-11-19 Roe Steven N Drug delivery pump drive using a shaped memory alloy wire
US20150118077A1 (en) * 2013-10-25 2015-04-30 Eberspächer Climate Control Systems GmbH & Co. KG Pump, especially for delivering liquid fuel for a vehicle heater

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201622036D0 (en) * 2016-12-22 2017-02-08 Lenel Ursula And Cambridge Mechatronics Variable valve infusion pump

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030198558A1 (en) * 2002-04-22 2003-10-23 Nason Clyde K. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US20050238503A1 (en) * 2002-10-09 2005-10-27 Rush Benjamin M Variable volume, shape memory actuated insulin dispensing pump
US20070112326A1 (en) * 2005-11-04 2007-05-17 David Bosshard Device for Automated Delivery of a Liquid Medicament into a Patient's Body
US20090283377A1 (en) * 2008-05-15 2009-11-19 Roe Steven N Drug delivery pump drive using a shaped memory alloy wire
US20150118077A1 (en) * 2013-10-25 2015-04-30 Eberspächer Climate Control Systems GmbH & Co. KG Pump, especially for delivering liquid fuel for a vehicle heater

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2600367A (en) * 2017-05-17 2022-04-27 Cambridge Mechatronics Ltd Shape memory alloy based drug delivery device
GB2600367B (en) * 2017-05-17 2022-07-27 Cambridge Mechatronics Ltd Shape memory alloy based drug delivery device
CN111730980A (zh) * 2020-06-18 2020-10-02 浙江大学 新型水下示踪储墨器
CN111730980B (zh) * 2020-06-18 2023-11-07 浙江大学 新型水下示踪储墨器
CN115500034A (zh) * 2022-10-19 2022-12-20 Oppo广东移动通信有限公司 电子设备的控制方法及电子设备

Also Published As

Publication number Publication date
GB2574535B (en) 2022-11-30
GB201702038D0 (en) 2017-03-22
GB201913010D0 (en) 2019-10-23
GB2574535A (en) 2019-12-11

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