WO2018154585A1

WO2018154585A1 - A gel formulation and a process for manufacturing the same

Info

Publication number: WO2018154585A1
Application number: PCT/IL2018/050216
Authority: WO
Inventors: Yoel GRINBOIM
Original assignee: Seacret Spa Ltd.
Priority date: 2017-02-27
Filing date: 2018-02-27
Publication date: 2018-08-30

Abstract

A carrageenan gel comprising water, one or more of xanthan gum, LBG and/or gellan gum, a nutrient supplement, a vitamin, and a preservative. Optionally, apple sugar syrup is added.

Description

A GEL FORMULATION AND A PROCESS FOR MANUFACTURING THE SAME

FIELD OF THE INVENTION

[001] The invention is directed to a dietary supplement or a nutraceutical composition, optionally in a form of a gel comprising one or more of xanthan gum, locust bean gum (LBG) and/or gellan gum, as well as water, a nutrient supplement, a vitamin and a preservative. Optionally, apple sugar syrup is added to the dietary supplement or a nutraceutical composition of the invention.

BACKGROUND OF THE INVENTION

[002] The human body requires that all essential nutrients be adequately supplied and utilized to optimize health and well-being. The human body acquires essential nutrients through the consumption of a variety of foods. Poor health may be a result of an imbalance of nutrients.

[003] Dietary supplements or nutraceutical compositions that contain food supplements, vitamins, plant extracts and the like may lead to the treatment of, or at least reduce, age related damages, cardiovascular events, diabetes and the like. They may also reduce physical or mental fatigue, enhance activity and the like.

[004] Dietary supplements or nutraceutical compositions may be in a form of a pill, capsule, powders, or liquids.

[005] Consuming dietary supplements in a form of a pill, capsule, powder, may lead to a compliance problem due to the inconvenience of using the same (need of drinking water together with the pill, capsule or powder). Further, liquid formulations require relatively large storage space and therefore are also disadvantageous.

[006] Thus, there is a need for dietary supplements or nutraceutical compositions having a high content of various plant extracts, food supplements, vitamins, minerals, and the like,, in a single package that facilitates the administration of various required food supplements to a subject. SUMMARY OF THE INVENTION

[007] Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition comprising: water in an amount; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts; nutrient supplement and a preservative.

[008] Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition comprising: water in an amount of about 15% to about 75% by weight; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.

[009] According to some embodiments, there is provided a dietary supplement or a nutraceutical composition comprising: water in an amount of about 15% to about 75% by weight; and xanthan gum, Locust Bean Gum (LBG) and gellan; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight; and a preservative.

[0010] In some embodiments, the dietary supplement or a nutraceutical composition comprises: water in an amount of about 15% to about 75% by weight; xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w; and/or gellan gum in an amount of between about 0.1-0.5 %w/w; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.

[0011] In some embodiments, the dietary supplement or a nutraceutical composition comprises: water in an amount of about 15% to about 75% by weight; xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w; and gellan gum in an amount of between about 0.1-0.5 %w/w; plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative. The dietary supplement may further comprise a sweetener. In some embodiments of the invention, the dietary supplement or a nutraceutical composition comprises: water in an amount of at least 15%, 20%, 25%, 30%, 40%, 50%, 55%, 60%, 65%, 70% or 75% by weight; and one or more of xanthan gum in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; LBG in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; and/or gellan gum in an amount of at least about 0.1, 0.15, 0.20, 0.25, 0.3, 0.4 or 0.5% %w/w. [0012] In some embodiments of the invention, the dietary supplement or a nutraceutical composition comprises: water in an amount of at least 15%, 20%, 25%, 30%, 40%, 50%, 55%, 60%, 65%, 70% or 75% by weight; xanthan gum in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; LBG in an amount of at least about 0.1, 0.2, 0.3, 0.4, 0.5 %w/w; and gellan gum in an amount of at least about 0.1, 0.15, 0.20 or 0.25 %w/w.

[0013] According to some embodiments, the amount of the xanthan gum is about 0.3 %w/w. According to some embodiments, the amount of the LBG is about 0.3 %w/w. According to some embodiments, the amount of the gellan gum is about 0.175 %w/w.

[0014] According to some embodiments, the dietary supplement or a nutraceutical composition further comprises apple sugar syrup. According to some embodiments, the amount of the apple sugar syrup is between about 15%-90%. According to some embodiments, the amount of the apple sugar syrup is between about 15-40 %w/w. According to some embodiments, the amount of the apple sugar syrup is between about 20-30 %w/w. According to some embodiments, the amount of the apple sugar syrup is between about 60-90 %w/w. According to some embodiments, the amount of the apple sugar syrup is between about 65-78 %w/w. According to some embodiments, the amount of the apple sugar syrup is between about 72 %w/w.

[0015] According to some embodiments when a sweetener is included, the sweetener is stevia extract or sucralose. According to some embodiments, the stevia extract or sucralose is in an amount of between about 0.03%-0.4%.

[0016] According to some embodiments, dietary supplement or the nutraceutical composition may further include palatinose. According to some embodiments, the palatinose is in an amount of between about 5-15% w/w. According to some embodiments, the palatinose is in an amount of between about 7-12% w/w. According to some embodiments, the palatinose is in an amount of between about 8-10% w/w. According to some embodiments, the palatinose is in an amount of about 9% w/w.

[0017] According to some embodiments, the dietary supplement or a nutraceutical composition further comprises an acid. According to some embodiments, the acid is citric acid, lactic acid, acetic acid, adipic acid, tartaric acid, phosphoric acid or malic acid or a combination thereof.

[0018] According to some embodiments, the amount of the preservative is between 0.01% to 0.20% w/w. According to some embodiments, the preservative is potassium sorbate. In some embodiments, the amount of the potassium sorbate is about 0.05% w/w. In some embodiments, the amount of the potassium sorbate is between about 0.01% w/w to 0.1% w/w. [0019] In some embodiments, the formulation further comprises tri- sodium citrate.

[0020] In some embodiments, the formulation further comprises tri- sodium citrate in an amount of between 0.05-1.00% w/w. In some embodiments, the formulation further comprises tri- sodium citrate in an amount of between 0.1-0.5% w/w. In some embodiments, the formulation further comprises tri-sodium citrate in an amount of between 0.2-0.4% w/w. In some embodiments of the invention the amount is about 0.3% w/w.

[0021] According to some embodiments, the plant extract is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba or paullinia cupana. According to some embodiments, the plant extract is one or more of Hops (Humulus lupulus), Melissa officinalis (lemon balm), Chamomile Matricaria chamomilla (German chamomile), Panax quinquefolius, Withania somnifera Ashwagandha (American ginseng), Passion flower (Passiflora incarnate) or Astragalus membranacus

[0022] According to some embodiments, the plant extract is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba paullinia cupana or Astragalus membranacus.

[0023] According to some embodiments, the plant extract acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba paullinia cupana and Astragalus membranacus

[0024] In some embodiments of the invention, the amount of the Astragalus membranacus is between 0.2-3%w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is between 0.4-2.5 %w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is between 0.5-2.0 %w/w. In some embodiments of the invention, the amount of the Astragalus membranacus is about 0.8 %w/w

[0025] According to some embodiments, the nutrient supplement is one or more resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf), or methylcobalamin (vitamin B12).

[0026] According to some embodiments, the nutrient supplement comprises resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf) and methylcobalamin (vitamin B12). [0027] According to some embodiments of the invention the dietary supplement or the nutraceutical composition further comprising one or two vitamin mix formulations.

[0028] In some embodiments of the invention, a flavor agent may be added such as, orange, apple, strawberry, or raspberry flavor agent. In some embodiments of the invention, a colorant may be added, such as, for example, tomato-o color and the like.

[0029] Further embodiments of the invention are directed to a method of manufacturing a gel comprising one or more of xanthan gum, LBG and/or gellan gum comprising the steps of:

mixing one or more of xanthan gum, LBG and/or gellan gum and apple sugar syrup constantly;

adding water while mixing;

gradually heating until reaching a temperature of between 60-95°C;

adding at least one plant extract, at least one nutritional supplement or both;

heating to between 85, 90, 95 about 120°C; and

cooling to 80°C or less, thereby obtaining a gel comprising one or more of xanthan gum, LBG and/or gellan gum.

[0030] Further embodiments of the invention are directed to a method of manufacturing a gel comprising xanthan gum, LBG and gellan gum comprising the steps of:

mixing the xanthan gum, LBG and gellan gum and apple sugar syrup constantly;

adding water while mixing;

gradually heating until reaching a temperature of between 60-95°C;

adding at least one plant extract, at least one nutritional supplement or both;

heating to between 85, 90, 95 about 120°C; and

cooling to 80°C or less, thereby obtaining a gel comprising of xanthan gum, LBG and gellan gum.

[0031] According to some embodiments, the method further comprises placing the gel comprising the one or more of xanthan gum, LBG, and/or gellan gum in packages.

BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The above and other characteristics and advantages of the invention will be better understood through the following illustrative and non-limitative detailed description of preferred embodiments thereof, with reference to the appended drawings, wherein: [0033] Figure 1 presents the absorption of folic acid in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of folic acid.

[0034] Figure 2 presents the absorption of B12 in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of B 12.

[0035] Figure 3 presents the absorption of vitamin E in the blood at different time in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of vitamin E.

[0036] Figure 4 presents the absorption of vitamin A in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of vitamin A.

[0037] Figure 5 presents the absorption of magnesium in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of magnesium.

[0038] Figure 6 presents the absorption of calcium in the blood at different time points in an experiment performed on healthy people administered with either a gel according to the embodiments of the invention or with a tablet containing the same amount of calcium.

DETAILED DESCRIPTION OF THE INVENTION

[0039] In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the invention. However, it will be understood by those skilled in the art that the present invention may be practiced without these specific details. In other instances, well-known methods, procedures, and components have not been described in detail so as not to obscure the present invention.

[0040] It is noted that throughout this application, the term about may be defined as encompassing +10% of the specifically disclosed value or range.

[0041] According to some embodiments, the invention is directed to a dietary supplement or a nutraceutical composition comprising water and one or more of xanthan gum, LBG and/or gellan gum, at least one nutrient supplement, and at least one preservative. According to some embodiments, the dietary supplement or the nutraceutical composition further comprises at least one plant extract. According to some embodiments, the dietary supplement or the nutraceutical composition further comprises at least one vitamin. It is noted that the plant extract and/or the vitamin may be a nutrient supplement. The dietary supplement or the nutraceutical composition may further contain a sweetener.

[0042] Embodiments of the invention are directed to a dietary supplement or a nutraceutical composition comprising: water in an amount; and one or more of xanthan gum, Locust Bean Gum (LBG) and/or gellan; plant extracts; nutrient supplement and a preservative.

[0043] According to some embodiments, the invention is directed to a dietary supplement or a nutraceutical composition comprising water and xanthan gum, LBG and gellan gum, at least one nutrient supplement and at least one preservative. According to some embodiments, the dietary supplement or the nutraceutical composition further comprises at least one plant extract. According to some embodiments, the dietary supplement or the nutraceutical composition further comprises at least one vitamin. It is noted that the plant extract and/or the vitamin may be a nutrient supplement.

[0044] According to some embodiments, the dietary supplement or the nutraceutical composition of the invention has a high capacity for carrying any of the additives thereto and therefore, relatively small volumes of the gel of the invention may include relatively high concentrations of nutrients, sweeteners, preservatives, plant extracts, and/or vitamins. According to some embodiments, the dietary supplement or the nutraceutical composition of the invention is formulated as a gel.

[0045] The invention provides a gel, which has a large capacity for vitamins and agents having a nutritional value. The gel enables the packaging of the formulation in relatively small volume, but with a large capacity of vitamins and nutritional agents. The packages include between 10-30 gram of a gel containing the nutritional supplements and such packages are sufficient for daily morning or night use.

[0046] In an embodiment of the invention, there is provided a dietary supplement or a nutraceutical composition comprising: water in an amount of about 10% to about 25% by weight; one or more of xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and/or gellan gum in an amount of between about 0.1- 0.50 %w/w; and plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about 1.5% to about 7% by weight and a preservative.

[0047] According to some embodiments, the amount of the xanthan gum is at least about 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w. According to some embodiments, the amount of the LBG is at least about 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w. According to some embodiments, the amount of the gellan gum is at least about 0.1, 0.125, 0.15, 0.175, 0.2, 0.225, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5 %w/w.

[0048] According to some embodiments, the xanthan gum is Ziboxan® F200- xanthan gum food grade. According to some embodiments, the gellan gum is Kelcogel® F gellan gum. According to some embodiments, the LBG is seedgum® A- 175 LBG.

[0049] In an embodiment of the invention, there is provided a dietary supplement or a nutraceutical composition comprising: water in an amount of about at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 2, 22, 23, 24, 25, 30% by weight; a gel comprising xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and gellan gum in an amount of between about 0.1-0.50 %w/w, plant extracts in an amount of at least about 0.2, 0.4, 0.6, 0.8, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5% or about 5% by weight; nutrient supplement in an amount of at least about 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5% or about 7% by weight and a preservative.

[0050] In some embodiments of the invention, the dietary supplement or a nutraceutical composition of the invention further comprises apple sugar syrup.

[0051] In some embodiments of the invention, the amount of the apple sugar syrup is between about 15%-90%. According to some embodiments, the amount of the apple sugar syrup is between about 20-30 %w/w. In some embodiments of the invention, the amount of the apple sugar syrup is at least about 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58 60, 65, 70, 71, 72, 73, 74, 75, 80, 82, 85 or about 90% by weight

[0052] In some embodiments of the invention, the dietary supplement or a nutraceutical composition further comprises a xanthan gum.

[0053] In some embodiments of the invention, the dietary supplement or a nutraceutical composition the xanthan gum is in an amount of between 0.1%-4% by weight. [0054] In some embodiments of the invention, the dietary supplement or a nutraceutical composition the xanthan gum is in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.7, 1, 1.3, 1.6, 1.8, 2, 2.3, 2.6, 2.9, 3.1, 3.3, 3.5, 3.7 or 4% by weight.

[0055] In some embodiments of the invention, if a sweetener is added, the sweetener in the dietary supplement or a nutraceutical composition is stevia extract or sucralose.

[0056] In some embodiments of the invention, the stevia extract or sucralose is in an amount of between about 0.03%-0.4%.

[0057] In some embodiments of the invention, the stevia extract or sucralose is in an amount of at least about 0.03, 0.05, 0.07, 0.09, 0.1, 0.2, 0.3 or 0.4%.

[0058] According to some embodiments, palatinose is added to the dietary supplement or the nutraceutical composition. According to some embodiments, the palatinose is in an amount of between about 5-15% w/w. According to some embodiments, the palatinose is in an amount of between about 7-12% w/w. According to some embodiments, the palatinose is in an amount of between about 8-10% w/w. According to some embodiments, the palatinose is in an amount of at least about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15% w/w.

[0059] In some embodiments of the invention the dietary supplement or a nutraceutical composition further comprises an acid. According to some embodiments the acid is selected from citric acid, lactic acid, acetic acid, adipic acid, tartaric acid, phosphoric acid or malic acid or a combination thereof.

[0060] In some embodiments the dietary supplement or a nutraceutical composition further comprises a vitamin and/or mineral mix. In some embodiments, the vitamin and/or mineral mix may further include food supplements or ingredients such as one or more of the ingredients in Table A:

Table A

Cellulose Fibers

Ethyl Cellulose

Gum Arabic

Maize Starch

Maltodextrin

Medium Chain Triglycerides

Modified Food Starch

Sucrose

Tocopherols Rich Extract dl-a-Tocopherol

In some embodiments, the vitamin and/or mineral mix may further include food supplements or ingredients such as one or more of the ingredients in Table B:

Table B

Cellulose Fibers

Ethyl Cellulose

Gum Arabic

Maize Starch

Maltodextrin

Medium Chain Triglycerides

Modified Food Starch

Sucrose

Tocopherols Rich Extract

dl-a-Tocopherol

[0061] In some embodiments, the vitamin and/or mineral mix may further include one or more of the following ingredients specified in Table C:

Table C

Selenium Sodium Selenite Pentahydrate

Zinc Zinc Gluconate

[0062] In some embodiments, the vitamin and/or mineral mix may further include one or more of the following ingredients specified in Table D:

Table D

[0063] Some embodiments, both described mixes as in Table C and D are added to the dietary supplement or a nutraceutical composition

[0064] In some embodiments, the dietary supplement or a nutraceutical composition comprises a preservative in an amount of between 0.01% to 0.50% by weight. In some embodiments, the preservative is potassium sorbate.

[0065] According to some embodiments of the invention, the amount of the potassium sorbate is 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1 or 0.15% by weight.

[0066] According to some embodiments, dietary supplement or a nutraceutical composition comprises a nutrient supplement. According to some embodiments, the nutrient supplement is one or more resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf), or methylcobalamin (vitamin B12).

[0067] According to some embodiments, dietary supplement or a nutraceutical composition may also be termed here as "formulation".

[0068] In some embodiments, the dietary supplement or a nutraceutical composition comprises a plant extract, which is one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida, sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba or paullinia cupana. In some embodiments these are the plant extracts included in the day formulation.

[0069] In some embodiments, the plant extracts and or active ingredients extracted from plants or synthetic materials (such as resveratrol or Coenzyme Q10) included in the dietary supplement or a nutraceutical composition are one or more of the following:

Table 1

Material Name

Green Tea Extract

Acai - Euterpe oleracea

Resveratrol

Coenzyme Q10

Ilex paraguariensis

(Yerba mate)

Paullinia cupana

(Guarana)

Ginkgo biloba

Rhodiola rosea

(Rhodiola)

Astragalus membranaceus

Sambucus nigra L. subsp.nigra

Sambucus nigra L. subsp.canadensis

Echinacea Angustifolia

Echinacea pallida

Echinacea purpurea

[0070] According to some embodiments of the invention the plant extract and or active ingredients extracted from plants included in the dietary supplement or a nutraceutical composition are derived from one more of the following suggested source or part of the plant: Table 2

[0071] In some embodiments, the dietary supplement or a nutraceutical composition comprises a plant extract that is one or more of Hops (Humulus lupulus), Melissa officinalis (lemon balm), Chamomile Matricaria chamomilla (German chamomile), Panax quinquefolius, Withania somnifera Ashwagandha (American ginseng), Passion flower (Passiflora incarnate). [0072] In some embodiments of the invention, these extracts are derived from one or more of the following sources/part of the plant.

Table 3

[0073] In an embodiment of the invention, the gel comprises the components as detailed in Table 4 below:

Table 4

[0074] In an embodiment of the invention, gel comprises the components as detailed in Table 5 below: Table 5

[0075] In an embodiment of the invention, the gel comprises the components as detailed in Table 6 below:

Table 6

Citric acid 2-3

Vitamin mix

Astragalus 0.8

membranaceus

beta-carotene color

Vitamin C

Ginkgo biloba 0.320

Tri-sodium citrate 0.3

Xanthan gum 0.3

Paullinia cupana

0.200

(Guarana)

Coenzyme Q10 0.120

Potassium Sorbate 0.050

Ilex paraguariensis

0.040

(Yerba mate)

Sambucus nigra L. Fruit 0.032

Echinacea pallida 0.032

Green Tea Extract 0.006

Acai - Euterpe oleracea 0.004

Resveratrol (Polygonum

0.004

cuspidatum)

Raspberry flavor 0.35

Gellan gum 0.3

LBG 0.175

Palatinose 9

[0076] In some embodiments of the invention, the formulation further includes from the following nutritional supplements:

Table 7 Nutrient

Vitamin A

Vitamin C

Calcium

Iron

Vitamin D

Vitamin E Vitamin K

Vitamin B 1

Vitamin B2

Vitamin B3

Vitamin B6

Folate

Vitamin B 12

Biotin

Vitamin B5

Phosphorus

Iodine

Magnesium

Zinc

Selenium

Copper

Manganese

Chromium

Molybdenum

Vitamin K2

L-methylfolate (5-mthf

Methylcobalamin (vitamin B12) ment, the formulation is as described in Table 8:

Table 8

Water

Apple sugar syrup

Vitamin mix MA 59

Vitamin mix MA 71

Citric acid

Vitamin C

Astragalus membranaceus

tomat - O color

beta-carotene color

Ginkgo biloba

LBG type A

Tri-sodium citrate

Xanthan gum

Paullinia cupana

(Guarana)

Gellan F

Orange flavor 2222351010 Coenzyme Q10

Potassium Sorbate

Ilex paraguariensis

(Yerba mate)

Sambucus nigra L. Fruit

Echinacea pallida

Green Tea Extract

Acai - Euterpe oleracea

Resveratrol US

Folic Acid

Vitamin B 12

Vitamin k2

Apple flavor

Strawberry flavor ome embodiment the formulation is as described in Table 9:

Table 9

Orange flavor Strawberry flavor

% by weight % by weight

Water 12-22 12-22

Apple sugar syrup 60-80 60-80

Vitamin mix MA 59 1-2.5 1-2.5

Vitamin mix MA 71 0.3-1 1.00

Citric acid 0.8-3 0.8-3

Vitamin C 0.8-1.8 0.8-1.8

Astragalus membranaceus 0.6-1 0.6-1 tomat - 0 color 0.3-1 beta-carotene color 0.3-1

Ginkgo biloba 0.1-0.7 0.1-0.7

LBG type A 0.05-4 0.05-4

Tri-sodium citrate 0.1-0.4 0.1-0.4

Xanthan gum 0.05-0.4 0.05-0.4

Paullinia cupana 0.05-0.4 0.05-0.4

(Guarana)

Gellan F 0.05-0.4 0.05-0.4

Orange flavor 2222351010 0.05-0.3

Coenzyme Q10 0.05-0.3 0.05-0.3

Potassium Sorbate 0.01-0.08 0.01-0.08

Ilex paraguariensis

0.01-0.07 0.01-0.07 (Yerba mate)

Sambucus nigra L. Fruit 0.01-0.07 0.01-0.07

Echinacea pallida 0.01-0.07 0.01-0.07

Green Tea Extract 0.003-0.009 0.003-0.009

Acai - Euterpe oleracea 0.001-0.007 0.001-0.007

Resveratrol US 0.001-0.007 0.001-0.007

Folic Acid Vitamin B12

Vitamin k2

Apple flavor

Strawberry flavor

[0079] In some embodiment the formulation is as described in Table 10:

Table 10

[0080] In some embodiments of the invention, the formulation is as described in Table 11 : Table 11

] In some embodiments of the invention, the formulation is as described in Table 12

Table 12

Water

Apple sugar syrup

Vitamin mix

Citric acid

Vitamin C

Astragalus membranaceus colorant

Ginkgo biloba

LBG

Tri-sodium citrate

Xanthan gum

Paullinia cupana

(Guarana)

Gellan F

Coenzyme Q.10

Potassium Sorbate

Ilex paraguariensis

(Yerba mate)

Sambucus nigra L. Fruit

Echinacea pallida

Green Tea Extract

Acai - Euterpe oleracea

esveratrol US

Folic Acid

Vitamin B12

Vitamin k2

Flavor agent

[0082] In some embodiments of the invention, vitamin mix MA 59 includes one or more of the following:

Table 13 A

Monohydrate

Molybdenum 0.1125 Sodium Molybdate 0.0379

Pantothenic Acid 15.0000 Calcium D-Pantothenate 2.1800

Selenium 0.0750 Sodium Selenite

0.0333

Pentahydrate

Vitamin A (RE) 0.5630 A Acetate 0.0862

Vitamin B 1 4.5000 Thiamine Mononitrate 0.7381

Vitamin B12 0.009 Vitamin B12

0.0012

(cyanocobalamin) (cyanocobalamin)

Vitamin B2 3.8250 Riboflavin 0.5100

Vitamin B6 4.0000 Pyridoxine 0.6507

Hydrochloride

Vitamin D 0.0100 Cholecalciferol (D3) 0.0013

Vitamin E(TE) 21.881 dl-a-Tocopheryl acetate 8.6942

Kl (Phytonadione) 0.0450 Vitamin Kl 0.0060

(Phytonadione)

Zinc 11.0000 Zinc Gluconate 11.2821

Total

[0083] In some embodiments of the invention, vitamin mix MA 71 includes one or more of the following:

Table 14

[0084] Further embodiments of the invention are directed to a method of manufacturing a xanthan gum, LBG, gellan gum gel comprising:

mixing xanthan gum, LBG, gellan gum and apple sugar syrup by agitating constantly;

adding water while continuing the agitation;

gradually heating to a temperature of between about 60-95°C;

adding at least one plant extract and/or at least one nutritional supplement;

heating to less than about 120°C; cooling to less than 80°C to obtain a xanthan gum, LBG, gellan gum gel. According to some embodiments, the xanthan gum, LBG, gellan gum gel is placed in a package.

[0085] Further embodiments of the invention are directed to a method of manufacturing a gel comprising xanthan gum, LBG and/or gellan gum comprising the steps of:

mixing one or more of xanthan gum, LBG, and/or gellan gum together with apple sugar syrup by agitating constantly;

adding water while continuing the agitation;

gradually heating to a temperature of between about 60-95°C;

adding at least one plant extract and/or at least one nutritional supplement;

heating to less than about 120°C;

cooling to less than 80°C to obtain a gel comprising one or more of xanthan gum, LBG and/or gellan gum. According to some embodiments, the gel is placed in a package.

[0086] In some embodiments, the mixing of the xanthan gum, LBG and gellan gum together with and apple sugar syrup may be between about one minute to one hour. In some embodiments the mixing of the one or more of xanthan gum, LBG and/or gellan gum and apple sugar syrup may be between about 10 minutes to twenty minutes. The xanthan gum, LBG and gellan gum and apple sugar syrup may be mixed until a homogenous mixture is reached. Water may be added to the mixture and the mixture may be agitated and heated to about 50, 55, 60, 65, 70, 75, 80, 85, 90 or 95°C until a homogenous solution is reached again. Plant extracts may then added together with the nutritional supplements and the composition may be heated to about 85. 90, 95, 100, 105, 110, 115 or 120°C and agitated until homogenously is achieved. The composition may then allowed to be cooled to about 80, 75, 70, 65°C or less by, for example, exposing the pot in which the composition is formed to cold water. The mixture, i.e., the xanthan gum, LBG, and gellan gum gel of the invention, may then divided into packages and the packages may then sealed.

EXAMPLES

[0087] A Pharmacokinetic Crossover Comparison Study of Absorption Characteristics of two Multivitamin mineral Formulations (gel vs. tablet/capsule)

[0088] Study Design:

14 patients were recruited to the study.

The study included two stages: 1. Capsule administration - 14 healthy volunteers were recruited to the study. The capsule was administered as a single dose after 12 hours of fasting. The participants were monitored during 6 hours for the level of minerals and Multivitamin minerals in the blood, adverse events and vital signs.

2. Gel administration - the gel was administrated to the same group of patients in the single dose after 12 hours of fasting. The participants were monitored during 6 hours for the level of minerals and Multivitamin minerals in the blood, adverse events and vital signs.

[0089] Blood tests for vitamins A, E, C, folic acid and minerals calcium and magnesium were performed at various time points between 15-36 minutes.

[0090] Safety monitoring was performed for 6 hours and included - vital signs and adverse events monitoring.

Study objectives:

Primary Objective

A comparison of mean fractional absorption of the two Multivitamin mineral formulations (gel vs. tablet/capsule).

Secondary Objective

A comparison of absorption rate across the two Multivitamin mineral formulations (gel vs. tablet/capsule).

[0091] Results are presented as mean ng/mL (plasma) vs. time.

[0092] The capsule/tablet formula included the following ingredients:

Raw material mg/serving

Acai Berry Extract 1

Ashwaganda 0.01

(2.5%)

Astragalus extract 200

Beta Carotene 150

(1%)

CoQIO 30

Echinacea 8

Gingko Biloba 80

Green Tea (20% 1.5

Catachine)

Guarana 22% 50

Maltodextrin - 306.05

Glucidex IT-19

Reseveratol 99% 1 Sambucus 8

(Elderberry)

Yerba Mate 10

Vitamin C 90

[0093] Vitamin mix MA59 and MA71 (described in Tables 13 and 14) were also added to the tested gel.

Experimental Results

Water soluble vitamins:

Folic Acid

[0094] Figure 1 presents the absorption of folic acid in the blood at different time points. The Average absorption of the folic acid from the gel was 58% i.e. 16% more than the average absorption of the folic acid from the tablets which was 42%.

Vitamin B12

[0095] Figure 2 presents the absorption of B12 in the blood at different time points. Average absorption of the vitamin B from the gel was 51% i.e. 2% more than the average absorption of the vitamin B from the tablets which was 49%.

Fat soluble vitamins

Vitamin E

[0096] Figure 3 presents the absorption of vitamin E in the blood at different time points. Average absorption of the vitamin E from the gel was 53% i.e. 6% more than the average absorption of the vitamin E from the tablets which was 47%.

Vitamin A

[0097] Figure 4 presents the absorption of vitamin A in the blood at different time points. Average absorption of the vitamin A from the gel was 55% i.e. 10% more than the average absorption of the vitamin A from the tablets which was 45%.

Minerals:

Magnesium [0098] Figure 5 presents the absorption of magnesium in the blood at different time points.

Average absorption of the magnesium from the gel was 55% i.e. 10% more than the average absorption of the magnesium from the tablets which was 45%.

Calcium

[0099] Figure 6 presents the absorption of calcium in the blood at different time points. Average absorption of the calcium from the gel was 57% i.e. 14% more than the average absorption of the calcium from the tablets which was 43%.

[00100] The inventions illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise indicated.

Claims

What is claimed is:

1. A dietary supplement or a nutraceutical composition comprising: water in an amount of about 15% to about 75% by weight; one or more of xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and/or gellan gum in an amount of between about 0.1-0.5 %w/w; and plant extracts in an amount of about 0.2% to about 5% by weight; nutrient supplement in an amount of about .10% to about 7% by weight; and a preservative.

2. The dietary supplement or a nutraceutical composition of claim 1, further comprising an apple sugar syrup.

3. The dietary supplement or a nutraceutical composition of claim 2, wherein the amount of the apple sugar syrup is between about 15%-90%.

4. The dietary supplement or a nutraceutical composition of any one of claims 1-3, wherein the dietary supplement or a nutraceutical composition further comprises palatinose.

5. The dietary supplement or a nutraceutical composition of claim 4, wherein the palatinose is in an amount of between 5%-15% by weight.

6. The dietary supplement or a nutraceutical composition of claim 1, the formulation further comprises a sweetener.

7. The dietary supplement or a nutraceutical composition of claim 6, wherein said sweetener is stevia extract or sucralose in an amount of between 0.03%-0.4%.

8. The dietary supplement or a nutraceutical composition of any one of claims 1-7, further comprising an acid.

9. The dietary supplement or a nutraceutical composition claim 10, wherein said acid is citric acid, lactic acid, acetic acid, adipic acid, tartaric acid, phosphoric acid or malic acid or a combination thereof.

10. The dietary supplement or a nutraceutical composition of any one of claims 1-9, wherein the amount of said preservative is between 0.01% to 0.20% w/w.

11. The dietary supplement or a nutraceutical composition of claim 10, wherein the preservative is potassium sorbate.

12. The dietary supplement or a nutraceutical composition of any one of claims 1-11, wherein said plant extract includes one or more of acai (Euterpe oleracea), green tea extract, Echinacea pallida ,sambucus nigra L. fruit, ilex paraguariensis, Ginkgo biloba, Astragalus membranaeus and/ or paullinia cupana.

13. The dietary supplement or a nutraceutical composition of any one of claims 1-12, wherein said plant extract includes one or more of Hops (Humulus lupulus), Melissa officinalis (lemon balm), Chamomile Matricaria chamomilla (German chamomile), Panax quinquefolius, Withania somnifera Ashwagandha (American ginseng) and/or Passion flower (Passiflora incarnate).

14. The dietary supplement or a nutraceutical composition of any one of claims 1-13, wherein said nutrient supplement is one or more of resveratrol, Coenzyme Q10, vitamin C, vitamin K2, L-methylfolate (5-mthf), and/or methylcobalamin (vitamin B12).

15. The dietary supplement or a nutraceutical composition of any one of claims 1-14, wherein the xanthan gum is in an amount of about 0.2 %w/w.

16. The dietary supplement or a nutraceutical composition of any one of claims 1-15, wherein the LBG is in an amount of about 0.2%w/w.

17. The dietary supplement or a nutraceutical composition of any one of claims 1-16, wherein the gellan gum is in an amount of about 0.2 %w/w.

18. The dietary supplement or a nutraceutical composition of any one of claims 1-14, wherein the dietary supplement or a nutraceutical composition comprises xanthan gum in an amount of between about 0.1-0.5 %w/w; LBG in an amount of between about 0.1-0.5 %w/w and gellan gum in an amount of between about 0.1-0.5 %w/w.

19. A method of manufacturing a gel comprising one or more of xanthan gum, LBG and/or gellan gum, said method comprising the step of:

mixing a xanthan gum, LBG and/or gellan gum and apple sugar syrup constantly;

adding water while mixing; gradually heating until reaching a temperature of between 60-95°C;

adding at least one plant extract, at least one nutritional supplement or both;

heating to about between 85% and 120°C; and

20. The method according to claim 19, further comprising placing the gel in packages.