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WO2018193369A1 - Compositions anti-bactériennes - Google Patents

Compositions anti-bactériennes Download PDF

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Publication number
WO2018193369A1
WO2018193369A1 PCT/IB2018/052650 IB2018052650W WO2018193369A1 WO 2018193369 A1 WO2018193369 A1 WO 2018193369A1 IB 2018052650 W IB2018052650 W IB 2018052650W WO 2018193369 A1 WO2018193369 A1 WO 2018193369A1
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WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
acceptable derivative
gram
formula
antibacterial agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/052650
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English (en)
Inventor
Sachin Subhash Bhagwat
Hemant Narendra KHANDE
Snehal Rameshwar PALWE
Prasad Keshav Deshpande
Satish Bhavsar
Mahesh Vithalbhai Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
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Filing date
Publication date
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Publication of WO2018193369A1 publication Critical patent/WO2018193369A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to antibacterial compositions and methods for treating or preventing bacterial infections.
  • Bacterial infections continue to remain one of the major causes contributing towards human diseases.
  • One of the key challenges in treatment of bacterial infections is the ability of bacteria to develop resistance to one or more antibacterial agents over time.
  • Examples of such bacteria that have developed resistance to typical antibacterial agents include: Penicillin-resistant Streptococcus pneumoniae, Vancomycin-resistant Enterococci, and Methicillin-resistant Staphylococcus aureus.
  • Penicillin-resistant Streptococcus pneumoniae Vancomycin-resistant Enterococci
  • Methicillin-resistant Staphylococcus aureus The problem of emerging drug-resistance in bacteria is often tackled by switching to newer antibacterial agents, which can be more expensive and sometimes more toxic. Additionally, this may not be a permanent solution as the bacteria often develop resistance to the newer antibacterial agents as well in due course.
  • bacteria are particularly efficient in developing resistance, because of their ability to multiply very rapidly and pass on the resistance genes as they replicate.
  • compositions comprising at least one antibacterial agent and certain nitrogen containing bicyclic compound exhibit unexpectedly synergistic antibacterial activity, even against highly resistant bacterial strains.
  • compositions comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof:
  • compositions comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof; wherein a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is present in the composition in an amount from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • methods for treating or preventing a bacterial infection in a subject comprising administering to said subject an effective amount of a pharmaceutical composition comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof; and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof.
  • methods for treating or preventing a bacterial infection in a subject comprising administering to said subject an effective amount of a pharmaceutical composition comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof; wherein a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is present in the composition in an amount from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • methods for treating or preventing a bacterial infection in a subject comprising administering to said subject an effective amount of: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof; and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof.
  • methods for treating or preventing a bacterial infection in a subject comprising administering to said subject an effective amount of: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof; wherein a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is administered in an amount from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • a pharmaceutical composition comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof exhibits unexpectedly improved antibacterial efficacy, even against highly resistant bacteria, including those producing extended spectrum beta-lactamase enzymes (ESBLs).
  • ESBLs extended spectrum beta-lactamase enzymes
  • infection or "bacterial infection” as used herein includes presence of bacteria, in or on a subject, which, if its growth were inhibited, would result in a benefit to the subject.
  • infection in addition to referring to the presence of bacteria also refers to presence of other floras, which are not desirable.
  • infection includes infection caused by bacteria.
  • treat refers to administration of a medicament, including a pharmaceutical composition, or one or more pharmaceutically active ingredients, for prophylactic and/or therapeutic purposes.
  • prophylactic treatment refers to treating a subject who is not yet infected, but who is susceptible to, or otherwise at a risk of infection (preventing the bacterial infection).
  • therapeutic treatment refers to administering treatment to a subject already suffering from infection.
  • treat also refer to administering compositions, or one or more of pharmaceutically active ingredients discussed herein, with or without additional pharmaceutically active or inert ingredients, in order to: (i) reduce or eliminate either a bacterial infection, or one or more symptoms of a bacterial infection, or (ii) retard progression of a bacterial infection, or one or more symptoms of a bacterial infection, or (iii) reduce severity of a bacterial infection, or one or more symptoms of a bacterial infection, or (iv) suppress clinical manifestation of a bacterial infection, or (v) suppress manifestation of adverse symptoms of a bacterial infection.
  • a “therapeutically effective amount” or “pharmaceutically effective amount” or “effective amount” as used herein refer to an amount, which has a therapeutic effect or is the amount required to produce a therapeutic effect in a subject.
  • a “therapeutically effective amount” or “pharmaceutically effective amount” or “effective amount” of an antibacterial agent or a pharmaceutical composition is the amount of the antibacterial agent or the pharmaceutical composition required to produce a desired therapeutic effect as may be judged by clinical trial results, model animal infection studies, and/or in vitro studies (e.g. in agar or broth media).
  • Such effective amount depends on several factors, including but not limited to, the microorganism (e.g.
  • a prophylactically effective amount is that amount which would be effective in preventing the bacterial infection.
  • administration refers to and includes delivery of a composition, or one or more pharmaceutically active ingredients to a subject, including for example, by any appropriate method, which serves to deliver the composition or its active ingredients or other pharmaceutically active ingredients to the site of infection.
  • the method of administration may vary depending on various factors, such as for example, the components of the pharmaceutical composition or type/nature of the pharmaceutically active or inert ingredients, site of the potential or actual infection, the microorganism involved, severity of the infection, age and physical condition of the subject and a like.
  • Some non-limiting examples of ways to administer a composition or a pharmaceutically active ingredient to a subject according to this invention include oral, intravenous, topical, intrarespiratory, intraperitoneal, intramuscular, parenteral, sublingual, transdermal, intranasal, aerosol, intraocular, intratracheal, intrarectal, vaginal, gene gun, dermal patch, eye drop and mouthwash.
  • a pharmaceutical composition comprising more than one ingredients (active or inert)
  • one of the ways of administering such composition is by admixing the ingredients (e.g. in the form of a suitable unit dosage form such as tablet, capsule, solution, powder or a like) and then administering the dosage form.
  • the ingredients may also be administered separately (simultaneously or one after the other) as long as these ingredients reach beneficial therapeutic levels such that the composition as a whole provides a synergistic and/or desired effect.
  • growth refers to a growth of one or more microorganisms and includes reproduction or population expansion of the microorganism (e.g. bacteria).
  • growth also includes maintenance of on-going metabolic processes of the microorganism, including the processes that keep the microorganism alive.
  • ⁇ refers to ability of a treatment, or a composition, or one or more pharmaceutically active ingredients to produce a desired biological effect in a subject.
  • antibacterial effectiveness refers to the ability of the composition or the antibacterial agent to prevent or treat bacterial infection in a subject.
  • separator or “synergy” as used herein refers to the interaction of two or more agents so that their combined effect is greater than their individual effects.
  • antibacterial agent refers to any substance, compound, a combination of substances, or a combination of compounds capable of: (i) inhibiting, reducing or preventing growth of bacteria; (ii) inhibiting or reducing ability of a bacteria to produce infection in a subject; or (iii) inhibiting or reducing ability of bacteria to multiply or remain infective in the environment.
  • antibacterial agent also refers to compounds capable of decreasing infectivity or virulence of bacteria.
  • beta-lactam antibacterial agent refers to compounds with antibacterial properties and containing a beta-lactam nucleus in their molecular structure.
  • beta-lactamase or "beta-lactamase enzyme” as used herein refers to any enzyme or protein or any other substance that breaks down a beta-lactam ring.
  • beta- lactamase includes enzymes that are produced by bacteria and have the ability to hydrolyse the beta-lactam ring in a beta-lactam compound, either partially or completely.
  • extended spectrum beta-lactamase includes those beta- lactamase enzymes, which are capable of conferring bacterial resistance to various beta-lactam antibacterial agents such as penicillins, cephalosporins, aztreonam and the like.
  • beta-lactamase inhibitor refers to a compound capable of inhibiting activity of one or more beta-lactamase enzymes, either partially or completely.
  • colony forming units or "CFU” as used herein refers to an estimate of number of viable bacterial cells per ml of the sample. Typically, a “colony of bacteria” refers to a mass of individual bacteria growing together.
  • pharmaceutically inert ingredient or “carrier” or “excipient” refers to and includes compounds or materials used to facilitate administration of a compound, for example, to increase the solubility of the compound.
  • solid carriers include starch, lactose, dicalcium phosphate, sucrose, and kaolin.
  • Typical, non-limiting examples of liquid carriers include sterile water, saline, buffers, non-ionic surfactants, and edible oils.
  • various adjuvants commonly used in the art may also be included. These and other such compounds are described in literature, e.g., in the Merck Index (Merck & Company, Rahway, N.J.).
  • subject refers to vertebrate or invertebrate, including a mammal.
  • subject includes human, animal, a bird, a fish, or an amphibian.
  • Typical, non-limiting examples of a “subject” include humans, cats, dogs, horses, sheep, bovine cows, pigs, lambs, rats, mice and guinea pigs.
  • pharmaceutically acceptable derivative refers to and includes any pharmaceutically acceptable salt, pro-drug, metabolite, ester, ether, hydrate, polymorph, solvate, complex, and adduct of a compound described herein which, upon administration to a subject, is capable of providing (directly or indirectly) the parent compound.
  • antibacterial agent or a pharmaceutically acceptable derivative thereof includes all derivatives of the antibacterial agent (such as salts, pro-drugs, metabolites, esters, ethers, hydrates, polymorphs, solvates, complexes, and adducts) which, upon administration to a subject, are capable of providing (directly or indirectly) the antibacterial agent.
  • pharmaceutically acceptable salt refers to one or more salts of a given compound which possesses desired pharmacological activity of the free compound and which is neither biologically nor otherwise undesirable.
  • pharmaceutically acceptable salts refer to salts that are suitable for use in contact with the tissues of human and animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio.
  • Pharmaceutically acceptable salts are well known in the art. For example, S. M. Berge, et al. (/. Pharmaceutical Sciences, 66; 1-19, 1977), incorporated herein by reference in its entirety, describes various pharmaceutically acceptable salts in details.
  • stereoisomer refers to and includes isomeric molecules that have the same molecular formula but differ in positioning of atoms and/or functional groups in the space. Stereoisomers may further be classified as enantiomers (where different isomers are mirror-images of each other) and diastereomers (where different isomers are not mirror-images of each other). Diastereomers include isomers such as conformers, meso compounds, cis-trans (E-Z) isomers, and non-enantiomeric optical isomers.
  • compositions comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof:
  • the compound of Formula (I) as used herein is also known as irans-Sulfuric acid mono- ⁇ 2-[5-(3-aminopropyl)-[l,3,4]oxadiazol-2-yl]-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl ⁇ ester.
  • a reference to irans-Sulfuric acid mono- ⁇ 2-[5-(3-aminopropyl)-[l,3,4]oxadiazol-2-yl]-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl ⁇ ester is intended to include its pharmaceutically acceptable salts, prodrugs, metabolites, esters, ethers, hydrates, polymorphs, solvates, complexes, enantiomers, adducts and its any other pharmaceutically acceptable derivative.
  • compound of Formula (I) is sodium salt of iraws-Sulfuric acid mono- ⁇ 2-[5-(3-aminopropyl)-[l,3,4]oxadiazol-2-yl]-7-oxo- l,6-diaza-bicyclo[3.2.1]oct-6-yl ⁇ ester or a stereoisomer or a pharmaceutically acceptable derivative thereof.
  • compositions comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof; wherein a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is present in the composition in an amount from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • Both, at least one antibacterial agent and a compound of Formula (I) may be present in the composition in their free forms or in the form of their pharmaceutically acceptable derivatives (such as salts, pro-drugs, metabolites, esters, ethers, hydrates, polymorphs, solvates, complexes, or adducts).
  • their pharmaceutically acceptable derivatives such as salts, pro-drugs, metabolites, esters, ethers, hydrates, polymorphs, solvates, complexes, or adducts.
  • a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and at least one antibacterial agent or pharmaceutically acceptable derivative thereof in the composition may vary depending on clinical requirements.
  • a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof in the composition is present in an amount from about 0.01 gram to about 10 gram.
  • at least one antibacterial agent or a pharmaceutically acceptable derivative thereof in the composition is present in an amount from about 0.01 gram to about 10 gram.
  • the pharmaceutical composition according to the invention comprises about 0.125 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 0.5 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.25 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 0.5 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.5 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 0.5 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 1 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 0.5 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof. In some embodiments, the pharmaceutical composition according to the invention comprises about 2 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 0.5 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.125 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.25 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.5 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 1 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 2 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 4 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 1 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof. In some embodiments, the pharmaceutical composition according to the invention comprises about 0.125 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.250 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 0.5 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 1 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 2 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition according to the invention comprises about 4 gram of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and about 2 gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • compositions according to the invention may include one or more pharmaceutically acceptable carriers or excipients or the like.
  • suitable, non-limiting examples of such carriers or excipients include mannitol, lactose, starch, magnesium stearate, sodium saccharine, talcum, cellulose, sodium crosscarmellose, glucose, gelatine, sucrose, magnesium carbonate, wetting agents, emulsifying agents, solubilizing agents, buffering agents, lubricants, preservatives, stabilizing agents, binding agents and the like.
  • compositions or the active ingredients according to the present invention may be formulated into a variety of dosage forms, such as solid, semi-solid, liquid and aerosol dosage forms.
  • dosage forms such as solid, semi-solid, liquid and aerosol dosage forms.
  • Typical, non-limiting examples of some dosage forms include tablets, capsules, powders, solutions, suspensions, suppositories, aerosols, granules, emulsions, syrups, elixirs and the like.
  • compositions according to the invention are in the form of a powder or a solution. In some other embodiments, pharmaceutical compositions according to the invention are present in the form of a powder or a solution that can be reconstituted by addition of a compatible reconstitution diluent prior to administration. In some other embodiments, pharmaceutical compositions according to the invention are in the form of a frozen composition that can be diluted with a compatible reconstitution diluent prior to administration. Typical, non-limiting example of suitable compatible reconstitution diluent includes water.
  • compositions according to the invention are present in the form ready to use for parenteral administration.
  • compositions according to the invention can be formulated into various dosage forms wherein the active ingredients and/or excipients may be present either together (e.g. as an admixture) or as separate components.
  • the various ingredients in the composition are formulated as a mixture, such compositions can be delivered by administering such a mixture to a subject using any suitable route of administration.
  • pharmaceutical compositions according to the invention may also be formulated into a dosage form wherein one or more ingredients (such as active or inactive ingredients) are present as separate components.
  • the composition or dosage form wherein the ingredients do not come as a mixture, but come as separate components, such composition/dosage form may be administered in several ways.
  • the ingredients may be mixed in the desired proportions and the mixture is reconstituted in suitable reconstitution diluent and is then administered as required.
  • the components or the ingredients may be separately administered (simultaneously or one after the other) in appropriate proportion so as to achieve the same or equivalent therapeutic level or effect as would have been achieved by administration of the equivalent mixture.
  • compositions according to the invention are formulated into a dosage form such that a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, are present in the composition as admixture or as a separate components.
  • pharmaceutical compositions according to the invention are formulated into a dosage form such that a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, are present in the composition as separate components.
  • compositions according to the invention are used in treatment or prevention of a bacterial infection.
  • a pharmaceutical composition comprising administering to said subject effective amount of a pharmaceutical composition according to the invention.
  • a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, and at least one antibacterial agent or a pharmaceutically acceptable derivative thereof are present in the composition as separate components; a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof may be administered before, after or simultaneously with the administration of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • methods for treating or preventing bacterial infections in a subject comprising administering to said subject an effective amount of: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof:
  • methods for treating or preventing bacterial infections in a subject comprising administering to said subject an effective amount of: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof; wherein amount of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof administered is from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • a method for treating or preventing a bacterial infection in a subject comprising administering to said subject: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, in any of the following amounts:
  • a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is administered in an amount from about 0.01 gram to about 10 gram. In some other embodiments, in the methods according to the invention, at least one antibacterial agent or a pharmaceutically acceptable derivative thereof is administered in an amount from about 0.01 gram to about 10 gram.
  • antibacterial agents include those belonging to a group of antibacterial agents such as Ansamycins, Carbacephems, Carbapenams, Carbapenems, Cephalosporins, Cephamycins, Cephems, Lincosamides, Lipopeptides, Macrolides, Ketolides, Monobactams, Nitrofurans, Oxacephems, Oxapenams, Oxazolidinones, Penams, Penems, Penicillins, Polypeptides, Quinolones, Sulfonamides, Tetracyclines, and a like.
  • antibacterial agents such as Ansamycins, Carbacephems, Carbapenams, Carbapenems, Cephalosporins, Cephamycins, Cephems, Lincosamides, Lipopeptides, Macrolides, Ketolides, Monobactams, Nitrofurans, Oxacephems, Oxapenams, Oxazolidinones, Penams, Penems
  • beta-lactam antibacterial agents include those generally known as Carbacephems, Carbapenams, Carbapenems, Cephalosporins, Cephamycins, Cephems, Monobactams, Oxacephems, Oxapenams, Penams, Penems, Penicillins and a like.
  • antibacterial agents include Cefacetrile, Cefaclor, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefamandole, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefbuperazone, Cefcapene, Cefclidin, Cefdaloxime, Cefdinir, Cefditoren, Cefepime, Cefetamet, Cefixime, Cefluprenam, Cefmenoxime, Cefmetazole, Cefminox, Cefodizime, Cefonicid, Cefoperazone, Ceforanide, Cefoselis, Cefotaxime, Cefotetan, Cefotiam, Cefovecin, Cefoxitin, Cefoxitin, Cefozopran, Cefpimizol
  • the antibacterial agent is a beta-lactam antibacterial agent.
  • the antibacterial agent is at least one selected from Cefaclor, Cefadroxil, Cefalexin, Cefdinir, Cefixime, Cefpodoxime, Cefprozil, Cefradine, Ceftibuten, Cefuroxime, Loracarbef or a pharmaceutically acceptable derivative thereof.
  • Aminoglycoside antibacterial agents include Amikacin, Gentamicin, Kanamycin, Neomycin, Netilmicin, Tobramycin, Paromomycin, Arbekacin, Streptomycin, Apramycin and a like.
  • Ansamycin antibacterial agents include Geldanamycin, Herbimycin and a like.
  • Carbapenem antibacterial agents include Ertapenem, Doripenem, Imipenem, Meropenem, Panipenem, Biapenem, Tebipenem, Lenapenem, Tomopenem and a like.
  • Lincosamide antibacterial agents include Clindamycin, Lincomycin and a like.
  • Macrolide antibacterial agents include Azithromycin, Clarithromycin, Dirithromycin, Erythromycin, Roxithromycin, Troleandomycin, Telithromycin, Spectinomycin, Solithromycin and a like.
  • Monobactams antibacterial agents include Aztreonam and a like.
  • Nitrofuran antibacterial agents include Furazolidone, Nitrofurantoin and a like.
  • Penicillin antibacterial agents include Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, MethiciUin, Nafcillin, Oxacillin, Penicillin G, Penicillin V, Piperacillin, Temocillin, TicarciUin and a like.
  • Polypeptide antibacterial agents include Bacitracin, Colistin, Polymyxin B and a like.
  • Quinolone antibacterial agents include Ciprofloxacin, Enoxacin, Gatifloxacin, Levofloxacin, Lomefloxacin, Moxifloxacin, Nalidixic acid, Levonadifloxacin, Norfloxacin, Ofloxacin, Trovafloxacin, Grepafloxacin, Sparfloxacin, Temafloxacin, Fleroxacin, Pefloxacin, Sitafloxacin and a like.
  • Sulfonamide antibacterial agents include Mafenide, Sulfonamidochrysoidine, Sulfacetamide, Sulfadiazine, Sulfamethizole, Sulfamethoxazole, Sulfasalazine, Sulfisoxazole, Trimethoprim and a like.
  • Tetracycline antibacterial agents include Demeclocyclme, Doxycycline, Minocycline, Oxytetracycline, Tetracycline, Tigecycline and a like.
  • Oxazolidinone antibacterial agents include Tedizolid, Linezolid, Ranbezolid, Torezolid, Radezolid and a like.
  • a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is administered before, after or simultaneously with the administration of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • the pharmaceutical composition and/or other pharmaceutically active ingredients disclosed herein may be administered by any appropriate method, which serves to deliver the composition, or its constituents, or the active ingredients to the desired site.
  • the method of administration can vary depending on various factors, such as for example, the components of the pharmaceutical composition and the nature of the active ingredients, the site of the potential or actual infection, the microorganism (e.g. bacteria) involved, severity of infection, age and physical condition of the subject.
  • the microorganism e.g. bacteria
  • compositions or one or more active ingredients according to the invention are administered parenterally.
  • a compound of Formula (I) is trans- Sulfuric acid mono- ⁇ 2-[5-(3-aminopropyl)-[l,3,4]oxadiazol-2- yl]-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl ⁇ ester.
  • a compound of Formula (I) is trans- Sulfuric acid mono- ⁇ 2- [5-(3-aminopropyl)- [ 1 ,3 ,4]oxadiazol-2-yl] -7-oxo- 1 ,6-diaza- bicyclo[3.2.1]oct-6-yl ⁇ ester.
  • a compound of Formula (I) is present as a sodium or potassium salt of trans- Sulfuric acid mono- ⁇ 2- [5-(3-aminopropyl)- [ 1 ,3 ,4]oxadiazol-2-yl] -7-oxo- 1 ,6-diaza- bicyclo[3.2.1]oct-6-yl ⁇ ester.
  • a method for increasing antibacterial effectiveness of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof in a subject comprising co -administering at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, with a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof.
  • a method for increasing antibacterial effectiveness of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof in a subject comprising co-administering at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, with a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof, wherein the amount of a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable derivative thereof is from about 0.125 gram to about 4 gram per gram of at least one antibacterial agent or a pharmaceutically acceptable derivative thereof.
  • bacterial infections can be treated or prevented using compositions and methods according to the invention.
  • Typical, non-limiting examples of bacterial infections that can be treated or prevented using methods and/or pharmaceutical compositions according to the invention include E. coli infections, Yersinia pestis (pneumonic plague), staphylococcal infection, mycobacteria infection, bacterial pneumonia, Shigella dysentery, Serratia infections, Candida infections, Cryptococcal infection, anthrax, tuberculosis or infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii or methicillin resistant Staphylococcus aurues (MRSA) etc.
  • E. coli infections E. coli infections, Yersinia pestis (pneumonic plague), staphylococcal infection, mycobacteria infection, bacterial pneumonia, Shigella dysentery, Serratia infections, Candida infections, Cryptococcal infection, anthrax, tuberculosis or infections caused by Pseudomona
  • compositions and methods according to the invention are useful in treatment or prevention of several infections, including for example, skin and soft tissue infections, febrile neutropenia, urinary tract infection, intraabdominal infections, respiratory tract infections, pneumonia (nosocomial), bacteremia meningitis, surgical infections and the like.
  • compositions and methods according to the invention are used in treatment or prevention of infections caused by resistant bacteria. In some other embodiments, the compositions and methods according to the invention are used in treatment or prevention of infections caused by bacteria producing one or more beta-lactamase enzymes.
  • compositions and methods disclosed herein are also effective in preventing or treating infections caused by bacteria that are considered to be less or not susceptible to one or more of known antibacterial agents or their known compositions.
  • bacteria known to have developed resistance to various antibacterial agents include Acinetobacter, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterobacter, Klebsiella, Citrobacter and a like.
  • MIC minimum inhibitory concentrations
  • MHA Muller Hinton Agar
  • CLSI Clinical and Laboratory Standards Institute
  • CFU colony forming units
  • Formula (I) exhibited antibacterial activity against resistant bacterial strains.
  • Sterile aztreonam was aseptically blended or mixed with sterile compound of Formula (I) for about 30 minutes at 8 rpm to obtain sterile dry powder for injection (compositions shown in Table 1). Each single vial of this formulation may be reconstituted with suitable reconstitution diluent prior to administration.

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Abstract

L'invention concerne des compositions pharmaceutiques comprenant au moins un agent antibactérien ou un dérivé pharmaceutiquement acceptable de celui-ci, et un composé de formule (I), ou un stéréoisomère, ou un dérivé pharmaceutiquement acceptable de celui-ci. (Formule I) (I)
PCT/IB2018/052650 2017-04-18 2018-04-17 Compositions anti-bactériennes Ceased WO2018193369A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013149121A1 (fr) * 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. Inhibiteurs de la 1,3,4-oxadiazole et de la 1,3,4-thiadiazole bêta-lactamase
US20150111864A1 (en) * 2013-10-02 2015-04-23 Cubist Pharmaceuticals, Inc. Crystalline form of a beta-lactamase inhibitor
WO2015159263A1 (fr) * 2014-04-18 2015-10-22 Wockhardt Limited Compositions pharmaceutiques comprenant des agents antibactériens
WO2017216765A1 (fr) * 2016-06-17 2017-12-21 Wockhardt Limited Compositions anti-bactériennes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013149121A1 (fr) * 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. Inhibiteurs de la 1,3,4-oxadiazole et de la 1,3,4-thiadiazole bêta-lactamase
US20150111864A1 (en) * 2013-10-02 2015-04-23 Cubist Pharmaceuticals, Inc. Crystalline form of a beta-lactamase inhibitor
WO2015159263A1 (fr) * 2014-04-18 2015-10-22 Wockhardt Limited Compositions pharmaceutiques comprenant des agents antibactériens
WO2017216765A1 (fr) * 2016-06-17 2017-12-21 Wockhardt Limited Compositions anti-bactériennes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GILMAN ET AL.: "Goodman and Gilman's: The Pharmacological Basis of Therapeutics", 1990, PERGAMON PRESS
S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19

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