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WO2018165992A1 - Appareil et procédé d'imagerie fonctionnelle multicanal du cerveau - Google Patents

Appareil et procédé d'imagerie fonctionnelle multicanal du cerveau Download PDF

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Publication number
WO2018165992A1
WO2018165992A1 PCT/CN2017/077461 CN2017077461W WO2018165992A1 WO 2018165992 A1 WO2018165992 A1 WO 2018165992A1 CN 2017077461 W CN2017077461 W CN 2017077461W WO 2018165992 A1 WO2018165992 A1 WO 2018165992A1
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photon
quantum
data
optical quantum
unit
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PCT/CN2017/077461
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English (en)
Chinese (zh)
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董孝峰
祝海龙
牛欣
孙媌媌
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博睿泰克科技（宁波）有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain

Definitions

  • the invention relates to a brain function imaging technology in the field of medical detection, in particular to a multi-channel brain function imaging device and method.
  • visual medical images can help medical workers make diagnoses based on changes in human physiology and pathology, and medical workers can accurately compare medical images with their familiar normal images to make a correct diagnosis.
  • the quality and quantity of information presented is the basis of diagnostic imaging, and the amount of information in the image is important for making a correct diagnosis.
  • Medical image imaging includes X-Ray, ultrasound, CT, MRI, MEG, PET, NIRS, etc.
  • medical image imaging technology is divided into two types: projection imaging and reconstruction imaging, such as fracture X-Ray imaging using tissue to X-Ray absorption.
  • Functional imaging techniques capable of presenting information that cannot be observed by morphological examination in image form, such as blood flow direction and flow velocity information, have emerged; functional imaging technology has broken through The morphological "diagnosis of defects", further application of imaging technology, currently, the main aspects involved, including neurophysiology and neuropsychology, are gradually expanding into auditory, language, cognitive and emotional functions such as cortex and memory. the study.
  • Functional imaging technology can provide sensitive, objective and accurate information evaluation for the research, diagnosis, progress estimation and evaluation of experimental intervention effects of neurological diseases.
  • Functional imaging studies of neuropathy in cranial neuropathy involve epilepsy, Parkinson's disease, Alzheimer's disease (AD), multiple brain sclerosis (MS), and cerebral infarction.
  • Functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) are functional imaging techniques for cranial neuropathy.
  • Functional imaging of fMRI and fNIRS images includes not only anatomy. Learn information and have nerves The reaction mechanism of the system.
  • fNIRS and fMRI use blood flow and blood oxygen changes to measure brain activity. The difference is that fMRI uses magnetic angiography, while fNIRS uses hemoglobin in blood vessels for near-infrared light scattering.
  • fMRI Functional magnetic resonance brain imaging
  • Functional near-infrared spectroscopy brain imaging (fNIRS) technology is a method for dynamic detection of brain function developed in recent years. It has the characteristics of being compatible with magnetic metal objects, allowing long-term continuous measurement and repeated measurement in a short time; it can be more accurate. Differentiating signals from different brain structures with a spatial resolution of 1-2 mm, not only that, the sampling rate of fNIRS can reach 0.1 second, much higher than functional magnetic resonance imaging, while the near-infrared optical imaging technology of diffuse optical imaging is more It represents the development direction of future cognitive neuroscience. At the same time, functional near-infrared spectroscopy brain imaging technology has the following disadvantages:
  • NIRS penetration is relatively poor, usually considered to penetrate only 3-8cm of skin
  • fNIRS has the same ability to resolve tissue components as fMRI technology. Due to its narrow frequency band, the spectrum of some molecular-scale substances overlaps with other substances in the spectrum, and the accuracy of scanning data is poor.
  • the optimal spectral range is between 2.0um and 2.5um, although the spectrum of glucose is independent, but within the spectral range and the human body.
  • the spectrum of other substances overlaps, which causes the near-infrared light to penetrate subcutaneously, and the absorbance of glucose is small.
  • No non-invasive experiments can provide evidence that the measured signal can be correlated to the actual blood glucose concentration, making it difficult to measure glucose by fNIRS;
  • fNIRS like fMRI, estimates brain tissue activity through oxygen consumption.
  • the measurement sensitivity is poor, unstable, low precision, and large time delay.
  • the technical problem to be solved by the present invention is that the existing brain function imaging scanning ability is poor, and the measurement sensitivity is poor, unstable, the accuracy is low, and the time delay is large.
  • the technical solution adopted by the present invention is to provide a multi-channel brain function imaging device.
  • Set including:
  • a central processing unit that issues a photon generation instruction and a strobe instruction
  • the photon generation and emission module generates and emits two photons according to the requirements of the photon generation instruction of the central processing unit;
  • the photon receiving module respectively receives one photon directly sent by the photon generating and transmitting module, and the state and the count change after the other passing through the detected brain tissue and being subjected to brain tissue including emission, refraction, scattering, absorption and actinic Light quantum, analyze the state and count of light quantum, and obtain corresponding analyzable light quantum data, thermal activity data and bioelectric activity data;
  • the gate control matrix module is configured to select one or more optical quantum transmit or receive antennas of the optical quantum generating and transmitting module or the optical quantum receiving module according to a gating command of the central processing unit;
  • the calculation and analysis module analyzes and calculates the received analyzable optical quantum data, the thermal activity data and the bioelectric activity data, and obtains component data of the detected tissue and final thermal activity data and bioelectric activity data of the detected tissue;
  • the imaging module performs the corresponding visual image reconstruction according to the component data of the detected tissue sent by the calculation analysis module and the final thermal activity and bioelectric activity data of the detected tissue.
  • the photon generation and emission module is composed of a photo quantum modulation matrix unit, a photon quantum generator, a photoquantum optical splitter, and a photon quantum transmitting antenna matrix;
  • the optical quantum modulation matrix unit modulates and encodes a frequency, a power, and a waveform of the output light quantum according to an occurrence instruction issued by the central processing unit; the optical quantum generator generates a light quantum according to the modulated signal; and the quantum optical splitter generates the generated light generator
  • the light quantum is divided into two paths; one or more antennas in the matrix of the optical quantum transmitting antenna are transmitted to the detected brain tissue, and the other is directly sent to the optical quantum receiving module.
  • the photon-receiving module includes a photon-receiving antenna matrix, a photo-quantum state detecting unit, an optical quantum signal amplifying unit, an optical quantum signal demodulating and decoding unit, a digital-to-analog converting unit, and a digital filtering unit;
  • One or more antennas of the matrix of photon-receiving antennas receive a quantum of light that is directly emitted by the photon-generating and transmitting module, and another path that passes through the detected brain tissue and is subjected to brain tissue including reflection, refraction, scattering, absorption, and actinic a photon whose state and count are changed after the action, and the state of the photon is detected by the photoquantity state detecting unit, and then amplified by the photoquantization signal amplifying unit, the optical quantum signal demodulation and decoding unit, the digital-to-analog conversion unit, and the filtering wave unit , demodulation decoding, digital-to-analog conversion and filtering, to obtain analyzable optical quantum data, thermal activity data and bioelectricity data.
  • the calculation and analysis module comprises a photo quantum statistical physics calculation unit, a photon energy spectrum analysis statistic unit, a photo quantum absorption resonance analysis unit and a scatter analysis unit, an optical quantum difference analysis unit, and a photo-quantum differential Doppler analysis unit;
  • the optical quantum absorption resonance analysis unit and the scattering analysis unit calculate the absorption spectrum and the scattering spectrum of the detected light on the incident light quantum by using the analyzable thermal activity and the bioelectric activity data analysis of the detected tissue;
  • the optical quantum energy spectrum analysis statistical unit performs energy spectrum analysis calculation on the received analyzable optical quantum data
  • the optical quantum statistical physics calculation unit statistically analyzes the calculation results of the absorption resonance unit, the scattering analysis unit, and the optical quantum energy spectrum analysis statistical unit, and analyzes the component data of the detected tissue and the final thermal activity and bioelectric activity of the detected tissue. data;
  • the optical quantum differential analysis unit and the optical quantum differential Doppler analysis unit analyze the blood flow rate or specific components.
  • the photon generated and emitted by the photon generation and emission modes includes non-entangled photons, entangled photon pairs, and non-entangled photons and entangled photons;
  • the photon generation and emission modes emit all of them to the brain tissue being detected, and the absorption, reflection, refraction, and scattering and actinic effects of the detected brain tissue change the state of the photon, and in the light.
  • the thermal activity and bioelectric activity of the detected brain tissue are changed, and the photon receiving module receives the photon of the changed state of the brain tissue and the thermal activity and bioelectric activity signal of the detected brain tissue, and performs state detection and amplification.
  • demodulation and decoding digital-to-analog conversion and filtering to obtain analyzable optical quantum data, thermal activity data and bioelectrical data
  • another non-entangled photon quantum is sent directly to the optical quantum receiving module as a contrast signal for state detection and amplification, demodulation and decoding.
  • digital-to-analog conversion and filtering to obtain analyzable standard optical quantum data
  • the computational analysis module compares the analyzable optical quantum data with the standard optical quantum data, and the analyzable optical quantum data, the analyzable thermal activity data, and Analytical calculation of bioelectric data Component measured data organization, and ultimately the final heat bioelectrical activity data transactions;
  • the photon generation and emission module emits one of the entangled photon pairs to the detected brain tissue; the other photon of the entangled photon pair is directly sent to the photon quantum receiving module,
  • the photon receiving module performs state detection and amplification, demodulation decoding, digital-to-analog conversion and filtering on the entangled light quantum directly sent to the photon quantum receiving module to obtain analyzable optical quantum data; and the calculating and analyzing module performs the analyzable optical quantum data Calculating and analyzing the component data, final thermal activity data and bioelectricity data of the tested tissue;
  • the photon generation and emission modes, the photon quantum receiving module and the computational analysis module are respectively processed according to the above-mentioned processing methods in which only non-entangled photons or entangled photon pairs are present;
  • the module then counts the component data, the final thermal activity data, and the bioelectricity data of the measured tissues obtained separately.
  • the photon generator includes a multi-band pulse photon generating unit that generates a multi-band pulse photon, a continuous wave photon generating unit that generates a continuous wave photon, and an entangled state photon pair generating unit that generates an entangled photon pair;
  • the photon-receiving antenna matrix includes a multi-band pulse photon receiving unit that receives multi-band pulsed photons, a continuous wave photon receiving unit that receives continuous wave photons, and an entangled state photon receiving unit that receives entangled photons.
  • the optical quantum transmitting antenna matrix and the optical quantum receiving antenna matrix respectively comprise a plurality of optical quantum transmitting antennas and optical quantum receiving antennas that operate independently;
  • One or more optical quantum transmitting antennas and one or more optical quantum receiving antennas are arranged according to a regular arrangement to form a matrix of reusable optical quantum transmitting and receiving antennas, each of the optical quantum transmitting antennas and the optical quantum receiving antennas having a fixed code and a three-dimensional spatial coordinate;
  • the antennas in the array are gated by the gate control matrix module.
  • a knowledge base-based data correction module is further included, and the knowledge base-based adjustment method is used to correct the data.
  • the invention also provides a multi-channel brain function imaging method, comprising the following steps:
  • Step S10 Select one or more antennas that are connected to the optical quantum transmitting antenna matrix and the corresponding optical quantum receiving antenna matrix according to an instruction of the central processing unit;
  • Step S20 according to the instruction requirements of the central processor, transmitting two optical quantum; one is transmitted to the detected tissue through the transmitting antenna, and the other is directly sent to the optical quantum receiving module;
  • Step S30 The photon receiving module respectively receives a photon directly emitted by the photon generation and emission module, and the state and the count change after the other path passes through the detected brain tissue and is subjected to brain tissue including emission, refraction, scattering, absorption, and actinic.
  • Light quantum analyzing the state and count of light quantum, obtaining analyzable optical quantum data as well as thermal activity data and bioelectrical data;
  • Step S40 analyzing and calculating the analyzable optical quantum data and the thermal activity data and the bioelectricity data, and obtaining the detected tissue component data and the final thermal activity and bioelectric activity data of the detected tissue;
  • Step S50 executing a central processor instruction according to the component of the detected tissue and detecting the final thermal activity and bioelectric activity data of the tissue, and performing corresponding image reconstruction.
  • the active mode of detection imaging is: the central processor issues an instruction, and the entangled photon or non-entangled photon of the continuous spectrum, the pulsed fixed spectrum is generated by the photon generator, transmitted through the antenna emission matrix, and received by the photon receiving module via the detected tissue. And then perform computational analysis to obtain tissue composition and the organization's final thermal activity and bioelectric activity data;
  • the passive mode of detection imaging is: the central processor issues an instruction, and the optical quantum receiving module receives the infrared signal and the electrical activity signal radiated by the measured tissue by the optical quantum scan, and then performs calculation and analysis to obtain the tissue composition and organize the final thermal activity and the biological activity. Electrical activity data.
  • the invention utilizes the non-entangled photon of the continuous spectrum and the entangled photon of the pulse spectrum to acquire the tissue composition information, the thermal activity, the bioelectric activity information and the displacement information of the human body, and the computer aided imaging; and has the following advantages:
  • FIG. 1 is a structural block diagram of a multi-channel brain function imaging apparatus provided by the present invention.
  • FIG. 2 is a structural block diagram of a photon quantum generator of the present invention
  • FIG. 3 is a structural block diagram of a photon quantum receiving module according to the present invention.
  • FIG. 4 is a schematic diagram of an embodiment of a reusable optical quantum transmit and receive antenna matrix in the present invention.
  • FIG. 5 is a schematic diagram of antenna distribution when the reusable optical quantum transmitting and receiving antenna matrix is operated in a helmet form according to the present invention
  • FIG. 6 is a schematic diagram showing the operation of a photo quantum transmitting antenna or a photon quantum receiving antenna of a reusable transmitting and receiving antenna matrix in the present invention, which is simultaneously present in several test arrays;
  • FIG. 7 is a flow chart of a multi-channel brain function imaging method provided by the present invention.
  • Figure 8 is a flow chart showing the operation of detecting an active working mode of imaging in the present invention.
  • Figure 9 is a flow chart showing the operation of detecting the passive working mode of imaging in the present invention.
  • Each molecule has a characteristic spectrum and a light-transmissive window, and the absorption resonance and scattering-refractive properties for a specific wavelength are used as fingerprints for identifying the molecules of the substance.
  • the invention uses continuous spectrum and pulse spectrum to scan the detected tissue, obtains data such as constituent components, thermal activity and bioelectric activity of the tissue, or uses pulse waves to locate and measure components of a specific tissue (such as brain tissue);
  • the basic theory has been improved to make full use of the continuous spectroscopy non-entangled photon quantum and optical quantum entangled state properties.
  • the photon entangled state is entangled.
  • the photon pair A is composed of photon A1 and A2 which is entangled with A1.
  • the change of photon A1 state will inevitably cause another photon A2 state change, so that the photon pair A in the entangled state
  • One photon A1 is emitted to the detected brain tissue, and the photon A1 is affected by the detected tissue components (such as resonance absorption, Rayleigh scattering, Raman scattering, refraction, reflection, actinization), photon A1 state and other physical properties occur.
  • the state data of the photon A1 can be acquired, thereby obtaining the composition of the detected tissue, the position of the detected component, the thermodynamic data of the detected tissue, and the bioelectric activity.
  • Data instead of inferring neuronal activity through oxygen consumption like fNIRS and fMRI, it directly detects neuronal thermodynamic activity data and completes image reconstruction.
  • the present invention provides a multi-channel brain functional imaging device for brain function imaging, tissue component analysis, brain function localization and component localization, including a central processing unit, a photon generation and emission module, and a photon quantum receiving module. , gating control matrix module, calculation analysis module and imaging module.
  • a central processing unit that issues a photon generation instruction and a strobe instruction
  • the photon generation and emission module generates and emits two photons according to the requirements of the photon generation instruction of the central processing unit.
  • the photon generation and emission module includes a photo quantum modulation matrix unit, a photon quantum generator, a photoquantitizer, and a photon quantum antenna matrix. among them,
  • the optical quantum modulation matrix unit modulates and encodes the frequency, power and waveform of the output light quantum according to an occurrence instruction issued by the central processor; the optical quantum generator generates a light quantum according to the modulated signal; the quantum optical splitter divides the light quantum generated by the generator into two paths; One or more antennas in the matrix of photon-transmitting antennas are transmitted to the detected brain tissue, and the other is directly sent to the photon-receiving module.
  • the photon-receiving module respectively receives a photon directly sent from the photon generation and emission module, and another state undergoes changes in state and count after passing through the detected brain tissue and being subjected to brain tissue including emission, refraction, scattering, absorption and actinic action.
  • the photon quantum receiving module comprises a photon quantum receiving antenna matrix, a photon quantum state detecting unit, an optical quantum signal amplifying unit, an optical quantum signal demodulating and decoding unit, a digital to analog converting unit and a digital filtering unit.
  • One or more antennas in the matrix of photon-receiving antennas receive a quantum of light that is directly emitted by the photon-generating and transmitting module, and another state that passes through the detected brain tissue and is subjected to reflection, refraction, scattering, absorption, and actinic effects on the brain tissue. And counting the light quantum that has changed, and detecting the state of the two light quantum by the light quantum state detecting unit, and then performing amplification, demodulation and decoding of the optical quantum signal amplifying unit, the optical quantum signal demodulating and decoding unit, the digital-to-analog conversion unit, and the filtering wave unit. Digital-to-analog conversion and filtering yields analyzable optical quantum data, thermal activity data, and bioelectrical data of the tissue being examined.
  • the gate control matrix module selectively selects one or more optical quantum transmit or receive antennas of the optical quantum generation and transmission module or the optical quantum receiving module according to a gating command of the central processing unit.
  • the calculation and analysis module analyzes and calculates the received analyzable optical quantum data, the thermal activity data and the bioelectricity data, and obtains the detected tissue component data, the final thermal activity data of the detected tissue, and the bioelectricity activity data.
  • the calculation analysis module includes a photo quantum statistical physics calculation unit, a photon energy spectrum analysis statistical unit, a photo quantum absorption resonance analysis unit, and a scattering analysis unit (including a Raman scattering analysis unit, a Rayleigh scattering analysis unit, etc.), and a light quantum difference. Analysis unit and optical quantum differential Doppler analysis unit.
  • the optical quantum absorption resonance analysis unit and the scattering analysis unit calculate the absorption spectrum and the scattering spectrum of the detected light on the incident light by using the analyzable thermal activity and bioelectric activity data analysis of the detected tissue.
  • the optical quantum energy spectrum analysis statistical unit performs energy spectrum analysis calculation on the received analyzable optical quantum data.
  • the quantum quantum statistical physics calculation unit statistically analyzes the calculation results of the absorption resonance unit, the scattering analysis unit, and the optical quantum energy spectrum analysis statistical unit, thereby analyzing the component data of the detected tissue and the final thermal activity data and bioelectric activity of the detected tissue. Data, etc.
  • the optical quantum differential analysis unit and the optical quantum differential Doppler analysis unit analyze the blood flow rate or the moving speed of specific components such as lymphocytes and drug components.
  • the imaging module performs the corresponding imaging according to the component data of the detected tissue sent by the calculation analysis module and the final thermal activity and bioelectric activity data of the detected tissue.
  • the imaging module includes a data correction module and a reconstruction imaging module, and the data correction module corrects the component data of the received detected tissue and the final thermal activity and bioelectric activity data of the tissue, and the reconstructed imaging module utilizes the corrected according to the central processor instruction. Detecting tissue composition data and tissue thermal activity and bioelectric activity data for image reconstruction.
  • the photon generated and emitted by the photon generation and emission modes includes non-entangled photons, entangled photon pairs, and non-entangled photons and entangled photons.
  • the photon generation and emission modes emit all the way to the brain tissue to be detected, and the absorption, reflection, refraction, and scattering and actinization of the detected brain tissue change the state of the photon, and The thermal activity and bioelectric activity of the brain tissue detected by actinic change are changed.
  • the photon receiving module receives the photon of the changed state of the brain tissue and the thermal activity and bioelectric activity signals of the detected brain tissue, and performs state detection and Amplification, demodulation and decoding, digital-to-analog conversion and filtering to obtain analyzable optical quantum data, thermal activity data and bioelectrical data; another non-entangled photon is directly transmitted to the optical quantum receiving module as a contrast signal for state detection and amplification and demodulation Decoding, digital-to-analog conversion, and filtering to obtain analyzable standard optical quantum data; the computational analysis module compares analyzable optical quantum data with standard optical quantum data, and analyzable optical quantum data, analyzable thermal activity data, and biological Analysis and calculation of electrical data, obtaining the measured group
  • the composition data, the final heat and final bioelectrical activity data and other data are examples of the composition data, the final heat and final bioelectrical activity data and other data.
  • the photon generation and emission module emits one photon (see one way) of the entangled photon pair as a probe to the detected brain tissue; another photon in the entangled photon pair (seeing the other way) as a shadow measurement probe directly sent to the photon quantum receiving module, the photon quantum receiving module performs state detection and amplification, demodulation decoding, digital-to-analog conversion and filtering on the entangled light quantum directly sent to the optical quantum receiving module.
  • the analyzed optical quantum data; the calculation and analysis module obtains the component data of the measured tissue, the final thermal activity data, and the bioelectricity data by performing calculation and analysis on the analyzable optical quantum data.
  • the photon generation and emission modes, the photon quantum receiving module and the computational analysis module are processed separately according to the above-mentioned processing methods in which only non-entangled photons or entangled photon pairs are present;
  • the analysis module then counts the component data, the final thermal activity data, and the bioelectricity data of the measured tissues obtained separately.
  • the photon generator includes a multi-band pulse photon generating unit that generates a multi-band pulse photon, a continuous wave photon generating unit that generates a continuous wave photon, and an entangled photon pair that produces an entangled photon pair. unit.
  • the photon quantum receiving module includes a multi-band pulse that receives a multi-band pulsed light quantum.
  • a photon quantum receiving unit a continuous wave photon receiving unit that receives the continuous wave photon, and an entangled state photon receiving unit that receives the entangled state photon.
  • the optical quantum transmitting antenna matrix and the optical quantum receiving antenna matrix respectively comprise a plurality of optical quantum transmitting antennas and optical quantum receiving antennas that can work independently; in the present invention, the plurality of optical quantum transmitting antennas can separately constitute a matrix of optical quantum transmitting antennas, and a plurality of The photon-receiving antenna may separately constitute a photon-receiving antenna matrix; or may be arranged by one or more photo-quantum transmitting antennas and one or more photo-receiving antennas according to a regular arrangement to form a multiplexable optical quantum transmitting and receiving antenna matrix, each photo-emissive transmitting antenna and The photon receive antenna has a fixed code and a three-dimensional space coordinate; the antenna in the array is gated by the gate control matrix module.
  • FIG. 4 it is an embodiment of a reusable optical quantum transmitting and receiving antenna matrix.
  • the black dot in the figure represents a transmitting antenna, and the white dot represents a receiving antenna, and the (X, Y) coordinates are (3, 3).
  • the center of the transmitting antenna may constitute a reciprocable optical quantum transmitting and receiving antenna matrix of 3X3, 5X5...nXn, but is not limited to the arrangement, as long as at least one of the transmitting antenna and the receiving antenna is ensured; as shown in FIG.
  • the spatial coordinates of each receive and transmit antenna are relatively fixed, and the photon is emitted by the transmit antenna-3 in Figure 5, and the photon is resonantly absorbed. , refraction, various scattering (including but not limited to Rayleigh scattering, Raman scattering, Thomson scattering, Compton scattering), part of the photon reaches the receiving antenna No. 1, No. 4, No. -2 (including but not limited to the 3
  • the mathematical position can be used to obtain the regional position coordinates of the black dispersion in Fig. 5, that is, the area of the lesion is obtained and is heavy. Image display coordinate data.
  • the "transmit and receive antenna matrix" receive antenna multiplexing as shown in Figure 4 is determined by the central processor module of Figure 1 to determine the number of the multiplexed antenna (receiver antenna and transmit antenna).
  • Figure 6 shows the operation of the multiplexable transmit and receive antenna matrix.
  • the optical quantum transmit antenna constitutes a photo-quantum transmit antenna array, that is, 0, 3, and 6 multiplexed optical quantum transmit antenna arrays, and transmit antenna arrays. Can be used for differential analysis and differential Doppler analysis and other non-example applications.
  • Figure 6 shows that a photon-emitter antenna or a photon-receiving antenna can appear in several test arrays simultaneously, and the gating control matrix controls the gating, such as Figure 6.
  • the test array Z1 can be constituted by No. 0, No. 1, No. 2, and can be composed of No. 0, No. 1, No. 2, No. 4, No. 5, and a test array Z2, or No. 1, No. 2, No. 3, No. 4, No. 5, which constitutes the test array Z3, or by 4 No. 5, No. 6, constitutes test array Z4.
  • a data correction module based on the knowledge base is further included, and the data correction module based on the knowledge base adopts a knowledge base based on the data obtained by the measurement, such as reading error, environmental error, and electrical aging.
  • the difference method corrects the data and overcomes the statistically based noise filtering defects.
  • the present invention provides a multi-channel brain function imaging method comprising the following steps:
  • Step S10 The strobe control matrix module selects one or more antennas of the photon generation and emission module and the photon quantum receiving module according to an instruction of the central processor.
  • Step S20 The photon generation and transmission module transmits two optical quantum according to the instruction requirement of the central processor; one is transmitted to the detected tissue through the transmitting antenna, and the other is directly sent to the optical quantum receiving module.
  • Step S30 The photon receiving module respectively receives a photon directly emitted by the photon generation and emission module, and the state and the count change after the other path passes through the detected brain tissue and is subjected to brain tissue including emission, refraction, scattering, absorption, and actinic.
  • the quantum of light which analyzes the state and count of light quantum, yields analyzable optical quantum data as well as thermal activity data and bioelectrical data.
  • Step S40 Perform analysis and calculation on the analyzable optical quantum data and the thermal activity data and the bioelectricity data to obtain the detected tissue component data and the detected tissue thermal activity and bioelectric activity data.
  • Step S50 executing a central processor instruction according to the component of the detected tissue and the final thermal activity data and the bioelectric activity data, and performing corresponding image reconstruction.
  • the present invention includes detecting an imaging active mode of operation and detecting an imaging passive mode of operation. among them,
  • the active mode of detecting imaging is issued by the central processing unit, and the entangled photon or non-entangled photon of the continuous spectrum, the pulsed fixed spectrum is generated by the photon generator, transmitted through the antenna emission matrix, and received by the photon receiving module via the detected tissue. Then, the calculation analysis is performed to obtain the detected tissue component data and the final thermal activity and bioelectric activity data of the detected tissue.
  • the detection imaging passive working mode is an instruction issued by the central processing unit, and the optical quantum receiving module receives the thermal activity signal and the bioelectric activity signal radiated by the measured tissue by the optical quantum scanning, and then performs calculation and analysis to obtain the tissue component data and the final thermal activity data. And bioelectric activity data.
  • the detection imaging passive working mode light quantum generator does not work, and the detection imaging passive working mode acquires less information than the active working mode.
  • the detecting the imaging active working mode specifically includes the following steps:
  • Step 101 The central processor sends an active detection command and a transmit antenna multiplexing coordinate.
  • Step 102 The optical quantum modulation matrix module gives an optical quantum modulation parameter and an optical quantum entanglement state, and the optical quantum modulation parameter includes a frequency, a power (a quantum number of light), and a waveform.
  • Step 103 The photon generator generates a continuous spectrum or a pulse spectrum non-entangled photon or entangled photon pair.
  • Step 104 The beam splitter performs splitting, and one photon of the entangled quantum pair enters the photon quantum transmitting antenna, and the other photon enters the photon quantum receiving module.
  • Step 105 The strobe control matrix module strobes the optical quantum transmitting antenna according to the transmit antenna multiplexing coordinates sent by the central processing unit.
  • Step 106 The quantum light emitting antenna matrix emits a light quantum.
  • Step 107 The optical quantum receiving antenna emitted by the central processing unit multiplexes the coordinate strobe light quantum receiving antenna to receive the optical quantum signal.
  • Step 108 The state detecting module detects a light quantum state.
  • Step 109 Amplify, demodulate, and analog-to-digital convert the optical quantum signal to convert the analog signal into a digital signal.
  • Step 110 The digital filtering module filters out noise and unwanted signals.
  • Step 111 Calculate and analyze the digital signal to obtain the components of the detected tissue and the final thermal activity and bioelectric activity data.
  • Step 112 Perform visual image reconstruction according to the components of the detected tissue and the final thermal activity and bioelectric activity data of the detected tissue.
  • step 111 includes optical quantum statistical physics calculation, optical quantum energy spectrum analysis calculation, optical quantum absorption spectrum calculation, scattering analysis calculation, differential Doppler analysis calculation and differential analysis calculation. Finally, the data is corrected based on the knowledge base.
  • FIG. 9 a flow chart of detecting an imaging passive operation mode is described.
  • the flow chart describes passively inspecting the infrared radiation emitted by the optical quantum scan of the tissue without active emission of the quantum signal, ie, infrared radiation. It is also a kind of photon radiation, which specifically includes the following steps:
  • Step 201 The central processing unit emits quantum receiving antenna multiplexing coordinates.
  • Step 202 The strobe control matrix strobes the photon quantum receiving antenna.
  • Step 203 The receiving antenna matrix receives the optical quantum signal.
  • Step 204 Amplify the optical quantum signal and convert it into a digital signal.
  • Step 205 Perform digital filtering of the electrical signal.
  • Step 206 Perform quantum quantum statistical physics calculation and energy spectrum calculation.
  • Step 207 Perform data deviation correction based on the knowledge base.
  • Step 208 Draw a digital image according to the calculation result.

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Abstract

L'invention concerne un appareil et un procédé pour l'imagerie fonctionnelle multicanal du cerveau. Le procédé comprend les étapes suivantes : selon une instruction d'une unité centrale de traitement, choisir de se connecter à une ou plusieurs antennes d'émission et antennes de réception (S10) ; émettre deux quanta de lumière, l'un étant émis, par l'intermédiaire de l'antenne d'émission, vers un tissu à détecter, et l'autre étant directement envoyé à un module de réception de quanta de lumière (S20) ; recevoir, par le module de réception de quanta de lumière, le quantum de lumière, qui est directement émis, et un autre quantum de lumière, qui est soumis à une réflexion, une réfraction, une diffusion et une réaction photochimique par le tissu à détecter et dont l'état est modifié (S30) ; analyser et calculer les états des quanta de lumière pour obtenir des données de composantes finales du tissu à détecter et l'activité thermique du tissu à détecter et des données d'activité bioélectrique concernant celui-ci (S40) ; et selon les données d'activité, exécuter l'instruction de l'unité centrale de traitement, et réaliser une reconstruction d'image correspondante (S50). L'appareil a une capacité de balayage relativement importante, la mesure de données est plus directe et plus sensible, le volume d'informations est plus grand et plus stable, et il n'y a pas de retard temporel.
PCT/CN2017/077461 2017-03-13 2017-03-21 Appareil et procédé d'imagerie fonctionnelle multicanal du cerveau WO2018165992A1 (fr)

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