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WO2018215005A1 - Utilisation de la levure kazachstania slooffiae pour améliorer la santé intestinale de porcs - Google Patents

Utilisation de la levure kazachstania slooffiae pour améliorer la santé intestinale de porcs Download PDF

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Publication number
WO2018215005A1
WO2018215005A1 PCT/DE2018/000119 DE2018000119W WO2018215005A1 WO 2018215005 A1 WO2018215005 A1 WO 2018215005A1 DE 2018000119 W DE2018000119 W DE 2018000119W WO 2018215005 A1 WO2018215005 A1 WO 2018215005A1
Authority
WO
WIPO (PCT)
Prior art keywords
slooffiae
yeast
kazachstania
piglets
pigs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2018/000119
Other languages
German (de)
English (en)
Inventor
Vladimir Urubschurov
Annette Zeyner
Wolfgang Bernhard SOUFFRANT
Kirsten Büsing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martin Luther Universitaet Halle Wittenberg
Original Assignee
Martin Luther Universitaet Halle Wittenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102017004217.9A external-priority patent/DE102017004217A1/de
Application filed by Martin Luther Universitaet Halle Wittenberg filed Critical Martin Luther Universitaet Halle Wittenberg
Priority to DE112018002320.6T priority Critical patent/DE112018002320A5/de
Publication of WO2018215005A1 publication Critical patent/WO2018215005A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065—Microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast

Definitions

  • porcine gastrointestinal tract represents a complex microcosm that is populated by various microorganisms that play an important role in the development of pigs
  • Carbohydrates to short chain fatty acids not only affects the whole
  • Piglet weaning is considered to be one of the most critical phases in pig farming and is often associated with stress, very often diarrheal diseases, which to varying degrees with impaired well-being, food intake and growth depression as well as increased levels
  • the object of the invention was to isolate an endemic in pig intestine yeast, which has such a stabilizing potential. Due to the dominance of the yeast K. slooffiae endemic to the pig intestine and the fact that it could only be isolated from the intestine of clinically unremarkable animals and its number correlated positively with the number of lactobacilli in the piglet intestine, the yeast K. slooffiae became further investigations selected. For this purpose, a strain of yeast was isolated and used.
  • the isolated strain was deposited on 7 March 2016 at the Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH in Brunswick under the Budapest Treaty under the name "Kazakhstania slooffiae MLU-TE-MiBi-Ks-2015/03" and under the number DSM 32274 registered.
  • the number K. slooffiae in the feces correlates positively with the concentration of volatile fatty acids (mainly to acetic, propionic, and butyric acids) and negatively with the pH.
  • volatile fatty acids are the products of enteral microbial fermentation with trophic effect on the mucosal cells in the colon and also serve as an energy source for the host.
  • the volatile fatty acids and the lower pH which is caused by the increase in volatile fatty acids, a protective effect
  • L0 has the diarrheal incidence and growth performance of weaned piglets.
  • the duration of daily supplementation was five days.
  • the control group received as placebo daily 5 ml of a saline solution by means of a syringe directly into the mouth.
  • the experimental group was administered over the 5 days 7.5 x 10 8 CFU / 5 ml (or per syringe) of the yeast Kazachstania slooffiae.
  • the feed was presented to the animals in a floury, non-pelleted form. Both groups received the same food from the day of weaning. No antibiotics, probiotic microorganisms or enzymes were added to the diet. Both the water and the feed were available ad libitum to the animals throughout the experimental period.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La levure Kazachstania slooffiae présente de façon endémique dans l'intestin des porcs est employée en tant qu'agent probiotique, prophylactique et/ou thérapeutique oral pour améliorer la santé intestinale et le microbiome gastro-intestinal, notamment chez les porcs.
PCT/DE2018/000119 2017-05-03 2018-04-27 Utilisation de la levure kazachstania slooffiae pour améliorer la santé intestinale de porcs Ceased WO2018215005A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112018002320.6T DE112018002320A5 (de) 2017-05-03 2018-04-27 Verwendung der Hefe Kazachstania slooffiae zur Verbesserung der Darmgesundheit von Schweinen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017004217.9 2017-05-03
DE102017004217.9A DE102017004217A1 (de) 2016-05-04 2017-05-03 Verwendung der Hefe Kazachstania sloofiae zur Verbesserung der Darmgesundheit von Schweinen

Publications (1)

Publication Number Publication Date
WO2018215005A1 true WO2018215005A1 (fr) 2018-11-29

Family

ID=63014287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2018/000119 Ceased WO2018215005A1 (fr) 2017-05-03 2018-04-27 Utilisation de la levure kazachstania slooffiae pour améliorer la santé intestinale de porcs

Country Status (2)

Country Link
DE (1) DE112018002320A5 (fr)
WO (1) WO2018215005A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113273649A (zh) * 2021-06-30 2021-08-20 北京局气网络技术有限公司 一种改善猪肠道菌群结构的添加剂及其制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SERVIN AL.: "Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens", FEMS MICROBIOL REV, vol. 28, 2004, pages 405 - 40, XP004564881
URUBSCHUROV V; JANCZYK P; PIEPER R ET AL.: "Biological diversity of yeasts in the gastrointestinal tract of weaned piglets kept under different farm conditions", FEMS YEAST RES, vol. 8, 2008, pages 1349 - 1356
URUBSCHUROV V; JANCZYK P; SOUFFRANT WB; FREYER G; ZEYNER A: "Establishment of intestinal microbiota with focus on yeasts of unweaned and weaned piglets kept under different farm conditions", FEMS MICROBIOL ECOL, vol. 77, 2011, pages 493 - 502
VLADIMIR URUBSCHUROV ET AL: "New insights into the role of the porcine intestinal yeast, Kazachstania slooffiae , in intestinal environment of weaned piglets", FEMS MICROBIOLOGY ECOLOGY, vol. 93, no. 2, 8 December 2016 (2016-12-08), pages fiw245, XP055513539, DOI: 10.1093/femsec/fiw245 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113273649A (zh) * 2021-06-30 2021-08-20 北京局气网络技术有限公司 一种改善猪肠道菌群结构的添加剂及其制备方法

Also Published As

Publication number Publication date
DE112018002320A5 (de) 2020-02-13

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