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WO2018174197A1 - Filtre de séparation de sang et méthode de séparation de composant sanguin - Google Patents

Filtre de séparation de sang et méthode de séparation de composant sanguin Download PDF

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Publication number
WO2018174197A1
WO2018174197A1 PCT/JP2018/011521 JP2018011521W WO2018174197A1 WO 2018174197 A1 WO2018174197 A1 WO 2018174197A1 JP 2018011521 W JP2018011521 W JP 2018011521W WO 2018174197 A1 WO2018174197 A1 WO 2018174197A1
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WO
WIPO (PCT)
Prior art keywords
blood
inflow
outflow
housing
chamber
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Application number
PCT/JP2018/011521
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English (en)
Japanese (ja)
Inventor
飯田直紀
Original Assignee
テルモ株式会社
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Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2018174197A1 publication Critical patent/WO2018174197A1/fr

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  • the present invention relates to a blood separation filter for separating a predetermined blood component from blood and a blood component separation method.
  • the blood separation filter includes a housing, a filter medium that divides the housing into a blood inflow chamber and a blood outflow chamber in a thickness direction, an inflow port that allows blood to flow into the blood inflow chamber, and a blood component from the blood outflow chamber by the filter medium. And an outflow port for flowing out the separated blood after the separation (see, for example, re-published WO2010 / 026891).
  • a blood bag containing blood before separation (before filtration) is suspended from a suspension base, and the housing is placed so that the inflow port is located above and the outflow port is located below. It arrange
  • the housing when the blood component is separated from the blood, the housing is arranged in the vertical direction, so that the blood accumulates under the blood inflow chamber due to the action of gravity. If it does so, since the upper side of a filter medium will not be used effectively, a filter medium effective area will reduce. A decrease in the effective area of the filter medium may cause a decrease in flow rate during filtration, leakage of blood components, clogging of filtration, hemolysis, and the like.
  • the housing when the housing is horizontally arranged so that the blood inflow chamber is located above the blood outflow chamber, the blood flowing into the blood inflow chamber from the inflow port starts to be filtered downward before spreading over the entire surface of the filter medium. Then, a so-called air block in which air (bubbles) remains on the surface of the filter medium may be generated. In this case, since the filtration of blood is not performed at the location where air remains in the filter medium, the effective area of the filter medium may be reduced.
  • the present invention has been made in consideration of such problems, and an object of the present invention is to provide a blood separation filter and a blood component separation method capable of preventing a reduction in the effective area of the filter medium.
  • a blood separation filter is a blood separation filter for separating a predetermined blood component from blood, and is provided with a housing and a blood inflow through the housing.
  • a filter medium partitioned into a chamber and a blood outflow chamber, an inflow port through which the blood flows into the blood inflow chamber, and an outflow through which the separated blood after the blood components are separated from the blood outflow chamber by the filter medium
  • An inflow tube for guiding the blood to the inflow port, and the blood inflow chamber is located below the filter medium in a state where the housing is suspended by the inflow tube.
  • the blood outflow chamber is located above the filter medium.
  • the housing may be configured such that the blood inflow chamber and the blood outflow chamber are opposed to each other in the vertical direction with the filter medium sandwiched between the housing and the housing. .
  • the occurrence of air blocks can be further suppressed.
  • At least a part of the inflow tube may be located on a center line passing through the center of gravity of the blood separation filter and extending in the thickness direction of the housing.
  • the housing With the housing suspended, the housing is laid in a state close to a horizontal position so that the blood outflow chamber is located below the filter medium and the blood outflow chamber is located above the filter member. Can do.
  • the inflow port may be provided at an outer edge portion of the housing, and an inflow fixing portion to which the inflow tube is fixed may be provided on an upper outer surface of the housing.
  • the housing when the housing is hung, it can be laid in a state close to a horizontal posture.
  • the outflow port is provided at an outer edge portion of the housing, the outflow port to which the separated blood is guided is connected to the outflow port, and the lower outer surface of the housing An outflow fixing part to which the outflow tube is fixed may be provided.
  • the housing when the housing is hung, it can be laid down in a state closer to a horizontal posture.
  • the inflow port is located on the opposite side of the centroid line with respect to the outflow port, and the inflow fixing portion and the outflow fixing portion are opposite to each other on the basis of the centroid line. It may extend toward the direction.
  • the housing can be laid down in a state closer to a horizontal posture.
  • the blood separation filter includes the inflow tube, and a plurality of the inflow ports are provided point-symmetrically with respect to the center of the housing, and the inflow tube has a center of gravity of the blood separation filter.
  • a branch portion passing through and extending in the thickness direction of the housing and positioned on the center of gravity line, a plurality of branch tubes branched from the branch portion, and connected to each inflow port from each of the branch tubes.
  • a plurality of inflow fixing portions fixed to the surface.
  • blood can be more evenly flowed into the blood inflow chamber from each inflow port.
  • production of an air block can be suppressed more reliably.
  • the housing when the housing is hung, it can be laid in a state close to a horizontal posture.
  • the blood separation filter includes an outflow tube connected to the outflow port to guide the separated blood, and the plurality of outflow ports are provided symmetrically with respect to the center of the housing.
  • a plurality of outflow fixing portions connected to the outflow ports and fixed to a lower outer surface of the housing; and a plurality of junction tubes connected to the outflow fixing portions so as to be separated from the housing.
  • the merging tubes may merge, and may have a merging portion extending on the center of gravity line.
  • the separated blood can be more evenly discharged from the blood outflow chamber to each outflow port. Further, when the housing is hung, it can be laid in a state closer to a horizontal posture.
  • the inflow port extends downward from the central portion of the upper outer surface of the housing through the filter medium to the blood inflow chamber, and the outflow port is formed on the lower outer surface of the housing. May extend upward from the center of the filter to the blood outflow chamber through the filter medium.
  • the housing when the housing is suspended with a simple configuration, it can be laid down in a state close to a horizontal position.
  • a blood separation filter includes a filter medium that separates a predetermined blood component from blood, a housing that contains the filter medium and is partitioned into a blood inflow chamber and a blood outflow chamber by the filter medium, and a blood inflow chamber.
  • a blood component separation method is a blood component separation method using a blood separation filter for separating a predetermined blood component from blood, and the blood separation filter is disposed in a housing and in the housing And after the blood component is separated by the filter medium from the blood outflow chamber, a filter medium that divides the inside of the housing into a blood inflow chamber and a blood outflow chamber, an inflow port through which the blood flows into the blood inflow chamber An arrangement of arranging the blood separation filter so that the blood inflow chamber is located below the filter medium and the blood outflow chamber is located above the filter medium.
  • the blood is allowed to flow from the inflow port into the blood inflow chamber, and the inside of the filter medium is circulated upward from the lower side in the vertical direction.
  • a plurality of each of the inflow port and the outflow port are provided on the outer edge portion of the housing in a point symmetry with respect to the center of the housing.
  • the blood may flow into the blood inflow chamber and the separated blood in the blood outflow chamber may flow out to the outflow ports.
  • blood can be made to flow more evenly into the blood inflow chamber and the separated blood in the blood outflow chamber can be made to flow more evenly.
  • a blood component separation method is a blood component separation method using a blood separation filter for separating a predetermined blood component from blood, and the blood separation filter is disposed in a housing and in the housing A filter medium for separating a predetermined blood component from the blood; an inflow port for allowing the blood to flow into the housing; and a separated blood after the blood component is separated by the filter medium from the housing. And an opening of the inflow hole of the inflow port with respect to the inner surface of the housing is located below the filter medium, and an opening of the outflow hole of the outflow port with respect to the inner surface of the housing is located above the filter medium.
  • the occurrence of air blocks can be further suppressed.
  • the blood inflow chamber is located below the filter medium and the blood outflow chamber is located above the filter medium in a state where the housing is suspended, the blood can be prevented from being biased in the blood inflow chamber and air Generation of blocks can be suppressed. Therefore, it is possible to prevent the effective area of the filter medium from decreasing.
  • FIG. 2 is a schematic explanatory diagram of a blood component separation method using the blood separation filter of FIG. It is a perspective view of the blood separation filter which concerns on 2nd Embodiment of this invention. It is a longitudinal cross-sectional view of the blood separation filter of FIG. It is a perspective view of the blood separation filter which concerns on 3rd Embodiment of this invention.
  • FIG. 7 is a longitudinal sectional view taken along line VII-VII in FIG. 6.
  • FIG. 7 is a longitudinal sectional view taken along line VIII-VIII in FIG. 6.
  • FIG. 10 is a longitudinal sectional view taken along line XX in FIG. 9.
  • FIG. 10 is a longitudinal sectional view taken along line XI-XI in FIG. 9.
  • It is a longitudinal cross-sectional view of the blood separation filter of FIG. It is a perspective view of the blood separation filter which concerns on 6th Embodiment of this invention.
  • a blood separation filter 10A shown in FIG. 1 separates or removes predetermined blood components such as white blood cells and platelets from blood, and includes an inflow tube 14 that guides blood into the housing 18 and blood from the housing 18. An outflow tube 16 is provided.
  • the blood separation filter 10 ⁇ / b> A is partitioned in a vertical direction (thickness direction perpendicular to the extending direction of the housing 18) into a housing 18 and a blood inflow chamber 20 and a blood outflow chamber 22 in the housing 18.
  • the filter member 24 including the filter medium 38, the inflow port 26 for allowing blood to flow into the blood inflow chamber 20, and blood after separation of blood components from the blood outflow chamber 22 by the filter member 24 (separated blood) ).
  • the housing 18 has a shape in which each rectangular short side is projected in an arc shape in a plan view. That is, the housing 18 extends in a planar shape.
  • the housing 18 is used by being disposed horizontally, and has a pair of resin cases (first case 30 and second case 32) that constitute walls opposite to each other in the vertical direction.
  • the first case 30 is configured as a lower wall portion of the housing 18, and the second case 32 is configured as an upper wall portion of the housing 18.
  • Each of the first case 30 and the second case 32 is made of a hard resin such as polycarbonate, for example.
  • the peripheral portions of the first case 30 and the second case 32 are joined to each other by fusion (ultrasonic fusion or the like) on the entire circumference.
  • fusion ultrasonic fusion or the like
  • a plurality of protrusions 34 are provided on the inner surface of the first case 30 that faces the filter member 24.
  • a plurality of protrusions 36 are provided on the inner surface of the second case 32 that faces the filter member 24. At least one of the protrusion 34 and the protrusion 36 may be omitted.
  • the filter member 24 is provided between the first case 30 and the second case 32.
  • the filter member 24 divides the housing 18 into a blood inflow chamber 20 and a blood outflow chamber 22 in the vertical direction. This is a member that separates or removes a predetermined blood component as a flow path when the blood moves to the blood outflow chamber 22.
  • the filter member 24 is configured by laminating a plurality of filter media 38 having the same shape in the thickness direction.
  • the filter medium 38 is made of a sheet-like porous body having a large number of fine continuous holes communicating from one surface to the other surface. Examples of such a porous body include polyurethane sponge sheets and nonwoven fabrics.
  • the number of filter media 38 stacked is, for example, about 2 to 10. In the filter member 24 of FIG. 2, six filter media 38 are laminated. The number of filter media 38 constituting the filter member 24 may be only one.
  • the peripheral portion of the filter member 24 includes a first convex portion 40 provided in the first case 30 in order to prevent blood from flowing from the blood inflow chamber 20 to the blood outflow chamber 22 via the outside of the filter member 24.
  • the filter member 24 is crimped by the second convex portion 42 provided in the second case 32 so as to be compressed inward in the stacking direction.
  • Each of the first convex portion 40 and the second convex portion 42 extends around the periphery of the filter member 24.
  • the blood inflow chamber 20 is formed between the first case 30 and the filter member 24, and the blood outflow chamber 22 is formed between the second case 32 and the filter member 24.
  • the inflow port 26 is located on the opposite side of the outflow port 28 across the center of gravity line Lg extending through the center of gravity G of the blood separation filter 10A and extending in the thickness direction.
  • the inflow port 26 allows blood to flow into the housing 18, and has an inflow hole 26 a communicating with the blood inflow chamber 20.
  • the inflow port 26 is provided integrally with the outer edge portion of the first case 30. However, the inflow port 26 configured as a separate member from the first case 30 may be joined to the first case 30 by fusion or the like.
  • the outflow port 28 allows the separated blood to flow out of the housing 18, and has an outflow hole 28 a communicating with the blood outflow chamber 22.
  • the outflow port 28 is provided integrally with the outer edge portion of the second case 32. However, the outflow port 28 configured as a separate member from the second case 32 may be joined to the second case 32 by fusion bonding.
  • the inflow tube 14 is a transparent and soft cylindrical tube made of resin, and is connected to the inflow port 26.
  • the inflow tube 14 is provided so that the blood inflow chamber 20 is positioned below the filter member 24 and the blood outflow chamber 22 is positioned above the filter member 24 with the housing 18 suspended. At least a part of the inflow tube 14 is located on the barycentric line Lg of the blood separation filter 10A.
  • the inflow tube 14 guides blood to the inflow port 26.
  • the inflow tube 14 extends from the center of gravity Lg to the inflow extension portion 44.
  • the inflow tube 14 extends from the inflow extension portion 44 to the inflow port 26.
  • an inflow fixing portion 46 fixed to the head.
  • the inflow extending portion 44 extends on the barycentric line Lg of the blood separation filter 10A.
  • One end (upper end) of the inflow extending portion 44 is connected to a blood bag 52 containing blood via a sealing member 50 (see FIG. 3).
  • the other end (lower end) of the inflow extension portion 44 is connected to one end of the inflow fixing portion 46, and the other end of the inflow fixing portion 46 is connected to the inflow port 26.
  • the inflow fixing portion 46 extends from the lower end of the inflow extension portion 44 to the outer edge portion of the housing 18 toward the inflow port 26 along the outer surface of the second case 32, and is curved downward at the outer edge portion of the housing 18.
  • the inlet port 26 is connected.
  • the inflow fixing portion 46 is fixed to the housing 18 by being joined to the outer surface of the second case 32 by fusion bonding.
  • the inflow fixing portion 46 may be fixed to the outer surface of the second case 32 by a method other than fusion (for example, an adhesive or the like).
  • the outflow tube 16 is a cylindrical tube made of a transparent and soft resin, to which the separated blood led out from the outflow port 28 is guided.
  • the outflow tube 16 is connected to the outflow port 28 and is connected to the outer surface of the first case 30.
  • an outflow extending portion 54 that is connected to the outflow fixing portion 56 and extends on the center of gravity line Lg.
  • One end of the outflow fixing portion 56 is connected to the outflow port 28, and the other end of the outflow fixing portion 56 is connected to one end (upper end) of the outflow extension portion 54.
  • the other end (lower end) of the outflow extension 54 is connected to a storage bag 58 in which separated blood is stored (see FIG. 3).
  • the outflow fixing portion 56 extends linearly from one end of the outflow extension portion 54 to the outer edge portion of the housing 18 toward the outflow port 28 along the outer surface of the first case 30, and upwards at the outer edge portion of the housing 18. Curved and connected to the outflow port 28.
  • the outflow fixing part 56 is fixed to the housing 18 by being joined to the outer surface of the first case 30 by fusion bonding. However, the outflow fixing part 56 may be fixed to the outer surface of the first case 30 by a method other than fusion (for example, an adhesive or the like).
  • the inflow fixing portion 46 and the outflow fixing portion 56 extend in opposite directions with respect to the center of gravity line Lg.
  • a blood component separation method using the blood separation filter 10A will be described.
  • a blood bag 52 containing blood is suspended from a suspension base and placed at a high place.
  • the housing 18 is suspended by the inflow tube 14 in the arranging step.
  • the blood inflow chamber 20 is positioned below the filter member 24 and the blood outflow chamber 22 is positioned above the filter member 24 so as to be in a state close to a horizontal position (ie, laid down).
  • the opening of the inflow hole 26 of the inflow port 26 with respect to the inner surface of the housing 18 is positioned below the filter medium 38, and the opening of the outflow hole 28 a of the outflow port 28 with respect to the inner surface of the housing 18 is positioned above the filter medium 38.
  • the blood treatment process is performed in the state of the arrangement process. Specifically, the sealing member 50 is broken, and blood in the blood bag 52 is transferred to the inflow extension portion 44 using a drop (gravity).
  • the blood transferred to the inflow extension portion 44 flows into the blood inflow chamber 20 of the housing 18 through the inflow fixing portion 46 and the inflow port 26.
  • the blood that has flowed into the blood inflow chamber 20 spreads throughout the blood inflow chamber 20, and the liquid level gradually rises.
  • blood components for example, white blood cells
  • air remaining in the housing 18 is removed from the outflow port 28 by introducing blood from the inflow port 26 into the filter medium 38 from the vertically downward direction.
  • the separated blood that has circulated through the filter member 24 is guided from the blood outflow chamber 22 to the outflow extension portion 54 through the outflow port 28 and the outflow fixing portion 56 and is stored in the storage bag 58.
  • the blood separation filter 10A is for separating a predetermined blood component from the blood.
  • This blood separation filter 10 ⁇ / b> A has a housing 18, a filter medium 38 that is disposed in the housing 18 and divides the housing 18 into a blood inflow chamber 20 and a blood outflow chamber 22, and allows blood to flow into the blood inflow chamber 20.
  • An inflow port 26 and an outflow port 28 through which separated blood flows out of the blood outflow chamber 22 are provided.
  • An inflow tube 14 that guides blood to the blood inflow chamber 20 is connected to the inflow port 26. With the housing 18 suspended by the inflow tube 14, the blood inflow chamber 20 is positioned below the filter medium 38 and the blood outflow chamber 22 is positioned above the filter medium 38.
  • the opening portion of the inflow hole 26 a of the inflow port 26 with respect to the inner surface of the housing 18 is positioned below the filter medium 38 and the outflow hole 28 a of the outflow port 28 of the housing 18.
  • the opening with respect to the inner surface is located above the filter medium 38.
  • the blood that has flowed into the blood inflow chamber 20 from the inflow port 26 spreads throughout the blood inflow chamber 20, and then the liquid level rises to contact substantially the entire surface (lower surface) of the filter medium 38. Then, it flows through the filter medium 38 from the bottom to the top and is guided to the blood outflow chamber 22. Thereby, it can suppress that the blood is biased in the blood inflow chamber 20. Moreover, since air can be reliably discharged from the blood inflow chamber 20, the occurrence of air blocks can be suppressed. Therefore, it is possible to prevent a decrease in the effective area of the filter medium.
  • the housing 18 is configured so that the blood inflow chamber 20 and the blood outflow chamber 22 face each other in the vertical direction with the filter medium 38 sandwiched between the housing 18 and the inflow tube 14. Thereby, generation
  • At least a part of the inflow tube 14 is located on the center of gravity line Lg that passes through the center of gravity G of the blood separation filter 10A and extends in the thickness direction.
  • the housing 18 is laid in a state close to a horizontal position so that the blood inflow chamber 20 is positioned below the filter medium 38 and the blood outflow chamber 22 is positioned above the filter medium 38 with the housing 18 suspended. Can do.
  • the inflow port 26 is provided at the outer edge portion of the housing 18 and is connected to the inflow tube 14.
  • An inflow fixing portion 46 to which the inflow tube 14 is fixed is provided on the upper outer surface of the housing 18. Thereby, when the housing 18 is suspended, it can be laid down in a state close to a horizontal posture.
  • the outflow port 28 is provided at the outer edge of the housing 18, and the outflow port 16 through which the separated blood is guided is connected to the outflow port 28.
  • An outflow fixing portion 56 to which the outflow tube 16 is fixed is provided on the lower outer surface of the housing 18. Thereby, when the housing 18 is suspended, it can be laid down in a state closer to a horizontal posture.
  • the inflow port 26 is located on the opposite side of the outflow port 28 across the center of gravity line Lg, and the inflow fixing portion 46 and the outflow fixing portion 56 extend in opposite directions with respect to the center of gravity line Lg. ing. Thereby, the housing 18 can be laid down in a state closer to the horizontal posture.
  • the blood separation filter 10 ⁇ / b> B includes a housing 62, a filter member 24 that divides the housing 62 into a blood inflow chamber 20 and a blood outflow chamber 22 in the vertical direction, and includes a filter medium 38. And an inflow port 64 for guiding blood into the blood inflow chamber 20, an outflow port 66 for guiding separated blood from the blood outflow chamber 22, and a connection sheet 68 extending outward from the filter member 24.
  • the housing 62 has a shape in which one short side of a rectangle is projected in an arc shape in a plan view. That is, the housing 62 extends in a planar shape.
  • the housing 62 has a pair of resin sheets (a first resin sheet 70 and a second resin sheet 72) that are formed in a bag shape and constitute opposite walls.
  • the first resin sheet 70 is configured as a lower wall portion of the housing 62
  • the second resin sheet 72 is configured as an upper wall portion of the housing 62.
  • the first resin sheet 70 and the second resin sheet 72 are made of a soft resin such as polyvinyl chloride, for example.
  • the peripheral portions of the first resin sheet 70 and the second resin sheet 72 are joined by fusion (high frequency fusion or the like) via the connection sheet 68 on the entire circumference except for the inflow port 64 and the outflow port 66. ing.
  • a plurality of ribs 76 extending in the longitudinal direction of the second resin sheet 72 are formed on the inner surface of the second resin sheet 72 facing the filter member 24. Is provided. A plurality of ribs similar to the ribs 76 may be provided on the inner surface of the first resin sheet 70 facing the filter member 24 in order to facilitate blood circulation in the blood inflow chamber 20. In the second resin sheet 72, the ribs 76 may be omitted.
  • the blood inflow chamber 20 is formed between the first resin sheet 70 of the housing 62 and the filter member 24, and the blood outflow chamber 22 is formed between the second resin sheet 72 of the housing 62 and the filter member 24. Yes.
  • the inflow port 64 is located on the opposite side of the outflow port 66 with a center line Lg passing through the center of gravity G of the blood separation filter 10B interposed therebetween.
  • the inflow port 64 allows blood to flow into the housing 62, and has an inflow hole 64 a communicating with the blood inflow chamber 20.
  • the inflow port 64 is made of a soft resin such as polyvinyl chloride.
  • the inflow port 64 is sandwiched between the first resin sheet 70 and the second resin sheet 72 at the outer edge portion of the housing 62 and joined thereto by fusion.
  • the outflow port 66 allows the separated blood to flow out of the housing 62, and has an outflow hole 66 a communicating with the blood outflow chamber 22.
  • the outflow port 66 is made of a soft resin such as polyvinyl chloride.
  • the outflow port 66 is sandwiched between the first resin sheet 70 and the second resin sheet 72 at the outer edge portion of the housing 62 and joined thereto by fusion bonding.
  • the inflow fixing portion 46 of the inflow tube 14 extends from the lower end of the inflow extension portion 44 to the outer edge portion of the housing 62 toward the inflow port 64 along the outer surface of the second resin sheet 72, and at the outer edge portion of the housing 62. Curved downward and connected to the inflow port 64.
  • the inflow fixing portion 46 is fixed to the housing 62 by being joined to the curved outer surface of the second resin sheet 72 by fusion bonding.
  • the inflow fixing portion 46 may be fixed to the outer surface of the second resin sheet 72 by a method other than fusion (for example, an adhesive or the like).
  • the outflow fixing portion 56 of the outflow tube 16 extends from the upper end of the outflow extension portion 54 to the outer edge of the housing 62 toward the outflow port 66 along the outer surface of the first resin sheet 70. Curved upward and connected to the outflow port 66.
  • the outflow fixing part 56 is fixed to the housing 62 by being joined to the curved outer surface of the first resin sheet 70 by fusion bonding. However, the outflow fixing part 56 may be fixed to the outer surface of the first resin sheet 70 by a method other than fusion (for example, an adhesive or the like).
  • the inflow fixing portion 46 and the outflow fixing portion 56 extend in opposite directions with respect to the center of gravity line Lg.
  • This embodiment has the same effect as the first embodiment.
  • the blood separation filter 10C includes an inflow tube 73 and an outflow tube 75.
  • the housing 18 is provided with two inflow ports 26 and two outflow ports 28.
  • each inflow port 26 has an inflow hole 26 a communicating with the blood inflow chamber 20.
  • the two inflow ports 26 are provided point-symmetrically with respect to the center of the housing 18. In other words, the two inflow ports 26 are provided so as to be symmetric with respect to the center of gravity line Lg.
  • each outflow port 28 has an outflow hole 28 a communicating with the blood outflow chamber 22.
  • the two outflow ports 28 are provided symmetrically with respect to the center of the housing 18. In other words, the two outflow ports 28 are provided so as to be symmetric with respect to the center of gravity line Lg.
  • the inflow tube 73 includes an introduction portion 77 located on the center of gravity line Lg, and two inflow extension portions 44 (branch tubes) branched from the introduction portion 77 via the branch portion 79. And two inflow fixing portions 46 connected to the inflow ports 26 from the inflow extending portions 44 and fixed to the outer surface of the second case 32.
  • the branch portion 79 is a connector that branches the blood in the introduction portion 77 into each inflow extension portion 44, and has a shape obtained by vertically inverting the Y-shape.
  • the two inflow extending portions 44 and the two inflow fixing portions 46 are provided symmetrically with respect to the center of gravity line Lg. That is, the two inflow extending portions 44 extend along the center of gravity line Lg in a state where they are arranged side by side.
  • the two inflow fixing portions 46 linearly extend from the lower ends of the inflow extension portions 44 toward the inflow ports 26 in the opposite directions along the outer surface of the second case 32 to the outer edge portion of the housing 18.
  • the outer edge of the housing 18 is curved downward and connected to each inflow port 26.
  • Each inflow fixing portion 46 is fixed to the housing 18 by being joined to the flat outer surface of the second case 32 by fusion. However, each inflow fixing portion 46 may be fixed to the outer surface of the second case 32 by a method other than fusion (for example, an adhesive or the like).
  • the outflow tube 75 includes two outflow fixing portions 56 connected to the outflow ports 28 and fixed to the outer surface of the first case 30, and the outflow tubes 75 so as to be separated from the housing 18.
  • a plurality of outflow extending portions 54 (merging tubes) connected to the fixed portion 56, and each outflow extending portion 54 merges via the converging portion 81 and has a lead-out portion 83 extending on the center of gravity line Lg. ing.
  • the two outflow fixing portions 56 and the two outflow extension portions 54 are provided symmetrically with respect to the center of gravity line Lg. That is, the two outflow extending portions 54 extend downward from the vicinity immediately below the center of gravity G of the blood separation filter 10 ⁇ / b> C in a state where they are juxtaposed.
  • the two outflow fixing portions 56 linearly extend from the upper end of each outflow extension portion 54 toward each outflow port 28 in the opposite directions along the outer surface of the first case 30 to the outer edge portion of the housing 18.
  • the outer edge of the housing 18 is curved upward and connected to each outflow port 28.
  • Each outflow fixing portion 56 is fixed to the housing 18 by being joined to the flat outer surface of the first case 30 by fusion bonding.
  • each outflow fixing part 56 may be fixed to the outer surface of the first case 30 by a method (for example, an adhesive) other than fusion.
  • the merging portion 81 is a connector for merging the separated blood flowing through each outflow extending portion 54 to the derivation portion 83, and has a Y shape.
  • the housing 18 is suspended by the inflow tube 73 in the arrangement step, as in the blood component separation method according to the first embodiment.
  • the blood inflow chamber 20 is positioned below the filter member 24 and the blood outflow chamber 22 is positioned above the filter member 24 so as to be in a state close to a horizontal position (ie, laid down).
  • the blood transferred from the blood bag 52 to the introduction part 77 using the head flows into each inflow extension part 44 through the branch part 79, and in the left and right direction ( After flowing to the side where the outer edge of the housing 18 is located), it flows into the blood inflow chamber 20 of the housing 18 via each inflow port 26.
  • the blood that has flowed into the blood inflow chamber 20 spreads from both sides of the outer edge of the housing 18 toward the center, and the liquid level gradually rises. Then, when the blood flows through the filter member 24 from the bottom to the top, the blood component is trapped by the filter member 24, whereby the blood component is separated or removed from the blood.
  • the separated blood that has circulated through the filter member 24 is guided from the blood outflow chamber 22 to each outflow extending portion 54 via each outflow port 28 and each outflow fixing portion 56, and joined to the outlet portion 83 by the confluence 81. It is accommodated in the accommodation bag 58.
  • a plurality (two) of the inflow ports 26 are provided point-symmetrically with respect to the center of the housing 18, and the inflow tube 73 has a branch portion 79 located on the center of gravity line Lg and a plurality ( Two inflow extension portions 44 (branch tubes), and a plurality of (two) inflow fixing portions that are connected to each inflow port 26 from each inflow extension portion 44 and are fixed to the upper outer surface of the second case 32. 46.
  • blood can flow more uniformly into the blood inflow chamber 20 from each inflow port 26. Therefore, generation
  • the housing 18 when the housing 18 is suspended, it can be laid down in a state close to a horizontal posture.
  • a plurality (two) of outflow ports 28 are provided point-symmetrically with respect to the center of the housing 18.
  • the outflow tubes 75 are connected to the respective outflow ports 28 and fixed to the lower outer surface of the first case 30.
  • the outflow tubes 75 are connected to the outflow fixing portions 56 so as to be separated from the housing 18.
  • a plurality of (two) continuous outflow extending portions 54 (merging tubes), and the respective outflow extending portions 54 merge and have a confluence portion 81 extending on the center of gravity line Lg. Thereby, the separated blood can be more evenly discharged from the blood outflow chamber 22 to each outflow port 28.
  • the housing 18 when the housing 18 is suspended, it can be laid down in a state closer to a horizontal posture.
  • each of the inflow port 26 and the outflow port 28 is not limited to two as in the third embodiment, and may be three or more. In this case, each of the plurality of inflow ports 26 and outflow ports 28 is provided point-symmetrically with respect to the center of the housing 18.
  • the housing 62 of the blood separation filter 10D is provided with two inflow ports 64 and two outflow ports 66, respectively.
  • Each inflow port 64 has an inflow hole 64 a communicating with the blood inflow chamber 20.
  • the two inflow ports 64 are provided point-symmetrically with respect to the center of the housing 62. In other words, the two inflow ports 64 are provided so as to be symmetric with respect to the center of gravity line Lg.
  • Each outflow port 66 has an outflow hole 66 a communicating with the blood outflow chamber 22.
  • the two outflow ports 66 are provided point-symmetrically with respect to the center of the housing 62. In other words, the two outflow ports 66 are provided so as to be symmetric with respect to the center of gravity line Lg.
  • the blood separation filter 10D includes an inflow tube 73 and an outflow tube 75.
  • This embodiment has the same effect as the third embodiment.
  • the blood separation filter 10E is provided with an inflow tube 92 and an outflow tube 94.
  • the blood separation filter 10E includes a housing 96, a filter member 97 that divides the housing 96 into a blood inflow chamber 20 and a blood outflow chamber 22 in the vertical direction, and includes a filter medium 38, and blood flows into the blood inflow chamber 20. And an outflow port 100 through which separated blood flows out from the blood outflow chamber 22.
  • the housing 96 is formed in a circular shape in plan view.
  • the housing 96 is used by being disposed horizontally, and has a pair of resin cases (a first case 102 and a second case 104) that constitute walls opposite to each other in the vertical direction.
  • the first case 102 is configured as a lower wall portion of the housing 96
  • the second case 104 is configured as an upper wall portion of the housing 96.
  • Each of the first case 102 and the second case 104 is made of a hard resin such as polycarbonate, for example.
  • the peripheral portions of the first case 102 and the second case 104 are joined together by fusion (ultrasonic fusion or the like) on the entire circumference.
  • the first case 102, the second case 104, and the filter member 97 are configured similarly to the first case 30, the second case 32, and the filter member 24 of the first embodiment, except that they are formed in an annular shape. Yes.
  • Each of the inflow port 98 and the outflow port 100 is provided at the center of the housing 96.
  • the inflow port 98 allows blood to flow into the housing 96, and has an inflow hole 98 a communicating with the blood inflow chamber 20.
  • the inflow port 98 is integrally provided at the center of the second case 104. Specifically, the inflow port 98 extends downward from the center of the second case 104 through the filter member 97 to the blood inflow chamber 20.
  • the inflow port 98 includes an inflow connection portion 99a to which the inflow tube 92 is connected, and a cylindrical inflow extension portion 99b that extends from the inflow connection portion 99a to the inside (downward) of the housing 96.
  • the flow passage cross-sectional area of the inflow extension portion 99b is smaller than the flow passage cross-sectional area of the inflow connection portion 99a.
  • the inflow extending portion 99 b is inserted through a through hole 106 formed in the central portion of the filter member 97.
  • the outflow port 100 allows the separated blood to flow out of the housing 96, and has an outflow hole 100 a communicating with the blood outflow chamber 22.
  • the outflow port 100 is provided at the center of the first case 102. Specifically, the outflow port 100 extends upward from the center portion of the first case 102 through the filter member 97 to the blood outflow chamber 22.
  • the outflow port 100 includes an outflow connection portion 101 a to which the outflow tube 94 is connected, and a cylindrical outflow extension portion 101 b that extends from the outflow connection portion 101 a to the inside (upward) of the housing 96.
  • the flow passage cross-sectional area of the outflow extension portion 101b is smaller than the flow passage cross-sectional area of the outflow connection portion 101a.
  • the outflow extension portion 101 b is inserted through the through hole 106 at the center of the filter member 97.
  • the outflow extension portion 101b and the inflow extension portion 99b are joined to each other at their opposing surfaces by fusion or the like.
  • the flow passage cross-sectional area of the inflow extension portion 99b and the flow passage cross-sectional area of the outflow extension portion 101b are substantially equal.
  • the inflow tube 92 extends on the center of gravity line Lg of the blood separation filter 10E.
  • One end (upper end) of the inflow tube 92 is connected to the blood bag 52 via the sealing member 50 (see FIG. 3).
  • the other end (lower end) of the inflow tube 92 is connected to the inflow port 98.
  • the outflow tube 94 extends on the center of gravity line Lg of the blood separation filter 10E. One end (upper end) of the outflow tube 94 is connected to the outflow port 100, and the other end (lower end) of the outflow tube 94 is connected to a storage bag 58 in which separated blood is stored (see FIG. 3).
  • the housing 96 is suspended by the inflow tube 92 in the arrangement step, as in the blood component separation method according to the first embodiment.
  • the housing 96 is in a state of being in a horizontal position (a laid state) such that the blood inflow chamber 20 is located below the filter member 97 and the blood outflow chamber 22 is located above the filter member 97.
  • the blood in the blood bag 52 is transferred to the inflow tube 92 using the head.
  • the blood transferred to the inflow tube 92 flows into the blood inflow chamber 20 of the housing 96 through the inflow port 98.
  • the blood that has flowed into the blood inflow chamber 20 spreads throughout the blood inflow chamber 20 from the center toward the outer edge, and the liquid level gradually rises.
  • the filter member 97 from the bottom to the top, the blood component is trapped by the filter member 97, so that the blood component is separated or removed from the blood.
  • the separated blood that has circulated through the filter member 97 is guided from the blood outflow chamber 22 to the outflow tube 94 through the outflow hole 100a of the outflow port 100, and stored in the storage bag 58.
  • the inflow port 98 extends downward from the center of the second case 104 through the filter member 97 to the blood inflow chamber 20, and the outflow port 100 extends from the center of the first case 102. To the blood outflow chamber 22 through the filter member 97.
  • the blood separation filter 10F is provided with an inflow tube 92 and an outflow tube 94.
  • the blood separation filter 10 ⁇ / b> F partitions the housing 122 into the blood inflow chamber 20 and the blood outflow chamber 22 in the vertical direction, and includes the filter medium 38 and the blood inflow chamber 20.
  • An inflow port 126, an outflow port 128 through which separated blood flows out from the blood outflow chamber 22, and a connection sheet 68 extending outward from the filter member 97 are provided.
  • the housing 122 is formed in a bag shape and has a pair of resin sheets (first resin sheet 130 and second resin sheet 132) that constitute opposite walls.
  • the first resin sheet 130 is configured as a lower wall portion of the housing 122
  • the second resin sheet 132 is configured as an upper wall portion of the housing 122.
  • the first resin sheet 130 and the second resin sheet 132 are made of a soft resin such as polyvinyl chloride, for example.
  • the peripheral portions of the first resin sheet 130 and the second resin sheet 132 are joined by fusion (high frequency fusion or the like) via the connection sheet 68 on the entire circumference.
  • the first resin sheet 130, the second resin sheet 132, and the filter member 97 are the same as the first resin sheet 70, the second resin sheet 72, and the filter member 24 of the second embodiment except that they are formed in an annular shape. It is configured.
  • Each of the inflow port 126 and the outflow port 128 is provided at the center of the housing 122.
  • the inflow port 126 allows blood before separation of blood components to flow into the housing 122, and has an inflow hole 126 a communicating with the blood inflow chamber 20.
  • the inflow port 126 is joined to the central portion of the second resin sheet 132 by fusion or the like. Specifically, the inflow port 126 extends downward from the center of the second resin sheet 132 through the filter member 97 to the blood inflow chamber 20.
  • the inflow port 126 includes an inflow connection portion 127 a to which the inflow tube 92 is connected, and a cylindrical inflow extension portion 127 b that extends from the inflow connection portion 127 a to the inside (downward) of the housing 122.
  • the flow passage cross-sectional area of the inflow extension portion 127b is smaller than the flow passage cross-sectional area of the inflow connection portion 127a.
  • the inflow extension portion 127 b is inserted through a through hole 134 formed in the center portion of the filter member 97.
  • the outflow port 128 allows the separated blood to flow out of the housing 122, and has an outflow hole 128 a communicating with the blood outflow chamber 22.
  • the outflow port 128 is joined to the central portion of the first resin sheet 130 by fusion or the like. Specifically, the outflow port 128 extends upward from the central portion of the first resin sheet 130 through the filter member 97 to the blood outflow chamber 22.
  • the outflow port 128 includes an outflow connection portion 129 a to which the outflow tube 94 is connected, and a cylindrical outflow extension portion 129 b that extends from the outflow connection portion 129 a inward (upward) of the housing 122.
  • the flow passage cross-sectional area of the outflow extension portion 129b is smaller than the flow passage cross-sectional area of the outflow connection portion 129a.
  • the outflow extension 129 b is inserted through the through hole 134 in the center of the filter member 97.
  • the outflow extension portion 129b and the inflow extension portion 127b are joined to each other at their opposing surfaces by fusion or the like.
  • the channel cross-sectional area of the inflow extension portion 127b and the channel cross-sectional area of the outflow extension portion 129b are substantially equal.
  • This embodiment has the same effect as the fifth embodiment.
  • the blood separation filter and the blood component separation method according to the present invention are not limited to the above-described embodiments, and it is needless to say that various configurations can be adopted without departing from the gist of the present invention.

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Abstract

Un filtre de séparation de sang (10A) à utiliser dans une méthode de séparation d'un composant sanguin est équipé d'un boîtier (18), d'un milieu de filtration (38) qui divise l'intérieur du boîtier (18) en une chambre d'entrée de sang (20) et une chambre d'évacuation de sang (22), un orifice d'entrée (26), et un orifice d'évacuation (28). L'orifice d'entrée (26) est relié à un tube d'entrée (14) pour guider le sang dans la chambre d'entrée de sang (20). Pendant que le boîtier (18) est suspendu par le tube d'entrée (14), la chambre d'entrée de sang (20) est positionnée au-dessous du milieu de filtration (38), et la chambre d'évacuation de sang (22) est positionnée au-dessus du milieu de filtration (38).
PCT/JP2018/011521 2017-03-24 2018-03-22 Filtre de séparation de sang et méthode de séparation de composant sanguin WO2018174197A1 (fr)

Applications Claiming Priority (2)

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JP2017058369 2017-03-24
JP2017-058369 2017-03-24

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WO2018174197A1 true WO2018174197A1 (fr) 2018-09-27

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500053A (ja) * 1996-07-09 2001-01-09 ポール・コーポレーション 多要素フィルター
US20020008063A1 (en) * 2000-03-27 2002-01-24 Peter Zuk High capacity gravity feed filter for filtering blood and blood products
US20050051486A1 (en) * 2003-09-05 2005-03-10 Peter Zuk Biological fluid filtration apparatus
JP2005237791A (ja) * 2004-02-27 2005-09-08 Asahi Kasei Medical Co Ltd 血液の濾過方法および血液の濾過システム

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500053A (ja) * 1996-07-09 2001-01-09 ポール・コーポレーション 多要素フィルター
US20020008063A1 (en) * 2000-03-27 2002-01-24 Peter Zuk High capacity gravity feed filter for filtering blood and blood products
US20050051486A1 (en) * 2003-09-05 2005-03-10 Peter Zuk Biological fluid filtration apparatus
JP2005237791A (ja) * 2004-02-27 2005-09-08 Asahi Kasei Medical Co Ltd 血液の濾過方法および血液の濾過システム

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