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WO2018148471A3 - Optics, device, and system for assaying - Google Patents

Optics, device, and system for assaying Download PDF

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Publication number
WO2018148471A3
WO2018148471A3 PCT/US2018/017504 US2018017504W WO2018148471A3 WO 2018148471 A3 WO2018148471 A3 WO 2018148471A3 US 2018017504 W US2018017504 W US 2018017504W WO 2018148471 A3 WO2018148471 A3 WO 2018148471A3
Authority
WO
WIPO (PCT)
Prior art keywords
assaying
optics
thing
fast
methods
Prior art date
Application number
PCT/US2018/017504
Other languages
French (fr)
Other versions
WO2018148471A2 (en
Inventor
Stephen Y. Chou
Wei Ding
Ji QI
Jun Tian
Yufan ZHANG
Wei Dong
Original Assignee
Essenlix Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essenlix Corporation filed Critical Essenlix Corporation
Priority to EP18751754.5A priority Critical patent/EP3580597A4/en
Priority to CN201880020973.8A priority patent/CN111465882B/en
Priority to US16/483,700 priority patent/US10972641B2/en
Priority to JP2019543054A priority patent/JP7177073B2/en
Priority to CA3053009A priority patent/CA3053009A1/en
Priority to CN202310507084.7A priority patent/CN116794819A/en
Priority to CN201880024948.7A priority patent/CN111194409B/en
Priority to US16/484,998 priority patent/US12350680B2/en
Priority to CN202411624401.4A priority patent/CN119738560A/en
Priority to PCT/US2018/018405 priority patent/WO2018152351A1/en
Priority to EP18753608.1A priority patent/EP3583423A4/en
Priority to CA3053295A priority patent/CA3053295A1/en
Priority to JP2019544049A priority patent/JP2020508043A/en
Priority to US16/485,126 priority patent/US11523752B2/en
Priority to PCT/US2018/018520 priority patent/WO2018152421A1/en
Priority to US16/485,347 priority patent/US10966634B2/en
Priority to JP2019544634A priority patent/JP7107953B2/en
Priority to PCT/US2018/018521 priority patent/WO2018152422A1/en
Priority to CA3053301A priority patent/CA3053301A1/en
Priority to CN202411044459.1A priority patent/CN120195095A/en
Priority to CN201880025156.1A priority patent/CN111448449B/en
Publication of WO2018148471A2 publication Critical patent/WO2018148471A2/en
Publication of WO2018148471A3 publication Critical patent/WO2018148471A3/en
Anticipated expiration legal-status Critical
Priority to US17/179,319 priority patent/US11463608B2/en
Priority to US17/896,973 priority patent/US12120407B2/en
Priority to US17/980,400 priority patent/US20230077906A1/en
Priority to US18/915,106 priority patent/US20250150692A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0008—Microscopes having a simple construction, e.g. portable microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/12—Condensers affording bright-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
    • G02B7/023—Mountings, adjusting means, or light-tight connections, for optical elements for lenses permitting adjustment
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/51—Housings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/55—Optical parts specially adapted for electronic image sensors; Mounting thereof
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/57—Mechanical or electrical details of cameras or camera modules specially adapted for being embedded in other devices
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/67—Focus control based on electronic image sensor signals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The present invention provides, among other thing, devices and methods for simple, fast, and sensitive assaying, including imaging.
PCT/US2018/017504 2017-02-08 2018-02-08 Optics, device, and system for assaying Ceased WO2018148471A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
EP18751754.5A EP3580597A4 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying
CN201880020973.8A CN111465882B (en) 2017-02-08 2018-02-08 Optical device, apparatus and system for assay
US16/483,700 US10972641B2 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying
JP2019543054A JP7177073B2 (en) 2017-02-08 2018-02-08 Assay optics, devices and systems
CA3053009A CA3053009A1 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying
CN202310507084.7A CN116794819A (en) 2017-02-08 2018-02-08 Optical device, apparatus and system for assay
CN201880024948.7A CN111194409B (en) 2017-02-15 2018-02-15 Measurement using rapid temperature changes
US16/484,998 US12350680B2 (en) 2017-02-15 2018-02-15 Assay with rapid temperature change
CN202411624401.4A CN119738560A (en) 2017-02-08 2018-02-15 Determination with rapid temperature change
PCT/US2018/018405 WO2018152351A1 (en) 2017-02-15 2018-02-15 Assay with rapid temperature change
EP18753608.1A EP3583423A4 (en) 2017-02-15 2018-02-15 FAST TEMPERATURE CHANGE TEST
CA3053295A CA3053295A1 (en) 2017-02-15 2018-02-15 Assay with rapid temperature change
JP2019544049A JP2020508043A (en) 2017-02-15 2018-02-15 Assays with rapid temperature changes
US16/485,126 US11523752B2 (en) 2017-02-16 2018-02-16 Assay for vapor condensates
CN201880025156.1A CN111448449B (en) 2017-02-16 2018-02-16 Measurement method and device using textured surface
US16/485,347 US10966634B2 (en) 2017-02-16 2018-02-16 Assay with textured surface
JP2019544634A JP7107953B2 (en) 2017-02-16 2018-02-16 Assays using textured surfaces
PCT/US2018/018521 WO2018152422A1 (en) 2017-02-16 2018-02-16 Assay with textured surface
CA3053301A CA3053301A1 (en) 2017-02-16 2018-02-16 Assay with textured surface
CN202411044459.1A CN120195095A (en) 2017-02-16 2018-02-16 Measurement method and device using textured surface
PCT/US2018/018520 WO2018152421A1 (en) 2017-02-16 2018-02-16 Assay for vapor condensates
US17/179,319 US11463608B2 (en) 2017-02-08 2021-02-18 Image-based assay using mark-assisted machine learning
US17/896,973 US12120407B2 (en) 2017-02-08 2022-08-26 Image-based assay using mark-assisted machine learning
US17/980,400 US20230077906A1 (en) 2017-02-16 2022-11-03 Assay for vapor condensates
US18/915,106 US20250150692A1 (en) 2017-02-08 2024-10-14 Image-Based Assay Using Mark-Assisted Machine Learning

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201762456598P 2017-02-08 2017-02-08
US201762456590P 2017-02-08 2017-02-08
US201762456504P 2017-02-08 2017-02-08
US62/456,504 2017-02-08
US62/456,598 2017-02-08
US62/456,590 2017-02-08
US201762457133P 2017-02-09 2017-02-09
US201762456904P 2017-02-09 2017-02-09
US62/457,133 2017-02-09
US62/456,904 2017-02-09
US201762459554P 2017-02-15 2017-02-15
US62/459,554 2017-02-15
US201762460062P 2017-02-16 2017-02-16
US201762460075P 2017-02-16 2017-02-16
US62/460,075 2017-02-16
US62/460,062 2017-02-16

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2018/017489 Continuation WO2018148458A1 (en) 2017-02-08 2018-02-08 Digital assay
PCT/US2018/017502 Continuation WO2018148470A1 (en) 2017-02-08 2018-02-08 Sample collection and handling for delayed analysis

Related Child Applications (5)

Application Number Title Priority Date Filing Date
US16/483,700 A-371-Of-International US10972641B2 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying
PCT/US2018/017492 Continuation WO2018148461A1 (en) 2017-02-09 2018-02-08 Assay with amplification
PCT/US2018/017713 Continuation WO2018148607A1 (en) 2017-02-09 2018-02-09 Assay using different spacing heights
US16/484,998 Continuation US12350680B2 (en) 2017-02-15 2018-02-15 Assay with rapid temperature change
US17/179,319 Continuation US11463608B2 (en) 2017-02-08 2021-02-18 Image-based assay using mark-assisted machine learning

Publications (2)

Publication Number Publication Date
WO2018148471A2 WO2018148471A2 (en) 2018-08-16
WO2018148471A3 true WO2018148471A3 (en) 2018-10-04

Family

ID=63107057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/017504 Ceased WO2018148471A2 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying

Country Status (5)

Country Link
EP (1) EP3580597A4 (en)
JP (1) JP7177073B2 (en)
CN (2) CN111465882B (en)
CA (1) CA3053009A1 (en)
WO (1) WO2018148471A2 (en)

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