WO2018151150A1 - Dispositif et procédé de mesure de concentration de corps diffusé - Google Patents
Dispositif et procédé de mesure de concentration de corps diffusé Download PDFInfo
- Publication number
- WO2018151150A1 WO2018151150A1 PCT/JP2018/005072 JP2018005072W WO2018151150A1 WO 2018151150 A1 WO2018151150 A1 WO 2018151150A1 JP 2018005072 W JP2018005072 W JP 2018005072W WO 2018151150 A1 WO2018151150 A1 WO 2018151150A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- living body
- irradiation
- light intensity
- wavelength
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 17
- 238000001514 detection method Methods 0.000 claims abstract description 107
- 238000010521 absorption reaction Methods 0.000 claims abstract description 87
- 230000001678 irradiating effect Effects 0.000 claims description 21
- 238000000149 argon plasma sintering Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 230000014509 gene expression Effects 0.000 claims description 3
- 239000002131 composite material Substances 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 description 28
- 150000002632 lipids Chemical class 0.000 description 26
- 239000008280 blood Substances 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 23
- 238000004364 calculation method Methods 0.000 description 20
- 238000004891 communication Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 6
- 238000012545 processing Methods 0.000 description 5
- 208000031226 Hyperlipidaemia Diseases 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 3
- 230000000291 postprandial effect Effects 0.000 description 3
- 238000000342 Monte Carlo simulation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- FTGYKWAHGPIJIT-UHFFFAOYSA-N hydron;1-[2-[(2-hydroxy-3-phenoxypropyl)-methylamino]ethyl-methylamino]-3-phenoxypropan-2-ol;dichloride Chemical compound Cl.Cl.C=1C=CC=CC=1OCC(O)CN(C)CCN(C)CC(O)COC1=CC=CC=C1 FTGYKWAHGPIJIT-UHFFFAOYSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000012886 linear function Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000001444 catalytic combustion detection Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
Definitions
- a step of detecting the received light intensity of 2 a step of calculating an absorption coefficient from the second received light intensity, a step of calculating a light scattering coefficient in the living body based on the first received light intensity and the absorption coefficient, and And calculating a scatterer concentration in the living body based on the light scattering coefficient.
- the scatterer concentration measurement apparatus 1 includes a first irradiation unit 21 and a second irradiation unit that irradiate light from a predetermined irradiation position A of the living body E toward the inside of the living body E. 22, a first light intensity detection unit 31 and a second light intensity detection unit that detect the light intensity at a predetermined detection position B of the living body E, and a third light that detects the light intensity at the predetermined detection position C.
- the light intensity detected by the intensity detector 33 and the first light intensity detector 31 is corrected using the light intensity detected by the second light intensity detector 32 and the third light intensity detector 33.
- a control unit 4 for calculating the corrected to calculate the scattering coefficient mu s of the light in the light intensity based vivo, scatterers in vivo based on the scattering coefficient of the calculated optical mu s (lipid) concentration.
- the second light intensity detection unit 32, and the third light intensity detection unit 33 are formed by increasing the distance between the first irradiation unit 21 and the second irradiation unit 22 and the first light intensity detection unit 31, the second light intensity detection unit 32, and the third light intensity detection unit 33. Since the optical path length becomes long, the number of collisions with lipids increases, and the detected light is greatly affected by scattering, so that it is easy to capture the influence of scattering that has been weak and difficult to detect.
- the control unit 4 has an absorption coefficient calculated from the received light intensity detected by the first light intensity detector 31 and the received light intensity detected by the second light intensity detector 32 and the third light intensity detector 33. Based on the above, the light scattering coefficient ⁇ s in the living body is calculated. Note that the scattering coefficient ⁇ s in the embodiment is not limited to a numerical value obtained by quantifying the efficiency of a general scattering process, and is a value obtained by quantifying the influence of scattering under a certain condition in consideration of a scattering phenomenon. Is also included.
- D is represents the diffusion coefficient
- mu a is the absorption coefficient
- the above equation (1) is expected to be applied to biological scatter measurement as a calculation formula that linearly approximates the measured light attenuation and derives the absorption coefficient from the intercept and the scattering coefficient from the slope.
- Figure 6 shows the results of correction of absorption coefficient in phantom measurement. As a result of multiplying the correction coefficient due to water absorption at 950 nm, it was confirmed that the absorption coefficient could be calculated accurately.
- the controller 4 causes the controller 4 to detect the light intensity of the first irradiation light detected by the first light intensity detector 31, the second light intensity detector 32, and Based on the absorption coefficient calculated from the received light intensity detected by the third light intensity detector 33, the light scattering coefficient ⁇ s in the living body is calculated.
- the method for calculating the scattering coefficient ⁇ s has been described above.
- the scatterer concentration can be calculated by acquiring the light intensity distribution emitted from the living body.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
[Problème] Mesurer un coefficient de diffusion dans un composite à diffusion absorbante avec une précision élevée. [Solution] La présente invention est pourvue de : une première unité d'irradiation qui irradie une lumière d'une première longueur d'onde à une première intensité d'irradiation vers l'intérieur d'un corps vivant depuis l'extérieur du corps vivant ; une deuxième unité d'irradiation qui irradie de la lumière d'une deuxième longueur d'onde à une deuxième intensité d'irradiation vers l'intérieur du corps vivant depuis l'extérieur du corps vivant ; une première unité de détection d'intensité de lumière qui détecte une première intensité de lumière reçue de la lumière de la première longueur d'onde émise par le corps vivant à une première position de détection à une première distance à partir d'une position d'irradiation de lumière par la première unité d'irradiation ; une deuxième unité de détection d'intensité de lumière qui détecte une deuxième intensité de lumière reçue de la lumière de la deuxième longueur d'onde émise par le corps vivant à une deuxième position de détection à une deuxième distance de la position d'irradiation de la lumière par la deuxième unité d'irradiation ; et une unité de commande qui calcule un coefficient d'absorption sur la base de la deuxième intensité de lumière reçue, calcule un coefficient de diffusion de la lumière à l'intérieur du corps vivant sur la base de la première intensité de lumière reçue et du coefficient d'absorption, et calcule une concentration de corps diffusé à l'intérieur du corps vivant sur la base du coefficient de diffusion de la lumière calculé.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018568564A JP6894088B2 (ja) | 2017-02-14 | 2018-02-14 | 散乱体濃度計測装置及びその方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017025311 | 2017-02-14 | ||
| JP2017-025311 | 2017-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2018151150A1 true WO2018151150A1 (fr) | 2018-08-23 |
Family
ID=63169349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2018/005072 WO2018151150A1 (fr) | 2017-02-14 | 2018-02-14 | Dispositif et procédé de mesure de concentration de corps diffusé |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6894088B2 (fr) |
| WO (1) | WO2018151150A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020138225A1 (fr) * | 2018-12-26 | 2020-07-02 | メディカルフォトニクス株式会社 | Dispositif de mesure de calories absorbées, procédé de mesure de calories absorbées et programme de mesure de calories absorbées |
| WO2020246455A1 (fr) * | 2019-06-04 | 2020-12-10 | メディカルフォトニクス株式会社 | Dispositif, procédé et programme de mesure non invasive |
| WO2022262221A1 (fr) * | 2021-06-18 | 2022-12-22 | 中国科学院深圳先进技术研究院 | Procédé de mesure d'hématocrite, appareil, terminal et support de stockage lisible |
| JP2024508717A (ja) * | 2021-02-11 | 2024-02-28 | 先陽科技有限公司 | 生体組織成分の検出方法、装置及びウェアラブル機器 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004517300A (ja) * | 2000-07-28 | 2004-06-10 | アボット・ラボラトリーズ | 組織の水分補給効果の補償による分析物濃度の非観血的決定方法 |
| JP2013070822A (ja) * | 2011-09-27 | 2013-04-22 | Seiko Epson Corp | 濃度定量装置、光吸収係数算出方法、等価散乱係数算出方法、濃度定量方法、光吸収係数の算出を行うプログラム及び濃度の算出を行うプログラム |
| WO2014087825A1 (fr) * | 2012-12-06 | 2014-06-12 | 国立大学法人北海道大学 | Mesureur non invasif de concentration en biolipides, dispositif non invasif de mesure de métabolisme de biolipides, procédé non invasif pour mesure la concentration en biolipides, et procédé non invasif pour examiner le métabolisme de biolipides |
| WO2016041073A1 (fr) * | 2014-09-17 | 2016-03-24 | 2352409 Ontario Inc. | Dispositif et procédé de surveillance d'équilibre de graisse |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5595534B2 (ja) * | 2007-05-15 | 2014-09-24 | キヤノン株式会社 | 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法 |
-
2018
- 2018-02-14 JP JP2018568564A patent/JP6894088B2/ja not_active Expired - Fee Related
- 2018-02-14 WO PCT/JP2018/005072 patent/WO2018151150A1/fr active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004517300A (ja) * | 2000-07-28 | 2004-06-10 | アボット・ラボラトリーズ | 組織の水分補給効果の補償による分析物濃度の非観血的決定方法 |
| JP2013070822A (ja) * | 2011-09-27 | 2013-04-22 | Seiko Epson Corp | 濃度定量装置、光吸収係数算出方法、等価散乱係数算出方法、濃度定量方法、光吸収係数の算出を行うプログラム及び濃度の算出を行うプログラム |
| WO2014087825A1 (fr) * | 2012-12-06 | 2014-06-12 | 国立大学法人北海道大学 | Mesureur non invasif de concentration en biolipides, dispositif non invasif de mesure de métabolisme de biolipides, procédé non invasif pour mesure la concentration en biolipides, et procédé non invasif pour examiner le métabolisme de biolipides |
| WO2016041073A1 (fr) * | 2014-09-17 | 2016-03-24 | 2352409 Ontario Inc. | Dispositif et procédé de surveillance d'équilibre de graisse |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020138225A1 (fr) * | 2018-12-26 | 2020-07-02 | メディカルフォトニクス株式会社 | Dispositif de mesure de calories absorbées, procédé de mesure de calories absorbées et programme de mesure de calories absorbées |
| JP2020106318A (ja) * | 2018-12-26 | 2020-07-09 | メディカルフォトニクス株式会社 | 吸収カロリー計測装置、吸収カロリー計測方法、及び、吸収カロリー計測プログラム |
| WO2020246455A1 (fr) * | 2019-06-04 | 2020-12-10 | メディカルフォトニクス株式会社 | Dispositif, procédé et programme de mesure non invasive |
| JP2024508717A (ja) * | 2021-02-11 | 2024-02-28 | 先陽科技有限公司 | 生体組織成分の検出方法、装置及びウェアラブル機器 |
| WO2022262221A1 (fr) * | 2021-06-18 | 2022-12-22 | 中国科学院深圳先进技术研究院 | Procédé de mesure d'hématocrite, appareil, terminal et support de stockage lisible |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2018151150A1 (ja) | 2020-01-09 |
| JP6894088B2 (ja) | 2021-06-30 |
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