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WO2018199303A1 - Sheet preparation containing miconazole and/or miconazole nitrate - Google Patents

Sheet preparation containing miconazole and/or miconazole nitrate Download PDF

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Publication number
WO2018199303A1
WO2018199303A1 PCT/JP2018/017251 JP2018017251W WO2018199303A1 WO 2018199303 A1 WO2018199303 A1 WO 2018199303A1 JP 2018017251 W JP2018017251 W JP 2018017251W WO 2018199303 A1 WO2018199303 A1 WO 2018199303A1
Authority
WO
WIPO (PCT)
Prior art keywords
miconazole
mass
polyoxyethylene
sheet
sterilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/017251
Other languages
French (fr)
Japanese (ja)
Inventor
祥平 小山
卓弥 菅
祐子 金光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Kanae Technos Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Kanae Technos Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd, Kanae Technos Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Priority to JP2019514665A priority Critical patent/JP7030110B2/en
Publication of WO2018199303A1 publication Critical patent/WO2018199303A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to a wiping sheet for pharmaceuticals, quasi-drugs, or cosmetics, in which an aqueous liquid antifungal agent containing miconazole is impregnated, and for wiping in which adsorption of miconazole to the base fabric is suppressed.
  • this invention relates to the aqueous liquid antifungal agent composition for wiping containing miconazole, and relates to the liquid agent which uses a composition as an active ingredient, and its manufacturing method.
  • Miconazole which is an azole antifungal agent, is widely used as an antifungal component for pharmaceuticals, quasi drugs and the like.
  • An antimicrobial cellulose sheet for paper towels containing a lotion composition that can contain miconazole as an antibacterial agent has also been proposed (see, for example, Patent Document 1).
  • a wiping sheet in which an aqueous solution containing miconazole as an antifungal component is supported on a base fabric is not disclosed.
  • an object of the present invention is to provide a sheet that can suppress the adsorption of miconazole to the base fabric and has an excellent feeling of use.
  • the present inventors have obtained an aqueous solution containing miconazole and a nonionic surfactant from specific amounts of isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben. It was found that by adding at least one phenol selected from the group consisting of, the adsorption of miconazole to the base fabric was kept low even with a low amount of nonionic surfactant, and the present invention was completed. It was.
  • the present invention [1] A sheet in which a disinfectant is carried on a base fabric made of a fiber material,
  • the sterilizing and disinfecting solution comprises 0.01 to 1% by mass of an antifungal component containing miconazole and / or miconazole nitrate, 0.1 to 10% by mass of nonionic surfactant and isopropyl based on the total mass of the disinfecting solution.
  • the nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene polyoxypropylene alkyl.
  • the sheet according to [1] or [2] above which is at least one selected from the group consisting of ether, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester and polyglycerin fatty acid ester, [4]
  • the sterilizing / disinfecting solution further contains an amino acid, and the content thereof is 0.005 to 5% by mass based on the total mass of the disinfecting solution.
  • a sheet according to claim 1 [5]
  • the sheet according to [4], wherein the amino acid is at least one selected from the group consisting of lysine, arginine, histidine, and hydrochlorides thereof.
  • the present invention further includes (1) a liquid containing miconazole, which has an effect of suppressing the adsorption of miconazole to the base fabric.
  • the liquid comprises 0.01 to 1% by weight of an antifungal component containing miconazole and / or miconazole nitrate, 0.1 to 10% by weight of a nonionic surfactant and isopropylmethylphenol, based on the total weight of the liquid,
  • a liquid which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben,
  • the nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene polyoxypropylene alkyl.
  • the liquid according to (1) which is at least one selected from the group consisting of ether, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, and polyglycerin fatty acid ester, (3)
  • the liquid according to (1) or (2), wherein the pH of the liquid is adjusted to 5 to 8.
  • the pH of the liquid also relates to the liquid described in (3) or (4) above, which is adjusted to 4 to 9.
  • the present invention further relates to a disinfecting solution in which an amino acid is blended and a sheet in which the disinfecting solution is supported on a base fabric.
  • a disinfecting solution in which an amino acid is blended and a sheet in which the disinfecting solution is supported on a base fabric.
  • the present invention is a sheet for pharmaceuticals, quasi-drugs or cosmetics in which a sterilizing and disinfecting liquid is supported on a base fabric composed of a fiber material,
  • the sterilizing and disinfecting solution is based on the total mass of the disinfecting solution, 0.01 to 1% by mass of an antifungal component containing miconazole, 0.1 to 10% by mass of a nonionic surfactant, isopropylmethylphenol, triclosan,
  • the present invention relates to a sheet which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of salicylic acid, methyl paraben, ethyl paraben and propyl paraben.
  • the fiber material in the base fabric composed of the fiber material that can be used in the present invention natural fibers such as cotton, hemp, silk, wool, synthetic fibers such as rayon, polyester, acrylic, polyethylene, nylon, polyethylene terephthalate, Examples thereof include materials composed of cellulose fibers such as pulp, or fibers obtained by mixing these fibers.
  • the base fabric include paper, nonwoven fabrics, towels, and fabrics composed of these fiber materials.
  • Preferred base fabrics are soft and soft paper, nonwoven fabric and the like.
  • Preferable examples include a non-woven fabric composed of cotton, a non-woven fabric composed of 70% rayon and 30% polyethylene terephthalate, and the like, and a non-woven fabric composed of 100% cotton that is soft and soft to the skin is preferred.
  • seat of this invention is comprised by carrying
  • the sterilizing / disinfecting solution that can be used in the present invention contains an azole antifungal agent, preferably miconazole, as an antifungal component. Unless otherwise specified, in this specification, when it is simply described as miconazole, it means any one selected from miconazole, miconazole nitrate and miconazole nitrate, or a mixture thereof.
  • the azole antifungal agents include miconazole, clotrimazole, econazole, thioconazole, oxyconazole, fluconazole, itraconazole, ketoconazole, croconazole, neticonazole, isconazole, sulconazole, bifonazole, nanoconazole, luriconazole and salts thereof.
  • the salt include nitrates and hydrochlorides.
  • the antifungal component can include, for example, at least one of the azole antifungal agents described above.
  • the antifungal component is contained in an amount of 0.01 to 1% by mass, preferably 0.01 to 0.75% by mass, more preferably 0.04 to 0.5% by mass, based on the total mass of the sterilizing solution. obtain.
  • the antifungal component is miconazole, it is 0.01 to 1% by weight, preferably 0.01 to 0.5% by weight, more preferably 0.02 to 0.2%, based on the total weight of the sterilizing solution. It may contain mass%.
  • the sterilizing liquid which can be used in the present invention contains a nonionic surfactant.
  • the nonionic active agent is not particularly limited as long as the nonionic active agent having an HLB of 10 or more is capable of solubilizing an antifungal component, and can be appropriately selected according to the purpose.
  • the nonionic surfactant one of the above listed types can be used alone, or two or more kinds can be mixed and used.
  • polyoxyethylene hydrogenated castor oil examples include, for example, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (30) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, and polyoxyethylene (50). Examples include hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, and polyoxyethylene (100) hydrogenated castor oil.
  • NIKKOL HCO-60 manufactured by Nikko Chemicals Co., Ltd., polyoxyethylene hydrogenated castor oil (PEG-60 hydrogenated castor oil), HLB: 14.0), NIKKOL HCO-40 (Nikko Chemicals Co., Ltd.) Company-made polyoxyethylene hydrogenated castor oil (PEG-40 hydrogenated castor oil), HLB: 12.5) and the like can also be used.
  • polyoxyethylene sorbitan fatty acid ester examples include, for example, polyoxyethylene sorbitan monolaurate (Tween 20), polyoxyethylene sorbitan monopalmitate (Tween 40), polyoxyethylene sorbitan monostearate (Tween 60) and poly Examples thereof include oxyethylene sorbitan monooleate (Tween 80).
  • Nonoxy LT-221 manufactured by NOF Corporation, polyoxyethylene sorbitan monolaurate (20E.O.), HLB: 16.7, NIKKOL TL-10 (manufactured by Nikko Chemicals Corporation), as polyoxyethylene sorbitan fatty acid ester Polyoxyethylene coconut oil fatty acid sorbitan (20E.O.), HLB: 16.9) and the like can also be used.
  • polyoxyethylene sorbite fatty acid ester examples include, for example, polyoxyethylene sorbit laurate, polyoxyethylene sorbite tetrastearate, polyoxyethylene sorbite tetraoleate, polyoxyethylene sorbite tetraisostearate and polyoxyethylene sorbite Examples thereof include oxyethylene sorbite pentaoleate.
  • polyglyceryl fatty acid ester examples include polyglyceryl monolaurate, polyglyceryl monostearate, polyglyceryl isostearate, polyglyceryl distearate, polyglyceryl monooleate, polyglyceryl dioleate, and decaglyceryl monomyristate.
  • polyoxyethylene glycerin fatty acid ester examples include polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl triisostearate, polyoxyethylene glyceryl laurate, and glyceryl polyoxyethylene oleate.
  • polyoxyethylene sterol examples include, for example, polyoxyethylene phytosterol.
  • polyoxyethylene alkyl ether examples include polyoxyethylene lauryl ether, polyoxyethylene cetyl ether and polyoxyethylene oleyl ether.
  • polyoxyethylene polyoxypropylene alkyl ether examples include polyoxyethylene polyoxypropylene stearyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether and polyoxyethylene polyoxypropylene cetyl ether.
  • Unisafe 34S-23 manufactured by NOF Corporation, polyoxyethylene polyoxypropylene stearyl ether, HLB: 10.8 or the like can also be used as the polyoxyethylene polyoxypropylene alkyl ether.
  • polyethylene glycol fatty acid ester examples include polyethylene glycol monolaurate, polyethylene glycol monostearate and polyethylene glycol monooleate.
  • the nonionic surfactant may be contained in an amount of 0.1 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 0.1 to 3% by weight, based on the total weight of the sterilizing liquid.
  • the nonionic surfactant is polyoxyethylene hydrogenated castor oil, preferably polyoxyethylene (60) hydrogenated castor oil, 0.1 to 10% by mass, preferably 0.
  • the content may be 1 to 5% by mass, more preferably 0.1 to 3% by mass.
  • the sterilizing / disinfecting solution that can be used in the present invention contains at least one phenol selected from the group consisting of isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben. These phenols can be used alone or in combination.
  • isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben are used to reduce the adsorption rate of miconazole to the base fabric, but are themselves fungicides, and therefore It can also function effectively in terms of adding a bactericidal action to the sheet.
  • the phenols may be included in an amount of 0.01 to 1% by mass, preferably 0.01 to 0.6% by mass, more preferably 0.01 to 0.4% by mass, based on the total mass of the sterilizing solution. .
  • the phenol is isopropylmethylphenol, triclosan, ethylparaben or propylparaben, 0.01 to 0.5% by mass, preferably 0.01 to 0.3% by mass, respectively, based on the total mass of the sterilizing solution. %, More preferably 0.01 to 0.2% by mass.
  • the phenol is salicylic acid or methylparaben, it contains 0.02 to 1% by mass, preferably 0.03 to 1% by mass, more preferably 0.05 to 1% by mass, based on the total mass of the sterilizing solution. obtain.
  • the phenols that can be used in the present invention are not limited to the above specific phenols, and phenols having a water solubility of 3 g / L or less can also be used. When such phenols are used, for example, phenols having a water solubility of 2.5 g / L or less and phenols having a water solubility of 0.5 g / L or less are preferable.
  • 0.01 to 1% by mass preferably 0.01 to 0.6% by mass, more preferably, based on the total mass of the sterilizing solution. It may be included in an amount of 0.01 to 0.4% by mass.
  • an aliphatic alcohol can be used instead of or in addition to phenols.
  • the aliphatic alcohol that can be used in this case include aliphatic alcohols having 2 to 8 carbon atoms, specifically, ethanol, propanol, isopropanol, butanol, octanol and the like, and ethanol is preferable.
  • the aliphatic alcohol is used to reduce the adsorption rate of miconazole to the base fabric, but is itself a bactericidal agent, and therefore also in terms of adding a bactericidal action to the sheet of the present invention. Can function effectively.
  • the sheet of the present invention has an effect of imparting a refreshing feeling, quick drying property, and miconazole solubility improvement.
  • the aliphatic alcohol may comprise 10 to 80% by weight, preferably 20 to 60% by weight, more preferably 20 to 40% by weight, based on the total weight of the sterilizing solution.
  • Preferred amounts for ethanol may comprise 10 to 60% by weight, preferably 20 to 50% by weight, more preferably 20 to 40% by weight, based on the total weight of the sterilizing solution.
  • the seat of the present invention may be used other than the human body, for example, a bed, a table, a chair, a wheelchair, a cane, a floor, a handrail, sandals, slippers, a urinal, a toilet, various care products, various medical devices, and other wet tissues. It is also useful as a miscellaneous goods.
  • the sterilizing / disinfecting solution that can be used in the present invention may further contain an amino acid.
  • Amino acids alone do not reduce the adsorption rate of miconazole to the base fabric, but when combined with a nonionic surfactant, and further combined with phenols, enhances the decrease in the adsorption rate of miconazole. be able to.
  • pH 4 to 7, preferably pH 5 to 6 the effect of enhancing the adsorption suppression of amino acids by the above combination is noticeable.
  • the amino acid for example, a basic amino acid is preferable, and specific examples include lysine, arginine, histidine, and hydrochlorides thereof.
  • amino acid one of the above-described amino acids can be used alone, or two or more of them can be used in combination.
  • the blending amount when amino acids are used is 0.01 to 1% by mass, preferably 0.01 to 0.3% by mass, more preferably 0.01 to 0%, based on the total mass of the sterilizing solution. It may contain 2% by weight.
  • the blending amount is 0.01 to 0.5% by mass, preferably 0.01 to 0.1% by mass, more preferably 0, based on the total mass of the sterilizing solution. 0.01 to 0.05% by mass.
  • the disinfectant solution that can be used in the present invention may further contain a miconazole solvent.
  • the solvent is not particularly limited as long as miconazole is dissolved and the effects of the present invention are not hindered, and examples thereof include diols.
  • the diols include butanediol, propanediol (1,3-propanediol, 1,2-propanediol), pentanediol, hexanediol, and octanediol. 1,2-propanediol (propylene Glycol) is preferred.
  • the blending amount may be 1 to 10% by mass, preferably 2 to 10% by mass, more preferably 3 to 10% by mass based on the total mass of the sterilizing liquid.
  • the blending amount when the diol is propylene glycol is 1 to 10% by mass, preferably 2 to 10% by mass, more preferably 3%, based on the total mass of the sterilizing liquid. To 10% by weight.
  • the sterilizing and disinfecting liquid that can be used in the present invention is an active ingredient such as a moisturizer, a refreshing agent, an anti-inflammatory agent, an ultraviolet absorber, an antioxidant, an antiseptic, as long as the purpose of the present invention is not impaired in addition to the components described above. Further, chelating agents, pH adjusters, solubilizers, solubilizers, stabilizers, fragrances, pigments, and the like can be blended. Furthermore, the sterilizing / disinfecting solution that can be used in the present invention contains water as a solvent in addition to the components described above. As water, purified water can be used. The amount of water contained in the sterilizing / disinfecting solution is usually a balance obtained by subtracting the total amount of each component described above from 100% by mass. The amount of water contained in the sterilizing / disinfecting solution is usually about 50 to 95% by mass, preferably about 85 to 95% by mass, based on the total mass of the sterilizing / disinfecting solution.
  • the sterilizing / disinfecting solution that can be used in the present invention is prepared, for example, by mixing the above-described components in water such as purified water and performing the treatment such as heating and stirring as necessary to dissolve the above-described components. obtain.
  • the obtained sterilizing / disinfecting liquid can be adjusted to a desired pH by adding a pH adjusting agent as necessary.
  • a pH adjusting agent organic acids and organic acid salts having a buffering action are generally used. Specifically, for example, citric acid, sodium citrate, anhydrous citric acid, succinic acid, phosphoric acid and the like can be used.
  • seat of this invention can be manufactured by impregnating the base fabric comprised from the fiber material with the disinfection liquid.
  • the amount of the sterilizing / disinfecting solution impregnated in the base fabric made of the fiber material is usually 2 to 4 times, preferably 3 to 4 times the mass of the base fabric.
  • the antiseptic solution that can be used in the present invention is at least one selected from the group consisting of an antifungal component containing miconazole, a nonionic surfactant, and isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben. If the pH of the disinfectant solution is adjusted to 5 to 8, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 30% or less.
  • Preferred antiseptic solutions that can be used in the present invention include antifungal components containing miconazole, polyoxyethylene (60) hydrogenated castor oil as a nonionic surfactant, and antiseptic solutions containing isopropylmethylphenol as phenols, If the pH of the disinfectant is adjusted to 6 to 8, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 20% or less.
  • the antiseptic solution that can be used in the present invention is at least one selected from the group consisting of an antifungal component containing miconazole, a nonionic surfactant, isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben.
  • an antifungal component containing miconazole a nonionic surfactant
  • isopropylmethylphenol triclosan
  • salicylic acid methylparaben
  • methylparaben ethylparaben
  • propylparaben propylparaben.
  • Another fungicidal solution that can be used in the present invention is an antifungal component containing miconazole, polyoxyethylene (60) hydrogenated castor oil as a nonionic surfactant, isopropylmethylphenol as a phenol, and arginine as an amino acid. If the pH of the disinfectant is adjusted to 5 to 9, preferably 5 to 6, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 20% or less. . Adjusting the pH to 5 to 6 is also preferable from the viewpoint of suppressing irritation to the skin.
  • the sheet of the present invention is useful as a miscellaneous product such as a sheet for pharmaceuticals, quasi-drugs or cosmetics or wet tissue because it can suppress the adsorption of miconazole to the base fabric and thereby effectively exert a bactericidal disinfection effect. is there.
  • the present invention is also a liquid that suppresses adsorption of miconazole to the base fabric,
  • the liquid comprises 0.01 to 1% by weight of an antifungal component containing miconazole, 0.1 to 10% by weight of a nonionic surfactant, and isopropylmethylphenol, triclosan, salicylic acid, methylparaben based on the total weight of the liquid.
  • the present invention also relates to a liquid which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of ethylparaben and propylparaben.
  • the liquid that suppresses the adsorption of miconazole on the base fabric of the present invention can be the same aqueous solution as the above-described sterilizing liquid. Therefore, the components that can be included in the liquid, the content of the components, etc. For this reason, the same as described above can be employed.
  • Examples of the liquid dosage form that suppresses the adsorption of miconazole to the base fabric of the present invention include a liquid agent.
  • a liquid agent the aspect which filled the liquid of this invention, ie, the above-mentioned disinfection liquid, for example in the container made from a synthetic resin, is mentioned.
  • the liquid agent is used in the above-described manner, it can be used by impregnating the base fabric with the liquid of the present invention in a container.
  • surfactant A to surfactant E, PG, IPMP and PET mean the following.
  • Surfactant A Polyoxyethylene hydrogenated castor oil (PEG-60 hydrogenated castor oil) (HLB: 14.0)
  • Surfactant B Polyoxyethylene hydrogenated castor oil (PEG-40 hydrogenated castor oil) (HLB: 12.5)
  • Surfactant C Polyoxyethylene sorbitan monolaurate (20E.O.) (HLB: 16.7)
  • Surfactant D Polyoxyethylene coconut oil fatty acid sorbitan (20E.O.) (HLB: 16.9)
  • Surfactant E Polyoxyethylene polyoxypropylene stearyl ether (HLB: 10.8)
  • PG Propylene glycol IPMP: Isopropyl methylphenol PET: Polyethylene terephthalate
  • Test Example 1 Effect of blending amount of nonionic surfactant A sterilizing / disinfecting solution was prepared with the blending amounts shown in Table 1, and the nonwoven fabric (cotton 100%) had a mass 3.5 times the mass of the nonwoven fabric. Sheets of Formulation Examples 1 to 6 were manufactured by impregnation with a sterilizing and disinfecting solution. After impregnating the base fabric with a sterilizing and disinfecting solution and storing it in a closed system for at least 12 hours so as not to dry, the sterilizing and disinfecting solution was squeezed out from the base fabric, and miconazole in the solution was quantified. The determination of miconazole was performed by a conventional method using liquid chromatography. The adsorption rate (%) of miconazole in each sheet was measured.
  • the adsorption rate (%) of miconazole is a value calculated by the following calculation formula.
  • Adsorption rate (%) 100 ⁇ (total amount of miconazole contained in the squeezed liquid (quantitative value) / total amount of miconazole contained in the liquid impregnated in the sheet (quantitative value) ⁇ 100)
  • MCI minimum inhibitory concentration test
  • Test Example 2 Effect of pH Sheets of Formulation Examples 7 to 11 in which the pH of the bactericidal disinfectant having the same blending ratio as Formulation Example 3 was adjusted were manufactured, and the adsorption rate (%) of miconazole was measured. (Measurement method is the same as Test Example 1) The results are summarized in Table 2. Results: In the neutral to weakly acidic region, the adsorption rate (%) of miconazole was kept low.
  • Test Example 3 Effect of blending with phenols, etc.
  • a sterilizing and disinfecting solution having the same blending ratio as Formulation Example 10 except that 0.1% by mass of isopropylmethylphenol, triclosan, salicylic acid, methylparaben or propylparaben is blended.
  • the sheets of Formulation Example 12 to Formulation Example 16 were produced, and the adsorption rate (%) of miconazole was measured and compared with the sheet of Formulation Example 10.
  • the results are shown in Table 3.
  • IPMP isopropylmethylphenol
  • Test Example 5 Influence of Amino Acid (L-Arginine) Formulation Formulation Example 21 which is a sterilizing / disinfecting solution having the same blending ratio and the same pH as Formulation Examples 8, 10, and 11 except that 0.02% by mass of L-arginine was blended Or the sheet
  • Test Example 6 Effect of combined use of phenols (isopropylmethylphenol (IPMP)) and amino acid (L-arginine) Formulation Example 12 and Formulation Examples 18 to 20 (Isopropylmethyl) except that 0.02% by mass of L-arginine was blended (Including phenol) at a blending ratio similar to that of Formulation Examples 24 to 29, which are sterilizing / disinfecting solutions having pH of 4.0, 5.0, 6.0, 7.0, 8.0, and 9.0. Sheets were produced, and the adsorption rate (%) of miconazole was measured and compared with the sheets of Formulation Example 12 and Formulation Examples 18-20. (Measurement method is the same as Test Example 1) The results are shown in Table 6.
  • IPMP isopropylmethylphenol
  • L-arginine amino acid
  • Test Example 7 Influence of amino acid type Except for changing L-arginine to lysine, the same blending ratio and the same pH as in Blending Example 22 (not including isopropylmethylphenol) and Blending Example 27 (including isopropylmethylphenol) Formulation Example 30 and Formulation 31 sheets that are sterilizing disinfectants, and Formulation Example 22 (not including isopropylmethylphenol) and Formulation Example 27 (including isopropylmethylphenol) except that L-arginine was changed to histidine, The sheet
  • Test Example 8 Effect of Nonionic Surfactant Type Surfactant A (nonionic surfactant) was changed to various other nonionic surfactants (surfactant B or surfactant E) and nonion
  • the sheets of Formulation Examples 34, 36, 38 and 40 which are sterilizing and disinfecting solutions having the same blending ratio and the same pH as Formulation Example 10 (not including isopropylmethylphenol and amino acids) except that the amount of the surfactant is changed
  • a sheet of Formulation Examples 35, 37, 39 and 41 which is a sterilizing and disinfecting solution having the same composition ratio and the same pH as Formulation Example 27 (including isopropylmethylphenol and amino acids), was produced, and the adsorption rate of miconazole (% ) was measured.
  • Test Example 9 Examination of Nonwoven Material Material Examples 10, 12, 15, and 16 except that the nonwoven material was changed from a 100% cotton nonwoven fabric to a nonwoven fabric made of 70% rayon and 30% polyethylene terephthalate, and the nonwoven fabric was changed. The same mixing ratio and the same pH as the sterilizing / disinfecting solution, but the same as the mixing examples 10, 12, 15 and 16 except that the sheets and nonwoven fabrics of the mixing examples 42 to 45 were changed and the pH was 5.0. Sheets of Formulation Example 46 to Formulation 49, which are sterilizing / disinfecting liquids at a blending ratio, were manufactured, and the adsorption rate (%) of miconazole on these nonwoven fabrics was measured. (Measurement method is the same as Test Example 1) The results are shown in Table 9.

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Abstract

[Problem] To provide a sheet that contains miconazole and/or miconazole nitrate. [Solution] A sheet that comprises a base fabric formed of a fiber material and a germicidal disinfectant solution held on the base fabric, wherein the germicidal disinfectant solution is an aqueous solution containing, relative to the total mass of the disinfectant solution, 0.01-1 mass% of an antifungal component comprising miconazole and/or miconazole nitrate, 0.1-10 mass% of a nonionic surfactant, and 0.01-1 mass% of one or more kinds of phenols selected from the group consisting of isopropyl methyl phenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben.

Description

ミコナゾール及び／又は硝酸ミコナゾールを含むシート製剤Sheet preparation containing miconazole and / or miconazole nitrate

　本発明は、ミコナゾールを含む水性液体抗真菌剤を基布に含浸させてなる医薬品、医薬部外品又は化粧品用の清拭用シートに関し、ミコナゾールの基布への吸着が抑制された清拭用シートに関する。
　また、本発明は、ミコナゾールを含む清拭用の水性液体抗真菌剤組成物に関し、組成物を有効成分とする液剤およびその製造方法に関する。 The present invention relates to a wiping sheet for pharmaceuticals, quasi-drugs, or cosmetics, in which an aqueous liquid antifungal agent containing miconazole is impregnated, and for wiping in which adsorption of miconazole to the base fabric is suppressed. Regarding the sheet.
Moreover, this invention relates to the aqueous liquid antifungal agent composition for wiping containing miconazole, and relates to the liquid agent which uses a composition as an active ingredient, and its manufacturing method.

　アゾール系抗真菌剤であるミコナゾールは、医薬品、医薬部外品等の抗真菌成分として広範に使用されている。
　また、抗菌剤としてミコナゾールを含み得るローション組成物を含むペーパータオル用の抗菌セルロースシートも提案されている（例えば、特許文献１参照）。
　しかし、抗真菌成分としてミコナゾールを含有する水性溶液を基布に担持させた清拭用シートは開示されていない。 Miconazole, which is an azole antifungal agent, is widely used as an antifungal component for pharmaceuticals, quasi drugs and the like.
An antimicrobial cellulose sheet for paper towels containing a lotion composition that can contain miconazole as an antibacterial agent has also been proposed (see, for example, Patent Document 1).
However, a wiping sheet in which an aqueous solution containing miconazole as an antifungal component is supported on a base fabric is not disclosed.

特表２００９－５１９０５５号公報Special table 2009-519055 gazette

　本発明者らは、ミコナゾールを含む抗真菌成分を含有する水性溶液を、繊維材料から構成された基布に担持させてシートとしたところ、ミコナゾールが基布に吸着されて基布から溶出され難くなり、十分な抗真菌活性を発揮できないという問題が生じることが分った。
　上記の問題は、ミコナゾールを含む抗真菌成分を含有する水性溶液に、ノニオン界面活性剤を配合することにより解消することを見出したが、一方で、ノニオン界面活性剤の配合量を増加するとべたつきが発生して使用感が悪くなり、また、コスト高になるという新たな問題が発生した。嗜好性が求められる化粧品等においては、べたつきを最小限に留め使用感を向上させる必要がある。 When the present inventors made an aqueous solution containing an antifungal component containing miconazole on a base fabric composed of a fiber material to form a sheet, miconazole was adsorbed on the base fabric and hardly eluted from the base fabric. As a result, it has been found that there is a problem that sufficient antifungal activity cannot be exhibited.
It has been found that the above problem can be solved by adding a nonionic surfactant to an aqueous solution containing an antifungal component containing miconazole. On the other hand, when the amount of the nonionic surfactant is increased, stickiness is increased. A new problem has arisen in that the feeling of use deteriorates and the cost increases. In cosmetics and the like that require palatability, it is necessary to minimize stickiness and improve the feeling of use.

　従って、本発明は、上記の問題を解決し得る、即ち、ミコナゾールを含有する水性溶液を繊維材料から構成された基布に担持させてなるシートであって、ノニオン界面活性剤の低い配合量においても、ミコナゾールの基布への吸着を低く抑え得る、使用感に優れるシートの提供を課題とする。 Therefore, the present invention can solve the above-described problem, that is, a sheet obtained by supporting an aqueous solution containing miconazole on a base fabric composed of a fiber material, and having a low nonionic surfactant content. However, an object of the present invention is to provide a sheet that can suppress the adsorption of miconazole to the base fabric and has an excellent feeling of use.

　本発明者らは、上記課題を解決するために鋭意検討した結果、ミコナゾール及びノニオン界面活性剤を含有する水性溶液に、特定量のイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を配合することにより、ノニオン界面活性剤の低い配合量においても、ミコナゾールの基布への吸着が低く抑えられることを見出し、本発明を完成させた。 As a result of intensive studies to solve the above-mentioned problems, the present inventors have obtained an aqueous solution containing miconazole and a nonionic surfactant from specific amounts of isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben. It was found that by adding at least one phenol selected from the group consisting of, the adsorption of miconazole to the base fabric was kept low even with a low amount of nonionic surfactant, and the present invention was completed. It was.

　すなわち本発明は、
［１］繊維材料から構成された基布に殺菌消毒液が担持されてなるシートであって、
　前記殺菌消毒液は、該消毒液の総質量に基づいて、ミコナゾール及び／又は硝酸ミコナゾールを含む抗真菌成分を０．０１ないし１質量％、ノニオン界面活性剤を０．１ないし１０質量％及びイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を０．０１ないし１質量％含有する水性溶液であるシート、
［２］前記シートが医薬品、医薬部外品又は化粧品用のシートである前記［１］記載のシート。
［３］前記ノニオン界面活性剤は、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンステロール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル及びポリグリセリン脂肪酸エステルからなる群から選択される少なくとも１種以上である前記［１］又は前記［２］記載のシート、
［４］前記殺菌消毒液は、更に、アミノ酸を含有し、その含有量は、前記消毒液の総質量に基づいて、０．００５ないし５質量％である前記［１］～［３］のいずれか１つに記載のシート、
［５］前記アミノ酸は、リシン、アルギニン、ヒスチジン及びそれらの塩酸塩からなる群から選択される少なくとも１種以上である前記［４］記載のシート、
［６］前記消毒液のｐＨは、５ないし８に調整されてなる前記［１］～［３］のいずれか１つに記載のシート、
［７］前記消毒液のｐＨは、４ないし９に調整されてなる前記［４］又は前記［５］記載のシート、
に関する。 That is, the present invention
[1] A sheet in which a disinfectant is carried on a base fabric made of a fiber material,
The sterilizing and disinfecting solution comprises 0.01 to 1% by mass of an antifungal component containing miconazole and / or miconazole nitrate, 0.1 to 10% by mass of nonionic surfactant and isopropyl based on the total mass of the disinfecting solution. A sheet which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of methylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben,
[2] The sheet according to [1], wherein the sheet is a sheet for pharmaceuticals, quasi drugs, or cosmetics.
[3] The nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene polyoxypropylene alkyl. The sheet according to [1] or [2] above, which is at least one selected from the group consisting of ether, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester and polyglycerin fatty acid ester,
[4] The sterilizing / disinfecting solution further contains an amino acid, and the content thereof is 0.005 to 5% by mass based on the total mass of the disinfecting solution. Or a sheet according to claim 1,
[5] The sheet according to [4], wherein the amino acid is at least one selected from the group consisting of lysine, arginine, histidine, and hydrochlorides thereof.
[6] The sheet according to any one of [1] to [3], wherein the pH of the disinfectant is adjusted to 5 to 8.
[7] The sheet according to [4] or [5], wherein the pH of the disinfectant is adjusted to 4 to 9.
About.

　本発明は、更に
（１）ミコナゾールを含有する液体であって、ミコナゾールの基布への吸着を抑制する効果を有する。
　前記液体は、該液体の総質量に基づいて、ミコナゾール及び／又は硝酸ミコナゾールを含む抗真菌成分を０．０１ないし１質量％、ノニオン界面活性剤を０．１ないし１０質量％及びイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を０．０１ないし１質量％含有する水性溶液である液体、
（２）前記ノニオン界面活性剤は、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンステロール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル及びポリグリセリン脂肪酸エステルからなる群から選択される少なくとも１種以上である前記（１）記載の液体、
（３）前記液体は、更に、アミノ酸を含有し、その含有量は、前記液体の総質量に基づいて、０．００５ないし５質量％である前記（１）又は前記（２）記載の液体、
（４）前記アミノ酸は、リシン、アルギニン、ヒスチジン及びそれらの塩酸塩からなる群から選択される少なくとも１種以上である前記（３）記載の液体、
（５）前記液体のｐＨは、５ないし８に調整されてなる前記（１）又は前記（２）記載の液体、
（６）前記液体のｐＨは、４ないし９に調整されてなる前記（３）又は前記（４）記載の液体
にも関する。 The present invention further includes (1) a liquid containing miconazole, which has an effect of suppressing the adsorption of miconazole to the base fabric.
The liquid comprises 0.01 to 1% by weight of an antifungal component containing miconazole and / or miconazole nitrate, 0.1 to 10% by weight of a nonionic surfactant and isopropylmethylphenol, based on the total weight of the liquid, A liquid which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben,
(2) The nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene polyoxypropylene alkyl. The liquid according to (1), which is at least one selected from the group consisting of ether, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, and polyglycerin fatty acid ester,
(3) The liquid according to (1) or (2), wherein the liquid further contains an amino acid, and the content is 0.005 to 5% by mass based on the total mass of the liquid,
(4) The liquid according to (3), wherein the amino acid is at least one selected from the group consisting of lysine, arginine, histidine, and hydrochlorides thereof.
(5) The liquid according to (1) or (2), wherein the pH of the liquid is adjusted to 5 to 8.
(6) The pH of the liquid also relates to the liquid described in (3) or (4) above, which is adjusted to 4 to 9.

　本発明のシート、液体組成物、水性液体抗真菌剤は、コットンやセルロースなど基布に含浸した場合でもミコナゾールが基布に吸着し難く、有効に抗真菌・抗菌活性を発揮するという利点を有する。また、中性から弱酸性で優れた抗真菌・抗菌活性を発揮し、清拭に使用するに際して、皮膚に対して低刺激性でべたつきが少ない。本発明は、少なくとも、これらの一つ以上の効果を発揮する。
　また、本発明のシートにおける消毒液（ミコナゾール、ノニオン界面活性剤及びフェノール類を含む）は、ｐＨ＝５～８の範囲において、ミコナゾールの基布に対する吸着率を低く、例えば、３０％以下に抑えることができる。 The sheet, liquid composition, and aqueous liquid antifungal agent of the present invention have the advantage that miconazole is hardly adsorbed on the base fabric even when impregnated on the base fabric such as cotton and cellulose, and effectively exhibits antifungal and antibacterial activity. . In addition, it is neutral to weakly acidic and exhibits excellent antifungal and antibacterial activity. When used for wiping, it is less irritating to the skin and less sticky. The present invention exhibits at least one or more of these effects.
Further, the disinfectant solution (including miconazole, nonionic surfactant and phenols) in the sheet of the present invention has a low adsorption rate of miconazole to the base fabric in the range of pH = 5 to 8, for example, 30% or less. be able to.

　また、本発明は、更に、アミノ酸が配合された消毒液および該消毒液を基布に担持させたシートにも関するが、このようにアミノ酸を配合することにより、該消毒液は、ｐＨ＝４～９という広い範囲においても、ミコナゾールの基布に対する吸着率を低く、例えば、３０％以下に抑えることができる。 Further, the present invention further relates to a disinfecting solution in which an amino acid is blended and a sheet in which the disinfecting solution is supported on a base fabric. By blending an amino acid in this way, the disinfecting solution has a pH of 4 Even in a wide range of ˜9, the adsorption rate of miconazole on the base fabric can be low, for example, 30% or less.

　本発明のミコナゾールの基布への吸着を抑制する液体は、該液体を基布に含浸させた際、該液体中のミコナゾールが基布に吸着し難く、容易に溶出するという利点を有する。
　また、本発明のミコナゾールの基布への吸着を抑制する液体は、ｐＨ＝５～８の範囲において、ミコナゾールの基布に対する吸着率を低く、例えば、３０％以下に抑えることができ、また、アミノ酸を配合することにより、ｐＨ＝４～９という広い範囲においても、ミコナゾールの基布に対する吸着率を低く、例えば、３０％以下に抑えることができる。 The liquid that suppresses the adsorption of miconazole on the base fabric of the present invention has the advantage that when the liquid is impregnated with the liquid, the miconazole in the liquid is difficult to adsorb on the base fabric and easily elutes.
Further, the liquid that suppresses the adsorption of miconazole to the base fabric of the present invention has a low adsorption rate to the base fabric of miconazole in the range of pH = 5 to 8, and can be suppressed to, for example, 30% or less. By incorporating an amino acid, the adsorption rate of miconazole on the base fabric can be kept low, for example, 30% or less, even in a wide range of pH = 4-9.

　更に詳細に本発明を説明する。
　本発明は、繊維材料から構成された基布に殺菌消毒液が担持されてなる医薬品、医薬部外品又は化粧品用のシートであって、
　前記殺菌消毒液は、該消毒液の総質量に基づいて、ミコナゾールを含む抗真菌成分を０．０１ないし１質量％、ノニオン界面活性剤を０．１ないし１０質量％及びイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を０．０１ないし１質量％含有する水性溶液であるシートに関する。 The present invention will be described in more detail.
The present invention is a sheet for pharmaceuticals, quasi-drugs or cosmetics in which a sterilizing and disinfecting liquid is supported on a base fabric composed of a fiber material,
The sterilizing and disinfecting solution is based on the total mass of the disinfecting solution, 0.01 to 1% by mass of an antifungal component containing miconazole, 0.1 to 10% by mass of a nonionic surfactant, isopropylmethylphenol, triclosan, The present invention relates to a sheet which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of salicylic acid, methyl paraben, ethyl paraben and propyl paraben.

　本発明に使用し得る繊維材料から構成された基布における繊維材料としては、コットン、麻、絹、羊毛などの天然繊維、レーヨン、ポリエステル、アクリル、ポリエチレン、ナイロン、ポリエチレンテレフタラートなどの合成繊維、パルプなどのセルロース繊維、又はこれら繊維を混用した繊維からなる材料が挙げられ、基布としては、これらの繊維材料から構成された紙、不織布、タオル、布などが挙げられる。好ましい基布は、柔らかく肌触りのよい紙、不織布等である。
　好ましくは、コットンから構成された不織布、レーヨン７０％及びポリエチレンテレフタラート３０％から構成された不織布等が挙げられ、また、柔らかく肌触りが良く肌に優しいコットン１００％から構成された不織布が好ましい。 As the fiber material in the base fabric composed of the fiber material that can be used in the present invention, natural fibers such as cotton, hemp, silk, wool, synthetic fibers such as rayon, polyester, acrylic, polyethylene, nylon, polyethylene terephthalate, Examples thereof include materials composed of cellulose fibers such as pulp, or fibers obtained by mixing these fibers. Examples of the base fabric include paper, nonwoven fabrics, towels, and fabrics composed of these fiber materials. Preferred base fabrics are soft and soft paper, nonwoven fabric and the like.
Preferable examples include a non-woven fabric composed of cotton, a non-woven fabric composed of 70% rayon and 30% polyethylene terephthalate, and the like, and a non-woven fabric composed of 100% cotton that is soft and soft to the skin is preferred.

　本発明のシートは、基布に殺菌消毒液を担持させることにより構成される。
　本発明に使用し得る殺菌消毒液は、抗真菌成分として、アゾール系抗真菌剤、好ましくはミコナゾールを含有する。本明細書において、特に断らない限り、単にミコナゾールと記載した場合、ミコナゾール、硝酸ミコナゾールおよびミコナゾール硝酸塩から選択されるいずれか、またはそれらの混合物を意味するものとする。
　上記のアゾール系抗真菌剤としては、例えば、ミコナゾール、クロトリマゾール、エコナゾール、チオコナゾール、オキシコナゾール、フルコナゾール、イトラコナゾール、ケトコナゾール、クロコナゾール、ネチコナゾール、イソコナゾール、スルコナゾール、ビフォナゾール、ナノコナゾール、ルリコナゾールおよびそれらの塩等が挙げられ、前記塩としては、硝酸塩、塩酸塩等が挙げられる。
　上記の抗真菌成分は、ミコナゾール以外に、例えば上記のアゾール系抗真菌剤の少なくとも１つ以上を含むことができる。
　抗真菌成分は、殺菌消毒液の総質量に基づいて、０．０１ないし１質量％、好ましくは、０．０１ないし０．７５質量％、より好ましくは、０．０４ないし０．５質量％含み得る。
　抗真菌成分がミコナゾールの場合、殺菌消毒液の総質量に基づいて、０．０１ないし１質量％、好ましくは、０．０１ないし０．５質量％、より好ましくは、０．０２ないし０．２質量％含み得る。 The sheet | seat of this invention is comprised by carrying | supporting a disinfection liquid on a base fabric.
The sterilizing / disinfecting solution that can be used in the present invention contains an azole antifungal agent, preferably miconazole, as an antifungal component. Unless otherwise specified, in this specification, when it is simply described as miconazole, it means any one selected from miconazole, miconazole nitrate and miconazole nitrate, or a mixture thereof.
Examples of the azole antifungal agents include miconazole, clotrimazole, econazole, thioconazole, oxyconazole, fluconazole, itraconazole, ketoconazole, croconazole, neticonazole, isconazole, sulconazole, bifonazole, nanoconazole, luriconazole and salts thereof. Examples of the salt include nitrates and hydrochlorides.
In addition to miconazole, the antifungal component can include, for example, at least one of the azole antifungal agents described above.
The antifungal component is contained in an amount of 0.01 to 1% by mass, preferably 0.01 to 0.75% by mass, more preferably 0.04 to 0.5% by mass, based on the total mass of the sterilizing solution. obtain.
When the antifungal component is miconazole, it is 0.01 to 1% by weight, preferably 0.01 to 0.5% by weight, more preferably 0.02 to 0.2%, based on the total weight of the sterilizing solution. It may contain mass%.

　本発明に使用し得る殺菌消毒液は、ノニオン界面活性剤を含有する。
　前記ノニオン活性剤は抗真菌成分を可溶化することができる点で、ＨＬＢが１０以上のノニオン活性剤であれば、特に制限はなく、目的に応じて適宜選択することができ、例えば、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンステロール、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル等が挙げられる。
　上記ノニオン界面活性剤は、上記に列挙した１種類を単独で使用することもできるが、２種以上を混合して使用することもできる。 The sterilizing liquid which can be used in the present invention contains a nonionic surfactant.
The nonionic active agent is not particularly limited as long as the nonionic active agent having an HLB of 10 or more is capable of solubilizing an antifungal component, and can be appropriately selected according to the purpose. Ethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether And polyethylene glycol fatty acid esters.
As the nonionic surfactant, one of the above listed types can be used alone, or two or more kinds can be mixed and used.

　ポリオキシエチレン硬化ヒマシ油の具体例としては、例えば、ポリオキシエチレン(２０)硬化ヒマシ油、ポリオキシエチレン(３０)硬化ヒマシ油、ポリオキシエチレン(４０)硬化ヒマシ油、ポリオキシエチレン(５０)硬化ヒマシ油、ポリオキシエチレン(６０)硬化ヒマシ油、ポリオキシエチレン(８０)硬化ヒマシ油及びポリオキシエチレン(１００)硬化ヒマシ油等が挙げられる。
　ポリオキシエチレン硬化ヒマシ油として、ＮＩＫＫＯＬ　ＨＣＯ－６０（日光ケミカルズ株式会社製、ポリオキシエチレン硬化ヒマシ油（ＰＥＧ－６０　水添ヒマシ油）、ＨＬＢ：１４．０）、ＮＩＫＫＯＬ　ＨＣＯ－４０（日光ケミカルズ株式会社製、ポリオキシエチレン硬化ヒマシ油（ＰＥＧ－４０　水添ヒマシ油）、ＨＬＢ：１２．５）等を用いることもできる。 Specific examples of the polyoxyethylene hydrogenated castor oil include, for example, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (30) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, and polyoxyethylene (50). Examples include hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, and polyoxyethylene (100) hydrogenated castor oil.
As polyoxyethylene hydrogenated castor oil, NIKKOL HCO-60 (manufactured by Nikko Chemicals Co., Ltd., polyoxyethylene hydrogenated castor oil (PEG-60 hydrogenated castor oil), HLB: 14.0), NIKKOL HCO-40 (Nikko Chemicals Co., Ltd.) Company-made polyoxyethylene hydrogenated castor oil (PEG-40 hydrogenated castor oil), HLB: 12.5) and the like can also be used.

　ポリオキシエチレンソルビタン脂肪酸エステルの具体例としては、例えば、ポリオキシエチレンソルビタンモノラウリン酸エステル（Ｔｗｅｅｎ２０）、ポリオキシエチレンソルビタンモノパルミチン酸エステル（Ｔｗｅｅｎ４０）、ポリオキシエチレンソルビタンモノステアリン酸エステル（Ｔｗｅｅｎ６０）及びポリオキシエチレンソルビタンモノオレイン酸エステル（Ｔｗｅｅｎ８０）等が挙げられる。
　ポリオキシエチレンソルビタン脂肪酸エステルとして、ノニオン　ＬＴ－２２１（日油株式会社製、モノラウリン酸ポリオキシエチレンソルビタン（２０Ｅ．Ｏ．）、ＨＬＢ：１６．７）、ＮＩＫＫＯＬ　ＴＬ－１０（日光ケミカルズ株式会社製、ポリオキシエチレンヤシ油脂肪酸ソルビタン（２０Ｅ．Ｏ．）、ＨＬＢ：１６．９）等を用いることもできる。 Specific examples of the polyoxyethylene sorbitan fatty acid ester include, for example, polyoxyethylene sorbitan monolaurate (Tween 20), polyoxyethylene sorbitan monopalmitate (Tween 40), polyoxyethylene sorbitan monostearate (Tween 60) and poly Examples thereof include oxyethylene sorbitan monooleate (Tween 80).
Nonoxy LT-221 (manufactured by NOF Corporation, polyoxyethylene sorbitan monolaurate (20E.O.), HLB: 16.7), NIKKOL TL-10 (manufactured by Nikko Chemicals Corporation), as polyoxyethylene sorbitan fatty acid ester Polyoxyethylene coconut oil fatty acid sorbitan (20E.O.), HLB: 16.9) and the like can also be used.

　ポリオキシエチレンソルビット脂肪酸エステルの具体例としては、例えば、ポリオキシエチレンソルビットラウリン酸エステル、ポリオキシエチレンソルビットテトラステアリン酸エステル、ポリオキシエチレンソルビットテトラオレイン酸エステル、ポリオキシエチレンソルビットテトライソステアリン酸エステル及びポリオキシエチレンソルビットペンタオレイン酸エステル等が挙げられる。 Specific examples of the polyoxyethylene sorbite fatty acid ester include, for example, polyoxyethylene sorbit laurate, polyoxyethylene sorbite tetrastearate, polyoxyethylene sorbite tetraoleate, polyoxyethylene sorbite tetraisostearate and polyoxyethylene sorbite Examples thereof include oxyethylene sorbite pentaoleate.

　ポリグリセリン脂肪酸エステルの具体例としては、例えば、モノラウリン酸ポリグリセリル、モノステアリン酸ポリグリセリル、イソステアリン酸ポリグリセリル、ジステアリン酸ポリグリセリル、モノオレイン酸ポリグリセリル、ジオレイン酸ポリグリセリル及びモノミリスチン酸デカグリセリル等が挙げられる。 Specific examples of the polyglyceryl fatty acid ester include polyglyceryl monolaurate, polyglyceryl monostearate, polyglyceryl isostearate, polyglyceryl distearate, polyglyceryl monooleate, polyglyceryl dioleate, and decaglyceryl monomyristate.

　ポリオキシエチレングリセリン脂肪酸エステルの具体例としては、例えば、イソステアリン酸ポリオキシエチレングリセリル、トリイソステアリン酸ポリオキシエチレングリセリル、ラウリン酸ポリオキシエチレングリセリル及びポリオキシエチレンオレイン酸グリセリル等が挙げられる。 Specific examples of the polyoxyethylene glycerin fatty acid ester include polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl triisostearate, polyoxyethylene glyceryl laurate, and glyceryl polyoxyethylene oleate.

　ポリオキシエチレンステロールの具体例としては、例えば、ポリオキシエチレンフィトステロール等が挙げられる。 Specific examples of polyoxyethylene sterol include, for example, polyoxyethylene phytosterol.

　ポリオキシエチレンアルキルエーテルの具体例としては、例えば、ポリオキシエチレンラウリルエーテル、ポリオキシエチレンセチルエーテル及びポリオキシエチレンオレイルエーテル等が挙げられる。 Specific examples of the polyoxyethylene alkyl ether include polyoxyethylene lauryl ether, polyoxyethylene cetyl ether and polyoxyethylene oleyl ether.

　ポリオキシエチレンポリオキシプロピレンアルキルエーテルの具体例としては、例えば、ポリオキシエチレンポリオキシプロピレンステアリルエーテル、ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル及びポリオキシエチレンポリオキシプロピレンセチルエーテル等が挙げられる。
　ポリオキシエチレンポリオキシプロピレンアルキルエーテルとして、ユニセーフ３４Ｓ－２３（日油株式会社製、ポリオキシエチレンポリオキシプロピレンステアリルエーテル、ＨＬＢ：１０．８）等を用いることもできる。 Specific examples of the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene polyoxypropylene stearyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether and polyoxyethylene polyoxypropylene cetyl ether.
Unisafe 34S-23 (manufactured by NOF Corporation, polyoxyethylene polyoxypropylene stearyl ether, HLB: 10.8) or the like can also be used as the polyoxyethylene polyoxypropylene alkyl ether.

　ポリエチレングリコール脂肪酸エステルの具体例としては、例えば、モノラウリン酸ポリエチレングリコール、モノステアリン酸ポリエチレングリコール及びモノオレイン酸ポリエチレングリコール等が挙げられる。
　ノニオン界面活性剤は、殺菌消毒液の総質量に基づいて、０．１ないし１０質量％、好ましくは、０．１ないし５質量％、より好ましくは、０．１ないし３質量％含み得る。
　ノニオン界面活性剤がポリオキシエチレン硬化ヒマシ油、好ましくはポリオキシエチレン(６０)硬化ヒマシ油の場合は、殺菌消毒液の総質量に基づいて、０．１ないし１０質量％、好ましくは、０．１ないし５質量％、より好ましくは、０．１ないし３質量％含み得る。 Specific examples of the polyethylene glycol fatty acid ester include polyethylene glycol monolaurate, polyethylene glycol monostearate and polyethylene glycol monooleate.
The nonionic surfactant may be contained in an amount of 0.1 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 0.1 to 3% by weight, based on the total weight of the sterilizing liquid.
When the nonionic surfactant is polyoxyethylene hydrogenated castor oil, preferably polyoxyethylene (60) hydrogenated castor oil, 0.1 to 10% by mass, preferably 0. The content may be 1 to 5% by mass, more preferably 0.1 to 3% by mass.

　本発明に使用し得る殺菌消毒液は、イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも１種以上のフェノール類を含有する。該フェノール類は、単独で用いることも、複数を組み合わせて用いることもできる。
　本発明において、イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンは、ミコナゾールの基布への吸着率を低下させるために用いられるが、それ自体が殺菌剤であり、そのため、本発明のシートに殺菌作用を追加するという点においても有効に機能し得る。
　フェノール類は、殺菌消毒液の総質量に基づいて、０．０１ないし１質量％、好ましくは、０．０１ないし０．６質量％、より好ましくは、０．０１ないし０．４質量％含み得る。
　フェノール類がイソプロピルメチルフェノール、トリクロサン、エチルパラベンまたはプロピルパラベンの場合、殺菌消毒液の総質量に基づいて、それぞれ、０．０１ないし０．５質量％、好ましくは、０．０１ないし０．３質量％、より好ましくは、０．０１ないし０．２質量％含み得る。フェノール類がサリチル酸またはメチルパラベンの場合、殺菌消毒液の総質量に基づいて、０．０２ないし１質量％、好ましくは、０．０３ないし１質量％、より好ましくは、０．０５ないし１質量％含み得る。 The sterilizing / disinfecting solution that can be used in the present invention contains at least one phenol selected from the group consisting of isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben. These phenols can be used alone or in combination.
In the present invention, isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben are used to reduce the adsorption rate of miconazole to the base fabric, but are themselves fungicides, and therefore It can also function effectively in terms of adding a bactericidal action to the sheet.
The phenols may be included in an amount of 0.01 to 1% by mass, preferably 0.01 to 0.6% by mass, more preferably 0.01 to 0.4% by mass, based on the total mass of the sterilizing solution. .
When the phenol is isopropylmethylphenol, triclosan, ethylparaben or propylparaben, 0.01 to 0.5% by mass, preferably 0.01 to 0.3% by mass, respectively, based on the total mass of the sterilizing solution. %, More preferably 0.01 to 0.2% by mass. When the phenol is salicylic acid or methylparaben, it contains 0.02 to 1% by mass, preferably 0.03 to 1% by mass, more preferably 0.05 to 1% by mass, based on the total mass of the sterilizing solution. obtain.

　本発明に使用し得るフェノール類としては、上記の特定のフェノール類に限らず、水への溶解度が３ｇ／Ｌ以下となるフェノール類を使用することもできる。
　このようなフェノール類を使用する場合、例えば、水への溶解度が２．５ｇ／Ｌ以下となるフェノール類や、水への溶解度が０．５ｇ／Ｌ以下となるフェノール類が好ましい。
　上記のようなフェノール類を用いる場合も、該フェノール類を殺菌消毒液の総質量に基づいて、０．０１ないし１質量％、好ましくは、０．０１ないし０．６質量％、より好ましくは、０．０１ないし０．４質量％含み得る。 The phenols that can be used in the present invention are not limited to the above specific phenols, and phenols having a water solubility of 3 g / L or less can also be used.
When such phenols are used, for example, phenols having a water solubility of 2.5 g / L or less and phenols having a water solubility of 0.5 g / L or less are preferable.
When using the above phenols, 0.01 to 1% by mass, preferably 0.01 to 0.6% by mass, more preferably, based on the total mass of the sterilizing solution. It may be included in an amount of 0.01 to 0.4% by mass.

　また、本発明の殺菌消毒液には、フェノール類に代えて、あるいは、フェノール類に加えて脂肪族アルコールを使用することができる。この際に使用できる脂肪族アルコールとしては、炭素数２～８の脂肪族アルコール、具体的には、エタノール、プロパノール、イソプロパノール、ブタノール、オクタノール等が挙げられ、エタノールが好ましい。
　本発明において、脂肪族アルコールは、ミコナゾールの基布への吸着率を低下させるために用いられるが、それ自体が殺菌剤であり、そのため、本発明のシートに殺菌作用を追加するという点においても有効に機能し得る。また、本発明のシートに清涼感、速乾性及びミコナゾールの溶解性の向上を与えるという効果も有する。
　脂肪族アルコールは、殺菌消毒液の総質量に基づいて、１０ないし８０質量％、好ましくは、２０ないし６０質量％、より好ましくは、２０ないし４０質量％含み得る。
　エタノールについての好ましい量は、殺菌消毒液の総質量に基づいて、１０ないし６０質量％、好ましくは、２０ないし５０質量％、より好ましくは、２０ないし４０質量％含み得る。
　また、本発明のシートは、人体以外の例えば、ベッド、テーブル、椅子、車いす、杖、床、手すり、サンダル、スリッパ、尿器、便器、各種介護用品、各種医療機器、その他に用いるウェットティッシュなどの雑貨としても有用である。 In the sterilizing / disinfecting solution of the present invention, an aliphatic alcohol can be used instead of or in addition to phenols. Examples of the aliphatic alcohol that can be used in this case include aliphatic alcohols having 2 to 8 carbon atoms, specifically, ethanol, propanol, isopropanol, butanol, octanol and the like, and ethanol is preferable.
In the present invention, the aliphatic alcohol is used to reduce the adsorption rate of miconazole to the base fabric, but is itself a bactericidal agent, and therefore also in terms of adding a bactericidal action to the sheet of the present invention. Can function effectively. In addition, the sheet of the present invention has an effect of imparting a refreshing feeling, quick drying property, and miconazole solubility improvement.
The aliphatic alcohol may comprise 10 to 80% by weight, preferably 20 to 60% by weight, more preferably 20 to 40% by weight, based on the total weight of the sterilizing solution.
Preferred amounts for ethanol may comprise 10 to 60% by weight, preferably 20 to 50% by weight, more preferably 20 to 40% by weight, based on the total weight of the sterilizing solution.
In addition, the seat of the present invention may be used other than the human body, for example, a bed, a table, a chair, a wheelchair, a cane, a floor, a handrail, sandals, slippers, a urinal, a toilet, various care products, various medical devices, and other wet tissues. It is also useful as a miscellaneous goods.

　本発明に使用し得る殺菌消毒液は、更に、アミノ酸を含有し得る。
　アミノ酸は、単体では、ミコナゾールの基布への吸着率を低下させるものではないが、ノニオン性界面活性剤と組み合わせることにより、さらに、フェノール類と組み合わせることにより、ミコナゾールの吸着率の低下を増強することができる。特に弱酸性領域、ｐＨ４～７、好ましくは、ｐＨ５～６において、前記組み合わせによるアミノ酸の吸着抑制増強効果が顕著に認められる。
　アミノ酸としては、例えば、塩基性アミノ酸が好ましく、具体的にはリシン、アルギニン、ヒスチジン及びそれらの塩酸塩等が挙げられる。
　上記アミノ酸は、上記に列挙した１種類を単独で使用することもできるが、２種以上を混合して使用することもできる。
　アミノ酸を使用する場合の配合量は、殺菌消毒液の総質量に基づいて、０．０１ないし１質量％、好ましくは、０．０１ないし０．３質量％、より好ましくは、０．０１ないし０．２質量％含み得る。
　アミノ酸としてアルギニンを使用する場合の配合量は、殺菌消毒液の総質量に基づいて、０．０１ないし０．５質量％、好ましくは、０．０１ないし０．１質量％、より好ましくは、０．０１ないし０．０５質量％含み得る。 The sterilizing / disinfecting solution that can be used in the present invention may further contain an amino acid.
Amino acids alone do not reduce the adsorption rate of miconazole to the base fabric, but when combined with a nonionic surfactant, and further combined with phenols, enhances the decrease in the adsorption rate of miconazole. be able to. Particularly in the weakly acidic region, pH 4 to 7, preferably pH 5 to 6, the effect of enhancing the adsorption suppression of amino acids by the above combination is noticeable.
As the amino acid, for example, a basic amino acid is preferable, and specific examples include lysine, arginine, histidine, and hydrochlorides thereof.
As the amino acid, one of the above-described amino acids can be used alone, or two or more of them can be used in combination.
The blending amount when amino acids are used is 0.01 to 1% by mass, preferably 0.01 to 0.3% by mass, more preferably 0.01 to 0%, based on the total mass of the sterilizing solution. It may contain 2% by weight.
When arginine is used as the amino acid, the blending amount is 0.01 to 0.5% by mass, preferably 0.01 to 0.1% by mass, more preferably 0, based on the total mass of the sterilizing solution. 0.01 to 0.05% by mass.

　本発明に使用し得る殺菌消毒液は、更に、ミコナゾールの溶剤を含有し得る。該溶剤は、ミコナゾールが溶解し、本発明の効果を妨げない限り、特に限定されないが、例えばジオール類が挙げられる。
　上記ジオール類としては、例えば、ブタンジオール、プロパンジオール（１，３－プロパンジオール、１，２－プロパンジオール）、ペンタンジオール、ヘキサンジオールまたはオクタンジオール等が挙げられ、１，２－プロパンジオール（プロピレングリコール）が好ましい。
　ジオール類を使用する場合の配合量は、殺菌消毒液の総質量に基づいて、１ないし１０質量％、好ましくは、２ないし１０質量％、より好ましくは、３ないし１０質量％含み得る。
　ジオール類を使用する場合で、ジオール類がプロピレングリコールの場合の配合量は、殺菌消毒液の総質量に基づいて、１ないし１０質量％、好ましくは、２ないし１０質量％、より好ましくは、３ないし１０質量％含み得る。 The disinfectant solution that can be used in the present invention may further contain a miconazole solvent. The solvent is not particularly limited as long as miconazole is dissolved and the effects of the present invention are not hindered, and examples thereof include diols.
Examples of the diols include butanediol, propanediol (1,3-propanediol, 1,2-propanediol), pentanediol, hexanediol, and octanediol. 1,2-propanediol (propylene Glycol) is preferred.
When the diol is used, the blending amount may be 1 to 10% by mass, preferably 2 to 10% by mass, more preferably 3 to 10% by mass based on the total mass of the sterilizing liquid.
When diols are used, the blending amount when the diol is propylene glycol is 1 to 10% by mass, preferably 2 to 10% by mass, more preferably 3%, based on the total mass of the sterilizing liquid. To 10% by weight.

　本発明に使用し得る殺菌消毒液は、上述した成分以外に、本発明の目的を損なわない範囲で、保湿剤、清涼剤、消炎剤などの有効成分、紫外線吸収剤、抗酸化剤、防腐剤、キレート剤、ｐＨ調整剤、可溶化剤、溶解補助剤、安定化剤、香料、色素等を配合する事もできる。
　さらに、本発明に使用し得る殺菌消毒液は、上述した成分以外に、溶媒として水を含む。
　水としては、精製水を用いることができる。殺菌消毒液中に含まれる水の量は、通常、上述した各成分の合計量を１００質量％から差し引いた残部である。
　殺菌消毒液に含まれる水の量は、通常、殺菌消毒液の総質量に基づいて、５０ないし９５質量％程度、好ましくは８５ないし９５質量％程度となる。 The sterilizing and disinfecting liquid that can be used in the present invention is an active ingredient such as a moisturizer, a refreshing agent, an anti-inflammatory agent, an ultraviolet absorber, an antioxidant, an antiseptic, as long as the purpose of the present invention is not impaired in addition to the components described above. Further, chelating agents, pH adjusters, solubilizers, solubilizers, stabilizers, fragrances, pigments, and the like can be blended.
Furthermore, the sterilizing / disinfecting solution that can be used in the present invention contains water as a solvent in addition to the components described above.
As water, purified water can be used. The amount of water contained in the sterilizing / disinfecting solution is usually a balance obtained by subtracting the total amount of each component described above from 100% by mass.
The amount of water contained in the sterilizing / disinfecting solution is usually about 50 to 95% by mass, preferably about 85 to 95% by mass, based on the total mass of the sterilizing / disinfecting solution.

　本発明に使用し得る殺菌消毒液は、例えば、精製水等の水に上記の成分を混合し、必要に応じて加熱、攪拌等の処理を行って、上記の成分を溶解することにより調製され得る。
　得られた殺菌消毒液は、必要に応じてｐＨ調整剤を添加して所望のｐＨに調整し得る。
　ｐＨ調整剤は、緩衝作用のある有機酸及び有機酸塩類が一般に用いられる。具体的には例えば、クエン酸、クエン酸ナトリウム、無水クエン酸、コハク酸、リン酸等を用いることができる。
　殺菌消毒液を、繊維材料から構成された基布に含浸させることにより、本発明のシートを製造することができる。
　繊維材料から構成された基布に含浸される殺菌消毒液の量は、通常、基布の質量の２ないし４倍、好ましくは３ないし４倍の質量である。 The sterilizing / disinfecting solution that can be used in the present invention is prepared, for example, by mixing the above-described components in water such as purified water and performing the treatment such as heating and stirring as necessary to dissolve the above-described components. obtain.
The obtained sterilizing / disinfecting liquid can be adjusted to a desired pH by adding a pH adjusting agent as necessary.
As the pH adjusting agent, organic acids and organic acid salts having a buffering action are generally used. Specifically, for example, citric acid, sodium citrate, anhydrous citric acid, succinic acid, phosphoric acid and the like can be used.
The sheet | seat of this invention can be manufactured by impregnating the base fabric comprised from the fiber material with the disinfection liquid.
The amount of the sterilizing / disinfecting solution impregnated in the base fabric made of the fiber material is usually 2 to 4 times, preferably 3 to 4 times the mass of the base fabric.

　本発明に使用し得る殺菌消毒液が、ミコナゾールを含む抗真菌成分、ノニオン界面活性剤及び、イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を含む場合、該消毒液のｐＨを、５ないし８に調整すれば、ミコナゾールの基布への吸着を低く、例えばミコナゾールの吸着率を３０％以下に抑えることができる。また、ミコナゾールの吸着率を２０％以下に抑えることが好ましく、ミコナゾールの吸着率を１０％以下に抑えることが更に好ましい。
　本発明に使用し得る好ましい殺菌消毒液として、ミコナゾールを含む抗真菌成分、ノニオン界面活性剤としてポリオキシエチレン（６０）硬化ヒマシ油及び、フェノール類としてイソプロピルメチルフェノールを含む殺菌消毒液が挙げられ、該消毒液のｐＨを、６ないし８に調整すれば、ミコナゾールの基布への吸着を低く、例えばミコナゾールの吸着率を２０％以下に抑えることができる。
　また、本発明に使用し得る殺菌消毒液が、ミコナゾールを含む抗真菌成分、ノニオン界面活性剤、イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類及びアミノ酸を含む場合、該消毒液のｐＨを、４ないし９に調整すれば、ミコナゾールの基布への吸着を低く、例えばミコナゾールの吸着率を３０％以下に抑えることができる。また、ミコナゾールの吸着率を２０％以下に抑えることが好ましく、ミコナゾールの吸着率を１０％以下に抑えることが更に好ましい。
　本発明に使用し得る別の殺菌消毒液として、ミコナゾールを含む抗真菌成分、ノニオン界面活性剤としてポリオキシエチレン（６０）硬化ヒマシ油、フェノール類としてイソプロピルメチルフェノール、及びアミノ酸としてアルギニンを含む殺菌消毒液が挙げられ、該消毒液のｐＨを、５ないし９、好ましくは５ないし６に調整すれば、ミコナゾールの基布への吸着を低く、例えばミコナゾールの吸着率を２０％以下に抑えることができる。ｐＨを５ないし６に調製することは、皮膚に対する刺激性を抑える観点からも好ましい。 The antiseptic solution that can be used in the present invention is at least one selected from the group consisting of an antifungal component containing miconazole, a nonionic surfactant, and isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben. If the pH of the disinfectant solution is adjusted to 5 to 8, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 30% or less. Moreover, it is preferable to suppress the adsorption rate of miconazole to 20% or less, and it is further preferable to suppress the adsorption rate of miconazole to 10% or less.
Preferred antiseptic solutions that can be used in the present invention include antifungal components containing miconazole, polyoxyethylene (60) hydrogenated castor oil as a nonionic surfactant, and antiseptic solutions containing isopropylmethylphenol as phenols, If the pH of the disinfectant is adjusted to 6 to 8, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 20% or less.
Further, the antiseptic solution that can be used in the present invention is at least one selected from the group consisting of an antifungal component containing miconazole, a nonionic surfactant, isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben, and propylparaben. In the case of containing the above phenols and amino acids, if the pH of the disinfectant is adjusted to 4 to 9, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 30% or less. Moreover, it is preferable to suppress the adsorption rate of miconazole to 20% or less, and it is further preferable to suppress the adsorption rate of miconazole to 10% or less.
Another fungicidal solution that can be used in the present invention is an antifungal component containing miconazole, polyoxyethylene (60) hydrogenated castor oil as a nonionic surfactant, isopropylmethylphenol as a phenol, and arginine as an amino acid. If the pH of the disinfectant is adjusted to 5 to 9, preferably 5 to 6, the adsorption of miconazole to the base fabric can be lowered, for example, the adsorption rate of miconazole can be suppressed to 20% or less. . Adjusting the pH to 5 to 6 is also preferable from the viewpoint of suppressing irritation to the skin.

　本発明のシートは、ミコナゾールの基布への吸着を抑制し、それにより有効に殺菌消毒効果を発揮し得るため、医薬品、医薬部外品又は化粧品用のシート又はウェットティッシュなどの雑貨として有用である。 The sheet of the present invention is useful as a miscellaneous product such as a sheet for pharmaceuticals, quasi-drugs or cosmetics or wet tissue because it can suppress the adsorption of miconazole to the base fabric and thereby effectively exert a bactericidal disinfection effect. is there.

　本発明はまた、ミコナゾールの基布への吸着を抑制する液体であって、
　前記液体は、該液体の総質量に基づいて、ミコナゾールを含む抗真菌成分を０．０１ないし１質量％、ノニオン界面活性剤を０．１ないし１０質量％及びイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも1種以上のフェノール類を０．０１ないし１質量％含有する水性溶液である液体にも関する。 The present invention is also a liquid that suppresses adsorption of miconazole to the base fabric,
The liquid comprises 0.01 to 1% by weight of an antifungal component containing miconazole, 0.1 to 10% by weight of a nonionic surfactant, and isopropylmethylphenol, triclosan, salicylic acid, methylparaben based on the total weight of the liquid. The present invention also relates to a liquid which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of ethylparaben and propylparaben.

　本発明のミコナゾールの基布への吸着を抑制する液体は、上述の殺菌消毒液と同一の水性溶液であり得、そのため、該液体に含み得る成分、成分の含有量等は、殺菌消毒液のための上記記載と同様のものを採用することができる。 The liquid that suppresses the adsorption of miconazole on the base fabric of the present invention can be the same aqueous solution as the above-described sterilizing liquid. Therefore, the components that can be included in the liquid, the content of the components, etc. For this reason, the same as described above can be employed.

　本発明のミコナゾールの基布への吸着を抑制する液体の剤形としては、例えば液剤が挙げられる。
　液剤としては、本発明の液体、即ち、上述の殺菌消毒液を、例えば、合成樹脂製の容器に充填した態様が挙げられる。
　液剤を上記の態様で使用する場合、容器内の本発明の液体を基布に含浸させて使用することができる。 Examples of the liquid dosage form that suppresses the adsorption of miconazole to the base fabric of the present invention include a liquid agent.
As a liquid agent, the aspect which filled the liquid of this invention, ie, the above-mentioned disinfection liquid, for example in the container made from a synthetic resin, is mentioned.
When the liquid agent is used in the above-described manner, it can be used by impregnating the base fabric with the liquid of the present invention in a container.

　以下、実施例を挙げて、本発明をより具体的に説明するが、本発明は下記の実施例に限定されるものではない。
　尚、実施例中の記載において、界面活性剤Ａないし界面活性剤Ｅ、ＰＧ、ＩＰＭＰ及びＰＥＴは以下を意味する。
界面活性剤Ａ：ポリオキシエチレン硬化ヒマシ油（ＰＥＧ－６０　水添ヒマシ油）（ＨＬＢ：１４．０）
界面活性剤Ｂ：ポリオキシエチレン硬化ヒマシ油（ＰＥＧ－４０　水添ヒマシ油）（ＨＬＢ：１２．５）
界面活性剤Ｃ：モノラウリン酸ポリオキシエチレンソルビタン（２０Ｅ．Ｏ．）（ＨＬＢ：１６．７）
界面活性剤Ｄ：ポリオキシエチレンヤシ油脂肪酸ソルビタン（２０Ｅ．Ｏ．）（ＨＬＢ：１６．９）
界面活性剤Ｅ：ポリオキシエチレンポリオキシプロピレンステアリルエーテル（ＨＬＢ：１０．８）
ＰＧ：プロピレングリコール
ＩＰＭＰ：イソプロピルメチルフェノール
ＰＥＴ：ポリエチレンテレフタラート EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated more concretely, this invention is not limited to the following Example.
In the description of the examples, surfactant A to surfactant E, PG, IPMP and PET mean the following.
Surfactant A: Polyoxyethylene hydrogenated castor oil (PEG-60 hydrogenated castor oil) (HLB: 14.0)
Surfactant B: Polyoxyethylene hydrogenated castor oil (PEG-40 hydrogenated castor oil) (HLB: 12.5)
Surfactant C: Polyoxyethylene sorbitan monolaurate (20E.O.) (HLB: 16.7)
Surfactant D: Polyoxyethylene coconut oil fatty acid sorbitan (20E.O.) (HLB: 16.9)
Surfactant E: Polyoxyethylene polyoxypropylene stearyl ether (HLB: 10.8)
PG: Propylene glycol IPMP: Isopropyl methylphenol PET: Polyethylene terephthalate

試験例１：ノニオン系界面活性剤の配合量の影響
　表１に記載される配合量で殺菌消毒液を調製し、不織布（コットン１００％）に、該不織布の質量の３．５倍の質量の殺菌消毒液を含浸させて配合例１ないし配合例６のシートを製造した。基布に殺菌消毒液を含浸させた後、乾燥しないように密閉系で少なくとも１２時間以上保存した後に、基布から殺菌消毒液を搾出し、液中のミコナゾールを定量した。ミコナゾールの定量は、液体クロマトグラフィーを用いて、常法にて行った。
　各シートにおけるミコナゾールの吸着率（％）を測定した。
　尚、ミコナゾールの吸着率（％）は、以下の計算式によって計算した値である。
吸着率（％）＝１００－（絞り液中に含まれるミコナゾールの総量（定量値）／シートに含浸させた液中に含まれるミコナゾールの総量（定量値）×１００）
　また、殺菌消毒液の抗菌作用、抗真菌作用は、最小発育阻止濃度試験（ＭＣＩ）により評価した。
　結果を表１に纏めた。
　尚、表中の各成分の量は、殺菌消毒液の総質量に基づく質量％を表す。

Figure JPOXMLDOC01-appb-T000001
結果：表１より、ノニオン系界面活性剤（界面活性剤Ａ：ポリオキシエチレン硬化ヒマシ油（ＰＥＧ－６０　水添ヒマシ油））の配合量を増やすことで、ミコナゾールの基布（不織布）への吸着率（％）を抑制できることが分った。しかし、ノニオン系界面活性剤の配合量を増やすとべたつきが生じた。
　また、搾出した殺菌消毒液が抗真菌・抗菌活性を有することをＭＩＣ法により確認した。 Test Example 1: Effect of blending amount of nonionic surfactant A sterilizing / disinfecting solution was prepared with the blending amounts shown in Table 1, and the nonwoven fabric (cotton 100%) had a mass 3.5 times the mass of the nonwoven fabric. Sheets of Formulation Examples 1 to 6 were manufactured by impregnation with a sterilizing and disinfecting solution. After impregnating the base fabric with a sterilizing and disinfecting solution and storing it in a closed system for at least 12 hours so as not to dry, the sterilizing and disinfecting solution was squeezed out from the base fabric, and miconazole in the solution was quantified. The determination of miconazole was performed by a conventional method using liquid chromatography.
The adsorption rate (%) of miconazole in each sheet was measured.
In addition, the adsorption rate (%) of miconazole is a value calculated by the following calculation formula.
Adsorption rate (%) = 100− (total amount of miconazole contained in the squeezed liquid (quantitative value) / total amount of miconazole contained in the liquid impregnated in the sheet (quantitative value) × 100)
Moreover, the antibacterial action and antifungal action of the bactericidal disinfectant were evaluated by a minimum inhibitory concentration test (MCI).
The results are summarized in Table 1.
In addition, the quantity of each component in a table | surface represents the mass% based on the total mass of a disinfection liquid.
Figure JPOXMLDOC01-appb-T000001
 Results: From Table 1, by increasing the amount of nonionic surfactant (Surfactant A: polyoxyethylene hydrogenated castor oil (PEG-60 hydrogenated castor oil)), miconazole was added to the base fabric (nonwoven fabric). It was found that the adsorption rate (%) can be suppressed. However, stickiness occurred when the amount of the nonionic surfactant was increased.
Further, it was confirmed by the MIC method that the sterilized antiseptic solution extracted had antifungal and antibacterial activities.

試験例２：ｐＨの影響
　配合例３と同様の配合割合の殺菌消毒液のｐＨを種々調整した配合例７ないし配合例１１のシートを製造し、ミコナゾールの吸着率（％）を測定した。（測定方法は、試験例１と同じ）
　結果を表２に纏めた。

Figure JPOXMLDOC01-appb-T000002
結果：中性ないし弱酸性領域では、ミコナゾールの吸着率（％）は低く抑えられた。 Test Example 2: Effect of pH Sheets of Formulation Examples 7 to 11 in which the pH of the bactericidal disinfectant having the same blending ratio as Formulation Example 3 was adjusted were manufactured, and the adsorption rate (%) of miconazole was measured. (Measurement method is the same as Test Example 1)
The results are summarized in Table 2.
Figure JPOXMLDOC01-appb-T000002
 Results: In the neutral to weakly acidic region, the adsorption rate (%) of miconazole was kept low.

試験例３：フェノール類等配合の影響
　フェノール類として、イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン又はプロピルパラベンを０．１質量％配合した以外は配合例１０と同様の配合割合の殺菌消毒液である配合例１２ないし配合例１６のシートを製造し、ミコナゾールの吸着率（％）を測定し、配合例１０のシートと比較した。また、エタノールを３０質量％配合した配合例１７のシートを製造し、ミコナゾールの吸着率（％）を測定した（測定方法は、試験例１と同じ）。
　結果を表３に示した。

Figure JPOXMLDOC01-appb-T000003
結果：配合例１２ないし１６はいずれも、配合例１０に比べて、顕著な吸着率の低下がみられた。ノニオン系界面活性剤とフェノール類（イソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン又はプロピルパラベン）を組合せて配合することにより、ミコナゾールの基布への吸着を顕著に抑制できた。すなわち、べたつきの問題がほとんど生じない少量のノニオン系界面活性剤とフェノール類を組み合わせることにより、ミコナゾールの基布への吸着を顕著に抑制できることが分かった。
　また、エタノールを配合する事により、ノニオン系界面活性剤の配合量が少量でも、ｐＨ＝７におけるミコナゾールの吸着率（％）を低くできることが分った。 Test Example 3: Effect of blending with phenols, etc. As a phenol, a sterilizing and disinfecting solution having the same blending ratio as Formulation Example 10 except that 0.1% by mass of isopropylmethylphenol, triclosan, salicylic acid, methylparaben or propylparaben is blended. The sheets of Formulation Example 12 to Formulation Example 16 were produced, and the adsorption rate (%) of miconazole was measured and compared with the sheet of Formulation Example 10. Moreover, the sheet | seat of the mixing example 17 which mix | blended 30 mass% of ethanol was manufactured, and the adsorption rate (%) of miconazole was measured (the measuring method is the same as the test example 1).
The results are shown in Table 3.
Figure JPOXMLDOC01-appb-T000003
 Results: In each of Formulation Examples 12 to 16, a significant decrease in the adsorption rate was observed as compared to Formulation Example 10. By combining a nonionic surfactant and a phenol (isopropylmethylphenol, triclosan, salicylic acid, methylparaben or propylparaben), it was possible to remarkably suppress the adsorption of miconazole on the base fabric. That is, it was found that the adsorption of miconazole to the base fabric can be remarkably suppressed by combining a small amount of a nonionic surfactant that hardly causes stickiness and phenols.
In addition, it was found that by adding ethanol, the adsorption rate (%) of miconazole at pH = 7 can be lowered even with a small amount of the nonionic surfactant.

試験例４：フェノール類（イソプロピルメチルフェノール（ＩＰＭＰ））配合におけるｐＨの影響
　配合例１２と同様の配合割合の殺菌消毒液のｐＨを種々調整した配合例１８ないし配合例２０のシートを製造し、ミコナゾールの吸着率（％）を測定し、イソプロピルメチルフェノールが配合されていない配合例８ないし配合例１１のシートと比較した。（測定方法は、試験例１と同じ）
　結果を表４に纏めた。

Figure JPOXMLDOC01-appb-T000004
結果：イソプロピルメチルフェノールの配合により、ｐＨ＝６～８の範囲においてミコナゾールの吸着率（％）を低くできることが確認された。
　一方、ｐＨ５においては、ノニオン系界面活性剤とフェノール類を組み合わせて配合しても、ミコナゾールの基布への吸着の抑制が十分に発揮されないことが示唆された。 Test Example 4: Effect of pH in the formulation of phenols (isopropylmethylphenol (IPMP)) Producing the sheets of Formulation Example 18 to Formulation Example 20 in which the pH of the sterilizing liquid having the same blending ratio as in Formulation Example 12 was adjusted, The adsorption rate (%) of miconazole was measured and compared with the sheets of Formulation Examples 8 to 11 in which isopropylmethylphenol was not blended. (Measurement method is the same as Test Example 1)
The results are summarized in Table 4.
Figure JPOXMLDOC01-appb-T000004
 Result: It was confirmed that the adsorption rate (%) of miconazole could be lowered in the range of pH = 6 to 8 by blending isopropylmethylphenol.
On the other hand, at pH 5, it was suggested that even if a nonionic surfactant and a phenol are combined, the adsorption of miconazole on the base fabric is not sufficiently suppressed.

試験例５：アミノ酸（Ｌ－アルギニン）配合の影響
　Ｌ－アルギニンを０．０２質量％配合した以外は配合例８、１０、１１と同様の配合割合及び同じｐＨの殺菌消毒液である配合例２１ないし配合例２３のシートを製造し、ミコナゾールの吸着率（％）を測定し、配合例８ないし１１のシートと比較した。（測定方法は、試験例１と同じ）
　結果を表５に示した。

Figure JPOXMLDOC01-appb-T000005
結果：アミノ酸（Ｌ－アルギニン）の配合により、ｐＨ５～８において、ミコナゾールの吸着率（％）が減少する傾向が観られた。 Test Example 5: Influence of Amino Acid (L-Arginine) Formulation Formulation Example 21 which is a sterilizing / disinfecting solution having the same blending ratio and the same pH as Formulation Examples 8, 10, and 11 except that 0.02% by mass of L-arginine was blended Or the sheet | seat of the mixing example 23 was manufactured, the adsorption rate (%) of miconazole was measured, and it compared with the sheet | seat of the mixing examples 8-11. (Measurement method is the same as Test Example 1)
The results are shown in Table 5.
Figure JPOXMLDOC01-appb-T000005
 Results: There was a tendency for the adsorption rate (%) of miconazole to decrease at pH 5 to 8 due to the incorporation of amino acid (L-arginine).

試験例６：フェノール類（イソプロピルメチルフェノール（ＩＰＭＰ））とアミノ酸（Ｌ－アルギニン）の併用の影響
　Ｌ－アルギニンを０．０２質量％配合した以外は配合例１２及び配合例１８ないし２０（イソプロピルメチルフェノールを含む）と同様の配合割合で、ｐＨが４．０、５．０、６．０、７．０、８．０及び９．０の殺菌消毒液である配合例２４ないし配合例２９のシートを製造し、ミコナゾールの吸着率（％）を測定し、配合例１２及び配合例１８ないし２０のシートと比較した。（測定方法は、試験例１と同じ）
　結果を表６に示した。

Figure JPOXMLDOC01-appb-T000006
結果：ノニオン系界面活性剤とフェノール類（イソプロピルメチルフェノール）との組合せに、さらにアミノ酸（Ｌ－アルギニン）を併用することにより、ｐＨ＝４～９）において、ミコナゾールの吸着率（％）が低く抑えられることが確認された。特にｐＨ５、６の弱酸性領域においては、Ｌ－アルギニン添加によるミコナゾール吸着抑制増強効果が顕著であった。 Test Example 6: Effect of combined use of phenols (isopropylmethylphenol (IPMP)) and amino acid (L-arginine) Formulation Example 12 and Formulation Examples 18 to 20 (Isopropylmethyl) except that 0.02% by mass of L-arginine was blended (Including phenol) at a blending ratio similar to that of Formulation Examples 24 to 29, which are sterilizing / disinfecting solutions having pH of 4.0, 5.0, 6.0, 7.0, 8.0, and 9.0. Sheets were produced, and the adsorption rate (%) of miconazole was measured and compared with the sheets of Formulation Example 12 and Formulation Examples 18-20. (Measurement method is the same as Test Example 1)
The results are shown in Table 6.
Figure JPOXMLDOC01-appb-T000006
 Result: By combining amino acid (L-arginine) in combination with nonionic surfactant and phenol (isopropylmethylphenol), the adsorption rate (%) of miconazole is low at pH = 4-9). It was confirmed that it could be suppressed. In particular, in the weakly acidic range of pH 5 and 6, the effect of suppressing the miconazole adsorption by adding L-arginine was remarkable.

試験例７：アミノ酸の種類の影響
　Ｌ－アルギニンをリジンに変更した以外は配合例２２（イソプロピルメチルフェノールを含まない）及び配合例２７（イソプロピルメチルフェノールを含む）と同様の配合割合及び同じｐＨの殺菌消毒液である配合例３０及び配合例３１のシート、並びに、Ｌ－アルギニンをヒスチジンに変更した以外は配合例２２（イソプロピルメチルフェノールを含まない）及び配合例２７（イソプロピルメチルフェノールを含む）と同様の配合割合及び同じｐＨの殺菌消毒液である配合例３２及び配合例３３のシートを製造し、ミコナゾールの吸着率（％）を測定した。（測定方法は、試験例１と同じ）
　結果を表７に示した。

Figure JPOXMLDOC01-appb-T000007
結果：　リジン及びヒスチジンについても、Ｌ－アルギニンの場合と同様の吸着抑制効果が認められた。 Test Example 7: Influence of amino acid type Except for changing L-arginine to lysine, the same blending ratio and the same pH as in Blending Example 22 (not including isopropylmethylphenol) and Blending Example 27 (including isopropylmethylphenol) Formulation Example 30 and Formulation 31 sheets that are sterilizing disinfectants, and Formulation Example 22 (not including isopropylmethylphenol) and Formulation Example 27 (including isopropylmethylphenol) except that L-arginine was changed to histidine, The sheet | seat of the mixing example 32 and the mixing example 33 which are the same mixing | blending ratio and the same pH disinfection liquid was manufactured, and the adsorption | suction rate (%) of miconazole was measured. (Measurement method is the same as Test Example 1)
The results are shown in Table 7.
Figure JPOXMLDOC01-appb-T000007
 Results: Lysine and histidine also showed the same adsorption inhibitory effect as L-arginine.

試験例８：ノニオン系界面活性剤の種類の影響
　界面活性剤Ａ（ノニオン系界面活性剤）を他の種々のノニオン系界面活性剤（界面活性剤Ｂないし界面活性剤Ｅ）に変更し及びノニオン系界面活性剤の配合量を変更した以外は配合例１０（イソプロピルメチルフェノール及びアミノ酸を含まない）と同様の配合割合及び同じｐＨの殺菌消毒液である配合例３４、３６、３８及び４０のシート、並びに、配合例２７（イソプロピルメチルフェノール及びアミノ酸を含む）と同様の配合割合及び同じｐＨの殺菌消毒液である配合例３５、３７、３９及び４１のシートを製造し、ミコナゾールの吸着率（％）を測定した。（測定方法は、試験例１と同じ）
　結果を表８に示した。

Figure JPOXMLDOC01-appb-T000008
結果：種々のノニオン系界面活性剤（界面活性剤Ｂないし界面活性剤Ｅ）において、それぞれ単独で、界面活性剤Ａと同様のミコナゾール吸着抑制効果が認められた。また、界面活性剤Ａと同様に、フェノール類（イソプロピルメチルフェノール）とアミノ酸（Ｌ－アルギニン）との組合わせにより、より強力なミコナゾールの吸着抑制効果が確認された。 Test Example 8: Effect of Nonionic Surfactant Type Surfactant A (nonionic surfactant) was changed to various other nonionic surfactants (surfactant B or surfactant E) and nonion The sheets of Formulation Examples 34, 36, 38 and 40, which are sterilizing and disinfecting solutions having the same blending ratio and the same pH as Formulation Example 10 (not including isopropylmethylphenol and amino acids) except that the amount of the surfactant is changed In addition, a sheet of Formulation Examples 35, 37, 39 and 41, which is a sterilizing and disinfecting solution having the same composition ratio and the same pH as Formulation Example 27 (including isopropylmethylphenol and amino acids), was produced, and the adsorption rate of miconazole (% ) Was measured. (Measurement method is the same as Test Example 1)
The results are shown in Table 8.
Figure JPOXMLDOC01-appb-T000008
 Results: In various nonionic surfactants (Surfactant B to Surfactant E), the same miconazole adsorption suppression effect as that of Surfactant A was observed. Similarly to surfactant A, a stronger miconazole adsorption inhibitory effect was confirmed by the combination of phenols (isopropylmethylphenol) and amino acids (L-arginine).

試験例９：不織布の材質検討
　不織布の材質を、コットン１００％不織布をレーヨン７０％及びポリエチレンテレフタラート３０％からなる不織布に変更し、及び不織布を変更した以外は配合例１０、１２、１５、１６と同様の配合割合及び同じｐＨの殺菌消毒液である配合例４２ないし配合例４５のシート並びに不織布を変更し且つｐＨを５．０とした以外は配合例１０、１２、１５、１６と同様の配合割合の殺菌消毒液である配合例４６ないし配合例４９のシートを製造し、これらの不織布へのミコナゾールの吸着率（％）を測定した。（測定方法は、試験例１と同じ）
　結果を表９に示した。

Figure JPOXMLDOC01-appb-T000009
　結果：レーヨン７０％及びポリエチレンテレフタラート３０％からなる不織布において、ｐＨ５及びｐＨ７でコットン１００％と同様に、フェノール類（イソプロピルメチルフェノール、メチルパラベン、プロピルパラベン）とノニオン系界面活性剤（界面活性剤Ａ）との併用によるミコナゾールの吸着抑制が確認された。 Test Example 9: Examination of Nonwoven Material Material Examples 10, 12, 15, and 16 except that the nonwoven material was changed from a 100% cotton nonwoven fabric to a nonwoven fabric made of 70% rayon and 30% polyethylene terephthalate, and the nonwoven fabric was changed. The same mixing ratio and the same pH as the sterilizing / disinfecting solution, but the same as the mixing examples 10, 12, 15 and 16 except that the sheets and nonwoven fabrics of the mixing examples 42 to 45 were changed and the pH was 5.0. Sheets of Formulation Example 46 to Formulation 49, which are sterilizing / disinfecting liquids at a blending ratio, were manufactured, and the adsorption rate (%) of miconazole on these nonwoven fabrics was measured. (Measurement method is the same as Test Example 1)
The results are shown in Table 9.
Figure JPOXMLDOC01-appb-T000009
 Result: In a non-woven fabric composed of 70% rayon and 30% polyethylene terephthalate, phenols (isopropylmethylphenol, methylparaben, propylparaben) and nonionic surfactant (surfactant A) as in the case of 100% cotton at pH 5 and pH 7. ) Was confirmed to suppress the adsorption of miconazole.

Claims (7)

　繊維材料から構成された基布に殺菌消毒液が担持されてなるシートであって、
　前記殺菌消毒液は、該消毒液の総質量に基づいて、ミコナゾール及び／又は硝酸ミコナゾールを含む抗真菌成分を０．０１ないし１質量％、ノニオン界面活性剤を０．１ないし１０質量％、及びイソプロピルメチルフェノール、トリクロサン、サリチル酸、メチルパラベン、エチルパラベン及びプロピルパラベンからなる群から選択される少なくとも１種以上のフェノール類を０．０１ないし１質量％含有する水性溶液であるシート。 A sheet in which a disinfectant is carried on a base fabric made of a fiber material,
The sterilizing and disinfecting solution is based on the total mass of the disinfecting solution, 0.01 to 1% by mass of an antifungal component containing miconazole and / or miconazole nitrate, 0.1 to 10% by mass of a nonionic surfactant, and A sheet which is an aqueous solution containing 0.01 to 1% by mass of at least one phenol selected from the group consisting of isopropylmethylphenol, triclosan, salicylic acid, methylparaben, ethylparaben and propylparaben. 　前記シートが医薬品、医薬部外品又は化粧品用のシートである請求項１記載のシート。 The sheet according to claim 1, wherein the sheet is a sheet for pharmaceuticals, quasi drugs or cosmetics. 　前記ノニオン界面活性剤は、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンステロール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル及びポリグリセリン脂肪酸エステルからなる群から選択される少なくとも１種以上である請求項１又は２記載のシート。 Nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sterol, polyoxyethylene polyoxypropylene alkyl ether, The sheet according to claim 1 or 2, wherein the sheet is at least one selected from the group consisting of oxyethylene alkyl ether, polyethylene glycol fatty acid ester and polyglycerin fatty acid ester. 　前記殺菌消毒液は、更に、アミノ酸を含有し、その含有量は、前記消毒液の総質量に基づいて、０．００５ないし５質量％である請求項１～３のいずれか１項記載のシート。 The sheet according to any one of claims 1 to 3, wherein the sterilizing liquid further contains an amino acid, and the content thereof is 0.005 to 5% by mass based on the total mass of the disinfecting liquid. . 　前記アミノ酸は、リシン、アルギニン、ヒスチジン及びそれらの塩酸塩からなる群から選択される少なくとも１種以上である請求項４記載のシート。 The sheet according to claim 4, wherein the amino acid is at least one selected from the group consisting of lysine, arginine, histidine, and hydrochlorides thereof. 　前記消毒液のｐＨは、５ないし８に調整されてなる請求項１～３のいずれか１項記載のシート。 The sheet according to any one of claims 1 to 3, wherein the pH of the disinfectant is adjusted to 5 to 8. 　前記消毒液のｐＨは、４ないし９に調整されてなる請求項４又は請求項５記載のシート。 The sheet according to claim 4 or 5, wherein the pH of the disinfectant is adjusted to 4 to 9.
PCT/JP2018/017251 2017-04-28 2018-04-27 Sheet preparation containing miconazole and/or miconazole nitrate Ceased WO2018199303A1 (en)

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JP2002363070A (en) * 2001-06-06 2002-12-18 Yuutoku Yakuhin Kogyo Kk Transdermal patch preparation
WO2004028502A1 (en) * 2002-09-27 2004-04-08 Mochida Pharmaceutical Co., Ltd. Cleansing composition containing antifungal agent and antibacterial agent
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JP2013249283A (en) * 2012-06-01 2013-12-12 Morishita Jintan Co Ltd Film preparation
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Publication number Priority date Publication date Assignee Title
WO2023210498A1 (en) * 2022-04-27 2023-11-02 花王株式会社 Wiping sheet
JPWO2023210498A1 (en) * 2022-04-27 2023-11-02
JP7646943B2 (en) 2022-04-27 2025-03-17 花王株式会社 Wiping Sheet

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