WO2018133123A1

WO2018133123A1 - Method and device for processing pulse wave

Info

Publication number: WO2018133123A1
Application number: PCT/CN2017/072268
Authority: WO
Inventors: 陈驰; 朱宇东
Original assignee: 悦享趋势科技（北京）有限责任公司
Priority date: 2017-01-23
Filing date: 2017-01-23
Publication date: 2018-07-26

Abstract

Disclosed are a method and a device for processing a pulse wave. The method comprises step S102: sending a first command to an electrocardiogram (ECG) electrode (22) attached to an organism, and receiving an electrocardiosignal acquired by the ECG electrode in response to the first command; step S104: sending a second command to an electromagnetic sensor (24) attached to the organism, and receiving a blood vessel vibration signal of the organism acquired by the electromagnetic sensor (24) in response to the second command; and step S106: acquiring pulse wave information according to the electrocardiosignal and the blood vessel vibration signal. The combined use of the ECG electrode (22) and the electromagnetic sensor (24) provides a novel, lightweight measurement method for measuring the pulse wave transit time PTT and the pulse wave velocity PWV.

Description

Pulse wave processing method and device

Technical field

The present invention relates to the field of pulse waves, and in particular to a pulse wave processing method and apparatus.

Background technique

The information included in the pulse wave is very helpful for understanding the physiological characteristics of the organism, and the conduction velocity of the pulse wave is one of them. The pulse wave velocity PWV refers to the pressure wave generated by the heart every beat pulse, the conduction velocity along the wall of the aorta. PWV is closely related to the elasticity of the arterial wall. As the elasticity of the arterial wall decreases, the pulse wave travels faster in the arterial system. PWV has a certain relationship with the biomechanical properties of the arterial wall, the geometric characteristics of the blood vessels, and the density of the blood, which can reflect the real-time changes in arterial function. The pulse wave velocity can be calculated if the time difference of the pulse wave propagation to the arterial wall located at two different positions of the body can be obtained and the length of the blood vessel between the two positions is known. However, the measurement of pulse wave velocity on portable devices is not a good solution in the prior art.

Summary of the invention

The embodiment of the invention provides a pulse wave processing method and device. The combination of the ECG electrode and the electromagnetic sensor solves the technical problem that the prior art has no good solution for the portable measurement of the pulse wave information.

According to an aspect of an embodiment of the present invention, a pulse wave processing method is provided, comprising: transmitting a first command to an electrocardiogram ECG electrode attached to a living body, and receiving the ECG electrode to be collected in response to the first command An ECG signal; transmitting a second command to an electromagnetic sensor attached to the living body, and receiving a blood vessel vibration signal of the living body collected by the electromagnetic sensor in response to the second command; according to the ECG signal And the blood vessel vibration signal acquires information of the pulse wave.

Further, transmitting the first command and the second command includes: simultaneously transmitting the first command and the second command, wherein the ECG electrode and the electromagnetic sensor respectively receive the first command The command and the second command start to work; or, the first command and the second command are sent, wherein the first command and the second command carry the ECG electrode and the electromagnetic The time at which the sensor starts working and/or ends working.

Further, the time when the ECG electrode and the electromagnetic sensor start to work and the time when the work ends with.

Further, transmitting the first command to an electrocardiogram ECG electrode attached to the living body comprises: attaching two separate stickers between the fourth intercostal space of the right sternal border of the living body and the fourth intercostal space of the left sternal border of the sternum The ECG electrode transmits the first command.

Further, transmitting the second command to the electromagnetic sensor attached to the living body includes transmitting the second command to an electromagnetic sensor attached to a superficial artery portion of the living body.

Further, the method further includes: displaying the pulse wave transit time PTT and the conduction velocity PWV on a screen of the mobile terminal.

According to another aspect of the embodiments of the present invention, a pulse wave processing apparatus is provided, including: an electrocardiogram ECG electrode for collecting an electrocardiogram signal of a living body; and an electromagnetic sensor for collecting a blood vessel vibration signal of the living body a processor for transmitting a signal to the ECG electrode and the electromagnetic sensor, and acquiring information of the pulse wave based on the received electrocardiographic signal and the blood vessel vibration signal.

Further, the device further includes a display for displaying the pulse wave transit time PTT and the conduction velocity PWV.

Further, the processor and the display are located in a mobile terminal.

In an embodiment of the present invention, the first command is sent to the electrocardiogram ECG electrode attached to the living body, and the ECG signal received by the ECG electrode in response to the first command is received; and attached to the living body The electromagnetic sensor transmits a second command and receives a blood vessel vibration signal of the living body collected by the electromagnetic sensor in response to the second command; and acquires information of the pulse wave according to the ECG signal and the blood vessel vibration signal. The combination of ECG electrodes and electromagnetic sensors provides a new, lightweight method for measuring pulse wave transit time and pulse wave velocity.

DRAWINGS

The drawings described herein are intended to provide a further understanding of the invention, and are intended to be a part of the invention. In the drawing:

1 is a flow chart of a pulse wave processing method according to an embodiment of the present invention;

2 is a block diagram showing the structure of a pulse wave processing apparatus according to an embodiment of the present invention.

detailed description

The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is an embodiment of the invention, but not all of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of the present invention.

It is to be understood that the terms "first", "second" and the like in the specification and claims of the present invention are used to distinguish similar objects, and are not necessarily used to describe a particular order or order. It is to be understood that the data so used may be interchanged where appropriate, so that the embodiments of the invention described herein can be implemented in a sequence other than those illustrated or described herein. In addition, the terms "comprises" and "comprises" and "the" and "the" are intended to cover a non-exclusive inclusion, for example, a process, method, system, product, or device that comprises a series of steps or units is not necessarily limited to Those steps or units may include other steps or units not explicitly listed or inherent to such processes, methods, products or devices.

In accordance with an embodiment of the present invention, a method embodiment of pulse wave processing is provided, it being noted that the steps illustrated in the flowchart of the figures may be performed in a computer system such as a set of computer executable instructions, and, although The logical order is shown in the flowchart, but in some cases the steps shown or described may be performed in a different order than the ones described herein.

1 is a flow chart of a pulse wave processing method according to an embodiment of the present invention. As shown in FIG. 1, the method includes the following steps:

Step S102, sending a first command to an electrocardiogram ECG electrode attached to the living body, and receiving an ECG signal collected by the ECG electrode in response to the first command;

Step S104, sending a second command to the electromagnetic sensor attached to the living body, and receiving a blood vessel vibration signal of the living body collected by the electromagnetic sensor in response to the second command;

Step S106, acquiring information of the pulse wave based on the electrocardiographic signal and the blood vessel vibration signal.

Wherein, according to the information of the pulse wave acquired by the electrocardiographic signal and the vascular vibration signal, the information of the pulse wave includes but is not limited to the heartbeat rhythm and the pulse wave transit time PTT, and the pulse wave transit time PTT can comprehensively consider multiple factors such as blood vessel characteristics and blood pressure. . The following is an example of the pulse wave information including the heartbeat rhythm and the pulse wave transit time PTT. It should be noted that the step S102 and the step S104 may be performed in the same order, for example, the first command and the second command may be simultaneously sent. Wherein, the ECG electrode and the electromagnetic sensor respectively start to work after receiving the first command and the second command. Alternatively, the first command and the second command may also be sent at different times, wherein the first command and the second command carry the time when the ECG electrode and the electromagnetic sensor start to work and/or end the work. If the ECG electrode and the electromagnetic sensor are required to start working at the same time, it is only necessary to carry the response time. Similarly, It is also possible to carry the same time to end the work, or to carry the start time work and the end time work are included.

According to an aspect of an embodiment of the present invention, an electrocardiographic signal and a blood vessel vibration signal are received, and a heartbeat rhythm and a pulse wave transit time PTT are acquired according to the electrocardiographic signal and the blood vessel vibration signal, and further, the pulse wave velocity can be derived PWV.

The ECG electrode can be attached to any position in the living body where the ECG signal can be collected. It is recommended to select two points from the following positions: v1: the fourth intercostal space on the right edge of the sternum, v2: the fourth intercostal space on the left sternal border, v3: v2 and The midpoint of the v4 line, v4: the intersection of the left clavicle midline and the 5th intercostal, v5: the left anterior line is at the same level as v4, v6: the left sac line is at the same level as v4, v7: the left sac line is at the same level as v4 , v8: the same level as the v4, the left and right upper limbs, the left and right lower limbs.

The setting of the ECG is an alternative embodiment in the present embodiment. The two separate stickers are attached to the fourth intercostal space of the right sternal border of the living body and the fourth intercostal space of the left sternal border, and of course can also be attached to the living body. Any other part of the body, such as the abdomen of the organism, when the organism is a human, can also be the position of the arm, and will not be described here. The electromagnetic sensor can be attached to any position in the living body, and in particular, a good measurement result can be obtained when attached to the surface of the living body where the superficial artery exists.

With the development of mobile terminal technology, the pulse wave transit time PTT and the conduction velocity PWV can be displayed on the screen of the mobile terminal. For example, the device shown in FIG. 2 can be processed and displayed by using a mobile terminal. Of course, the mobile terminal can also be used. Any device with a processor and/or display can be implemented, for example, it can be a professional device. . The pulse wave processing apparatus will be described below.

Optionally, transmitting the second command to the electromagnetic sensor attached to the living body comprises: transmitting a second command to the electromagnetic sensor attached to the superficial artery site of the living body. In other words, when implemented, the electromagnetic sensor can be attached to the superficial artery portion of the living body.

In this embodiment, a pulse wave processing device is also provided. FIG. 2 is a structural block diagram of a pulse wave processing device according to an embodiment of the present invention. As shown in FIG. 2, the device includes:

An electrocardiogram ECG electrode 22 for collecting an electrocardiogram signal of the living body;

An electromagnetic sensor 24 for collecting a blood vessel vibration signal of the living body;

The processor 26 is configured to send a signal to the ECG electrode and the electromagnetic sensor, and acquire information of the pulse wave according to the received ECG signal and the blood vessel vibration signal.

With the above apparatus, a processing scheme of pulse wave information is provided. The scheme is relatively simple to implement, as long as the electromagnetic sensor is placed on the living body, and the electromagnetic sensor can be made into a patch shape and attached to any part of the living body.

As an alternative embodiment, a particular display (eg, a display in a mobile terminal) can also be used to display information about the pulse wave. The processor 26 and the display are located in the mobile terminal. At this time, the signals of the ECG electrode and the electromagnetic sensor are collected by the mobile terminal for processing and display, which is convenient for the user.

The above embodiment can use the ECG electrocardiographic sensor and the electromagnetic sensor having 2 to 3 electrodes to work synchronously, thereby collecting the time difference from the ejection of the heart ejection and the pulse wave to the wall of the artery located at different positions of the body, and the time difference is approximated. The pulse transit time PTT. The two-lead ECG ECG signal sensor is placed on the chest, and the electrodes are attached to the upper skin area of the left and right ventricles to collect the electrocardiogram signal. The electromagnetic sensor is placed directly above the skin of the superficial superficial layer of the vascular aorta or artery (the dorsal artery, the femoral artery, the radial artery, the radial artery, the common carotid artery, the facial artery, the superficial temporal artery, the subclavian artery), and emits wirelessly. The signal receives the reflected signal, thereby collecting a pulse wave signal caused by the vibration and displacement of the blood flowing through the blood vessel wall. The two sets of sensors are controlled by the mobile device to allow them to simultaneously start collecting signals and transmitting the signals to the mobile device. The mobile device obtains a stable approximate pulse wave transit time by calculating the time difference between the ECG ECG signal R wave and the stable signal feature point position in the pulse wave signal (for example, the highest peak of the pulse wave, 1/2 of the pulse wave rising curve, etc.) PTT. At the same time, according to the characteristic value of the specific user's height and the like, the distance D of the artery from the heart to the position where the electromagnetic sensor is placed is derived, so that the PWV=D/PTT of the heart to the artery can be derived.

The first unit is a single-lead ECG ECG signal acquisition unit. The unit is in contact with the skin of the outer surface of the body by two separate conductive electrodes on the outer surface of the human body (directly above the atrium), and the connected mobile device controls the start and end of the collection. ECG signal. The second unit is an electromagnetic sensor that can be attached to the skin and acts on multiple aorta in the superficial layer of the skin. It is also controlled by the connected mobile device to start and end the vascular vibration signal of the artery. The third unit is a mobile control unit that connects the first unit and the second unit by wire or wirelessly, sends a command signal, and controls the first unit and the second unit to simultaneously start and end the signal collection work. Receiving raw biological information collected by the first unit and the second unit. The ECG ECG signal and the arterial pulse signal collected by the first unit and the second unit are processed, and the pulse wave transit time PTT of the aorta where the pulse wave is located from the heart to the whole body of the skin is calculated, and the corresponding pulse is derived. The wave conduction velocity PWV, then, displays relevant sensor unit information and processing results.

In an alternative embodiment, a set of inflated cuffs embedded in the piezoelectric sensor can replace the electromagnetic sensor described above, and obtain a pulse wave signal that fluctuates with the contraction of the human artery with the heart through the inflatable cuff worn on the limbs, and combines another set. The ECG signal collected by the ECG ECG signal calculates the pulse wave transit time PTT from the heart to the extremities. The inflatable cuff embedded with the piezoelectric sensor array can be used to obtain the pulse wave signal of the arteries fluctuating with the contraction of the heart by wearing the arm and the leg at the same time, and then calculating the pulse wave transit time PTT between the extremities, thereby calculating the conduction velocity. PWV. .

In another optional embodiment, a set of optical generating receiving sensors can also be used to illuminate the human finger The pulse wave is collected, a set of ECG ECG signals are used to collect the ECG signal, and then the conduction time from the heart to the finger tip is calculated according to the signals collected by the two groups, and then the conduction velocity PWV is calculated.

For example, two sets of optical generating receiving sensors can be respectively irradiated into two different positions of the human body, and after converting the received optical information into image information, image signal processing is performed to obtain a PPG signal, and then two measured according to the length measuring unit. The distance between different positions obtains the pulse wave transit time PTT and the conduction velocity PWV between the two positions.

Compared with the above two methods, the use of the electromagnetic sensor can greatly improve the measurement experience of the pulse wave transit time PTT and the conduction velocity PWV and reduce the measurement cost. In addition, there are some problems with the use of inflatable cuffs, which are typically mounted on the upper arms of the patient's sides and the two ankles, respectively, using four inflatable cuffs. The subject needs to lie flat and endure the pressure and irritation. The application scenarios of pulse wave velocity measurement are mostly in hospitals or physical examination centers. The equipment is bulky and expensive, and it is difficult to popularize it for civilian use. Compared with the use of electromagnetic sensors, it is only necessary to attach a 10mm*20mm electromagnetic sensor to the outer skin corresponding to the position of the arterial vessel, and start it to work, without any pressure or any stimulation. Its portable and wearable product form allows residents to easily measure PWV at home or outside the hospital. A large amount of PWV data is of great significance for daily cardiovascular health care.

Another benefit of using an electromagnetic sensor is that it is not limited by the specific measurement position of the human body. For example, cuff pressure can only be applied to limb measurements, such as PTT and PWV from the upper arm to the ankle, or PTT and PWV from the heart to the ankle. Photoelectric sensors can only be applied to the tip of the finger. In this embodiment, because the wireless working principle of the electromagnetic sensor can penetrate a certain thickness of tissue, the power and frequency of the wireless transmitting signal can be adjusted, and the artery below the whole body can be flexibly measured: the dorsal artery, the femoral artery, the radial artery , radial artery, common carotid artery, facial artery, superficial temporal artery, subclavian artery. After the heart is ejected, the corresponding PTT and PWV can be calculated from the pulse wave reaching the above position. Multi-position acquired pulse waves can provide important data for vascular health analysis at specific sites.

In an embodiment of the invention, the cardiac contraction ejection time is extracted from the ECG signal and approximated as the start time of pulse wave delivery. By comparing the time when the pulse wave measured by the electromagnetic sensor reaches the arterial wall, the pulse transit time PTT (pulse transi t t ime) is calculated, and then the distance from the heart to the measured artery is estimated from the individual biosignal, and then the distance can be calculated. Pulse wave velocity PWV.

The serial numbers of the embodiments of the present invention are merely for the description, and do not represent the advantages and disadvantages of the embodiments.

In the above-mentioned embodiments of the present invention, the descriptions of the various embodiments are different, and the parts that are not detailed in a certain embodiment can be referred to the related descriptions of other embodiments.

In the several embodiments provided by the present application, it should be understood that the technical content introduced may be through other The way to achieve. The device embodiments described above are only schematic. For example, the division of the unit may be a logical function division. In actual implementation, there may be another division manner, for example, multiple units or components may be combined or may be Integrate into another system, or some features can be ignored or not executed. In addition, the mutual coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interface, unit or module, and may be electrical or otherwise.

The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.

The integrated unit, if implemented in the form of a software functional unit and sold or used as a standalone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention, which is essential or contributes to the prior art, or all or part of the technical solution, may be embodied in the form of a software product stored in a storage medium. A number of instructions are included to cause a computer device (which may be a personal computer, server or network device, etc.) to perform all or part of the steps of the methods described in various embodiments of the present invention. The foregoing storage medium includes: a U disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a removable hard disk, a magnetic disk, or an optical disk, and the like. .

The above description is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can also make several improvements and retouchings without departing from the principles of the present invention. It should be considered as the scope of protection of the present invention.

Claims

A pulse wave processing method, comprising:

Transmitting a first command to an electrocardiogram ECG electrode attached to the living body, and receiving an ECG signal collected by the ECG electrode in response to the first command;

Transmitting a second command to an electromagnetic sensor attached to the living body, and receiving a blood vessel vibration signal of the living body collected by the electromagnetic sensor in response to the second command;

Information of the pulse wave is acquired based on the electrocardiographic signal and the blood vessel vibration signal.
The method of claim 1, wherein transmitting the first command and the second command comprises:

Simultaneously transmitting the first command and the second command, wherein the ECG electrode and the electromagnetic sensor respectively start to work after receiving the first command and the second command; or

Transmitting the first command and the second command, wherein the first command and the second command carry a time when the ECG electrode and the electromagnetic sensor start to work and/or end work.
The method of claim 2 wherein said ECG electrode and said electromagnetic sensor begin to operate at the same time and end of operation.
The method of claim 1 wherein transmitting the first command to an electrocardiogram ECG electrode attached to the living body comprises:

The first command is sent to two separate ECG electrodes attached between the fourth intercostal space of the sternal right edge of the organism and the fourth intercostal space of the left sternal border.
The method of claim 1 wherein transmitting the second command to the electromagnetic sensor attached to the living body comprises:

The second command is sent to an electromagnetic sensor attached to a superficial artery site of the organism.
The method according to any one of claims 1 to 5, further comprising:

The pulse wave transit time PTT and the conduction velocity PWV are displayed on the screen of the mobile terminal.
A pulse wave processing device, comprising:

An electrocardiogram ECG electrode for collecting an electrocardiogram signal of a living body;

An electromagnetic sensor for collecting a blood vessel vibration signal of the living body;

And a processor configured to send a signal to the ECG electrode and the electromagnetic sensor, and acquire information of the pulse wave according to the received ECG signal and the blood vessel vibration signal.
The device according to claim 7, wherein the device further comprises:

A display for displaying the pulse wave transit time PTT and the conduction velocity PWV.
Apparatus according to claim 7 or claim 8 wherein said processor and said display are located in a mobile terminal.