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WO2024156461A1 - Dispositif d'évaporation d'un agent de stérilisation liquide et procédé de nettoyage du dispositif - Google Patents

Dispositif d'évaporation d'un agent de stérilisation liquide et procédé de nettoyage du dispositif Download PDF

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Publication number
WO2024156461A1
WO2024156461A1 PCT/EP2023/087832 EP2023087832W WO2024156461A1 WO 2024156461 A1 WO2024156461 A1 WO 2024156461A1 EP 2023087832 W EP2023087832 W EP 2023087832W WO 2024156461 A1 WO2024156461 A1 WO 2024156461A1
Authority
WO
WIPO (PCT)
Prior art keywords
evaporator
supply line
cleaning
sterilizing agent
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2023/087832
Other languages
German (de)
English (en)
Inventor
Martin Gerhards
Thomas Herold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KHS GmbH
Original Assignee
KHS GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KHS GmbH filed Critical KHS GmbH
Publication of WO2024156461A1 publication Critical patent/WO2024156461A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/208—Hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/24—Apparatus using programmed or automatic operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01B—BOILING; BOILING APPARATUS ; EVAPORATION; EVAPORATION APPARATUS
    • B01B1/00—Boiling; Boiling apparatus for physical or chemical purposes ; Evaporation in general
    • B01B1/005—Evaporation for physical or chemical purposes; Evaporation apparatus therefor, e.g. evaporation of liquids for gas phase reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
    • B08B9/0328—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid by purging the pipe with a gas or a mixture of gas and liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/11—Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/23—Containers, e.g. vials, bottles, syringes, mail

Definitions

  • the invention relates to a device for evaporating a liquid sterilizing agent according to the preamble of claim 1.
  • the invention further relates to a method for cleaning such a device according to the preamble of claim 9 and a container treatment system according to claim 14.
  • Container treatment systems such as container manufacturing machines and/or container filling machines, are complex process systems that are used, for example, for the production and/or filling of PET bottles or the like.
  • a container treatment machine The basic structure of a container treatment machine is described, for example, in DE 42 12 583 25 A1.
  • Hydrogen peroxide in an aqueous solution is usually used in container treatment machines to sterilize the containers or their preforms or machine elements.
  • the aqueous solution is first placed in an evaporator and converted into a gaseous state.
  • the hydrogen peroxide-containing gas thus produced is then made available for a sterilization process in which in which the gas is applied by means of one or more nozzles to the inside and/or outside of the containers or their preforms or to the machine elements, for example by spraying or the like.
  • the aqueous solution is usually provided with additives or stabilizers.
  • additives or stabilizers can fail for a variety of reasons during the evaporation process, during forwarding and also during sterilization and lead to deposits within the evaporator and/or the container treatment system. These deposits are usually salts. In particular, the deposits can clog the evaporator and/or the downstream lines and nozzles or even get into the containers or preforms.
  • the relevant components of the evaporation device, and possibly also the lines or equipment of a container treatment plant supplied by the evaporation device, must be serviced at regular intervals.
  • the relevant components are removed, cleaned and then reinstalled. This can sometimes be very time-consuming and lead to long downtimes for the evaporation device and/or the container treatment plant, i.e. times when the container treatment plant is idle and cannot be used for the production and/or filling of containers.
  • the maintenance also incurs corresponding personnel costs.
  • the object of the present invention is therefore to address at least one of the above-mentioned problems.
  • devices and methods are to be provided which enable a low-maintenance supply of container treatment systems with a sterilization fluid.
  • the device for evaporating a liquid sterilizing agent according to claim 1.
  • the device is particularly designed to be able to feed both a liquid sterilizing agent and a cleaning fluid into the evaporator and has corresponding supply lines for this purpose.
  • a container treatment plant is understood here to mean, in particular, process plants that are designed to produce and/or fill containers.
  • An example of a container treatment system is a so-called blow molding machine, which produces containers from preforms made of a thermoplastic using a blow molding process, preferably a stretch blow molding machine, in which the forming takes place using a stretch rod.
  • This also includes forming machines in which the preform is formed into the container and the container is filled simultaneously by using the filling material as a forming fluid, in particular also using a stretch rod.
  • This also includes filling machines in which finished containers are filled with a filling material.
  • sealers that seal filled containers, e.g. sealing containers with caps or screw caps.
  • the device proposed here for evaporating a liquid sterilizing agent is in particular designed to be connected to such a container treatment system in a fluid-conducting manner, for example via corresponding lines.
  • the device for evaporating the liquid sterilizing agent has at least one evaporator and two supply lines, wherein the two supply lines are connected to the evaporator in a fluid-conducting manner, in particular in order to supply the evaporator with a sterilizing agent and with a cleaning fluid.
  • One of the supply lines is designed to supply a liquid sterilizing agent and the other supply line is designed to supply a cleaning fluid.
  • the supply line for the liquid sterilizing agent can also be referred to as the sterilizing agent supply line.
  • the sterilizing agent supply line is preferably designed to be fluid-tight with respect to the liquid sterilizing agent and/or is connected to the evaporator in a fluid-conducting manner, for example via a supply line section, in particular in such a way that the liquid sterilizing agent reaches the evaporator and can be evaporated there.
  • the sterilizing agent can be any agent that is suitable for sterilizing a container treatment system and/or workpieces processed therein.
  • the sterilizing agent preferably has a liquid state under standard conditions, i.e. at a temperature of 0°C and a pressure of 1.01325 bar and/or under laboratory conditions, i.e. at a temperature of 20°C and a pressure of 1.01325 bar.
  • the sterilizing agent is therefore in particular a liquid sterilizing agent, such as an aqueous solution with hydrogen peroxide (H2O2).
  • the evaporator is essentially made up of a container and a heating element.
  • the term container describes the property of the evaporator to store a quantity of of fluid to be evaporated, that is to say to provide a free volume for receiving this fluid, e.g. in the form of channels or also in the form of a pot.
  • the heating element is preferably arranged inside the evaporator or container and/or is designed to heat and/or warm and/or evaporate gaseous and/or liquid fluids inside the container.
  • the evaporator is preferably designed to evaporate a liquid sterilizing agent and/or heat a liquid cleaning fluid.
  • the heating element is therefore designed to heat the interior of the container and/or wall areas of the container to a temperature of 100 °C or more, in particular to a temperature which is above the boiling point of the liquid sterilizing agent, in particular above, for example, 120 °C or 130 °C or 150 °C or more.
  • evaporator can be designed, for example, as an aluminum cylinder in which a flow channel in the form of a spiral is milled, whereby a desired residence time of the fluid flowing through the channel is achieved.
  • On the top of the aluminum cylinder there can be holes for heating rods as heating elements and a temperature sensor. Materials other than aluminum are possible, but are considered less advantageous.
  • the evaporator could essentially also be designed as a pot with an internal heating plate in which the fluid to be subjected to heating energy flows through an opening onto a hot surface of the heating plate, is heated on this surface and exits through a second opening.
  • the evaporator could also be designed as a tube, the wall of which is heated and the fluid flowing through is heated by contact with the wall.
  • the sterilizing agent is preferably fed into the evaporator in atomized form.
  • the vaporizer is designed such that the sterilization fluid and/or the cleaning fluid flow through the vaporizer, wherein these fluids are heated during the flow.
  • the evaporation device preferably has a supply line section for supplying the evaporator with the sterilizing agent and/or the cleaning fluid, and which is arranged in particular in an upper region of the evaporator and/or is fluidly connected to the sterilizing agent and/or the cleaning agent supply line.
  • the evaporator further comprises a line which is arranged in particular in a lower region of the evaporator and/or is intended for is designed to be connected to a line and/or a nozzle of a container treatment plant.
  • "Below" means located vertically underneath.
  • the device also has a supply line for a cleaning agent.
  • the supply line is preferably designed to transport and/or hold a liquid cleaning agent.
  • the supply line is therefore designed to be fluid-tight, in particular with respect to the liquid cleaning agent.
  • the supply line can also be referred to as a cleaning agent supply line.
  • the cleaning agent supply line is preferably designed to be fluid-tight and is connected to the supply line section in a fluid-conducting manner.
  • the cleaning fluid can be any liquid and/or gaseous agent that is suitable for cleaning an evaporator and/or its inlet and outlet lines and/or lines and/or nozzles of a container treatment system, such as water, water with additives, distilled water, mild acids or the like. Since salts usually have to be removed, the cleaning fluid has particularly good salt-dissolving properties.
  • the cleaning fluid preferably has a liquid state under standard conditions, i.e. at a temperature of 0°C and a pressure of 1.01325 bar and/or under laboratory conditions, i.e. at a temperature of 20°C and a pressure of 1.01325 bar.
  • the cleaning fluid is therefore in particular a liquid cleaning agent, such as a weak acid, so as not to attack the material of the evaporator, e.g. aluminum.
  • Citric acid or a solution with citric acid is a preferred cleaning fluid.
  • the cleaning fluid is preferably free of hydrogen peroxide and/or different from the liquid sterilizing agent.
  • the cleaning fluid is preferably warmed or heated in the evaporator, but in particular not evaporated. The cleaning fluid therefore leaves the evaporator in liquid form and is then fed into the lines of the container treatment system, for example.
  • the device has a storage container for the sterilization agent and/or a storage container for the cleaning fluid.
  • these media could also be provided by external supply devices.
  • a device for evaporating a liquid sterilizing agent for container treatment systems which is also designed to feed a cleaning fluid into the evaporator and to heat it.
  • This can be achieved, for example, by the cleaning agent supply line opening into the sterilizing agent supply line and/or into a supply line section of the evaporator into which the sterilizing agent supply line also opens.
  • the cleaning agent supply line is therefore, Just like the sterilizing agent supply line, from a process engineering point of view it is arranged in front of the evaporator so that the cleaning fluid flows through the evaporator.
  • part of the supply line used for the sterilizing agent supply line is also cleaned.
  • the advantage of the cleaning fluid is that it is not fed into the evaporator in an atomized form.
  • the advantage of the described solution is in particular that the device is designed to evaporate a sterilizing agent and also has a self-cleaning function, in particular for additives that have precipitated from the sterilizing agent, e.g. salts.
  • the proposed cleaning agent supply line makes it possible in particular to clean both the evaporator and the lines and/or the nozzles of the container treatment system at regular maintenance intervals, thereby increasing the availability of the container treatment system.
  • the sterilizing agent is preferably an aqueous solution comprising hydrogen peroxide (H2O2).
  • the aqueous solution preferably also contains additives and/or stabilizers that limit the catalytic decomposition of the hydrogen peroxide, particularly when the hydrogen peroxide is converted into a gaseous state within the evaporator by heating.
  • the aqueous solution preferably contains at least 3 percent by mass, more preferably at least 10 percent by mass, more preferably at least 25 percent by mass, particularly between 30 and 35 percent by mass, of hydrogen peroxide.
  • the sterilizing agent is preferably, for example, a 35 percent aqueous hydrogen peroxide solution.
  • the cleaning fluid is preferably an acid, especially a weak acid.
  • a weak acid is understood to be an acid that is not completely dissociated.
  • a weak acid has the advantage that salts are dissolved well, but the materials being rinsed through are treated gently.
  • the cleaning fluid comprises an aqueous solution with citric acid (CeHsO?) and/or is citric acid.
  • the cleaning fluid is free of hydrogen peroxide and/or different from the liquid sterilizing agent.
  • the evaporator is temperature-controlled.
  • the evaporator has, for example, a heating element and/or a temperature sensor, which are preferably arranged inside the evaporator.
  • the heating element and the temperature temperature sensor generates a control loop, in particular to adjust the temperature inside the evaporator.
  • the heating element can be formed for this purpose, for example, from one or more heating rods, heating plates, heating coils or similar heating devices.
  • the device also has a supply line for a carrier medium or carrier fluid.
  • the supply line is preferably designed to transport and/or hold a gaseous carrier medium.
  • the supply line is therefore designed to be fluid-tight, in particular with respect to the gaseous carrier medium.
  • This supply line can also be referred to as a carrier medium supply line.
  • a typical carrier fluid is, for example, air, in particular sterile air.
  • the carrier medium supply line is preferably designed to be fluid-tight and in particular is connected in a fluid-conducting manner to the supply line section of the evaporator, in particular such that the carrier fluid flows through the evaporator.
  • the carrier fluid can be any liquid and/or gaseous medium that is suitable for guiding the sterilizing fluid and/or cleaning fluid described herein and/or the rinsing fluid described herein through the evaporator and/or its supply and discharge lines and/or the lines and/or the nozzles of the container treatment system.
  • the cleaning fluid and/or the rinsing fluid are not mixed with the carrier fluid.
  • the carrier fluid is used, for example, to atomize the sterilizing fluid before the evaporator in order to supply the sterilizing fluid in atomized form to the evaporator.
  • the carrier fluid preferably has a gaseous state under standard conditions, i.e.
  • the carrier fluid is therefore in particular a gaseous carrier medium, such as air, in particular sterile air, which is in particular pressurized with a pressure of, for example, 1 to 2 bar or more, in order to guide the sterilizing fluid described here through the evaporator and/or the lines and/or the nozzles of the container treatment system.
  • the carrier fluid is preferably free of hydrogen peroxide and/or the cleaning fluid and/or the liquid sterilizing agent. It is also conceivable that the carrier fluid is also used at least partially as a rinsing fluid.
  • the device further comprises a supply line for a rinsing agent or a rinsing fluid.
  • the supply line is preferably designed to transport and/or hold a liquid rinsing agent.
  • the supply line is therefore designed to be fluid-tight, in particular with respect to the liquid rinsing agent.
  • This supply line can also be referred to as a rinsing agent supply line.
  • the rinsing agent supply line is designed to be fluid-tight and in particular fluid-conductingly connected to the supply line section of the evaporator, in particular such that the flushing fluid flows through the evaporator.
  • the flushing fluid can be any liquid and/or gaseous medium that is suitable for flushing the evaporator and/or its inlet and outlet lines and/or the lines and/or the nozzles of the container treatment system.
  • the flushing fluid preferably has a liquid state and/or a solid state under standard conditions, i.e. at a temperature of 0°C and a pressure of 1.01325 bar and/or under laboratory conditions, i.e. at a temperature of 20°C and a pressure of 1.01325 bar.
  • the flushing fluid is therefore in particular a liquid flushing agent, such as water, which is in particular pressurized with a pressure of, for example, 1 to 2 bar in order to flush the evaporator and/or its inlet and outlet lines and/or the lines and/or the nozzles of the container treatment system.
  • a liquid flushing agent such as water
  • the rinsing fluid is free of hydrogen peroxide and/or the carrier fluid and/or the cleaning fluid and/or the liquid sterilizing agent.
  • the device further comprises a common feed point, in which the cleaning agent supply line and/or the carrier agent supply line and/or the rinsing agent supply line open into the supply line section, in particular so that the cleaning fluid and/or carrier fluid and/or rinsing fluid flows through the supply line section and is thereby treated.
  • the common feed point is connected to the supply line section in a fluid-conducting manner, in particular so that the liquid sterilizing agent and/or the cleaning fluid and/or the carrier fluid and/or the rinsing fluid flows through the supply line section at least in sections.
  • the device further comprises a controllable valve arranged in the sterilizing agent supply line for adjusting a volume flow.
  • a controllable shut-off valve can also be provided, preferably downstream of the valve adjusting the volume flow.
  • the volume flow can also be adjusted, for example, via a pump that conveys the sterilizing agent, e.g. via its speed.
  • the device further comprises a controllable valve arranged in the cleaning agent supply line for adjusting a volume flow.
  • a controllable shut-off valve can additionally be provided, preferably downstream of the valve adjusting the volume flow.
  • the device further comprises a controllable valve arranged in the carrier medium supply line for adjusting a volume flow.
  • a controllable shut-off valve can additionally be provided, preferably downstream of the valve adjusting the volume flow.
  • the device further comprises a controllable valve arranged in the detergent supply line for adjusting a volume flow.
  • a controllable shut-off valve can additionally be provided, preferably downstream of the valve adjusting the volume flow.
  • valves for setting a volume flow can be designed as pressure reducing valves, for example. This means that a pre-pressure is set manually, for example, and in conjunction with the pipe or nozzle cross-section, a volume flow is produced.
  • controllable valves in the sterilization agent supply line and/or the cleaning agent supply line and/or the carrier agent supply line and/or the rinsing agent supply line are connected to a control unit, in particular a control unit as described below.
  • the controllable valves mentioned are the above-mentioned shut-off valves and/or the valves for adjusting a volume flow.
  • control unit is designed to control the valves in the sterilization agent supply line and/or the cleaning agent supply line and/or the carrier agent supply line and/or the rinsing agent supply line and/or to communicate with a control unit of the container treatment system, for example via a bus system, or alternatively wirelessly.
  • the control unit of the container treatment system can also be referred to as a container treatment system control unit.
  • the device for evaporating a liquid sterilizing agent thus comprises in particular a control unit which is designed to control the individual volume flows within the various supply lines and/or their blocking state, in particular by means of controllable valves which are arranged within the supply lines.
  • This control relates to opening and closing corresponding valves at desired times and for desired periods of time and/or to controlling the volume flows.
  • the control unit is designed to carry out a method described below for cleaning a device for evaporating a liquid sterilizing agent and/or a sterilization process and/or a cleaning process.
  • the device further comprises a line from the evaporator to the container treatment system, which is designed to guide the sterilizing agent and/or the cleaning fluid and/or the carrier fluid and/or the rinsing fluid to the container treatment system.
  • a line from the evaporator to the container treatment system which is designed to guide the sterilizing agent and/or the cleaning fluid and/or the carrier fluid and/or the rinsing fluid to the container treatment system.
  • the evaporator is therefore connected in particular via a line to the container treatment system or the corresponding components in a fluid-conducting manner, such as lines and/or nozzles of the container treatment system.
  • the stated object can also be achieved with a cleaning method with the features of claim 9.
  • the method is preferably carried out with a device for evaporating a liquid sterilizing agent as described above and/or below.
  • the device for evaporating the liquid sterilizing agent or the container treatment system is preferably set up to carry out a sterilization method or sterilization process, in particular as described herein and/or by means of a liquid sterilizing agent, such as a hydrogen peroxide solution.
  • the sterilization method or the sterilization process can, for example, be part of a manufacturing process in which preforms are inflated and sterilized by means of the container treatment machine.
  • the liquid sterilizing agent is atomized, for example, by means of an air jet and then fed into the evaporator.
  • the liquid sterilizing agent is then heated until it evaporates, so that the sterilizing agent changes into a gaseous state.
  • the gaseous sterilizing agent is then fed via a line from the evaporator to the container treatment machine and is applied to the preforms and/or containers using a nozzle, for example.
  • the evaporator can have an operating temperature of over 100 °C, for example around 150 °C.
  • the evaporator is designed to set an operating temperature that is above the boiling point of the sterilizing agent.
  • the proposed cleaning method can therefore be used in particular for a cleaning process of an evaporation device with an evaporator, possibly also of the lines running to the container treatment system including the nozzles supplied by it.
  • the proposed method or the fluids used are preferably selected so that deposits in the evaporator and/or the lines and/or the nozzles of the container treatment system can be removed that have arisen through the sterilization process, for example due to precipitated additives from the sterilization agent, for example precipitated as salts.
  • containers are treated by the container treatment machine and the sterilization fluid is evaporated in the evaporator and fed to the container treatment machine for use, e.g. for sterilizing preforms, containers, closures, etc. and/or handling devices (pliers, mandrels, etc.) and/or system areas that come into contact with these workpieces (blowing nozzle, stretching rod, filling devices, etc.).
  • a cleaning operation that is to be distinguished from this treatment operation, i.e.
  • a second operating mode of the evaporation device and, for example, the container treatment machine supplied by it, the evaporator and, if necessary, other lines and other devices that are supplied by the evaporator are cleaned.
  • the container treatment operation is interrupted and, for example, continued after the cleaning operation has ended.
  • the evaporator is first brought from a current temperature to a corresponding operating temperature for cleaning operation. If the current temperature of the evaporator, for example 150 °C, is above the corresponding operating temperature of, for example, 95 °C, which is the case if the evaporator was previously in processing operation and, for example, supplied a container treatment machine with a sterilizing agent, the evaporator can be cooled down, for example using a rinsing agent, e.g. water or air. In other words, the evaporator is cooled from the operating temperature for providing the sterilizing fluid, e.g. 150 °C, to an operating temperature for cleaning the evaporator, e.g. below 100 °C.
  • a rinsing agent e.g. water or air.
  • the operating temperature of the evaporator is therefore at different temperatures in these two operating modes. If the current temperature of the evaporator, for example 20 °C, is below the corresponding operating temperature in cleaning operation of, for example, 95 °C, which is the case, for example, if the evaporator is started after a longer standstill, the evaporator can be cooled down, for example using the heating element. heated up.
  • the operating temperature during cleaning depends in particular on the cleaning fluid used. This operating temperature is preferably below 100 °C, in particular so that the cleaning fluid remains in a liquid state. For example, the operating temperature is between 75 °C and 95 °C.
  • the cleaning fluid e.g. citric acid or other cleaning fluids mentioned above
  • the cleaning fluid is fed to the evaporator and warmed or heated in the evaporator, in particular until the cleaning fluid has a corresponding temperature that essentially corresponds to the operating temperature of the evaporator in cleaning mode.
  • the cleaning fluid is not evaporated, so it retains its liquid state.
  • the cleaning fluid heated in this way is then fed from the evaporator, for example, into a line that is connected to the lines or nozzles of the container treatment system, in particular the lines or nozzles through which the sterilization agent previously flowed.
  • the heated cleaning fluid can be introduced into the lines at intervals and/or repeated cyclically, in particular in such a way that the evaporator and/or the lines and/or the nozzles of the container treatment system are repeatedly flowed through by heated cleaning fluid.
  • the evaporator and/or the lines and/or the nozzles of the container treatment system can also be cleaned with water.
  • the evaporator and/or the lines and/or the nozzles of the container treatment system are, for example, regularly rinsed with water and, at longer intervals, also additionally with a weak acid, such as citric acid.
  • the operating temperature of the evaporator is adjusted to the temperature of the cleaning operation by flushing the evaporator with compressed air and/or by flushing the evaporator with water and/or by alternately flushing the evaporator with compressed air and water and/or by waiting.
  • the evaporator and/or the line from the evaporator to the container treatment system is rinsed with compressed air and/or water, in particular to remove residues of the cleaning fluid from the evaporator and/or the line from the evaporator to the container treatment system. Rinsing with water is particularly preferred.
  • the evaporator is then further preferably heated again and rinsed with air, in particular sterile air, in order to dry off all cleaning agents or all water, e.g. in order to then return the evaporator to the operating state in which a sterilizing agent is evaporated and made available to a container treatment machine.
  • the above rinsing and/or the other rinsing steps are also carried out in all lines and/or nozzles of the container treatment system that have come into contact with the cleaning fluid.
  • the operating temperature of the evaporator is monitored and, if necessary, controlled or regulated during the entire process or during the entire cleaning process, in particular so that the temperature in the evaporator remains essentially constant.
  • the temperature in the evaporator can be kept constant, for example, by rinsing with water or by activating the heating elements. This preferably also applies to the post-rinsing.
  • the cleaning method is activated automatically and/or semi-automatically and/or manually.
  • the cleaning method can be activated, for example, by a specialist, in particular after a certain operating time has been reached and/or after completion of a manufacturing operation, and/or when no sterilization process is pending and/or no containers need to be manufactured and/or filled. The cleaning method is therefore carried out in particular when the container treatment plant is to be shut down.
  • the cleaning method can also be activated if contamination is detected in the evaporator and/or its supply or discharge lines and/or a line and/or a nozzle of the container treatment system. The contamination can be detected, for example, by a specialist and/or by any sensors in the lines, for example by a flow sensor, which is arranged in particular behind the evaporator.
  • the cleaning method is carried out automatically and/or repeated at regular intervals.
  • the cleaning method is carried out after the evaporation device has previously been operated in evaporation mode for evaporating the sterilizing agent, so that the evaporator is still at a high operating temperature and its thermal energy can be used for the cleaning process, or the treatment system supplied by it has been operated in a treatment mode for treating containers.
  • the cleaning method can be activated automatically or semi-automatically.
  • the control unit of the device and/or the container treatment system control unit can have a program which, in addition to a manufacturing and/or filling and/or sterilization process, also includes a cleaning process which includes a cleaning method described herein.
  • the evaporation device and the container treatment system supplied by it can be operated in two operating modes, e.g. controlled by the control units mentioned, namely in a cleaning mode in which a cleaning process can be carried out, and in a treatment mode in which the container treatment system carries out its intended treatment of containers and the evaporator evaporates the liquid sterilizing agent and supplies it to the container treatment system.
  • the container treatment plant is preferably designed as a container manufacturing and/or container filling machine, in particular as described above and/or below.
  • the container treatment system comprises at least one device described above and/or below for evaporating a liquid sterilizing agent and/or a container treatment system control unit which is designed to initiate and/or carry out a method described above and/or below and/or a nozzle which is connected to a device described above and/or below and is designed to apply the sterilizing agent to or into a workpiece, in particular a preform or a container.
  • the container treatment system preferably comprises a device for forming a preform into a container and/or a device for filling and/or closing and/or labeling a container.
  • Other devices for handling containers not mentioned above are possible.
  • a container is understood here to mean finished containers of any kind as well as preforms.
  • the container is preferably made of a thermoplastic material such as polyethylene terephthalate (PET).
  • treatment or “container treatment” is understood to include, in particular, filling, forming, closing, sterilizing, but also transporting containers.
  • Fig. 1 shows schematically and by way of example a container treatment plant, preferably a machine for blow molding containers.
  • Fig. 2 shows schematically and by way of example a container treatment plant with a device for evaporating a liquid sterilizing agent.
  • Fig. 3 shows schematically and by way of example a method for cleaning a device for evaporating a liquid sterilizing agent.
  • the basic structure of a container treatment plant 100 is explained below using a container manufacturing machine that is designed to produce a container from a preform by blow molding.
  • the basic structure of the container treatment plant 100 would remain unchanged if the forming the preforms would not be introduced into the containers by blowing air, but by simultaneous forming with simultaneous filling.
  • the structure of the device 200 for evaporating a liquid sterilizing agent described below would also remain unchanged if the container treatment system 100 were different.
  • Fig. 1 shows schematically and by way of example a container treatment system 100 which is designed as a container manufacturing machine.
  • the container manufacturing machine is preferably set up to form a container from a preform, in particular by means of a blow molding machine B which is provided with a heating device H with a circulation path 20 and with a rotating blowing wheel 25.
  • a preform input 26 the preforms 1 are transported by transfer wheels 27, 28, 29 into the heating device H and into the area of the circulation path 20.
  • the preforms 1 are transferred from a transfer wheel 29 to a transport device 33.
  • Heating devices 30 and blowers 31 are arranged along the circulation path 20 in order to control the temperature of the preforms 1.
  • the part of the circulation path 20 which runs along the heating devices 30 is referred to in the present application as the heating path 24.
  • the preforms 1 After the preforms 1 have been sufficiently tempered, they are transferred to the blowing wheel 25, in the area of which blowing stations 3 are arranged.
  • a transfer wheel 35 removes the preforms from the transport devices 33 in a removal area.
  • the finished blow-molded containers are fed to an output line 32 by further transfer wheels.
  • thermoplastic materials In order to be able to transform a preform 1 into a container in such a way that the container has material properties that ensure that the food, particularly drinks, filled into the container can be used for a long time, special process steps must be followed when heating and orienting the preforms 1. In addition, advantageous effects can be achieved by adhering to special dimensioning regulations.
  • suitable materials include PET, PEN or PP.
  • the expansion of the preform 1 during the orientation process is carried out by supplying compressed air.
  • the compressed air supply is divided into a pre-blowing phase, in which gas, for example compressed air, is supplied at a low pressure level, and a subsequent main blowing phase, in which gas is supplied at a higher pressure level.
  • gas for example compressed air
  • main blowing phase in which gas is supplied at a higher pressure level.
  • compressed air is typically supplied at a pressure in the interval from 10 bar to 25 bar is used and during the main blowing phase compressed air is supplied at a pressure in the interval from 25 bar to 40 bar.
  • the circulating path (20) is formed from a plurality of circulating transport devices 33 which are arranged in a chain-like manner and guided along deflection wheels 34.
  • the idea is to use the chain-like arrangement to create a substantially rectangular basic contour.
  • a single relatively large deflection wheel (34), the head wheel is used in the area of the extension of the circulating path 20 facing the feed wheel 29 and a removal wheel 35, and two comparatively smaller deflection wheels 36 are used in the area of adjacent deflections.
  • any other circulating path contours are also conceivable.
  • the arrangement shown proves to be particularly expedient, since three deflection wheels 34, 36 are positioned in the area of the corresponding extension of the circulation path 20, namely the smaller deflection wheels 36 in the area of the transition to the linear circulation sections of the circulation path 24 and the larger deflection wheel 34, head wheel, in the immediate transfer area to the feed wheel 29 and the removal wheel 35.
  • the chain-like connected support devices 33 rotate around the described deflection wheels 34, 36 and along the circulating path 20.
  • one of the deflection wheels eg the head wheel 34, or several of the deflection wheels can be designed to be rotationally driven, eg by a motor driving the head wheel 34, or eg by a mechanical coupling to the rotation of the blowing wheel 25, which can have a rotary drive, for example.
  • the feed wheel 29 transfers preforms 1 to support devices 33, which arrive in a feed area of the circulating path without preforms.
  • the carrying devices 33 which are now provided with a preform 1, guide the preform 1 clockwise along the circulation path 20, first in the direction of the remote deflection wheel 34, then around this deflection wheel 34 and then back in the direction of the removal wheel 35.
  • the preform 1 which has at this point undergone the heating required for forming, is removed from the carrying device 33 or transferred to the removal wheel 35 and rotated by this. continued towards the blowing wheel 25.
  • the carrying device 33 which is devoid of preforms after this removal process, now runs along the circulation path 20 from the removal area to the feed area in order to pick up a preform 1 there again.
  • the feed and removal wheels 29 and 35 shown can have, for example, tong-like feed and removal means. Since these wheels, which are collectively referred to as transfer wheels, are not important for the present invention, no further description is required.
  • the blowing wheel 25 also does not require a detailed description for the same reason.
  • These wheels can be designed in a wide variety of ways, as is known in the prior art.
  • the containers After the containers have been blown, they are guided out of the area of the blowing stations 3 by a removal wheel 37 and transported to the output line 32 via the transfer wheel 28 and an output wheel 38.
  • the heating section 24 shown in Figure 1 can be modified, for example, by providing a larger number of heating devices 30 in order to be able to temper a larger number of preforms 1 per unit of time.
  • the heating devices 30 described above are designed as heating boxes in which NIR radiators are arranged. This is to be understood as merely an example of usable heating devices.
  • a large number of designs are known in the prior art that serve to condition the temperature of preforms and can therefore be referred to as heating devices.
  • Heating methods other than irradiation with IR or NIR radiation are also known in the prior art, e.g. heating the preforms by microwave irradiation.
  • the invention is independent of the specific appearance of the heating devices 30 and also of the specific appearance of the heating section 24 and the circulation section 20.
  • FIG. 2 shows schematically and by way of example a container treatment plant 100, as shown for example in Figure 1, with a device 200 for evaporating a liquid sterilizing agent.
  • the device 200 for evaporating a liquid sterilizing agent comprises a sterilizing agent supply line 210, an evaporator 220, a cleaning agent supply line 230, a carrier agent supply line 240, a rinsing agent supply line 250, a common feed point 260, a control unit 270 and a line 280 which is connected to the container treatment system 100, and in particular to a nozzle 180 of the container treatment system 100.
  • the sterilizing agent supply line 210 is connected to the evaporator 220 via a supply line section 221, in particular in order to introduce an aqueous solution with hydrogen peroxide into the evaporator 220.
  • the sterilizing agent supply line 210 has a controllable valve 212 which is connected to the control unit 270. This can be a shut-off valve, for example.
  • the cleaning agent supply line 230, the carrier agent supply line 240 and the rinsing agent supply line 250 open into a common feed point 260, which is connected to the supply line section 221 of the evaporator 220.
  • the cleaning agent supply line 230, the carrier agent supply line 240 and the rinsing agent supply line 250 also each have a controllable valve 232, 242, 252, which are also connected to the control unit 270.
  • the cleaning agent supply line 230 and/or the carrier agent supply line 240 can have further safety-relevant components 234, 244, such as a ball check valve.
  • the evaporator 220 has a temperature sensor 224 and corresponding heating elements 226, for example and purely by way of example in the form of three heating rods, which are arranged at least in sections in the container 222 of the evaporator 220.
  • the temperature sensor 224 is used to control the temperature and a corresponding temperature or operating temperature can be set in the evaporator 220.
  • the device 200 for evaporating a liquid sterilizing agent is preferably controlled by means of the control unit 270, for example as shown in Fig. 3.
  • the control unit 270 is preferably designed to carry out at least one sterilization process and/or one cleaning process, in particular as described herein.
  • the device 200 for evaporating a liquid sterilizing agent can be controlled in a sterilization operation and in a cleaning operation by the control unit 270.
  • an aqueous solution with hydrogen peroxide is fed into the evaporator 220 via the sterilizing agent feed line 210.
  • the aqueous solution can be atomized beforehand in a manner not shown.
  • the aqueous solution is superheated, converted into a gaseous state and transferred to the container treatment system 100 via the line 280, in particular in such a way that the hydrogen peroxide can be applied in and/or onto the containers and/or preforms, for example by means of a nozzle arranged at the end of the feed line 280.
  • the evaporator 270 or the line 280 and thus also the downstream lines and the nozzle of the container treatment system 100 are cleaned, for example with citric acid or another suitable cleaning fluid from the cleaning agent supply line 230.
  • the cleaning process can also include rinsing the evaporator, the lines and nozzles with water and/or compressed air.
  • control unit 270 of the device 200 is connected to the container treatment plant control unit 170, for example via a common bus system. Appropriate communication between the control unit 170, 270 ensures that the cleaning process is only carried out when the container treatment plant is not in production or treatment mode.
  • Fig. 3 shows schematically and by way of example a method 300 for cleaning a device 200 for evaporating a liquid sterilizing agent, in particular as shown in Fig. 2.
  • the cleaning or the cleaning process preferably takes place following a sterilization process of a container or a preform of the container treatment system 100.
  • a first step 310 the agents or fluids required for the cleaning method described herein are provided, such as citric acid, water and (compressed) air.
  • a sterilization process can be carried out in a next step 320.
  • an aqueous solution of hydrogen peroxide can first be atomized and added to the evaporator.
  • the aqueous solution is then converted into a gaseous state by superheating and transferred to the container treatment system 100 and applied to the containers or preforms.
  • an operating temperature is first set in the evaporator in a step 330, which is preferably below the boiling temperature of the cleaning fluid. This can be done, for example, by flushing 335 the evaporator and/or by waiting 336.
  • the cleaning fluid is first introduced into the evaporator and from there into the downstream lines and nozzles.
  • the cleaning fluid is first fed to the evaporator, then heated by the evaporator, in particular to operating temperature, and fed into a line from the evaporator to the container treatment system.
  • rinsing can be carried out, for example with compressed air and/or water, in particular in such a way that no cleaning fluid, e.g. no citric acid, is present in the evaporator and/or in the lines and/or the nozzles.
  • no cleaning fluid e.g. no citric acid
  • the temperature in the evaporator can be monitored and, if necessary, adjusted during the entire cleaning process, e.g. even during rinsing.
  • a sterilization process can be carried out again using the device or container treatment system.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne un dispositif (200) pour évaporer un agent de stérilisation liquide, en particulier pour un système de traitement de récipient (100), de préférence pour une machine de production de récipient et/ou de remplissage de récipient, le dispositif comprenant : une conduite d'alimentation en agent de stérilisation (210) pour introduire l'agent de stérilisation liquide dans un évaporateur ; et un évaporateur (220) qui est relié à la conduite d'alimentation en agent de stérilisation (210) par l'intermédiaire d'une partie de conduite d'alimentation (221) et est conçu pour transformer l'agent de stérilisation liquide en un état d'agrégat gazeux et ensuite l'alimenter dans un système de traitement de récipient. Le dispositif comprend également une conduite d'alimentation en agent de nettoyage (230) pour introduire un fluide de nettoyage dans l'évaporateur (220), en particulier par l'intermédiaire de la partie de conduite d'alimentation (221).
PCT/EP2023/087832 2023-01-26 2023-12-27 Dispositif d'évaporation d'un agent de stérilisation liquide et procédé de nettoyage du dispositif Pending WO2024156461A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102023101887.6A DE102023101887A1 (de) 2023-01-26 2023-01-26 Vorrichtung zum Verdampfen eines flüssigen Sterilisationsmittels sowie Verfahren zum Reinigen der Vorrichtung
DE102023101887.6 2023-01-26

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WO2024156461A1 true WO2024156461A1 (fr) 2024-08-02

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170197352A1 (en) * 2014-07-13 2017-07-13 Khs Corpoplast Gmbh Method and blow-molding machine for the blow-molding production of containers that are sterile at least in certain regions
US20200046867A1 (en) * 2017-02-20 2020-02-13 Dai Nippon Printing Co., Ltd. Gasifier for sterilizer and cleaning method of gasifier for sterilizer
JP2022189349A (ja) * 2021-06-11 2022-12-22 大日本印刷株式会社 殺菌剤のガス化装置及び殺菌剤のガス化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6760343B2 (ja) 2018-08-31 2020-09-23 大日本印刷株式会社 無菌充填機及びその浄化方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170197352A1 (en) * 2014-07-13 2017-07-13 Khs Corpoplast Gmbh Method and blow-molding machine for the blow-molding production of containers that are sterile at least in certain regions
US20200046867A1 (en) * 2017-02-20 2020-02-13 Dai Nippon Printing Co., Ltd. Gasifier for sterilizer and cleaning method of gasifier for sterilizer
JP2022189349A (ja) * 2021-06-11 2022-12-22 大日本印刷株式会社 殺菌剤のガス化装置及び殺菌剤のガス化方法

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